PubMed:9028321
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 287-292 | gene:355 | denotes | Apo-1 |
| T1 | 444-483 | disease:C1328840 | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 287-292 | gene:355 | denotes | Apo-1 |
| T3 | 485-489 | disease:C1328840 | denotes | ALPS |
| T4 | 544-547 | gene:355 | denotes | Fas |
| T5 | 444-483 | disease:C1328840 | denotes | autoimmune lymphoproliferative syndrome |
| T6 | 544-547 | gene:2194 | denotes | Fas |
| T7 | 444-483 | disease:C1328840 | denotes | autoimmune lymphoproliferative syndrome |
| T8 | 544-547 | gene:355 | denotes | Fas |
| T9 | 485-489 | disease:C1328840 | denotes | ALPS |
| T10 | 544-547 | gene:2194 | denotes | Fas |
| T11 | 485-489 | disease:C1328840 | denotes | ALPS |
| R1 | T0 | T1 | associated_with | Apo-1,autoimmune lymphoproliferative syndrome |
| R2 | T2 | T3 | associated_with | Apo-1,ALPS |
| R3 | T4 | T5 | associated_with | Fas,autoimmune lymphoproliferative syndrome |
| R4 | T6 | T7 | associated_with | Fas,autoimmune lymphoproliferative syndrome |
| R5 | T8 | T9 | associated_with | Fas,ALPS |
| R6 | T10 | T11 | associated_with | Fas,ALPS |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 9028321-0#26#29#gene355 | 26-29 | gene355 | denotes | Fas |
| 9028321-0#48#87#diseaseC1328840 | 48-87 | diseaseC1328840 | denotes | autoimmune lymphoproliferative syndrome |
| 26#29#gene35548#87#diseaseC1328840 | 9028321-0#26#29#gene355 | 9028321-0#48#87#diseaseC1328840 | associated_with | Fas,autoimmune lymphoproliferative syndrome |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 1169-1174 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T2 | 264-277 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-128 | Sentence | denotes | Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. |
| TextSentencer_T2 | 129-278 | Sentence | denotes | Programmed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system. |
| TextSentencer_T3 | 279-553 | Sentence | denotes | The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene. |
| TextSentencer_T4 | 554-730 | Sentence | denotes | We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis. |
| TextSentencer_T5 | 731-875 | Sentence | denotes | The children share common clinical features including splenomegaly and lymphadenopathy, but only one developed severe autoimmune manifestations. |
| TextSentencer_T6 | 876-1267 | Sentence | denotes | In all three siblings, we demonstrated the presence of anergic CD3+CD4-CD8- (double negative, [DN]) T cells; moreover, a chronic lymphocyte activation was found, as demonstrated by the presence of high levels of HLA-DR expression on peripheral CD3+ cells and by the presence of high levels of serum activation markers such as soluble interleukin-2 receptor (slL-2R) and soluble CD30 (sCD30). |
| T1 | 0-128 | Sentence | denotes | Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. |
| T2 | 129-278 | Sentence | denotes | Programmed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system. |
| T3 | 279-553 | Sentence | denotes | The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene. |
| T4 | 554-730 | Sentence | denotes | We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis. |
| T5 | 731-875 | Sentence | denotes | The children share common clinical features including splenomegaly and lymphadenopathy, but only one developed severe autoimmune manifestations. |
| T6 | 876-1267 | Sentence | denotes | In all three siblings, we demonstrated the presence of anergic CD3+CD4-CD8- (double negative, [DN]) T cells; moreover, a chronic lymphocyte activation was found, as demonstrated by the presence of high levels of HLA-DR expression on peripheral CD3+ cells and by the presence of high levels of serum activation markers such as soluble interleukin-2 receptor (slL-2R) and soluble CD30 (sCD30). |
PubCasesHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| AB1 | 785-797 | HP:0001744 | denotes | splenomegaly |
| AB2 | 802-817 | HP:0002716 | denotes | lymphadenopathy |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 264-277 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| PD-UBERON-AE-B_T2 | 1169-1174 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PubCasesORDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TI1 | 48-87 | ORDO:3261 | denotes | autoimmune lymphoproliferative syndrome |
| AB1 | 444-483 | ORDO:3261 | denotes | autoimmune lymphoproliferative syndrome |
| AB2 | 485-489 | ORDO:3261 | denotes | ALPS |
| AB3 | 586-590 | ORDO:3261 | denotes | ALPS |
NCBIDiseaseCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease:D056735 | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease:D056735 | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease:D056735 | denotes | ALPS |
| T4 | 586-590 | SpecificDisease:D056735 | denotes | ALPS |
| T5 | 785-797 | DiseaseClass:D013163 | denotes | splenomegaly |
| T6 | 802-817 | DiseaseClass:D008206 | denotes | lymphadenopathy |
| T7 | 849-874 | DiseaseClass:D001327 | denotes | autoimmune manifestations |
ncbi-valid-gpt-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-490 | CompositeMention | denotes | autoimmune lymphoproliferative syndrome (ALPS) |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
| T7 | 842-848 | Modifier | denotes | severe |
| T8 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
ncbi-valid-gpt-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
ncbi-valid-gpt-nr-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
ncbi-valid
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | DiseaseClass | denotes | splenomegaly |
| T6 | 802-817 | DiseaseClass | denotes | lymphadenopathy |
| T7 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
ncbi-valid-gemini-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | DiseaseClass | denotes | splenomegaly |
| T6 | 802-817 | DiseaseClass | denotes | lymphadenopathy |
ncbi-valid-gpt-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 586-590 | SpecificDisease | denotes | ALPS |
| T6 | 785-817 | CompositeMention | denotes | splenomegaly and lymphadenopathy |
| T7 | 842-848 | Modifier | denotes | severe |
| T8 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
| T9 | 997-1004 | Modifier | denotes | chronic |
ncbi-valid-gemini-nr-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
| T7 | 842-874 | DiseaseClass | denotes | severe autoimmune manifestations |
ncbi-valid-gemini-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | SpecificDisease | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 842-874 | DiseaseClass | denotes | severe autoimmune manifestations |
| T6 | 976-983 | DiseaseClass | denotes | T cells |
ncbi-valid-deepseek-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-18 | Modifier | denotes | Missense mutations |
| T2 | 26-34 | CompositeMention | denotes | Fas gene |
| T3 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 155-164 | DiseaseClass | denotes | apoptosis |
| T5 | 283-301 | CompositeMention | denotes | Fas/Apo-1 receptor |
| T6 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T7 | 397-413 | CompositeMention | denotes | MRL-lpr/lpr mice |
| T8 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T9 | 485-489 | SpecificDisease | denotes | ALPS |
| T10 | 544-552 | CompositeMention | denotes | Fas gene |
| T11 | 643-661 | Modifier | denotes | missense mutations |
| T12 | 720-729 | DiseaseClass | denotes | apoptosis |
| T13 | 785-797 | DiseaseClass | denotes | splenomegaly |
| T14 | 802-817 | DiseaseClass | denotes | lymphadenopathy |
| T15 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
| T16 | 931-942 | CompositeMention | denotes | anergic CD3 |
| T17 | 942-946 | CompositeMention | denotes | +CD4 |
| T18 | 946-950 | CompositeMention | denotes | -CD8 |
| T19 | 950-968 | CompositeMention | denotes | - (double negative |
| T20 | 976-983 | CompositeMention | denotes | T cells |
| T21 | 997-1026 | DiseaseClass | denotes | chronic lymphocyte activation |
| T22 | 1088-1094 | CompositeMention | denotes | HLA-DR |
| T23 | 1120-1123 | CompositeMention | denotes | CD3 |
| T24 | 1202-1232 | CompositeMention | denotes | soluble interleukin-2 receptor |
| T25 | 1234-1240 | CompositeMention | denotes | slL-2R |
| T26 | 1246-1258 | CompositeMention | denotes | soluble CD30 |
| T27 | 1260-1265 | CompositeMention | denotes | sCD30 |
ncbi-valid-deepseek-nr-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
ncbi-valid-deepseek-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
ncbi-valid-deepseek-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T5 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
| T6 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
ncbi-valid-gemini-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | SpecificDisease | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
| T7 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
ncbi-valid-gemini-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
ncbi-valid-gpt-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | DiseaseClass | denotes | splenomegaly |
| T6 | 802-817 | DiseaseClass | denotes | lymphadenopathy |
ncbi-valid-deepseek-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T3 | 485-489 | SpecificDisease | denotes | ALPS |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
NCBI-Disease-Develop
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T417 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome | D056735 |
| T418 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome | D056735 |
| T419 | 485-489 | SpecificDisease | denotes | ALPS | D056735 |
| T420 | 586-590 | SpecificDisease | denotes | ALPS | D056735 |
| T421 | 785-797 | DiseaseClass | denotes | splenomegaly | D013163 |
| T422 | 802-817 | DiseaseClass | denotes | lymphadenopathy | D008206 |
| T423 | 849-874 | DiseaseClass | denotes | autoimmune manifestations | D001327 |
NCBI-Disease-Corpus-All
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T417 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome | D056735 |
| T418 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome | D056735 |
| T419 | 485-489 | SpecificDisease | denotes | ALPS | D056735 |
| T420 | 586-590 | SpecificDisease | denotes | ALPS | D056735 |
| T421 | 785-797 | DiseaseClass | denotes | splenomegaly | D013163 |
| T422 | 802-817 | DiseaseClass | denotes | lymphadenopathy | D008206 |
| T423 | 849-874 | DiseaseClass | denotes | autoimmune manifestations | D001327 |
NCBI-Disease-Corpus-2stage-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | SpecificDisease | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 485-489 | SpecificDisease | denotes | ALPS |
| T5 | 586-590 | SpecificDisease | denotes | ALPS |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
NCBI-Disease-Corpus-rezarta-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T3 | 444-483 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T4 | 586-590 | SpecificDisease | denotes | ALPS |
| T5 | 785-797 | SpecificDisease | denotes | splenomegaly |
| T6 | 802-817 | SpecificDisease | denotes | lymphadenopathy |
| T7 | 849-874 | DiseaseClass | denotes | autoimmune manifestations |
NCBI-Disease-Corpus-4oGuideline-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 444-490 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome (ALPS) |
| T3 | 586-590 | SpecificDisease | denotes | ALPS |
NCBI-Disease-Corpus-Simple-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-87 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome |
| T2 | 155-164 | DiseaseClass | denotes | apoptosis |
| T3 | 344-353 | DiseaseClass | denotes | apoptosis |
| T4 | 374-393 | DiseaseClass | denotes | lymphoproliferation |
| T5 | 444-490 | SpecificDisease | denotes | autoimmune lymphoproliferative syndrome (ALPS) |
| T6 | 586-590 | SpecificDisease | denotes | ALPS |
| T7 | 720-729 | DiseaseClass | denotes | apoptosis |
| T8 | 785-797 | Modifier | denotes | splenomegaly |
| T9 | 802-817 | Modifier | denotes | lymphadenopathy |
| T10 | 849-874 | CompositeMention | denotes | autoimmune manifestations |