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sentences

Id Subject Object Predicate Lexical cue
T1 0-190 Sentence denotes Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells.
T2 191-378 Sentence denotes The tax gene product of the type I human T-cell leukemia virus (HTLV-I) transactivates interleukin-2 (IL-2) gene through activation of an enhancer termed CD28 responsive element (CD28RE).
T3 379-493 Sentence denotes Tax activation of the CD28RE is partially mediated by a member of the nuclear factor of activated T cells, NF-AT1.
T4 494-715 Sentence denotes We have previously shown that NF-AT1 is constitutively active in Jurkat T cells stably transfected with the Tax cDNA, although the underlying molecular mechanism and physiological relevance of this finding remain unclear.
T5 716-867 Sentence denotes In this report, we demonstrate that the active form of NF-AT1 is also present in the nuclei of HTLV-I-transformed T cells that express the Tax protein.
T6 868-979 Sentence denotes Interestingly, the constitutive activation of NF-AT1 in these T cells is associated with its dephosphorylation.
T7 980-1179 Sentence denotes Furthermore, the dephosphorylated NF-AT1 can be rapidly rephosphorylated when the cells are incubated with cyclosporin A, an immunosuppressant inhibiting the serine/threonine phosphatase calcineurin.
T8 1180-1369 Sentence denotes These results suggest that activation of NF-AT1 in Tax-expressing and HTLV-I-transformed T cells results from its dephosphorylation, which in turn may be due to deregulation of calcineurin.
T1 0-190 Sentence denotes Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells.
T2 191-378 Sentence denotes The tax gene product of the type I human T-cell leukemia virus (HTLV-I) transactivates interleukin-2 (IL-2) gene through activation of an enhancer termed CD28 responsive element (CD28RE).
T3 379-493 Sentence denotes Tax activation of the CD28RE is partially mediated by a member of the nuclear factor of activated T cells, NF-AT1.
T4 494-715 Sentence denotes We have previously shown that NF-AT1 is constitutively active in Jurkat T cells stably transfected with the Tax cDNA, although the underlying molecular mechanism and physiological relevance of this finding remain unclear.
T5 716-867 Sentence denotes In this report, we demonstrate that the active form of NF-AT1 is also present in the nuclei of HTLV-I-transformed T cells that express the Tax protein.
T6 868-979 Sentence denotes Interestingly, the constitutive activation of NF-AT1 in these T cells is associated with its dephosphorylation.
T7 980-1179 Sentence denotes Furthermore, the dephosphorylated NF-AT1 can be rapidly rephosphorylated when the cells are incubated with cyclosporin A, an immunosuppressant inhibiting the serine/threonine phosphatase calcineurin.
T8 1180-1369 Sentence denotes These results suggest that activation of NF-AT1 in Tax-expressing and HTLV-I-transformed T cells results from its dephosphorylation, which in turn may be due to deregulation of calcineurin.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 65-100 protein denotes nuclear factor of activated T cells
T2 102-108 protein denotes NF-AT1
T3 113-189 cell_type denotes Tax-expressing and type I human T-cell leukemia virus-infected human T cells
T4 278-303 DNA denotes interleukin-2 (IL-2) gene
T5 345-368 DNA denotes CD28 responsive element
T6 370-376 DNA denotes CD28RE
T7 379-382 protein denotes Tax
T8 401-407 DNA denotes CD28RE
T9 449-484 protein denotes nuclear factor of activated T cells
T10 486-492 protein denotes NF-AT1
T11 524-530 protein denotes NF-AT1
T12 559-573 cell_line denotes Jurkat T cells
T13 602-610 DNA denotes Tax cDNA
T14 771-777 protein denotes NF-AT1
T15 811-837 cell_type denotes HTLV-I-transformed T cells
T16 855-866 protein denotes Tax protein
T17 914-920 protein denotes NF-AT1
T18 930-937 cell_type denotes T cells
T19 1014-1020 protein denotes NF-AT1
T20 1138-1166 protein denotes serine/threonine phosphatase
T21 1167-1178 protein denotes calcineurin
T22 1221-1227 protein denotes NF-AT1
T23 1231-1276 cell_line denotes Tax-expressing and HTLV-I-transformed T cells
T24 1357-1368 protein denotes calcineurin

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-190 Sentence denotes Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells.
S2 191-378 Sentence denotes The tax gene product of the type I human T-cell leukemia virus (HTLV-I) transactivates interleukin-2 (IL-2) gene through activation of an enhancer termed CD28 responsive element (CD28RE).
S3 379-493 Sentence denotes Tax activation of the CD28RE is partially mediated by a member of the nuclear factor of activated T cells, NF-AT1.
S4 494-715 Sentence denotes We have previously shown that NF-AT1 is constitutively active in Jurkat T cells stably transfected with the Tax cDNA, although the underlying molecular mechanism and physiological relevance of this finding remain unclear.
S5 716-867 Sentence denotes In this report, we demonstrate that the active form of NF-AT1 is also present in the nuclei of HTLV-I-transformed T cells that express the Tax protein.
S6 868-979 Sentence denotes Interestingly, the constitutive activation of NF-AT1 in these T cells is associated with its dephosphorylation.
S7 980-1179 Sentence denotes Furthermore, the dephosphorylated NF-AT1 can be rapidly rephosphorylated when the cells are incubated with cyclosporin A, an immunosuppressant inhibiting the serine/threonine phosphatase calcineurin.
S8 1180-1369 Sentence denotes These results suggest that activation of NF-AT1 in Tax-expressing and HTLV-I-transformed T cells results from its dephosphorylation, which in turn may be due to deregulation of calcineurin.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 49-100 NP denotes a member of the nuclear factor of activated T cells
C2 102-108 NP denotes NF-AT1
C3 132-189 NP denotes type I human T-cell leukemia virus-infected human T cells
C4 326-377 NP denotes an enhancer termed CD28 responsive element (CD28RE)
C5 397-407 NP denotes the CD28RE
C6 433-484 NP denotes a member of the nuclear factor of activated T cells
C7 486-492 NP denotes NF-AT1
C8 524-530 NP denotes NF-AT1
C9 771-777 NP denotes NF-AT1
C11 811-837 NP denotes HTLV-I-transformed T cells
C12 838-842 NP denotes that
C10 811-866 NP denotes HTLV-I-transformed T cells that express the Tax protein
C13 914-920 NP denotes NF-AT1
C14 924-937 NP denotes these T cells
C16 957-960 NP denotes its
C15 957-978 NP denotes its dephosphorylation
C17 1058-1067 NP denotes the cells
C18 1087-1100 NP denotes cyclosporin A
C19 1102-1178 NP denotes an immunosuppressant inhibiting the serine/threonine phosphatase calcineurin
C20 1221-1227 NP denotes NF-AT1
C21 1250-1276 NP denotes HTLV-I-transformed T cells
C23 1290-1293 NP denotes its
C22 1290-1311 NP denotes its dephosphorylation
C24 1313-1318 NP denotes which
R1 C2 C1 coref-appos NF-AT1,a member of the nuclear factor of activated T cells
R2 C5 C4 coref-ident the CD28RE,an enhancer termed CD28 responsive element (CD28RE)
R3 C6 C1 coref-ident a member of the nuclear factor of activated T cells,a member of the nuclear factor of activated T cells
R4 C7 C6 coref-appos NF-AT1,a member of the nuclear factor of activated T cells
R5 C8 C6 coref-ident NF-AT1,a member of the nuclear factor of activated T cells
R6 C9 C8 coref-ident NF-AT1,NF-AT1
R7 C11 C3 coref-ident HTLV-I-transformed T cells,type I human T-cell leukemia virus-infected human T cells
R8 C12 C11 coref-relat that,HTLV-I-transformed T cells
R9 C13 C9 coref-ident NF-AT1,NF-AT1
R10 C14 C10 coref-ident these T cells,HTLV-I-transformed T cells that express the Tax protein
R11 C16 C13 coref-pron its,NF-AT1
R12 C17 C14 coref-ident the cells,these T cells
R13 C19 C18 coref-appos an immunosuppressant inhibiting the serine/threonine phosphatase calcineurin,cyclosporin A
R14 C20 C13 coref-ident NF-AT1,NF-AT1
R15 C21 C11 coref-ident HTLV-I-transformed T cells,HTLV-I-transformed T cells
R16 C23 C20 coref-pron its,NF-AT1
R17 C22 C15 coref-ident its dephosphorylation,its dephosphorylation
R18 C24 C22 coref-relat which,its dephosphorylation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-30 other_name denotes Constitutive dephosphorylation
T2 65-100 protein_molecule denotes nuclear factor of activated T cells
T3 102-108 protein_molecule denotes NF-AT1
T4 219-253 virus denotes type I human T-cell leukemia virus
T5 255-261 virus denotes HTLV-I
T6 278-293 DNA_domain_or_region denotes interleukin-2 (
T7 293-297 protein_molecule denotes IL-2
T8 345-368 DNA_domain_or_region denotes CD28 responsive element
T9 370-376 DNA_domain_or_region denotes CD28RE
T10 379-382 protein_molecule denotes Tax
T11 401-407 DNA_domain_or_region denotes CD28RE
T12 449-484 protein_molecule denotes nuclear factor of activated T cells
T13 486-492 protein_molecule denotes NF-AT1
T14 524-530 protein_molecule denotes NF-AT1
T15 559-573 cell_line denotes Jurkat T cells
T16 602-605 protein_molecule denotes Tax
T17 771-777 protein_molecule denotes NF-AT1
T18 801-807 cell_component denotes nuclei
T19 811-817 virus denotes HTLV-I
T20 855-858 protein_molecule denotes Tax
T21 914-920 protein_molecule denotes NF-AT1
T22 930-937 cell_type denotes T cells
T23 1014-1020 protein_molecule denotes NF-AT1
T24 1087-1100 other_organic_compound denotes cyclosporin A
T25 1105-1122 other_organic_compound denotes immunosuppressant
T26 1138-1144 amino_acid_monomer denotes serine
T27 1144-1154 amino_acid_monomer denotes /threonine
T28 1167-1178 protein_molecule denotes calcineurin
T29 1221-1227 protein_molecule denotes NF-AT1
T30 1294-1311 other_name denotes dephosphorylation
T31 1357-1368 protein_molecule denotes calcineurin

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 105-108 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T2 145-160 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T3 232-247 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T4 489-492 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T5 527-530 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T6 774-777 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T7 917-920 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T8 1017-1020 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T9 1224-1227 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 139-144 OrganismTaxon denotes human 9606
T2 176-181 OrganismTaxon denotes human 9606
T3 226-231 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 145-151 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 232-238 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 152-160 Phenotype denotes leukemia HP:0001909
T2 239-247 Phenotype denotes leukemia HP:0001909

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 93-100 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 132-138 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T4 145-151 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T5 182-189 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 219-225 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T8 232-238 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T9 477-484 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T10 566-573 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T11 830-837 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T12 930-937 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T13 1269-1276 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084