PubMed:8998264 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":39},"obj":"Sentence"},{"id":"T2","span":{"begin":40,"end":291},"obj":"Sentence"},{"id":"T3","span":{"begin":292,"end":477},"obj":"Sentence"},{"id":"T4","span":{"begin":478,"end":628},"obj":"Sentence"},{"id":"T5","span":{"begin":629,"end":722},"obj":"Sentence"},{"id":"T6","span":{"begin":723,"end":900},"obj":"Sentence"},{"id":"T7","span":{"begin":901,"end":1041},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":39},"obj":"Sentence"},{"id":"T2","span":{"begin":40,"end":291},"obj":"Sentence"},{"id":"T3","span":{"begin":292,"end":477},"obj":"Sentence"},{"id":"T4","span":{"begin":478,"end":628},"obj":"Sentence"},{"id":"T5","span":{"begin":629,"end":722},"obj":"Sentence"},{"id":"T6","span":{"begin":723,"end":900},"obj":"Sentence"},{"id":"T7","span":{"begin":901,"end":1041},"obj":"Sentence"}],"text":"[Cortisone-resistant bronchial asthma].\nThere is general agreement on the inflammatory pathogenesis of bronchial asthma: an accumulation of activated eosinophils, degranulated mast cells, T lymphocytes and in very severe forms, granulocytes has constantly been found in the bronchial mucosa. In allergic bronchial asthma, inflammation seems to be orchestrated predominantly by a subset of T lymphocytes, with a phenotype similar to the Th2 subset able to produce IL-4 and IL-5. Although corticosteroids are the most potent therapeutic agents used for this disease, their anti-inflammatory effect differs from patient to patient. Some criteria which can be used to define steroid-resistant bronchial asthma are listed here. This review analyzes various molecular alterations responsible for the deficient response to corticosteroid treatment observed in steroid-resistant bronchial asthmatic subjects. New knowledge on the mechanism of steroid resistance may have important implications for the treatment of chronic asthma and other diseases."}

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