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sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.
T2 131-296 Sentence denotes T cell receptor (TCR) stimulation induces rapid tyrosine phosphorylation of cellular proteins, including Cbl, a protooncogene product whose function remains unclear.
T3 297-646 Sentence denotes As a first step toward elucidating the function of Cbl in TCR-initiated signaling, we evaluated the ability of wild-type Cbl or a transforming Cbl mutant (70Z/3) to induce transcriptional activation of a nuclear factor of activated T cells (NFAT) element derived from the interleukin 2 (IL2) promoter in transiently cotransfected Jurkat-TAg T cells.
T4 647-820 Sentence denotes 70Z/3, but not Cbl, caused NFAT activation which was significantly enhanced by stimulation with calcium ionophore, and was drastically reduced by cyclosporin A pretreatment.
T5 821-1142 Sentence denotes A point mutation of a potential phosphatidylinositol 3-kinase (PI3-K) binding site (Y731EAM to Y731EAC) in 70Z/3 disrupted the association of PI3-K with 70Z/3, but did not reduce the induction of NFAT activity, suggesting that the interaction between Cbl and PI3-K is not required in the 70Z/3-mediated induction of NFAT.
T6 1143-1302 Sentence denotes Additional mapping studies indicated that defined deletions of C-terminal 70Z/3 sequences affected to a variable degree its ability to stimulate NFAT activity.
T7 1303-1431 Sentence denotes Strikingly, deletion of 346 C-terminal residues augmented this activity, whereas removal of 20 additional residues abolished it.
T8 1432-1607 Sentence denotes Coexpression of dominant negative Ras abrogated the basal or ionomycin-stimulated, 70Z/3-mediated NFAT activation, suggesting a functional Ras is required for this activation.
T9 1608-1702 Sentence denotes These results implicate Cbl in Ras-dependent signaling pathways which lead to NFAT activation.
T1 0-130 Sentence denotes Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.
T2 131-296 Sentence denotes T cell receptor (TCR) stimulation induces rapid tyrosine phosphorylation of cellular proteins, including Cbl, a protooncogene product whose function remains unclear.
T3 297-646 Sentence denotes As a first step toward elucidating the function of Cbl in TCR-initiated signaling, we evaluated the ability of wild-type Cbl or a transforming Cbl mutant (70Z/3) to induce transcriptional activation of a nuclear factor of activated T cells (NFAT) element derived from the interleukin 2 (IL2) promoter in transiently cotransfected Jurkat-TAg T cells.
T4 647-820 Sentence denotes 70Z/3, but not Cbl, caused NFAT activation which was significantly enhanced by stimulation with calcium ionophore, and was drastically reduced by cyclosporin A pretreatment.
T5 821-1142 Sentence denotes A point mutation of a potential phosphatidylinositol 3-kinase (PI3-K) binding site (Y731EAM to Y731EAC) in 70Z/3 disrupted the association of PI3-K with 70Z/3, but did not reduce the induction of NFAT activity, suggesting that the interaction between Cbl and PI3-K is not required in the 70Z/3-mediated induction of NFAT.
T6 1143-1302 Sentence denotes Additional mapping studies indicated that defined deletions of C-terminal 70Z/3 sequences affected to a variable degree its ability to stimulate NFAT activity.
T7 1303-1431 Sentence denotes Strikingly, deletion of 346 C-terminal residues augmented this activity, whereas removal of 20 additional residues abolished it.
T8 1432-1607 Sentence denotes Coexpression of dominant negative Ras abrogated the basal or ionomycin-stimulated, 70Z/3-mediated NFAT activation, suggesting a functional Ras is required for this activation.
T9 1608-1702 Sentence denotes These results implicate Cbl in Ras-dependent signaling pathways which lead to NFAT activation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes Ras
T2 45-80 protein denotes nuclear factor of activated T cells
T3 108-118 protein denotes Cbl mutant
T4 122-129 cell_type denotes T cells
T5 131-146 protein denotes T cell receptor
T6 148-151 protein denotes TCR
T7 207-224 protein denotes cellular proteins
T8 236-239 protein denotes Cbl
T9 243-264 protein denotes protooncogene product
T10 348-351 protein denotes Cbl
T11 355-358 protein denotes TCR
T12 408-421 protein denotes wild-type Cbl
T13 440-450 protein denotes Cbl mutant
T14 501-551 DNA denotes nuclear factor of activated T cells (NFAT) element
T15 569-597 DNA denotes interleukin 2 (IL2) promoter
T16 627-645 cell_line denotes Jurkat-TAg T cells
T17 647-652 protein denotes 70Z/3
T18 662-665 protein denotes Cbl
T19 674-678 protein denotes NFAT
T20 853-903 DNA denotes phosphatidylinositol 3-kinase (PI3-K) binding site
T21 905-912 DNA denotes Y731EAM
T22 916-923 DNA denotes Y731EAC
T23 928-933 protein denotes 70Z/3
T24 963-968 protein denotes PI3-K
T25 974-979 protein denotes 70Z/3
T26 1017-1021 protein denotes NFAT
T27 1072-1075 protein denotes Cbl
T28 1080-1085 protein denotes PI3-K
T29 1109-1114 protein denotes 70Z/3
T30 1137-1141 protein denotes NFAT
T31 1217-1222 protein denotes 70Z/3
T32 1288-1292 protein denotes NFAT
T33 1327-1350 protein denotes 346 C-terminal residues
T34 1448-1469 protein denotes dominant negative Ras
T35 1515-1520 protein denotes 70Z/3
T36 1530-1534 protein denotes NFAT
T37 1560-1574 protein denotes functional Ras
T38 1632-1635 protein denotes Cbl
T39 1639-1642 protein denotes Ras
T40 1686-1690 protein denotes NFAT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-130 Sentence denotes Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.
S2 131-296 Sentence denotes T cell receptor (TCR) stimulation induces rapid tyrosine phosphorylation of cellular proteins, including Cbl, a protooncogene product whose function remains unclear.
S3 297-646 Sentence denotes As a first step toward elucidating the function of Cbl in TCR-initiated signaling, we evaluated the ability of wild-type Cbl or a transforming Cbl mutant (70Z/3) to induce transcriptional activation of a nuclear factor of activated T cells (NFAT) element derived from the interleukin 2 (IL2) promoter in transiently cotransfected Jurkat-TAg T cells.
S4 647-820 Sentence denotes 70Z/3, but not Cbl, caused NFAT activation which was significantly enhanced by stimulation with calcium ionophore, and was drastically reduced by cyclosporin A pretreatment.
S5 821-1142 Sentence denotes A point mutation of a potential phosphatidylinositol 3-kinase (PI3-K) binding site (Y731EAM to Y731EAC) in 70Z/3 disrupted the association of PI3-K with 70Z/3, but did not reduce the induction of NFAT activity, suggesting that the interaction between Cbl and PI3-K is not required in the 70Z/3-mediated induction of NFAT.
S6 1143-1302 Sentence denotes Additional mapping studies indicated that defined deletions of C-terminal 70Z/3 sequences affected to a variable degree its ability to stimulate NFAT activity.
S7 1303-1431 Sentence denotes Strikingly, deletion of 346 C-terminal residues augmented this activity, whereas removal of 20 additional residues abolished it.
S8 1432-1607 Sentence denotes Coexpression of dominant negative Ras abrogated the basal or ionomycin-stimulated, 70Z/3-mediated NFAT activation, suggesting a functional Ras is required for this activation.
S9 1608-1702 Sentence denotes These results implicate Cbl in Ras-dependent signaling pathways which lead to NFAT activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 45-80 NP denotes nuclear factor of activated T cells
C2 84-118 NP denotes a constitutively active Cbl mutant
C3 236-239 NP denotes Cbl
C5 241-264 NP denotes a protooncogene product
C6 265-270 NP denotes whose
C4 241-295 NP denotes a protooncogene product whose function remains unclear
C7 348-351 NP denotes Cbl
C8 425-458 NP denotes a transforming Cbl mutant (70Z/3)
C9 647-652 NP denotes 70Z/3
C10 662-665 NP denotes Cbl
C11 674-689 NP denotes NFAT activation
C12 690-695 NP denotes which
C13 928-933 NP denotes 70Z/3
C14 963-968 NP denotes PI3-K
C15 974-979 NP denotes 70Z/3
C16 1017-1030 NP denotes NFAT activity
C17 1072-1075 NP denotes Cbl
C18 1080-1085 NP denotes PI3-K
C19 1137-1141 NP denotes NFAT
C20 1263-1266 NP denotes its
C21 1288-1301 NP denotes NFAT activity
C22 1361-1374 NP denotes this activity
C23 1428-1430 NP denotes it
C24 1480-1545 NP denotes the basal or ionomycin-stimulated, 70Z/3-mediated NFAT activation
C25 1591-1606 NP denotes this activation
C26 1632-1635 NP denotes Cbl
C27 1639-1671 NP denotes Ras-dependent signaling pathways
C28 1672-1677 NP denotes which
R1 C6 C5 coref-relat whose,a protooncogene product
R2 C4 C3 coref-appos a protooncogene product whose function remains unclear,Cbl
R3 C7 C3 coref-ident Cbl,Cbl
R4 C8 C2 coref-ident a transforming Cbl mutant (70Z/3),a constitutively active Cbl mutant
R5 C9 C8 coref-ident 70Z/3,a transforming Cbl mutant (70Z/3)
R6 C10 C7 coref-ident Cbl,Cbl
R7 C12 C11 coref-relat which,NFAT activation
R8 C13 C9 coref-ident 70Z/3,70Z/3
R9 C15 C13 coref-ident 70Z/3,70Z/3
R10 C17 C10 coref-ident Cbl,Cbl
R11 C18 C14 coref-ident PI3-K,PI3-K
R12 C19 C1 coref-ident NFAT,nuclear factor of activated T cells
R13 C20 C15 coref-pron its,70Z/3
R14 C21 C16 coref-ident NFAT activity,NFAT activity
R15 C22 C21 coref-ident this activity,NFAT activity
R16 C23 C22 coref-pron it,this activity
R17 C25 C24 coref-ident this activation,"the basal or ionomycin-stimulated, 70Z/3-mediated NFAT activation"
R18 C26 C17 coref-ident Cbl,Cbl
R19 C28 C27 coref-relat which,Ras-dependent signaling pathways

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_family_or_group denotes Ras
T2 15-19 atom denotes Ca2+
T3 45-80 protein_molecule denotes nuclear factor of activated T cells
T4 108-118 protein_molecule denotes Cbl mutant
T5 122-129 cell_type denotes T cells
T6 131-146 protein_family_or_group denotes T cell receptor
T7 148-151 protein_family_or_group denotes TCR
T8 179-187 amino_acid_monomer denotes tyrosine
T9 207-224 protein_family_or_group denotes cellular proteins
T10 236-239 protein_molecule denotes Cbl
T11 243-264 protein_molecule denotes protooncogene product
T12 348-351 protein_molecule denotes Cbl
T13 355-358 protein_family_or_group denotes TCR
T14 408-417 protein_molecule denotes wild-type
T15 418-421 protein_molecule denotes Cbl
T16 440-443 protein_molecule denotes Cbl
T17 501-528 protein_family_or_group denotes nuclear factor of activated
T18 529-536 cell_type denotes T cells
T19 538-542 protein_family_or_group denotes NFAT
T20 569-582 protein_molecule denotes interleukin 2
T21 584-587 protein_molecule denotes IL2
T22 627-637 cell_line denotes Jurkat-TAg
T23 638-645 cell_type denotes T cells
T24 647-652 protein_molecule denotes 70Z/3
T25 662-665 protein_molecule denotes Cbl
T26 674-678 protein_family_or_group denotes NFAT
T27 743-760 other_organic_compound denotes calcium ionophore
T28 793-806 other_organic_compound denotes cyclosporin A
T29 853-882 protein_molecule denotes phosphatidylinositol 3-kinase
T30 884-889 protein_molecule denotes PI3-K
T31 905-912 DNA_domain_or_region denotes Y731EAM
T32 916-923 DNA_domain_or_region denotes Y731EAC
T33 928-933 protein_molecule denotes 70Z/3
T34 963-968 protein_molecule denotes PI3-K
T35 974-979 protein_molecule denotes 70Z/3
T36 1017-1021 protein_family_or_group denotes NFAT
T37 1072-1075 protein_molecule denotes Cbl
T38 1080-1085 protein_molecule denotes PI3-K
T39 1109-1114 protein_molecule denotes 70Z/3
T40 1137-1141 protein_family_or_group denotes NFAT
T41 1217-1222 protein_molecule denotes 70Z/3
T42 1288-1292 protein_family_or_group denotes NFAT
T43 1327-1350 protein_domain_or_region denotes 346 C-terminal residues
T44 1448-1469 protein_molecule denotes dominant negative Ras
T45 1493-1514 other_name denotes ionomycin-stimulated,
T46 1515-1520 protein_molecule denotes 70Z/3
T47 1530-1534 protein_family_or_group denotes NFAT
T48 1560-1574 protein_family_or_group denotes functional Ras
T49 1632-1635 protein_molecule denotes Cbl
T50 1639-1642 protein_molecule denotes Ras
T51 1686-1690 protein_family_or_group denotes NFAT

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 131-137 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 73-80 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 122-129 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 131-137 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 529-536 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 638-645 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 1484-1489 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324