> top > docs > PubMed:8995236 > annotations

PubMed:8995236 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos15-Species-PubTator

Id Subject Object Predicate Lexical cue db_id
3 0-23 Species denotes Mycobacterium smegmatis 1772
40 182-198 Species denotes Mycobacterium sp 1785
47 661-684 Species denotes Mycobacterium smegmatis 1772

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 247-257 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1532-1540 Glycan_Motif denotes arabinan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G22535ZZ

sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans.
T2 64-144 Sentence denotes Structure and localization of alkali-labile and alkali-stable phosphoinositides.
T3 145-269 Sentence denotes Lipoarabinomannans from fast growing Mycobacterium sp., namely AraLAMs, stimulate the early events of macrophage activation.
T4 270-491 Sentence denotes The immunological activities of all of these AraLAMs drastically decrease with the loss of the mild alkali groups, which were believed to be restricted to the fatty acid residues from the phosphatidyl-myo-inositol anchor.
T5 492-723 Sentence denotes This report reveals the presence and the structure of mild alkali-labile phosphoinositide units linked via the phosphate to the C-5 of the beta-D-Araf in the AraLAMs of Mycobacterium smegmatis, a fast growing mycobacterial species.
T6 724-1049 Sentence denotes Their structure was unambiguously established with a strategy based on both one-dimensional 31P and two-dimensional 1H-31P heteronuclear multiple quantum correlation spectroscopy (HMQC) and HMQC-homonuclear Hartmann-Hahn spectroscopy NMR experiments applied to native AraLAMs and to AraLAMs treated in mild alkali conditions.
T7 1050-1464 Sentence denotes Next to these alkali-labile phosphoinositides estimated at three per molecule, two other mild alkali-stable phosphoinositide units were identified: the expected (myo-inositol-1)-phosphate-(3-glycerol) unit typifying the well known glycosylphosphatidylinositol anchor of the mannan core and, more surprisingly, one (myo-inositol-1)-phosphate-(5-beta-D-Araf) unit having the same structure as the alkali-labile ones.
T8 1465-1553 Sentence denotes Moreover, these four phosphoinositide units were found capping the arabinan side chains.
T9 1554-1686 Sentence denotes Thus, their different behavior toward mild alkaline hydrolysis was explained according to their accessibility to the alkali reagent.
T10 1687-1867 Sentence denotes This novel class of LAMs, namely phosphoinositols-glyceroarabinomannans (PI-GAMs), are characterized by their phosphoinositide units but also by the absence of fatty acid residues.
T11 1868-2037 Sentence denotes These PI-GAMs were found to elicit the secretion of tumor necrosis factor-alpha, suggesting that phosphoinositides are the major PI-GAM epitope involved in this process.
T1 0-63 Sentence denotes Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans.
T2 64-144 Sentence denotes Structure and localization of alkali-labile and alkali-stable phosphoinositides.
T3 145-269 Sentence denotes Lipoarabinomannans from fast growing Mycobacterium sp., namely AraLAMs, stimulate the early events of macrophage activation.
T4 270-491 Sentence denotes The immunological activities of all of these AraLAMs drastically decrease with the loss of the mild alkali groups, which were believed to be restricted to the fatty acid residues from the phosphatidyl-myo-inositol anchor.
T5 492-723 Sentence denotes This report reveals the presence and the structure of mild alkali-labile phosphoinositide units linked via the phosphate to the C-5 of the beta-D-Araf in the AraLAMs of Mycobacterium smegmatis, a fast growing mycobacterial species.
T6 724-1049 Sentence denotes Their structure was unambiguously established with a strategy based on both one-dimensional 31P and two-dimensional 1H-31P heteronuclear multiple quantum correlation spectroscopy (HMQC) and HMQC-homonuclear Hartmann-Hahn spectroscopy NMR experiments applied to native AraLAMs and to AraLAMs treated in mild alkali conditions.
T7 1050-1464 Sentence denotes Next to these alkali-labile phosphoinositides estimated at three per molecule, two other mild alkali-stable phosphoinositide units were identified: the expected (myo-inositol-1)-phosphate-(3-glycerol) unit typifying the well known glycosylphosphatidylinositol anchor of the mannan core and, more surprisingly, one (myo-inositol-1)-phosphate-(5-beta-D-Araf) unit having the same structure as the alkali-labile ones.
T8 1465-1553 Sentence denotes Moreover, these four phosphoinositide units were found capping the arabinan side chains.
T9 1554-1686 Sentence denotes Thus, their different behavior toward mild alkaline hydrolysis was explained according to their accessibility to the alkali reagent.
T10 1687-1867 Sentence denotes This novel class of LAMs, namely phosphoinositols-glyceroarabinomannans (PI-GAMs), are characterized by their phosphoinositide units but also by the absence of fatty acid residues.
T11 1868-2037 Sentence denotes These PI-GAMs were found to elicit the secretion of tumor necrosis factor-alpha, suggesting that phosphoinositides are the major PI-GAM epitope involved in this process.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1532-1540 https://glytoucan.org/Structures/Glycans/G22535ZZ denotes arabinan

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1532-1540 http://www.glycoepitope.jp/epitopes/EP0508 denotes arabinan

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1532-1540 Glycan denotes arabinan

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1920-1925 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1920-1925 Phenotype denotes tumor HP:0002664

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1532-1540 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes arabinan http://www.glycoepitope.jp/epitopes/EP0508

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1920-1925 Phenotype denotes tumor HP:0002664

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-23 OrganismTaxon denotes Mycobacterium smegmatis 1772
T2 182-195 OrganismTaxon denotes Mycobacterium 1763
T3 661-684 OrganismTaxon denotes Mycobacterium smegmatis 1772

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 247-257 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 247-257 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1920-1925 Disease denotes tumor MONDO:0005070

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1532-1540 Glycan denotes arabinan https://api.glycosmos.org/wurcs2image/latest/png/binary/G22535ZZ

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans.
T2 64-144 Sentence denotes Structure and localization of alkali-labile and alkali-stable phosphoinositides.
T3 145-269 Sentence denotes Lipoarabinomannans from fast growing Mycobacterium sp., namely AraLAMs, stimulate the early events of macrophage activation.
T4 270-491 Sentence denotes The immunological activities of all of these AraLAMs drastically decrease with the loss of the mild alkali groups, which were believed to be restricted to the fatty acid residues from the phosphatidyl-myo-inositol anchor.
T5 492-723 Sentence denotes This report reveals the presence and the structure of mild alkali-labile phosphoinositide units linked via the phosphate to the C-5 of the beta-D-Araf in the AraLAMs of Mycobacterium smegmatis, a fast growing mycobacterial species.
T6 724-1049 Sentence denotes Their structure was unambiguously established with a strategy based on both one-dimensional 31P and two-dimensional 1H-31P heteronuclear multiple quantum correlation spectroscopy (HMQC) and HMQC-homonuclear Hartmann-Hahn spectroscopy NMR experiments applied to native AraLAMs and to AraLAMs treated in mild alkali conditions.
T7 1050-1464 Sentence denotes Next to these alkali-labile phosphoinositides estimated at three per molecule, two other mild alkali-stable phosphoinositide units were identified: the expected (myo-inositol-1)-phosphate-(3-glycerol) unit typifying the well known glycosylphosphatidylinositol anchor of the mannan core and, more surprisingly, one (myo-inositol-1)-phosphate-(5-beta-D-Araf) unit having the same structure as the alkali-labile ones.
T8 1465-1553 Sentence denotes Moreover, these four phosphoinositide units were found capping the arabinan side chains.
T9 1554-1686 Sentence denotes Thus, their different behavior toward mild alkaline hydrolysis was explained according to their accessibility to the alkali reagent.
T10 1687-1867 Sentence denotes This novel class of LAMs, namely phosphoinositols-glyceroarabinomannans (PI-GAMs), are characterized by their phosphoinositide units but also by the absence of fatty acid residues.
T11 1868-2037 Sentence denotes These PI-GAMs were found to elicit the secretion of tumor necrosis factor-alpha, suggesting that phosphoinositides are the major PI-GAM epitope involved in this process.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1532-1540 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes arabinan http://www.glycoepitope.jp/epitopes/EP0508

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 247-257 Body_part denotes macrophage FMA:63261

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-23 OrganismTaxon denotes Mycobacterium smegmatis 1772
T2 182-195 OrganismTaxon denotes Mycobacterium 1763
T3 661-684 OrganismTaxon denotes Mycobacterium smegmatis 1772

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 247-257 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235