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PubMed:8977934 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 717-730 cell_type denotes T lymphocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-60 Sentence denotes [Molecular mechanisms of age-related lymphocyte dysfunction]
S2 62-143 Sentence denotes Aging is classically accompanied by a dysregulation of the immunologic machinery.
S3 144-308 Sentence denotes As a consequence, the immune response developed in senescent organisms is usually inappropriate, often inefficient, sometimes aberrant, and potentially detrimental.
S4 309-510 Sentence denotes The age-associated immune dysfunction may be implicated to some degree in the extreme susceptibility of the elderly to infection and neoplasia and may even participate in various aspects of senescence.
S5 511-614 Sentence denotes The current understanding of the molecular mechanisms underlying immunosenescence is still fragmentary.
S6 615-742 Sentence denotes The most extensively studied phenomenon is the progressive decline in the proliferative capacities of T lymphocytes with aging.
S7 743-863 Sentence denotes The loss of proliferative potential in response to antigenic challenge is a characteristic feature of immune senescence.
S8 864-944 Sentence denotes It is directly implicated in the emergence of the age-related immune deficiency.
S9 945-1159 Sentence denotes The purpose of this review is to show how the accumulation of various biochemical lesions with advancing age leads to the failure of a critical cell function, namely the activation-induced lymphocyte proliferation.
S10 1160-1309 Sentence denotes The biochemical modifications responsible for the defect in transduction and execution of the proliferative signal are analyzed as a function of age.
S11 1310-1550 Sentence denotes The multiple alterations observed on the various biochemical pathways may appear as a consequence of a unique deleterious mechanism more fundamentally related to the process of senescence such as the inability to cope with oxidative stress.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 309-346 NP denotes The age-associated immune dysfunction
C4 499-509 NP denotes senescence
C5 845-862 NP denotes immune senescence
C2 910-943 NP denotes the age-related immune deficiency
C3 1487-1497 NP denotes senescence
R1 C5 C4 coref-ident immune senescence,senescence
R2 C2 C1 coref-other the age-related immune deficiency,The age-associated immune dysfunction
R3 C3 C4 coref-ident senescence,senescence

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 25-59 other_name denotes age-related lymphocyte dysfunction
T2 121-142 body_part denotes immunologic machinery
T3 166-181 other_name denotes immune response
T4 195-214 mono_cell denotes senescent organisms
T5 313-346 other_name denotes age-associated immune dysfunction
T6 417-424 multi_cell denotes elderly
T7 428-437 other_name denotes infection
T8 442-451 other_name denotes neoplasia
T9 544-564 other_name denotes molecular mechanisms
T10 576-592 other_name denotes immunosenescence
T11 689-713 other_name denotes proliferative capacities
T12 717-730 cell_type denotes T lymphocytes
T13 914-943 other_name denotes age-related immune deficiency
T14 1015-1034 other_name denotes biochemical lesions
T15 1115-1158 other_name denotes activation-induced lymphocyte proliferation
T16 1164-1189 other_name denotes biochemical modifications
T17 1359-1379 other_name denotes biochemical pathways
T18 1533-1549 other_name denotes oxidative stress