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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.
T2 117-128 Sentence denotes BACKGROUND:
T3 129-234 Sentence denotes Glucocorticoids are important medications used to control the airway inflammation associated with asthma.
T4 235-330 Sentence denotes Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).
T5 331-339 Sentence denotes METHODS:
T6 340-663 Sentence denotes We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.
T7 664-859 Sentence denotes Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.
T8 860-868 Sentence denotes RESULTS:
T9 869-1088 Sentence denotes Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.
T10 1089-1461 Sentence denotes The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.
T11 1462-1632 Sentence denotes In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.
T12 1633-1727 Sentence denotes Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.
T13 1728-1881 Sentence denotes The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.
T14 1882-1893 Sentence denotes CONCLUSION:
T15 1894-2136 Sentence denotes These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.
T1 0-116 Sentence denotes Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.
T2 117-128 Sentence denotes BACKGROUND:
T3 129-234 Sentence denotes Glucocorticoids are important medications used to control the airway inflammation associated with asthma.
T4 235-330 Sentence denotes Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).
T5 331-339 Sentence denotes METHODS:
T6 340-663 Sentence denotes We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.
T7 664-859 Sentence denotes Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.
T8 860-868 Sentence denotes RESULTS:
T9 869-1088 Sentence denotes Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.
T10 1089-1461 Sentence denotes The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.
T11 1462-1632 Sentence denotes In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.
T12 1633-1727 Sentence denotes Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.
T13 1728-1881 Sentence denotes The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.
T14 1882-1893 Sentence denotes CONCLUSION:
T15 1894-2136 Sentence denotes These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 491-509 protein denotes phytohemagglutinin
T2 518-551 cell_type denotes peripheral blood mononuclear cell
T3 698-701 protein denotes GCR
T4 1628-1631 protein denotes GCR
T5 1706-1709 protein denotes GCR
T6 1732-1735 protein denotes GCR
T7 1978-1981 protein denotes GCR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.
S2 117-234 Sentence denotes BACKGROUND: Glucocorticoids are important medications used to control the airway inflammation associated with asthma.
S3 235-330 Sentence denotes Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).
S4 331-663 Sentence denotes METHODS: We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.
S5 664-859 Sentence denotes Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.
S6 860-1088 Sentence denotes RESULTS: Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.
S7 1089-1461 Sentence denotes The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.
S8 1462-1632 Sentence denotes In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.
S9 1633-1727 Sentence denotes Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.
S10 1728-1881 Sentence denotes The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.
S11 1882-2136 Sentence denotes CONCLUSION: These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 11-26 NP denotes glucocorticoids
C34 69-115 NP denotes steroid-sensitive and steroid-resistant asthma
C36 55-115 NP denotes patients with steroid-sensitive and steroid-resistant asthma
C2 129-144 NP denotes Glucocorticoids
C3 235-260 NP denotes Synthetic glucocorticoids
C6 269-274 NP denotes their
C5 296-329 NP denotes the glucocorticoid receptor (GCR)
C4 269-329 NP denotes their binding affinity for the glucocorticoid receptor (GCR)
C31 439-449 NP denotes budesonide
C7 352-449 NP denotes hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide
C8 465-470 NP denotes their
C35 589-613 NP denotes steroid-sensitive asthma
C39 571-613 NP denotes six patients with steroid-sensitive asthma
C10 638-662 NP denotes steroid-resistant asthma
C38 618-662 NP denotes seven patients with steroid-resistant asthma
C13 779-798 NP denotes both patient groups
C15 916-935 NP denotes all glucocorticoids
C14 939-958 NP denotes both patient groups
C16 965-992 NP denotes the steroid-resistant group
C17 1033-1048 NP denotes glucocorticoids
C20 1150-1182 NP denotes lymphocyte proliferation (IC50s)
C18 1187-1214 NP denotes the steroid-sensitive group
C19 1327-1354 NP denotes the steroid-resistant group
C30 1402-1412 NP denotes budesonide
C21 1547-1578 NP denotes lymphocyte proliferation (IC50)
C27 1607-1620 NP denotes dexamethasone
C22 1624-1631 NP denotes the GCR
C23 1633-1671 NP denotes Patients with steroid-resistant asthma
C25 1728-1767 NP denotes The GCR binding affinity for budesonide
C24 1796-1807 NP denotes both groups
C26 1849-1853 NP denotes that
C28 1867-1880 NP denotes dexamethasone
C29 1918-1933 NP denotes glucocorticoids
C32 1942-1952 NP denotes budesonide
C33 1967-1972 NP denotes their
R1 C2 C1 coref-ident Glucocorticoids,glucocorticoids
R2 C3 C2 coref-part-whole Synthetic glucocorticoids,Glucocorticoids
R3 C4 C3 coref-pron their binding affinity for the glucocorticoid receptor (GCR),Synthetic glucocorticoids
R4 C8 C7 coref-ident their,"hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide"
R5 C35 C34 coref-part-whole steroid-sensitive asthma,steroid-sensitive and steroid-resistant asthma
R6 C39 C36 coref-part-whole six patients with steroid-sensitive asthma,patients with steroid-sensitive and steroid-resistant asthma
R7 C10 C34 coref-part-whole steroid-resistant asthma,steroid-sensitive and steroid-resistant asthma
R8 C38 C36 coref-part-whole seven patients with steroid-resistant asthma,patients with steroid-sensitive and steroid-resistant asthma
R9 C13 C38 coref-whole-part both patient groups,seven patients with steroid-resistant asthma
R10 C13 C39 coref-whole-part both patient groups,six patients with steroid-sensitive asthma
R11 C15 C7 coref-ident all glucocorticoids,"hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide"
R12 C14 C13 coref-ident both patient groups,both patient groups
R13 C16 C38 coref-ident the steroid-resistant group,seven patients with steroid-resistant asthma
R14 C17 C3 coref-ident glucocorticoids,Synthetic glucocorticoids
R15 C18 C39 coref-part-whole the steroid-sensitive group,six patients with steroid-sensitive asthma
R16 C19 C16 coref-ident the steroid-resistant group,the steroid-resistant group
R17 C30 C31 coref-ident budesonide,budesonide
R18 C21 C20 coref-ident lymphocyte proliferation (IC50),lymphocyte proliferation (IC50s)
R19 C22 C5 coref-ident the GCR,the glucocorticoid receptor (GCR)
R20 C23 C38 coref-ident Patients with steroid-resistant asthma,seven patients with steroid-resistant asthma
R21 C24 C14 coref-ident both groups,both patient groups
R22 C26 C25 coref-pron that,The GCR binding affinity for budesonide
R23 C28 C27 coref-ident dexamethasone,dexamethasone
R24 C29 C17 coref-ident glucocorticoids,glucocorticoids
R25 C32 C30 coref-ident budesonide,budesonide
R26 C33 C29 coref-pron their,glucocorticoids

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 11-26 lipid denotes glucocorticoids
T2 30-51 other_name denotes lymphocyte activation
T3 55-63 multi_cell denotes patients
T4 129-144 lipid denotes Glucocorticoids
T5 191-210 other_name denotes airway inflammation
T6 227-233 other_name denotes asthma
T7 245-260 lipid denotes glucocorticoids
T8 352-366 lipid denotes hydrocortisone
T9 368-395 lipid denotes beclomethasone dipropionate
T10 397-420 lipid denotes triamcinolone acetonide
T11 422-433 other_organic_compound denotes flunisolide
T12 439-449 other_organic_compound denotes budesonide
T13 491-509 protein_molecule denotes phytohemagglutinin
T14 518-551 cell_type denotes peripheral blood mononuclear cell
T15 575-583 multi_cell denotes patients
T16 589-606 other_name denotes steroid-sensitive
T17 607-613 other_name denotes asthma
T18 624-632 multi_cell denotes patients
T19 638-662 other_name denotes steroid-resistant asthma
T20 698-701 protein_family_or_group denotes GCR
T21 725-738 lipid denotes dexamethasone
T22 743-753 other_organic_compound denotes budesonide
T23 784-791 multi_cell denotes patient
T24 810-835 other_name denotes radioligand binding assay
T25 840-858 other_name denotes Scatchard analysis
T26 869-894 other_name denotes Dose-dependent inhibition
T27 920-935 lipid denotes glucocorticoids
T28 944-951 multi_cell denotes patient
T29 969-992 multi_cell denotes steroid-resistant group
T30 1033-1048 lipid denotes glucocorticoids
T31 1150-1174 other_name denotes lymphocyte proliferation
T32 1176-1181 other_name denotes IC50s
T33 1249-1259 other_organic_compound denotes budesonide
T34 1284-1298 lipid denotes hydrocortisone
T35 1317-1322 other_name denotes IC50s
T36 1331-1354 multi_cell denotes steroid-resistant group
T37 1402-1412 other_organic_compound denotes budesonide
T38 1446-1460 lipid denotes hydrocortisone
T39 1547-1571 other_name denotes lymphocyte proliferation
T40 1573-1577 other_name denotes IC50
T41 1607-1620 lipid denotes dexamethasone
T42 1628-1631 protein_family_or_group denotes GCR
T43 1647-1671 other_name denotes steroid-resistant asthma
T44 1706-1709 protein_family_or_group denotes GCR
T45 1732-1735 protein_family_or_group denotes GCR
T46 1757-1767 other_organic_compound denotes budesonide
T47 1821-1842 other_name denotes dissociation constant
T48 1867-1880 lipid denotes dexamethasone
T49 1918-1933 lipid denotes glucocorticoids
T50 1942-1952 other_organic_compound denotes budesonide
T51 1978-1981 protein_family_or_group denotes GCR
T52 2033-2057 other_name denotes lymphocyte proliferation
T53 2108-2135 other_name denotes difficult-to-control asthma