PubMed:8956035
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 753-757 | gene:8266 | denotes | G6PD |
| T1 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| T2 | 753-757 | gene:2539 | denotes | G6PD |
| T3 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| T4 | 845-849 | gene:8266 | denotes | G6PD |
| T5 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| T6 | 845-849 | gene:2539 | denotes | G6PD |
| T7 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| T8 | 861-865 | gene:8266 | denotes | G6PD |
| T9 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| T10 | 861-865 | gene:2539 | denotes | G6PD |
| T11 | 784-801 | disease:C0149676 | denotes | enzyme deficiency |
| R1 | T0 | T1 | associated_with | G6PD,enzyme deficiency |
| R2 | T2 | T3 | associated_with | G6PD,enzyme deficiency |
| R3 | T4 | T5 | associated_with | G6PD,enzyme deficiency |
| R4 | T6 | T7 | associated_with | G6PD,enzyme deficiency |
| R5 | T8 | T9 | associated_with | G6PD,enzyme deficiency |
| R6 | T10 | T11 | associated_with | G6PD,enzyme deficiency |
DisGeNET5_variant_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 8956035-3#195#208#geners5030872 | 600-613 | geners5030872 | denotes | 181 Asp-->Val |
| 8956035-3#66#72#diseaseC0015702 | 471-477 | diseaseC0015702 | denotes | favism |
| 195#208#geners503087266#72#diseaseC0015702 | 8956035-3#195#208#geners5030872 | 8956035-3#66#72#diseaseC0015702 | associated_with | 181 Asp-->Val,favism |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 8956035-3#14#18#gene2539 | 419-423 | gene2539 | denotes | G6PD |
| 8956035-3#66#72#diseaseC0015702 | 471-477 | diseaseC0015702 | denotes | favism |
| 14#18#gene253966#72#diseaseC0015702 | 8956035-3#14#18#gene2539 | 8956035-3#66#72#diseaseC0015702 | associated_with | G6PD,favism |
NCBIDiseaseCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier:D005955 | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease:D005236 | denotes | favism |
| T3 | 784-801 | DiseaseClass:D008661 | denotes | enzyme deficiency |
ncbi-valid
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
| T3 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
ncbi-valid-gpt-nr-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
ncbi-valid-gpt-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-442 | SpecificDisease | denotes | G6PD deficient patients |
| T2 | 471-477 | SpecificDisease | denotes | favism |
| T3 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
| T4 | 803-812 | Modifier | denotes | class III |
ncbi-valid-gpt-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-442 | SpecificDisease | denotes | G6PD deficient patients |
| T2 | 462-477 | SpecificDisease | denotes | clinical favism |
| T3 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
| T4 | 803-812 | Modifier | denotes | class III |
ncbi-valid-gpt-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
ncbi-valid-gemini-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
| T3 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T4 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T5 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T6 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
| T7 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T8 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
ncbi-valid-gemini-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 57-101 | SpecificDisease | denotes | human glucose 6-phosphate dehydrogenase gene |
| T2 | 154-167 | SpecificDisease | denotes | G6PD variants |
| T3 | 397-403 | SpecificDisease | denotes | G6PD A |
| T4 | 419-433 | Modifier | denotes | G6PD deficient |
| T5 | 462-477 | SpecificDisease | denotes | clinical favism |
| T6 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T7 | 707-713 | SpecificDisease | denotes | G6PD A |
| T8 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T9 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T10 | 784-801 | SpecificDisease | denotes | enzyme deficiency |
| T11 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T12 | 861-876 | SpecificDisease | denotes | G6PD Santamaria |
| T13 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
| T14 | 1062-1068 | SpecificDisease | denotes | G6PD A |
| T15 | 1073-1084 | SpecificDisease | denotes | G6PD Malaga |
| T16 | 1239-1245 | SpecificDisease | denotes | G6PD B |
| T17 | 1405-1415 | SpecificDisease | denotes | G6PD locus |
ncbi-valid-gemini-nr-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 462-477 | SpecificDisease | denotes | clinical favism |
| T2 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
ncbi-valid-deepseek-nr-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-11 | Modifier | denotes | Independent |
| T2 | 12-18 | Modifier | denotes | origin |
| T3 | 22-28 | Modifier | denotes | single |
| T4 | 33-39 | Modifier | denotes | double |
| T5 | 40-49 | Modifier | denotes | mutations |
| T6 | 57-62 | Modifier | denotes | human |
| T7 | 63-70 | Modifier | denotes | glucose |
| T8 | 71-82 | Modifier | denotes | 6-phosphate |
| T9 | 83-96 | Modifier | denotes | dehydrogenase |
| T10 | 97-101 | Modifier | denotes | gene |
| T11 | 103-106 | Modifier | denotes | The |
| T12 | 107-111 | Modifier | denotes | vast |
| T13 | 112-120 | Modifier | denotes | majority |
| T14 | 129-140 | Modifier | denotes | polymorphic |
| T15 | 145-153 | Modifier | denotes | sporadic |
| T16 | 154-158 | SpecificDisease | denotes | G6PD |
| T17 | 159-167 | Modifier | denotes | variants |
| T18 | 172-175 | Modifier | denotes | due |
| T19 | 179-185 | Modifier | denotes | single |
| T20 | 186-194 | Modifier | denotes | missense |
| T21 | 195-204 | Modifier | denotes | mutations |
| T22 | 209-212 | Modifier | denotes | the |
| T23 | 213-217 | Modifier | denotes | four |
| T24 | 218-229 | Modifier | denotes | polymorphic |
| T25 | 249-252 | Modifier | denotes | two |
| T26 | 253-258 | Modifier | denotes | point |
| T27 | 259-268 | Modifier | denotes | mutations |
| T28 | 270-273 | Modifier | denotes | one |
| T29 | 294-300 | Modifier | denotes | always |
| T30 | 301-304 | Modifier | denotes | 376 |
| T31 | 305-306 | Modifier | denotes | A |
| T32 | 309-310 | Modifier | denotes | G |
| T33 | 312-315 | Modifier | denotes | 126 |
| T34 | 316-319 | Modifier | denotes | Asn |
| T35 | 322-325 | Modifier | denotes | Asp |
| T36 | 328-333 | Modifier | denotes | which |
| T37 | 337-340 | Modifier | denotes | its |
| T38 | 341-344 | Modifier | denotes | own |
| T39 | 345-350 | Modifier | denotes | gives |
| T40 | 351-355 | Modifier | denotes | rise |
| T41 | 359-362 | Modifier | denotes | the |
| T42 | 363-375 | Modifier | denotes | nondeficient |
| T43 | 376-387 | Modifier | denotes | polymorphic |
| T44 | 388-395 | Modifier | denotes | variant |
| T45 | 397-401 | SpecificDisease | denotes | G6PD |
| T46 | 405-407 | Modifier | denotes | In |
| T47 | 410-415 | Modifier | denotes | study |
| T48 | 434-442 | Modifier | denotes | patients |
| T49 | 447-456 | Modifier | denotes | presented |
| T50 | 462-470 | Modifier | denotes | clinical |
| T51 | 471-477 | SpecificDisease | denotes | favism |
| T52 | 481-1416 | CompositeMention | denotes | Spain, we have found a new polymorphic variant that we have called G6PD Malaga, whose only abnormality is a 542 A-->T (181 Asp-->Val) mutation. This is the same mutation as previously found in association with the mutation of G6PD A in the double mutant, G6PD Santamaria. G6PD Malaga is associated with enzyme deficiency (class III), and the enzymic properties of G6PD Malaga and G6PD Santamaria are quite similar, indicating that in this case the effects of the two mutations are additive rather than synergistic. G6PD Santamaria might have been produced by recombination between G6PD A and G6PD Malaga; however haplotype analysis, including the use of a new silent polymorphism, suggests that the same 542 A-->T mutation has taken place independently in a G6PD B gene to give G6PD Malaga and in a G6PD A gene to give G6PD Santamaria. These findings help to outline the relationship and evolution of mutations in the human G6PD locus. |
ncbi-valid-deepseek-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 63-101 | CompositeMention | denotes | glucose 6-phosphate dehydrogenase gene |
| T2 | 129-140 | Modifier | denotes | polymorphic |
| T3 | 145-153 | Modifier | denotes | sporadic |
| T4 | 154-167 | CompositeMention | denotes | G6PD variants |
| T5 | 301-310 | CompositeMention | denotes | 376 A-->G |
| T6 | 363-375 | Modifier | denotes | nondeficient |
| T7 | 397-403 | CompositeMention | denotes | G6PD A |
| T8 | 471-477 | SpecificDisease | denotes | favism |
| T9 | 548-559 | CompositeMention | denotes | G6PD Malaga |
| T10 | 589-598 | CompositeMention | denotes | 542 A-->T |
| T11 | 736-751 | CompositeMention | denotes | G6PD Santamaria |
| T12 | 803-812 | DiseaseClass | denotes | class III |
| T13 | 962-970 | Modifier | denotes | additive |
| T14 | 983-994 | Modifier | denotes | synergistic |
| T15 | 1239-1250 | CompositeMention | denotes | G6PD B gene |
ncbi-valid-deepseek-r-g
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 154-167 | DiseaseClass | denotes | G6PD variants |
| T2 | 397-403 | SpecificDisease | denotes | G6PD A |
| T3 | 419-433 | SpecificDisease | denotes | G6PD deficient |
| T4 | 462-477 | SpecificDisease | denotes | clinical favism |
| T5 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T6 | 707-713 | SpecificDisease | denotes | G6PD A |
| T7 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T8 | 784-813 | DiseaseClass | denotes | enzyme deficiency (class III) |
ncbi-valid-gemini-r-ng
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 154-167 | DiseaseClass | denotes | G6PD variants |
| T2 | 179-204 | Modifier | denotes | single missense mutations |
| T3 | 253-268 | Modifier | denotes | point mutations |
| T4 | 301-326 | Modifier | denotes | 376 A-->G (126 Asn-->Asp) |
| T5 | 363-375 | Modifier | denotes | nondeficient |
| T6 | 376-395 | Modifier | denotes | polymorphic variant |
| T7 | 397-403 | SpecificDisease | denotes | G6PD A |
| T8 | 419-433 | Modifier | denotes | G6PD deficient |
| T9 | 462-477 | SpecificDisease | denotes | clinical favism |
| T10 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T11 | 589-623 | Modifier | denotes | 542 A-->T (181 Asp-->Val) mutation |
| T12 | 707-713 | SpecificDisease | denotes | G6PD A |
| T13 | 721-734 | Modifier | denotes | double mutant |
| T14 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T15 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T16 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
| T17 | 803-812 | Modifier | denotes | class III |
| T18 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T19 | 861-876 | SpecificDisease | denotes | G6PD Santamaria |
| T20 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
| T21 | 1062-1068 | SpecificDisease | denotes | G6PD A |
| T22 | 1073-1084 | SpecificDisease | denotes | G6PD Malaga |
| T23 | 1185-1203 | Modifier | denotes | 542 A-->T mutation |
| T24 | 1382-1391 | Modifier | denotes | mutations |
ncbi-valid-gemini-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
| T3 | 784-801 | DiseaseClass | denotes | enzyme deficiency |
ncbi-valid-gpt-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
ncbi-valid-deepseek-r-m
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | Modifier | denotes | G6PD deficient |
| T2 | 462-477 | SpecificDisease | denotes | clinical favism |
NCBI-Disease-Develop
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T608 | 419-433 | Modifier | denotes | G6PD deficient | D005955 |
| T609 | 471-477 | SpecificDisease | denotes | favism | D005236 |
| T610 | 784-801 | DiseaseClass | denotes | enzyme deficiency | D008661 |
NCBI-Disease-Corpus-All
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T608 | 419-433 | Modifier | denotes | G6PD deficient | D005955 |
| T609 | 471-477 | SpecificDisease | denotes | favism | D005236 |
| T610 | 784-801 | DiseaseClass | denotes | enzyme deficiency | D008661 |
NCBI-Disease-Corpus-2stage-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 154-167 | SpecificDisease | denotes | G6PD variants |
| T2 | 230-238 | DiseaseClass | denotes | variants |
| T3 | 397-403 | SpecificDisease | denotes | G6PD A |
| T4 | 419-433 | Modifier | denotes | G6PD deficient |
| T5 | 471-477 | SpecificDisease | denotes | favism |
| T6 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T7 | 707-713 | SpecificDisease | denotes | G6PD A |
| T8 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T9 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T10 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T11 | 861-876 | SpecificDisease | denotes | G6PD Santamaria |
| T12 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
| T13 | 1062-1068 | SpecificDisease | denotes | G6PD A |
| T14 | 1073-1084 | SpecificDisease | denotes | G6PD Malaga |
| T15 | 1239-1250 | Modifier | denotes | G6PD B gene |
| T16 | 1259-1270 | SpecificDisease | denotes | G6PD Malaga |
| T17 | 1280-1291 | Modifier | denotes | G6PD A gene |
| T18 | 1300-1315 | SpecificDisease | denotes | G6PD Santamaria |
| T19 | 1405-1415 | Modifier | denotes | G6PD locus |
NCBI-Disease-Corpus-rezarta-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 154-167 | Modifier | denotes | G6PD variants |
| T2 | 397-403 | SpecificDisease | denotes | G6PD A |
| T3 | 419-433 | Modifier | denotes | G6PD deficient |
| T4 | 471-477 | SpecificDisease | denotes | favism |
| T5 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T6 | 707-713 | SpecificDisease | denotes | G6PD A |
| T7 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T8 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T9 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T10 | 861-876 | SpecificDisease | denotes | G6PD Santamaria |
| T11 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
| T12 | 1062-1068 | SpecificDisease | denotes | G6PD A |
| T13 | 1073-1084 | SpecificDisease | denotes | G6PD Malaga |
| T14 | 1239-1245 | Modifier | denotes | G6PD B |
| T15 | 1259-1270 | SpecificDisease | denotes | G6PD Malaga |
| T16 | 1280-1286 | SpecificDisease | denotes | G6PD A |
| T17 | 1300-1315 | SpecificDisease | denotes | G6PD Santamaria |
| T18 | 1405-1415 | Modifier | denotes | G6PD locus |
NCBI-Disease-Corpus-4oGuideline-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-433 | SpecificDisease | denotes | G6PD deficient |
| T2 | 471-477 | SpecificDisease | denotes | favism |
| T3 | 784-813 | SpecificDisease | denotes | enzyme deficiency (class III) |
NCBI-Disease-Corpus-Simple-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 154-167 | SpecificDisease | denotes | G6PD variants |
| T2 | 397-403 | SpecificDisease | denotes | G6PD A |
| T3 | 419-442 | SpecificDisease | denotes | G6PD deficient patients |
| T4 | 471-477 | SpecificDisease | denotes | favism |
| T5 | 548-559 | SpecificDisease | denotes | G6PD Malaga |
| T6 | 707-713 | SpecificDisease | denotes | G6PD A |
| T7 | 736-751 | SpecificDisease | denotes | G6PD Santamaria |
| T8 | 753-764 | SpecificDisease | denotes | G6PD Malaga |
| T9 | 784-813 | Modifier | denotes | enzyme deficiency (class III) |
| T10 | 845-856 | SpecificDisease | denotes | G6PD Malaga |
| T11 | 861-876 | SpecificDisease | denotes | G6PD Santamaria |
| T12 | 996-1011 | SpecificDisease | denotes | G6PD Santamaria |
| T13 | 1062-1068 | SpecificDisease | denotes | G6PD A |
| T14 | 1073-1084 | SpecificDisease | denotes | G6PD Malaga |
| T15 | 1239-1250 | SpecificDisease | denotes | G6PD B gene |
| T16 | 1259-1270 | SpecificDisease | denotes | G6PD Malaga |
| T17 | 1280-1291 | SpecificDisease | denotes | G6PD A gene |
| T18 | 1300-1315 | SpecificDisease | denotes | G6PD Santamaria |
| T19 | 1405-1415 | SpecificDisease | denotes | G6PD locus |