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sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
T2 114-289 Sentence denotes The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.
T3 290-422 Sentence denotes To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.
T4 423-557 Sentence denotes We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.
T5 558-769 Sentence denotes This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.
T6 770-895 Sentence denotes Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.
T7 896-1015 Sentence denotes In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.
T8 1016-1151 Sentence denotes The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).
T9 1152-1297 Sentence denotes This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.
T10 1298-1543 Sentence denotes Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.
T11 1544-1654 Sentence denotes ZAP-70 will then be able to effectively control phosphorylation of its substrates and lead to gene activation.
T1 0-113 Sentence denotes Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
T2 114-289 Sentence denotes The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.
T3 290-422 Sentence denotes To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.
T4 423-557 Sentence denotes We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.
T5 558-769 Sentence denotes This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.
T6 770-895 Sentence denotes Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.
T7 896-1015 Sentence denotes In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.
T8 1016-1151 Sentence denotes The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).
T9 1152-1297 Sentence denotes This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.
T10 1298-1543 Sentence denotes Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.
T11 1544-1654 Sentence denotes ZAP-70 will then be able to effectively control phosphorylation of its substrates and lead to gene activation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 37-50 protein denotes kinase domain
T2 54-60 protein denotes ZAP-70
T3 78-93 protein denotes T-cell receptor
T4 118-141 protein denotes protein-tyrosine kinase
T5 142-148 protein denotes ZAP-70
T6 182-192 protein denotes Src kinase
T7 193-201 protein denotes p56(lck)
T8 266-269 protein denotes TCR
T9 339-345 protein denotes ZAP-70
T10 447-465 cell_line denotes Jurkat T-cell line
T11 466-472 protein denotes ZAP-70
T12 543-556 protein denotes kinase domain
T13 580-583 protein denotes TCR
T14 606-641 protein denotes nuclear factor of activated T cells
T15 702-705 protein denotes Ras
T16 730-768 protein denotes extracellular signal-regulated kinases
T17 780-783 protein denotes TCR
T18 811-818 protein denotes pp36-38
T19 927-943 protein denotes wild-type ZAP-70
T20 979-1014 protein denotes nuclear factor of activated T cells
T21 1020-1026 protein denotes ZAP-70
T22 1106-1120 protein denotes TCR zeta chain
T23 1142-1150 protein denotes p56(lck)
T24 1276-1284 protein denotes p56(lck)
T25 1290-1296 protein denotes ZAP-70
T26 1368-1371 protein denotes TCR
T27 1379-1385 protein denotes ZAP-70
T28 1421-1429 protein denotes p56(lck)
T29 1520-1526 protein denotes ZAP-70
T30 1544-1550 protein denotes ZAP-70

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-113 Sentence denotes Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
S2 114-289 Sentence denotes The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.
S3 290-422 Sentence denotes To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.
S4 423-557 Sentence denotes We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.
S5 558-769 Sentence denotes This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.
S6 770-895 Sentence denotes Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.
S7 896-1015 Sentence denotes In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.
S8 1016-1151 Sentence denotes The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).
S9 1152-1297 Sentence denotes This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.
S10 1298-1543 Sentence denotes Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.
S11 1544-1654 Sentence denotes ZAP-70 will then be able to effectively control phosphorylation of its substrates and lead to gene activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C11 12-29 NP denotes tyrosines 492/493
C1 54-60 NP denotes ZAP-70
C10 33-60 NP denotes the kinase domain of ZAP-70
C12 69-112 NP denotes multiple T-cell receptor signaling pathways
C2 114-148 NP denotes The protein-tyrosine kinase ZAP-70
C18 178-201 NP denotes the Src kinase p56(lck)
C3 316-329 NP denotes the mechanism
C4 333-338 NP denotes which
C5 339-345 NP denotes ZAP-70
C6 466-472 NP denotes ZAP-70
C7 484-503 NP denotes Tyr-492 and Tyr-493
C9 539-542 NP denotes its
C8 539-556 NP denotes its kinase domain
C16 558-569 NP denotes This mutant
C26 580-584 NP denotes TCR-
C14 606-641 NP denotes nuclear factor of activated T cells
C27 780-784 NP denotes TCR-
C13 855-869 NP denotes these pathways
C15 979-1014 NP denotes nuclear factor of activated T cells
C17 1016-1046 NP denotes The ZAP-70 mutant studied here
C19 1142-1150 NP denotes p56(lck)
C20 1182-1201 NP denotes Tyr-492 and Tyr-493
C21 1276-1284 NP denotes p56(lck)
C22 1290-1296 NP denotes ZAP-70
C23 1332-1339 NP denotes a model
C24 1343-1348 NP denotes which
C25 1364-1371 NP denotes the TCR
C28 1421-1429 NP denotes p56(lck)
C29 1431-1436 NP denotes which
C30 1460-1482 NP denotes Tyr-492 and/or Tyr-493
C31 1544-1550 NP denotes ZAP-70
C32 1611-1614 NP denotes its
R1 C2 C1 coref-ident The protein-tyrosine kinase ZAP-70,ZAP-70
R2 C4 C3 coref-relat which,the mechanism
R3 C5 C2 coref-ident ZAP-70,The protein-tyrosine kinase ZAP-70
R4 C6 C5 coref-ident ZAP-70,ZAP-70
R5 C7 C11 coref-ident Tyr-492 and Tyr-493,tyrosines 492/493
R6 C9 C6 coref-pron its,ZAP-70
R7 C8 C10 coref-ident its kinase domain,the kinase domain of ZAP-70
R8 C27 C26 coref-ident TCR-,TCR-
R9 C13 C12 coref-ident these pathways,multiple T-cell receptor signaling pathways
R10 C15 C14 coref-ident nuclear factor of activated T cells,nuclear factor of activated T cells
R11 C17 C16 coref-ident The ZAP-70 mutant studied here,This mutant
R12 C19 C18 coref-ident p56(lck),the Src kinase p56(lck)
R13 C20 C7 coref-ident Tyr-492 and Tyr-493,Tyr-492 and Tyr-493
R14 C21 C19 coref-ident p56(lck),p56(lck)
R15 C22 C6 coref-ident ZAP-70,ZAP-70
R16 C24 C23 coref-relat which,a model
R17 C25 C27 coref-ident the TCR,TCR-
R18 C28 C21 coref-ident p56(lck),p56(lck)
R19 C29 C28 coref-relat which,p56(lck)
R20 C30 C20 coref-ident Tyr-492 and/or Tyr-493,Tyr-492 and Tyr-493
R21 C31 C22 coref-ident ZAP-70,ZAP-70
R22 C32 C31 coref-pron its,ZAP-70

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-21 amino_acid_monomer denotes tyrosines
T2 22-29 amino_acid_monomer denotes 492/493
T3 37-50 protein_domain_or_region denotes kinase domain
T4 54-60 protein_molecule denotes ZAP-70
T5 78-93 protein_family_or_group denotes T-cell receptor
T6 118-141 protein_family_or_group denotes protein-tyrosine kinase
T7 142-148 protein_molecule denotes ZAP-70
T8 182-192 protein_family_or_group denotes Src kinase
T9 193-201 protein_molecule denotes p56(lck)
T10 241-266 other_name denotes T-cell antigen receptor (
T11 266-269 protein_family_or_group denotes TCR
T12 339-345 protein_molecule denotes ZAP-70
T13 388-421 other_name denotes dominant-negative mutant approach
T14 447-465 cell_line denotes Jurkat T-cell line
T15 466-472 protein_molecule denotes ZAP-70
T16 484-491 amino_acid_monomer denotes Tyr-492
T17 496-503 amino_acid_monomer denotes Tyr-493
T18 543-556 protein_domain_or_region denotes kinase domain
T19 580-583 protein_family_or_group denotes TCR
T20 606-623 protein_family_or_group denotes nuclear factor of
T21 624-633 cell_type denotes activated
T22 634-641 cell_type denotes T cells
T23 667-680 other_name denotes intracellular
T24 681-688 atom denotes calcium
T25 702-705 protein_molecule denotes Ras
T26 730-768 protein_family_or_group denotes extracellular signal-regulated kinases
T27 780-783 protein_family_or_group denotes TCR
T28 811-818 protein_molecule denotes pp36-38
T29 927-936 protein_molecule denotes wild-type
T30 937-943 protein_molecule denotes ZAP-70
T31 979-996 protein_molecule denotes nuclear factor of
T32 997-1006 cell_type denotes activated
T33 1007-1014 cell_type denotes T cells
T34 1020-1026 protein_molecule denotes ZAP-70
T35 1074-1082 amino_acid_monomer denotes tyrosine
T36 1106-1120 protein_subunit denotes TCR zeta chain
T37 1142-1150 protein_molecule denotes p56(lck)
T38 1182-1189 amino_acid_monomer denotes Tyr-492
T39 1194-1201 amino_acid_monomer denotes Tyr-493
T40 1276-1284 protein_molecule denotes p56(lck)
T41 1290-1296 protein_molecule denotes ZAP-70
T42 1368-1371 protein_family_or_group denotes TCR
T43 1379-1385 protein_molecule denotes ZAP-70
T44 1421-1429 protein_molecule denotes p56(lck)
T45 1460-1467 amino_acid_monomer denotes Tyr-492
T46 1475-1482 amino_acid_monomer denotes Tyr-493
T47 1520-1526 protein_molecule denotes ZAP-70
T48 1544-1550 protein_molecule denotes ZAP-70
T49 1638-1653 other_name denotes gene activation

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 78-84 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 241-247 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T3 454-460 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T4 667-680 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 730-743 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 78-84 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 241-247 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T3 454-460 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T4 634-641 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 1007-1014 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084