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PubMed:8955068 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.
T2 87-273 Sentence denotes A novel alteration in exon 1 of KRAS was detected by single strand conformational polymorphism analysis of DNA amplified from the bone marrow of a 4-year-old child with myeloid leukemia.
T3 274-421 Sentence denotes Sequencing of this mutant allele revealed an insertion of three nucleotides between codons 10 and 11 resulting in an in-frame insertion of glycine.
T4 422-601 Sentence denotes Expression of the mutant protein in NIH 3T3 cells caused cellular transformation, and expression in COS cells activated the Ras-mitogen-activated protein kinase signaling pathway.
T5 602-770 Sentence denotes Surprisingly, Ras.GTP levels measured in COS cells established that this novel mutant accumulates to 90% in the GTP state, considerably higher than a residue 12 mutant.
T6 771-947 Sentence denotes Biochemical analysis confirmed that the higher Ras.GTP levels correspond to a dramatic decrease in intrinsic GTP hydrolysis as well as resistance to GTPase-activating proteins.
T7 948-1156 Sentence denotes This mutation is the first dominant Ras mutation found in human cancer that does not involve residues 12, 13, or 61, and its biochemical properties should help elucidate the mechanism of oncogenic activation.
T1 0-86 Sentence denotes Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.
T2 87-273 Sentence denotes A novel alteration in exon 1 of KRAS was detected by single strand conformational polymorphism analysis of DNA amplified from the bone marrow of a 4-year-old child with myeloid leukemia.
T3 274-421 Sentence denotes Sequencing of this mutant allele revealed an insertion of three nucleotides between codons 10 and 11 resulting in an in-frame insertion of glycine.
T4 422-601 Sentence denotes Expression of the mutant protein in NIH 3T3 cells caused cellular transformation, and expression in COS cells activated the Ras-mitogen-activated protein kinase signaling pathway.
T5 602-770 Sentence denotes Surprisingly, Ras.GTP levels measured in COS cells established that this novel mutant accumulates to 90% in the GTP state, considerably higher than a residue 12 mutant.
T6 771-947 Sentence denotes Biochemical analysis confirmed that the higher Ras.GTP levels correspond to a dramatic decrease in intrinsic GTP hydrolysis as well as resistance to GTPase-activating proteins.
T7 948-1156 Sentence denotes This mutation is the first dominant Ras mutation found in human cancer that does not involve residues 12, 13, or 61, and its biochemical properties should help elucidate the mechanism of oncogenic activation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 217-228 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T2 217-221 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

DisGeNET

Id Subject Object Predicate Lexical cue
T0 119-123 gene:3845 denotes KRAS
T1 256-272 disease:C0023470 denotes myeloid leukemia
R1 T0 T1 associated_with KRAS,myeloid leukemia

PennBioIE

Id Subject Object Predicate Lexical cue
T1 40-44 protein denotes KRAS
T2 45-54 protein denotes insertion
T3 55-63 protein denotes mutation
T4 109-115 protein denotes exon 1
T5 119-123 protein denotes KRAS
T6 319-349 protein denotes insertion of three nucleotides
T7 350-374 protein denotes between codons 10 and 11
T8 391-409 protein denotes in-frame insertion
T9 413-420 protein denotes glycine
T10 440-454 protein denotes mutant protein
T11 546-549 protein denotes Ras
T12 550-582 protein denotes mitogen-activated protein kinase
T13 616-619 protein denotes Ras
T14 681-687 protein denotes mutant
T15 752-762 protein denotes residue 12
T16 763-769 protein denotes mutant
T17 818-821 protein denotes Ras
T18 920-926 protein denotes GTPase
T19 953-961 protein denotes mutation
T20 984-987 protein denotes Ras
T21 1041-1049 protein denotes residues
T22 1054-1056 protein denotes 13
T23 1061-1063 protein denotes 61

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8955068-0#40#44#gene3845 40-44 gene3845 denotes KRAS
8955068-0#77#85#diseaseC0023418 77-85 diseaseC0023418 denotes leukemia
8955068-1#32#36#gene3845 119-123 gene3845 denotes KRAS
8955068-1#169#185#diseaseC0023470 256-272 diseaseC0023470 denotes myeloid leukemia
40#44#gene384577#85#diseaseC0023418 8955068-0#40#44#gene3845 8955068-0#77#85#diseaseC0023418 associated_with KRAS,leukemia
32#36#gene3845169#185#diseaseC0023470 8955068-1#32#36#gene3845 8955068-1#169#185#diseaseC0023470 associated_with KRAS,myeloid leukemia

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 77-85 HP:0001909 denotes leukemia
AB1 256-272 HP:0012324 denotes myeloid leukemia

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 217-228 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 77-85 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T2 256-272 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T3 1012-1018 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 71-76 OrganismTaxon denotes human 9606
T2 413-420 OrganismTaxon denotes glycine 3846
T3 1006-1011 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 217-228 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 77-85 Phenotype denotes leukemia HP:0001909
T2 256-272 Phenotype denotes myeloid leukemia HP:0012324
T3 1012-1018 Phenotype denotes cancer HP:0002664