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sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
T2 151-337 Sentence denotes Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
T3 338-462 Sentence denotes MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
T4 463-587 Sentence denotes We report herein the isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library.
T5 588-714 Sentence denotes The nucleotide sequence predicts that MAPKKK5 encodes an open reading frame of 1374 amino acids with all 11 kinase subdomains.
T6 715-978 Sentence denotes The putative catalytic domain of MAPKKK5 shows significant sequence homology to the kinase domains of the MAPKKK/MEKK level protein kinases from mouse MEKK2 and -3, Drosophila melanogaster PK92B, Saccharomyces cerevisiae STE11, and Schizosaccharomyces pombe BYR2.
T7 979-1085 Sentence denotes Northern blot analysis showed that MAPKKK5 transcript is abundantly expressed in human heart and pancreas.
T8 1086-1239 Sentence denotes When transiently expressed in COS and 293 cells, MAPKKK5 markedly activated c-Jun N-terminal kinase or stress-activated protein kinase, but not MAPK/ERK.
T9 1240-1470 Sentence denotes Furthermore, MAPKKK5 that was immunoprecipitated from transfected 293 cells was able to phosphorylate and activate MKK4 in vitro, suggesting that MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway.
T1 0-150 Sentence denotes Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
T2 151-337 Sentence denotes Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
T3 338-462 Sentence denotes MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
T4 463-587 Sentence denotes We report herein the isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library.
T5 588-714 Sentence denotes The nucleotide sequence predicts that MAPKKK5 encodes an open reading frame of 1374 amino acids with all 11 kinase subdomains.
T6 715-978 Sentence denotes The putative catalytic domain of MAPKKK5 shows significant sequence homology to the kinase domains of the MAPKKK/MEKK level protein kinases from mouse MEKK2 and -3, Drosophila melanogaster PK92B, Saccharomyces cerevisiae STE11, and Schizosaccharomyces pombe BYR2.
T7 979-1085 Sentence denotes Northern blot analysis showed that MAPKKK5 transcript is abundantly expressed in human heart and pancreas.
T8 1086-1239 Sentence denotes When transiently expressed in COS and 293 cells, MAPKKK5 markedly activated c-Jun N-terminal kinase or stress-activated protein kinase, but not MAPK/ERK.
T9 1240-1470 Sentence denotes Furthermore, MAPKKK5 that was immunoprecipitated from transfected 293 cells was able to phosphorylate and activate MKK4 in vitro, suggesting that MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1066-1071 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 1076-1084 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1066-1071 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 1076-1084 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1076-1084 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 562-567 OrganismTaxon denotes human 9606
T2 860-865 OrganismTaxon denotes mouse 10088|10090
T4 880-903 OrganismTaxon denotes Drosophila melanogaster 7227
T5 911-935 OrganismTaxon denotes Saccharomyces cerevisiae 4932
T6 947-972 OrganismTaxon denotes Schizosaccharomyces pombe 4896
T7 1060-1065 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 226-239 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 568-578 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 1066-1071 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T7 1076-1084 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 568-578 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394