> top > docs > PubMed:8922951 > annotations

PubMed:8922951 JSONTXT

Annnotations TAB JSON ListView MergeView

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 145-149 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T2 145-149 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T3 270-282 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T4 320-324 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T5 320-324 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T6 335-339 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T7 335-339 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T8 375-386 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T9 414-423 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T10 414-423 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T11 931-954 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T12 931-954 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T13 1121-1125 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T14 1121-1125 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T15 1321-1332 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T16 1474-1478 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T17 1474-1478 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T18 1496-1500 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T19 1496-1500 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T20 1766-1787 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T21 1984-1988 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T22 1984-1988 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T23 2053-2065 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T24 2212-2216 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T25 2212-2216 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T26 2342-2353 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T27 2459-2463 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T28 2459-2463 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 145-149 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T3 270-282 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 320-324 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T6 335-339 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T8 360-386 Glycan_Motif denotes 9-O-acetylated sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G47325QT
T9 375-386 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 414-423 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T12 931-954 Glycan_Motif denotes N-acetylneuraminic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T14 1121-1125 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T16 1321-1332 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T17 1474-1478 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T19 1496-1500 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T21 1766-1787 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB
T22 1984-1988 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T24 2038-2065 Glycan_Motif denotes 9-O-acetylated sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G47325QT
T25 2053-2065 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T26 2212-2216 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T28 2327-2353 Glycan_Motif denotes 9-O-acetylated sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G47325QT
T29 2342-2353 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T30 2459-2463 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
TextSentencer_T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
TextSentencer_T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
TextSentencer_T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
TextSentencer_T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
TextSentencer_T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
TextSentencer_T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
TextSentencer_T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
TextSentencer_T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
TextSentencer_T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
TextSentencer_T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
TextSentencer_T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
TextSentencer_T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.
T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.
T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 145-149 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T2 145-149 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T3 270-282 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T4 320-324 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T5 320-324 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T6 335-339 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T7 335-339 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T8 360-386 https://glytoucan.org/Structures/Glycans/G47325QT denotes 9-O-acetylated sialic acid
T9 375-386 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T10 414-423 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T11 414-423 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T12 931-954 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T13 931-954 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T14 1121-1125 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T15 1121-1125 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T16 1321-1332 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T17 1474-1478 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T18 1474-1478 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T19 1496-1500 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T20 1496-1500 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T21 1766-1787 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T22 1984-1988 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T23 1984-1988 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T24 2038-2065 https://glytoucan.org/Structures/Glycans/G47325QT denotes 9-O-acetylated sialic acids
T25 2053-2065 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T26 2212-2216 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T27 2212-2216 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T28 2327-2353 https://glytoucan.org/Structures/Glycans/G47325QT denotes 9-O-acetylated sialic acid
T29 2342-2353 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T30 2459-2463 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T31 2459-2463 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 145-149 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T2 320-324 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T3 335-339 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T4 1121-1125 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T5 1474-1478 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T6 1496-1500 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T7 1984-1988 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T8 2212-2216 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
T9 2459-2463 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 98-121 FMAID:82788 denotes O-acetylneuraminic acid
_T2 98-121 FMAID:196782 denotes O-acetylneuraminic acid
_T3 133-144 FMAID:82816 denotes ganglioside
_T4 133-144 FMAID:196811 denotes ganglioside
_T5 210-224 FMAID:167177 denotes immunoglobulin
_T6 210-224 FMAID:62871 denotes immunoglobulin
_T7 210-226 FMAID:62875 denotes immunoglobulin G
_T8 210-226 FMAID:167185 denotes immunoglobulin G
_T9 210-226 FMAID:62876 denotes immunoglobulin G
_T10 210-226 FMAID:167187 denotes immunoglobulin G
_T11 210-226 FMAID:167183 denotes immunoglobulin G
_T12 210-226 FMAID:62874 denotes immunoglobulin G
_T13 210-226 FMAID:167178 denotes immunoglobulin G
_T14 210-226 FMAID:62872 denotes immunoglobulin G
_T15 210-226 FMAID:167181 denotes immunoglobulin G
_T16 210-226 FMAID:62873 denotes immunoglobulin G
_T17 414-423 FMAID:82794 denotes galactose
_T18 414-423 FMAID:196789 denotes galactose
_T19 478-490 FMAID:82737 denotes carbohydrate
_T20 478-490 FMAID:197276 denotes carbohydrate
_T21 535-543 FMAID:167180 denotes antibody
_T22 642-654 FMAID:197276 denotes carbohydrate
_T23 642-654 FMAID:82737 denotes carbohydrate
_T24 682-684 FMAID:179042 denotes MD
_T25 701-716 FMAID:196731 denotes oligosaccharide
_T26 701-716 FMAID:82742 denotes oligosaccharide
_T27 922-930 FMAID:214710 denotes internal
_T28 931-954 FMAID:82789 denotes N-acetylneuraminic acid
_T29 931-954 FMAID:196782 denotes N-acetylneuraminic acid
_T30 931-954 FMAID:82788 denotes N-acetylneuraminic acid
_T31 931-954 FMAID:82799 denotes N-acetylneuraminic acid
_T32 931-954 FMAID:196783 denotes N-acetylneuraminic acid
_T33 931-954 FMAID:196794 denotes N-acetylneuraminic acid
_T34 979-981 FMAID:179042 denotes MD
_T35 1077-1092 FMAID:82742 denotes oligosaccharide
_T36 1077-1092 FMAID:196731 denotes oligosaccharide
_T37 1126-1137 FMAID:196811 denotes ganglioside
_T38 1126-1137 FMAID:82816 denotes ganglioside
_T39 1384-1395 FMAID:196811 denotes ganglioside
_T40 1384-1395 FMAID:82816 denotes ganglioside
_T41 1616-1626 FMAID:196733 denotes saccharide
_T42 1616-1626 FMAID:82744 denotes saccharide
_T43 1766-1787 FMAID:82786 denotes N-acetylgalactosamine
_T44 1766-1787 FMAID:196780 denotes N-acetylgalactosamine
_T45 1888-1899 FMAID:82816 denotes ganglioside
_T46 1888-1899 FMAID:196811 denotes ganglioside
_T47 2005-2013 FMAID:67257 denotes proteins
_T48 2005-2013 FMAID:165447 denotes proteins
_T49 2268-2271 FMAID:167179 denotes IgG
_T50 2292-2297 FMAID:167330 denotes serum
_T51 2563-2570 FMAID:165447 denotes protein
_T52 2563-2570 FMAID:67257 denotes protein

uniprot-human

Id Subject Object Predicate Lexical cue
T1 931-954 http://www.uniprot.org/uniprot/Q9BXD5 denotes N-acetylneuraminic acid
T2 931-954 http://www.uniprot.org/uniprot/Q9NR45 denotes N-acetylneuraminic acid

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 440-447 http://www.uniprot.org/uniprot/Q9EQE5 denotes spatial
T2 1637-1644 http://www.uniprot.org/uniprot/Q9EQE5 denotes spatial

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 601-606 http://purl.bioontology.org/ontology/STY/T096 denotes group
T2 772-775 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non
T3 1051-1060 http://purl.bioontology.org/ontology/STY/T053 denotes behaviour
T4 1735-1740 http://purl.bioontology.org/ontology/STY/T096 denotes group
T5 1942-1947 http://purl.bioontology.org/ontology/STY/T096 denotes group
T6 2134-2139 http://purl.bioontology.org/ontology/STY/T096 denotes group
T7 2542-2547 http://purl.bioontology.org/ontology/STY/T096 denotes group

GO-BP

Id Subject Object Predicate Lexical cue
T1 1051-1060 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviour
T2 2438-2444 http://purl.obolibrary.org/obo/GO_0032259 denotes methyl
T3 2445-2451 http://purl.obolibrary.org/obo/GO_0023052 denotes signal

GO-MF

Id Subject Object Predicate Lexical cue
T1 180-187 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1973-1980 http://purl.obolibrary.org/obo/GO_0070026 denotes Binding
T3 180-187 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T4 1973-1980 http://purl.obolibrary.org/obo/GO_0003680 denotes Binding
T5 180-187 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T6 1973-1980 http://purl.obolibrary.org/obo/GO_0017091 denotes Binding
T7 180-187 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8 1973-1980 http://purl.obolibrary.org/obo/GO_0005488 denotes Binding
T9 210-224 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T10 535-543 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 448-457 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension
T2 2292-2297 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 0-18 http://edamontology.org/topic_0176 denotes Molecular dynamics
T2 44-70 http://edamontology.org/topic_0602 denotes intramolecular interaction
T3 59-70 http://edamontology.org/topic_0602 denotes interaction
T4 154-157 http://edamontology.org/topic_0593 denotes NMR
T5 193-198 http://edamontology.org/topic_2815 denotes human
T6 478-490 http://edamontology.org/topic_0152 denotes carbohydrate
T7 529-534 http://edamontology.org/topic_2815 denotes human
T8 560-565 http://edamontology.org/topic_3678 denotes study
T9 642-654 http://edamontology.org/topic_0152 denotes carbohydrate
T10 662-680 http://edamontology.org/topic_0176 denotes molecular dynamics
T11 838-843 http://edamontology.org/topic_3678 denotes study
T12 1231-1234 http://edamontology.org/topic_0593 denotes NMR
T13 1269-1274 http://edamontology.org/topic_3678 denotes study
T14 1312-1320 http://edamontology.org/topic_0749 denotes terminal
T15 1409-1420 http://edamontology.org/topic_0602 denotes interaction
T16 1518-1536 http://edamontology.org/topic_0176 denotes molecular dynamics
T17 1679-1691 http://edamontology.org/topic_0602 denotes interactions
T18 1857-1868 http://edamontology.org/topic_0602 denotes interaction
T19 2005-2013 http://edamontology.org/topic_0078 denotes proteins
T20 2184-2187 http://edamontology.org/topic_0593 denotes NMR
T21 2188-2193 http://edamontology.org/topic_3678 denotes study
T22 2286-2291 http://edamontology.org/topic_2815 denotes human
T23 2512-2523 http://edamontology.org/topic_0602 denotes interaction
T24 2557-2562 http://edamontology.org/topic_2815 denotes human
T25 2563-2570 http://edamontology.org/topic_0078 denotes protein

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 0-18 http://edamontology.org/operation_2476 denotes Molecular dynamics
T2 44-79 http://edamontology.org/operation_2948 denotes intramolecular interaction analysis
T3 71-79 http://edamontology.org/operation_2945 denotes analysis
T4 164-172 http://edamontology.org/operation_2945 denotes analysis
T5 424-431 http://edamontology.org/data_1756 denotes residue
T6 504-515 http://edamontology.org/operation_2423 denotes recognition
T7 662-697 http://edamontology.org/operation_2476 denotes molecular dynamics (MD) simulations
T8 982-994 http://edamontology.org/operation_3438 denotes calculations
T9 1178-1186 http://edamontology.org/operation_3642 denotes dimethyl
T10 1235-1247 http://edamontology.org/data_3108 denotes measurements
T11 1421-1429 http://edamontology.org/operation_2945 denotes analysis
T12 1518-1548 http://edamontology.org/operation_2476 denotes molecular dynamics simulations
T13 1813-1825 http://edamontology.org/operation_3438 denotes calculations
T14 2005-2013 http://edamontology.org/data_1467 denotes proteins
T15 2005-2013 http://edamontology.org/format_1208 denotes proteins
T16 2563-2570 http://edamontology.org/format_1208 denotes protein
T17 2563-2570 http://edamontology.org/data_1467 denotes protein

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 145-149 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T2 320-324 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T3 335-339 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T4 1121-1125 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T5 1474-1478 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T6 1496-1500 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T7 1984-1988 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T8 2212-2216 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T9 2459-2463 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a
PD-GlycoEpitope-B_T10 360-386 http://www.glycoepitope.jp/epitopes/EP0065 denotes 9-O-acetylated sialic acid
PD-GlycoEpitope-B_T11 2038-2065 http://www.glycoepitope.jp/epitopes/EP0065 denotes 9-O-acetylated sialic acids
PD-GlycoEpitope-B_T12 2327-2353 http://www.glycoepitope.jp/epitopes/EP0065 denotes 9-O-acetylated sialic acid

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 772-775 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 772-775 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 772-775 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 772-775 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 772-775 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 772-775 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 772-775 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 772-775 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 772-775 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 772-775 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 772-775 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 2292-2297 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 448-457 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 145-149 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T2 320-324 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T3 335-339 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T4 360-386 Glycan denotes 9-O-acetylated sialic acid https://api.glycosmos.org/wurcs2image/latest/png/binary/G47325QT
T5 1121-1125 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T6 1474-1478 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T7 1496-1500 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T8 1984-1988 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T9 2212-2216 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T10 2327-2353 Glycan denotes 9-O-acetylated sialic acid https://api.glycosmos.org/wurcs2image/latest/png/binary/G47325QT
T11 2459-2463 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 145-149 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T2 320-324 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T3 335-339 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T4 1121-1125 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T5 1474-1478 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T6 1496-1500 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T7 1984-1988 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T8 2212-2216 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T9 2459-2463 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 145-149 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T2 320-324 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T3 335-339 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T4 1121-1125 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T5 1474-1478 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T6 1496-1500 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T7 1984-1988 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T8 2212-2216 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T9 2459-2463 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 448-457 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 193-198 Organism denotes human 9606
T2 529-534 Organism denotes human 9606
T3 2286-2291 Organism denotes human 9606
T4 2557-2562 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 145-149 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T2 320-324 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T3 335-339 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T4 1121-1125 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T5 1474-1478 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T6 1496-1500 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T7 1984-1988 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T8 2212-2216 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056
T9 2459-2463 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 2292-2297 Body_part denotes serum FMA:63083

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 193-198 OrganismTaxon denotes human 9606
T2 529-534 OrganismTaxon denotes human 9606
T3 2286-2291 OrganismTaxon denotes human 9606
T4 2557-2562 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 448-457 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106