PubMed:8910586 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8910586","sourcedb":"PubMed","sourceid":"8910586","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8910586","text":"cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.\nWe have cloned cDNAs corresponding to the human interleukin 13 receptor alpha chain (IL-13Ralpha). The protein has 76% homology to murine IL-13Ralpha, with 95% amino acid identity in the cytoplasmic domain. Only weak IL-13 binding activity was found in cells transfected with only IL-13Ralpha; however, the combination of both IL-13Ralpha and IL-4Ralpha resulted in substantial binding activity, with a Kd of approximately 400 pM, indicating that both chains are essential components of the IL-13 receptor. Whereas IL-13Ralpha serves as an alternative accessory protein to the common cytokine receptor gamma chain (gammac) for IL-4 signaling, it could not replace the function of gammac in allowing enhanced IL-2 binding activity. Nevertheless, the overall size and length of the cytoplasmic domain of IL-13Ralpha and gammac are similar, and like gammac, IL-13Ralpha is located on chromosome X.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":47,"end":82},"obj":"protein"},{"id":"T2","span":{"begin":132,"end":167},"obj":"protein"},{"id":"T3","span":{"begin":169,"end":180},"obj":"protein"},{"id":"T4","span":{"begin":222,"end":233},"obj":"protein"},{"id":"T5","span":{"begin":301,"end":306},"obj":"protein"},{"id":"T6","span":{"begin":365,"end":376},"obj":"protein"},{"id":"T7","span":{"begin":411,"end":422},"obj":"protein"},{"id":"T8","span":{"begin":427,"end":437},"obj":"protein"},{"id":"T9","span":{"begin":575,"end":589},"obj":"protein"},{"id":"T10","span":{"begin":599,"end":610},"obj":"protein"},{"id":"T11","span":{"begin":668,"end":697},"obj":"protein"},{"id":"T12","span":{"begin":699,"end":705},"obj":"protein"},{"id":"T13","span":{"begin":711,"end":715},"obj":"protein"},{"id":"T14","span":{"begin":764,"end":770},"obj":"protein"},{"id":"T15","span":{"begin":792,"end":796},"obj":"protein"},{"id":"T16","span":{"begin":886,"end":897},"obj":"protein"},{"id":"T17","span":{"begin":902,"end":908},"obj":"protein"},{"id":"T18","span":{"begin":931,"end":937},"obj":"protein"},{"id":"T19","span":{"begin":939,"end":950},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"},{"subj":"T13","pred":"source","obj":"AIMed"},{"subj":"T14","pred":"source","obj":"AIMed"},{"subj":"T15","pred":"source","obj":"AIMed"},{"subj":"T16","pred":"source","obj":"AIMed"},{"subj":"T17","pred":"source","obj":"AIMed"},{"subj":"T18","pred":"source","obj":"AIMed"},{"subj":"T19","pred":"source","obj":"AIMed"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":182},"obj":"Sentence"},{"id":"T3","span":{"begin":183,"end":290},"obj":"Sentence"},{"id":"T4","span":{"begin":291,"end":590},"obj":"Sentence"},{"id":"T5","span":{"begin":591,"end":814},"obj":"Sentence"},{"id":"T6","span":{"begin":815,"end":978},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":182},"obj":"Sentence"},{"id":"T3","span":{"begin":183,"end":290},"obj":"Sentence"},{"id":"T4","span":{"begin":291,"end":590},"obj":"Sentence"},{"id":"T5","span":{"begin":591,"end":814},"obj":"Sentence"},{"id":"T6","span":{"begin":815,"end":978},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":41,"end":46},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":126,"end":131},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":271,"end":282},"obj":"Body_part"},{"id":"T2","span":{"begin":864,"end":875},"obj":"Body_part"},{"id":"T3","span":{"begin":965,"end":975},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005737"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/GO_0005737"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/GO_0005694"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#beec93","default":true},{"id":"sentences","color":"#ec93d8"},{"id":"NCBITAXON","color":"#93ece6"},{"id":"Anatomy-UBERON","color":"#eccc93"}]}]}}