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PubMed:8910398 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.
T2 141-227 Sentence denotes Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway.
T3 228-509 Sentence denotes To define the mechanism underlying signal transducer and activator of transcription (STAT) protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-10 in different cell populations were first defined using electrophoretic mobility shift assays.
T4 510-702 Sentence denotes In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct DNA binding complexes that contained different combinations of these two transcription factors.
T5 703-793 Sentence denotes IL-10 also activated Stat5 in Ba/F3 cells that stably expressed the murine IL-10 receptor.
T6 794-1057 Sentence denotes Using a structure-function mutagenesis approach, two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5.
T7 1058-1264 Sentence denotes Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.
T8 1265-1393 Sentence denotes In contrast, tyrosine-phosphorylated peptides containing Tyr374 or Tyr396 did not interact with Stat3 or block Stat3 activation.
T9 1394-1616 Sentence denotes These data demonstrate that Stat3 but not Stat1 or Stat5 is directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant receptor intracellular domain sequences containing phosphotyrosine.
T10 1617-1867 Sentence denotes This study thus supports the concept that utilization of distinct STAT proteins by different cytokine receptors is dependent on the expression of particular ligand-activatable, tyrosine-containing STAT docking sites in receptor intracellular domains.
T1 0-140 Sentence denotes Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.
T2 141-227 Sentence denotes Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway.
T3 228-509 Sentence denotes To define the mechanism underlying signal transducer and activator of transcription (STAT) protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-10 in different cell populations were first defined using electrophoretic mobility shift assays.
T4 510-702 Sentence denotes In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct DNA binding complexes that contained different combinations of these two transcription factors.
T5 703-793 Sentence denotes IL-10 also activated Stat5 in Ba/F3 cells that stably expressed the murine IL-10 receptor.
T6 794-1057 Sentence denotes Using a structure-function mutagenesis approach, two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5.
T7 1058-1264 Sentence denotes Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.
T8 1265-1393 Sentence denotes In contrast, tyrosine-phosphorylated peptides containing Tyr374 or Tyr396 did not interact with Stat3 or block Stat3 activation.
T9 1394-1616 Sentence denotes These data demonstrate that Stat3 but not Stat1 or Stat5 is directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant receptor intracellular domain sequences containing phosphotyrosine.
T10 1617-1867 Sentence denotes This study thus supports the concept that utilization of distinct STAT proteins by different cytokine receptors is dependent on the expression of particular ligand-activatable, tyrosine-containing STAT docking sites in receptor intracellular domains.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes Stat3
T2 34-87 protein denotes ligand-induced, tyrosine-phosphorylated docking sites
T3 95-139 protein denotes interleukin-10 receptor intracellular domain
T4 168-173 protein denotes IL-10
T5 200-203 protein denotes JAK
T6 203-208 protein denotes -STAT
T7 263-326 protein denotes signal transducer and activator of transcription (STAT) protein
T8 346-377 protein denotes interleukin 10 (IL-10) receptor
T9 383-396 protein denotes STAT proteins
T10 410-415 protein denotes IL-10
T11 531-536 protein denotes IL-10
T12 547-552 protein denotes Stat1
T13 557-562 protein denotes Stat3
T14 607-628 protein denotes DNA binding complexes
T15 680-701 protein denotes transcription factors
T16 703-708 protein denotes IL-10
T17 724-729 protein denotes Stat5
T18 733-744 cell_line denotes Ba/F3 cells
T19 778-792 protein denotes IL-10 receptor
T20 892-912 protein denotes intracellular domain
T21 927-932 protein denotes IL-10
T22 1024-1029 protein denotes Stat3
T23 1042-1047 protein denotes Stat1
T24 1051-1056 protein denotes Stat5
T25 1139-1158 protein denotes phosphorylated form
T26 1174-1179 protein denotes Stat3
T27 1188-1193 protein denotes Stat1
T28 1206-1211 protein denotes IL-10
T29 1220-1225 protein denotes Stat3
T30 1361-1366 protein denotes Stat3
T31 1376-1381 protein denotes Stat3
T32 1422-1427 protein denotes Stat3
T33 1436-1441 protein denotes Stat1
T34 1445-1450 protein denotes Stat5
T35 1480-1511 protein denotes ligand-activated IL-10 receptor
T36 1549-1588 protein denotes receptor intracellular domain sequences
T37 1683-1696 protein denotes STAT proteins
T38 1710-1728 protein denotes cytokine receptors
T39 1794-1832 protein denotes tyrosine-containing STAT docking sites
T40 1836-1866 protein denotes receptor intracellular domains

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-140 Sentence denotes Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.
S2 141-227 Sentence denotes Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway.
S3 228-509 Sentence denotes To define the mechanism underlying signal transducer and activator of transcription (STAT) protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-10 in different cell populations were first defined using electrophoretic mobility shift assays.
S4 510-702 Sentence denotes In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct DNA binding complexes that contained different combinations of these two transcription factors.
S5 703-793 Sentence denotes IL-10 also activated Stat5 in Ba/F3 cells that stably expressed the murine IL-10 receptor.
S6 794-1057 Sentence denotes Using a structure-function mutagenesis approach, two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5.
S7 1058-1264 Sentence denotes Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.
S8 1265-1393 Sentence denotes In contrast, tyrosine-phosphorylated peptides containing Tyr374 or Tyr396 did not interact with Stat3 or block Stat3 activation.
S9 1394-1616 Sentence denotes These data demonstrate that Stat3 but not Stat1 or Stat5 is directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant receptor intracellular domain sequences containing phosphotyrosine.
S10 1617-1867 Sentence denotes This study thus supports the concept that utilization of distinct STAT proteins by different cytokine receptors is dependent on the expression of particular ligand-activatable, tyrosine-containing STAT docking sites in receptor intracellular domains.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C15 91-139 NP denotes the interleukin-10 receptor intracellular domain
C1 168-173 NP denotes IL-10
C12 342-377 NP denotes the interleukin 10 (IL-10) receptor
C2 410-415 NP denotes IL-10
C3 531-536 NP denotes IL-10
C6 547-552 NP denotes Stat1
C20 557-562 NP denotes Stat3
C22 547-562 NP denotes Stat1 and Stat3
C4 592-628 NP denotes three distinct DNA binding complexes
C5 629-633 NP denotes that
C7 670-701 NP denotes these two transcription factors
C8 703-708 NP denotes IL-10
C33 724-729 NP denotes Stat5
C10 733-744 NP denotes Ba/F3 cells
C11 745-749 NP denotes that
C13 767-792 NP denotes the murine IL-10 receptor
C14 916-941 NP denotes the murine IL-10 receptor
C16 888-941 NP denotes the intracellular domain of the murine IL-10 receptor
C17 843-941 NP denotes two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor
C19 1024-1029 NP denotes Stat3
C26 1010-1029 NP denotes activation of Stat3
C31 1042-1047 NP denotes Stat1
C32 1051-1056 NP denotes Stat5
C18 1108-1158 NP denotes these two tyrosine residues in phosphorylated form
C21 1174-1179 NP denotes Stat3
C23 1188-1193 NP denotes Stat1
C24 1206-1212 NP denotes IL-10-
C25 1361-1366 NP denotes Stat3
C27 1376-1392 NP denotes Stat3 activation
C28 1422-1427 NP denotes Stat3
C29 1436-1441 NP denotes Stat1
C30 1445-1450 NP denotes Stat5
C34 1642-1653 NP denotes the concept
C35 1654-1658 NP denotes that
R1 C2 C1 coref-ident IL-10,IL-10
R2 C3 C2 coref-ident IL-10,IL-10
R3 C5 C4 coref-relat that,three distinct DNA binding complexes
R4 C7 C6 coref-ident these two transcription factors,Stat1
R5 C8 C3 coref-ident IL-10,IL-10
R6 C11 C10 coref-relat that,Ba/F3 cells
R7 C13 C12 coref-part-whole the murine IL-10 receptor,the interleukin 10 (IL-10) receptor
R8 C14 C13 coref-ident the murine IL-10 receptor,the murine IL-10 receptor
R9 C16 C15 coref-ident the intracellular domain of the murine IL-10 receptor,the interleukin-10 receptor intracellular domain
R10 C19 C20 coref-ident Stat3,Stat3
R11 C31 C22 coref-ident Stat1,Stat1 and Stat3
R12 C32 C33 coref-ident Stat5,Stat5
R13 C18 C17 coref-ident these two tyrosine residues in phosphorylated form,two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor
R14 C21 C19 coref-ident Stat3,Stat3
R15 C23 C31 coref-ident Stat1,Stat1
R16 C24 C8 coref-ident IL-10-,IL-10
R17 C25 C21 coref-ident Stat3,Stat3
R18 C27 C26 coref-ident Stat3 activation,activation of Stat3
R19 C28 C25 coref-ident Stat3,Stat3
R20 C29 C23 coref-ident Stat1,Stat1
R21 C30 C32 coref-ident Stat5,Stat5
R22 C35 C34 coref-relat that,the concept

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes Stat3
T2 34-87 protein_domain_or_region denotes ligand-induced, tyrosine-phosphorylated docking sites
T3 95-118 protein_molecule denotes interleukin-10 receptor
T4 168-173 protein_molecule denotes IL-10
T5 200-203 protein_family_or_group denotes JAK
T6 203-208 protein_family_or_group denotes -STAT
T7 263-326 protein_molecule denotes signal transducer and activator of transcription (STAT) protein
T8 346-360 protein_molecule denotes interleukin 10
T9 362-367 protein_molecule denotes IL-10
T10 383-396 protein_family_or_group denotes STAT proteins
T11 410-415 protein_molecule denotes IL-10
T12 471-508 other_name denotes electrophoretic mobility shift assays
T13 531-536 protein_molecule denotes IL-10
T14 547-552 protein_molecule denotes Stat1
T15 557-562 protein_molecule denotes Stat3
T16 607-628 protein_complex denotes DNA binding complexes
T17 680-701 protein_family_or_group denotes transcription factors
T18 703-708 protein_molecule denotes IL-10
T19 724-729 protein_molecule denotes Stat5
T20 733-744 cell_line denotes Ba/F3 cells
T21 778-783 protein_molecule denotes IL-10
T22 847-864 amino_acid_monomer denotes tyrosine residues
T23 866-872 amino_acid_monomer denotes Tyr427
T24 877-883 amino_acid_monomer denotes Tyr477
T25 892-912 protein_domain_or_region denotes intracellular domain
T26 927-932 protein_molecule denotes IL-10
T27 984-1001 other_name denotes receptor function
T28 1024-1029 protein_molecule denotes Stat3
T29 1042-1047 protein_molecule denotes Stat1
T30 1051-1056 protein_molecule denotes Stat5
T31 1065-1084 peptide denotes amino acid peptides
T32 1118-1135 amino_acid_monomer denotes tyrosine residues
T33 1139-1158 protein_molecule denotes phosphorylated form
T34 1174-1179 protein_molecule denotes Stat3
T35 1188-1193 protein_molecule denotes Stat1
T36 1206-1211 protein_molecule denotes IL-10
T37 1220-1225 protein_molecule denotes Stat3
T38 1247-1263 other_name denotes cell-free system
T39 1278-1310 peptide denotes tyrosine-phosphorylated peptides
T40 1322-1328 amino_acid_monomer denotes Tyr374
T41 1332-1338 amino_acid_monomer denotes Tyr396
T42 1361-1366 protein_molecule denotes Stat3
T43 1376-1381 protein_molecule denotes Stat3
T44 1422-1427 protein_molecule denotes Stat3
T45 1436-1441 protein_molecule denotes Stat1
T46 1445-1450 protein_molecule denotes Stat5
T47 1480-1511 protein_molecule denotes ligand-activated IL-10 receptor
T48 1549-1557 protein_domain_or_region denotes receptor
T49 1558-1578 protein_domain_or_region denotes intracellular domain
T50 1600-1615 amino_acid_monomer denotes phosphotyrosine
T51 1683-1696 protein_family_or_group denotes STAT proteins
T52 1710-1728 protein_molecule denotes cytokine receptors
T53 1794-1832 protein_domain_or_region denotes tyrosine-containing STAT docking sites
T54 1836-1866 protein_domain_or_region denotes receptor intracellular domains

AIMed

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes Stat3
T2 95-118 protein denotes interleukin-10 receptor
T3 168-173 protein denotes IL-10
T4 346-377 protein denotes interleukin 10 (IL-10) receptor
T5 410-415 protein denotes IL-10
T6 531-536 protein denotes IL-10
T7 547-552 protein denotes Stat1
T8 557-562 protein denotes Stat3
T9 703-708 protein denotes IL-10
T10 724-729 protein denotes Stat5
T11 778-792 protein denotes IL-10 receptor
T12 927-941 protein denotes IL-10 receptor
T13 1024-1029 protein denotes Stat3
T14 1042-1047 protein denotes Stat1
T15 1174-1179 protein denotes Stat3
T16 1188-1193 protein denotes Stat1
T17 1206-1211 protein denotes IL-10
T18 1220-1225 protein denotes Stat3
T19 1361-1366 protein denotes Stat3
T20 1376-1381 protein denotes Stat3
T21 1422-1427 protein denotes Stat3
T22 1436-1441 protein denotes Stat1
T23 1445-1450 protein denotes Stat5
T24 1497-1511 protein denotes IL-10 receptor

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 119-132 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T2 892-905 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 1558-1571 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 1845-1858 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622