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PubMed:8909998 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 550-559 Glycan_Motif denotes T-antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 612-623 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 820-829 Glycan_Motif denotes T-antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 550-559 http://www.glycoepitope.jp/epitopes/EP0020 denotes T-antigen
T2 820-829 http://www.glycoepitope.jp/epitopes/EP0020 denotes T-antigen

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
TextSentencer_T2 140-355 Sentence denotes We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate (Lesuffleur et al., 1990, Cancer Res 50:
TextSentencer_T3 356-560 Sentence denotes 6334-43), in the presence of benzyl-N-acetyl-alpha-galactosaminide (GalNAc alpha-O-benzyl), which is a potential competitive inhibitor of the beta 1,3-galactosyltransferase that synthesizes the T-antigen.
TextSentencer_T4 561-695 Sentence denotes The main observation was a 13-fold decrease in the sialic acid content of mucins after 24 h of exposure to 5 mM GalNAc alpha-O-benzyl.
TextSentencer_T5 696-830 Sentence denotes This effect was accompanied by an increased reactivity of these mucins to peanut lectin, testifying to the higher amount of T-antigen.
TextSentencer_T6 831-939 Sentence denotes The second observation was a decrease in the secretion of the mucins by GalNAc alpha-O-benzyl treated cells.
TextSentencer_T7 940-1294 Sentence denotes The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells.
T1 0-139 Sentence denotes Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
T2 140-355 Sentence denotes We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate (Lesuffleur et al., 1990, Cancer Res 50:
T3 356-560 Sentence denotes 6334-43), in the presence of benzyl-N-acetyl-alpha-galactosaminide (GalNAc alpha-O-benzyl), which is a potential competitive inhibitor of the beta 1,3-galactosyltransferase that synthesizes the T-antigen.
T4 561-695 Sentence denotes The main observation was a 13-fold decrease in the sialic acid content of mucins after 24 h of exposure to 5 mM GalNAc alpha-O-benzyl.
T5 696-830 Sentence denotes This effect was accompanied by an increased reactivity of these mucins to peanut lectin, testifying to the higher amount of T-antigen.
T6 831-939 Sentence denotes The second observation was a decrease in the secretion of the mucins by GalNAc alpha-O-benzyl treated cells.
T7 940-1294 Sentence denotes The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 550-559 https://glytoucan.org/Structures/Glycans/G00031MO denotes T-antigen
T2 612-623 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 820-829 https://glytoucan.org/Structures/Glycans/G00031MO denotes T-antigen

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 246-251 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 246-261 Disease denotes colon carcinoma http://purl.obolibrary.org/obo/MONDO_0002032
T2 341-347 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 246-251 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 252-261 Phenotype denotes carcinoma HP:0030731
T2 341-347 Phenotype denotes Cancer HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 424-430 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 673-679 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 903-909 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 1031-1037 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 1228-1233 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 252-261 Phenotype denotes carcinoma HP:0030731
T2 341-347 Phenotype denotes Cancer HP:0002664

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 246-251 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 1198-1211 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
TextSentencer_T2 140-355 Sentence denotes We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate (Lesuffleur et al., 1990, Cancer Res 50:
TextSentencer_T3 356-560 Sentence denotes 6334-43), in the presence of benzyl-N-acetyl-alpha-galactosaminide (GalNAc alpha-O-benzyl), which is a potential competitive inhibitor of the beta 1,3-galactosyltransferase that synthesizes the T-antigen.
TextSentencer_T4 561-695 Sentence denotes The main observation was a 13-fold decrease in the sialic acid content of mucins after 24 h of exposure to 5 mM GalNAc alpha-O-benzyl.
TextSentencer_T5 696-830 Sentence denotes This effect was accompanied by an increased reactivity of these mucins to peanut lectin, testifying to the higher amount of T-antigen.
TextSentencer_T6 831-939 Sentence denotes The second observation was a decrease in the secretion of the mucins by GalNAc alpha-O-benzyl treated cells.
TextSentencer_T7 940-1294 Sentence denotes The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells.
T1 0-139 Sentence denotes Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
T2 140-355 Sentence denotes We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate (Lesuffleur et al., 1990, Cancer Res 50:
T3 356-560 Sentence denotes 6334-43), in the presence of benzyl-N-acetyl-alpha-galactosaminide (GalNAc alpha-O-benzyl), which is a potential competitive inhibitor of the beta 1,3-galactosyltransferase that synthesizes the T-antigen.
T4 561-695 Sentence denotes The main observation was a 13-fold decrease in the sialic acid content of mucins after 24 h of exposure to 5 mM GalNAc alpha-O-benzyl.
T5 696-830 Sentence denotes This effect was accompanied by an increased reactivity of these mucins to peanut lectin, testifying to the higher amount of T-antigen.
T6 831-939 Sentence denotes The second observation was a decrease in the secretion of the mucins by GalNAc alpha-O-benzyl treated cells.
T7 940-1294 Sentence denotes The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
T2 140-355 Sentence denotes We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate (Lesuffleur et al., 1990, Cancer Res 50:
T3 356-560 Sentence denotes 6334-43), in the presence of benzyl-N-acetyl-alpha-galactosaminide (GalNAc alpha-O-benzyl), which is a potential competitive inhibitor of the beta 1,3-galactosyltransferase that synthesizes the T-antigen.
T4 561-695 Sentence denotes The main observation was a 13-fold decrease in the sialic acid content of mucins after 24 h of exposure to 5 mM GalNAc alpha-O-benzyl.
T5 696-830 Sentence denotes This effect was accompanied by an increased reactivity of these mucins to peanut lectin, testifying to the higher amount of T-antigen.
T6 831-939 Sentence denotes The second observation was a decrease in the secretion of the mucins by GalNAc alpha-O-benzyl treated cells.
T7 940-1294 Sentence denotes The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 550-559 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T-antigen http://www.glycoepitope.jp/epitopes/EP0020
T2 820-829 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T-antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 246-261 Disease denotes colon carcinoma MONDO:0002032
T2 341-347 Disease denotes Cancer MONDO:0004992

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 240-245 OrganismTaxon denotes human 9606

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 246-251 Body_part denotes colon FMA:14543

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 246-251 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 424-430 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 550-559 Glycan denotes T-antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T3 673-679 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 820-829 Glycan denotes T-antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T5 903-909 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 1031-1037 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 1228-1233 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 240-245 OrganismTaxon denotes human 9606

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 550-559 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T-antigen http://www.glycoepitope.jp/epitopes/EP0020
T2 820-829 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T-antigen http://www.glycoepitope.jp/epitopes/EP0020

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 246-251 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 1198-1211 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622