> top > docs > PubMed:8872113 > annotations

PubMed:8872113 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 372-382 Glycan_Motif denotes Tn antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G57321FI
T2 456-462 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 635-645 Glycan_Motif denotes Tn antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G57321FI
T4 694-704 Glycan_Motif denotes TF antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T5 828-839 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 1279-1290 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins.
TextSentencer_T2 129-330 Sentence denotes Previously, beta 1,3-galactosyltransferase-deficient (Tn+) and normal (TF+) T-lymphocyte clones have been established from a patient suffering from Tn-syndrome [Thurnher et al. (1992) Eur J Immunol 22:
TextSentencer_T3 331-340 Sentence denotes 1835-42].
TextSentencer_T4 341-660 Sentence denotes Tn+ T lymphocytes express only Tn antigen GalNAc alpha 1-O-R) while other O-glycan structures such as sialosyl-Tn (Neu5Ac alpha 2,6GalNAc alpha 1-O-R) or TF (Gal beta 1-3GalNAc alpha 1-O-R) antigens are absent from these cells as shown by flow cytometry using specific mABs for TF and sialosyl-Tn antigen, respectively.
TextSentencer_T5 661-729 Sentence denotes Normal T lymphocytes express the TF antigen and derivatives thereof.
TextSentencer_T6 730-856 Sentence denotes The surface glycans of Tn+ and TF+ cells were then analysed by flow cytometry using the following sialic acid-binding lectins:
TextSentencer_T7 857-977 Sentence denotes Amaranthus caudatus (ACA), Maackia amurensis (MAA), Limax flavus (LFA), Sambucus nigra (SNA) and Triticum vulgare (WGA).
TextSentencer_T8 978-1052 Sentence denotes Equal and weak binding of MAA and SNA to both TF+ and Tn+ cells was found.
TextSentencer_T9 1053-1121 Sentence denotes WGA, LFA and ACA bound more strongly to TF+ cells than to Tn+ cells.
TextSentencer_T10 1122-1189 Sentence denotes Binding of ACA to TF+ cells was enhanced after sialidase treatment.
TextSentencer_T11 1190-1455 Sentence denotes To investigate the possible biological consequences of hyposialylation, binding of three sialic acid-dependent adhesion molecules to Tn+ and TF+ cells was estimated using radiolabelled Fc-chimeras of sialoadhesin (Sn), myelin-associated glycoprotein (MAG) and CD22.
TextSentencer_T12 1456-1531 Sentence denotes Equal and strong binding of human CD22 to both TF+ and Tn+ cells was found.
TextSentencer_T13 1532-1655 Sentence denotes Whereas binding of Sn and MAG to TF+ cells was strong (100%), binding to Tn+ cells amounted only to 33% (Sn) and 19% (MAG).
TextSentencer_T14 1656-1851 Sentence denotes These results indicate that the in vivo interactions of T lymphocytes in the Tn syndrome with CD22 are not likely to be affected, whereas adhesion mediated by Sn or MAG could be strongly reduced.
T1 0-128 Sentence denotes Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins.
T2 129-330 Sentence denotes Previously, beta 1,3-galactosyltransferase-deficient (Tn+) and normal (TF+) T-lymphocyte clones have been established from a patient suffering from Tn-syndrome [Thurnher et al. (1992) Eur J Immunol 22:
T3 331-340 Sentence denotes 1835-42].
T4 341-660 Sentence denotes Tn+ T lymphocytes express only Tn antigen GalNAc alpha 1-O-R) while other O-glycan structures such as sialosyl-Tn (Neu5Ac alpha 2,6GalNAc alpha 1-O-R) or TF (Gal beta 1-3GalNAc alpha 1-O-R) antigens are absent from these cells as shown by flow cytometry using specific mABs for TF and sialosyl-Tn antigen, respectively.
T5 661-729 Sentence denotes Normal T lymphocytes express the TF antigen and derivatives thereof.
T6 730-856 Sentence denotes The surface glycans of Tn+ and TF+ cells were then analysed by flow cytometry using the following sialic acid-binding lectins:
T7 857-977 Sentence denotes Amaranthus caudatus (ACA), Maackia amurensis (MAA), Limax flavus (LFA), Sambucus nigra (SNA) and Triticum vulgare (WGA).
T8 978-1052 Sentence denotes Equal and weak binding of MAA and SNA to both TF+ and Tn+ cells was found.
T9 1053-1121 Sentence denotes WGA, LFA and ACA bound more strongly to TF+ cells than to Tn+ cells.
T10 1122-1189 Sentence denotes Binding of ACA to TF+ cells was enhanced after sialidase treatment.
T11 1190-1455 Sentence denotes To investigate the possible biological consequences of hyposialylation, binding of three sialic acid-dependent adhesion molecules to Tn+ and TF+ cells was estimated using radiolabelled Fc-chimeras of sialoadhesin (Sn), myelin-associated glycoprotein (MAG) and CD22.
T12 1456-1531 Sentence denotes Equal and strong binding of human CD22 to both TF+ and Tn+ cells was found.
T13 1532-1655 Sentence denotes Whereas binding of Sn and MAG to TF+ cells was strong (100%), binding to Tn+ cells amounted only to 33% (Sn) and 19% (MAG).
T14 1656-1851 Sentence denotes These results indicate that the in vivo interactions of T lymphocytes in the Tn syndrome with CD22 are not likely to be affected, whereas adhesion mediated by Sn or MAG could be strongly reduced.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 372-382 https://glytoucan.org/Structures/Glycans/G57321FI denotes Tn antigen
T2 456-462 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T3 635-645 https://glytoucan.org/Structures/Glycans/G57321FI denotes Tn antigen
T4 694-704 https://glytoucan.org/Structures/Glycans/G00031MO denotes TF antigen
T5 828-839 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1279-1290 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 372-382 http://www.glycoepitope.jp/epitopes/EP0021 denotes Tn antigen
T2 635-645 http://www.glycoepitope.jp/epitopes/EP0021 denotes Tn antigen

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 150-181 Disease denotes galactosyltransferase-deficient http://purl.obolibrary.org/obo/MONDO_0010381

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 372-382 Glycan denotes Tn antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI
T2 383-389 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 456-462 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 635-645 Glycan denotes Tn antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 372-382 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Tn antigen http://www.glycoepitope.jp/epitopes/EP0021
T2 635-645 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Tn antigen http://www.glycoepitope.jp/epitopes/EP0021

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 150-181 Disease denotes galactosyltransferase-deficient http://purl.obolibrary.org/obo/MONDO_0010381

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 30-35 OrganismTaxon denotes human 9606
T2 254-261 OrganismTaxon denotes patient 9606
T3 857-876 OrganismTaxon denotes Amaranthus caudatus 3567
T4 878-881 OrganismTaxon denotes ACA 3567
T5 884-901 OrganismTaxon denotes Maackia amurensis 37501
T6 903-906 OrganismTaxon denotes MAA 37501
T7 909-921 OrganismTaxon denotes Limax flavus 36461
T8 923-926 OrganismTaxon denotes LFA 36461
T9 929-943 OrganismTaxon denotes Sambucus nigra 4202
T10 945-948 OrganismTaxon denotes SNA 4202
T11 954-970 OrganismTaxon denotes Triticum vulgare 4565
T12 1004-1007 OrganismTaxon denotes MAA 37501
T13 1012-1015 OrganismTaxon denotes SNA 4202
T14 1058-1061 OrganismTaxon denotes LFA 36461
T15 1066-1069 OrganismTaxon denotes ACA 3567
T16 1133-1136 OrganismTaxon denotes ACA 3567
T17 1484-1489 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 36-48 Cell denotes T-lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T2 38-48 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 205-217 Cell denotes T-lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T4 207-217 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T5 345-358 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T6 668-681 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T7 1712-1725 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 36-48 Body_part denotes T-lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T2 205-217 Body_part denotes T-lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T3 345-358 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T4 668-681 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T5 868-876 Body_part denotes caudatus http://purl.obolibrary.org/obo/UBERON_0001873
T6 1409-1415 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T7 1712-1725 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins.
TextSentencer_T2 129-330 Sentence denotes Previously, beta 1,3-galactosyltransferase-deficient (Tn+) and normal (TF+) T-lymphocyte clones have been established from a patient suffering from Tn-syndrome [Thurnher et al. (1992) Eur J Immunol 22:
TextSentencer_T3 331-340 Sentence denotes 1835-42].
TextSentencer_T4 341-660 Sentence denotes Tn+ T lymphocytes express only Tn antigen GalNAc alpha 1-O-R) while other O-glycan structures such as sialosyl-Tn (Neu5Ac alpha 2,6GalNAc alpha 1-O-R) or TF (Gal beta 1-3GalNAc alpha 1-O-R) antigens are absent from these cells as shown by flow cytometry using specific mABs for TF and sialosyl-Tn antigen, respectively.
TextSentencer_T5 661-729 Sentence denotes Normal T lymphocytes express the TF antigen and derivatives thereof.
TextSentencer_T6 730-856 Sentence denotes The surface glycans of Tn+ and TF+ cells were then analysed by flow cytometry using the following sialic acid-binding lectins:
TextSentencer_T7 857-977 Sentence denotes Amaranthus caudatus (ACA), Maackia amurensis (MAA), Limax flavus (LFA), Sambucus nigra (SNA) and Triticum vulgare (WGA).
TextSentencer_T8 978-1052 Sentence denotes Equal and weak binding of MAA and SNA to both TF+ and Tn+ cells was found.
TextSentencer_T9 1053-1121 Sentence denotes WGA, LFA and ACA bound more strongly to TF+ cells than to Tn+ cells.
TextSentencer_T10 1122-1189 Sentence denotes Binding of ACA to TF+ cells was enhanced after sialidase treatment.
TextSentencer_T11 1190-1455 Sentence denotes To investigate the possible biological consequences of hyposialylation, binding of three sialic acid-dependent adhesion molecules to Tn+ and TF+ cells was estimated using radiolabelled Fc-chimeras of sialoadhesin (Sn), myelin-associated glycoprotein (MAG) and CD22.
TextSentencer_T12 1456-1531 Sentence denotes Equal and strong binding of human CD22 to both TF+ and Tn+ cells was found.
TextSentencer_T13 1532-1655 Sentence denotes Whereas binding of Sn and MAG to TF+ cells was strong (100%), binding to Tn+ cells amounted only to 33% (Sn) and 19% (MAG).
TextSentencer_T14 1656-1851 Sentence denotes These results indicate that the in vivo interactions of T lymphocytes in the Tn syndrome with CD22 are not likely to be affected, whereas adhesion mediated by Sn or MAG could be strongly reduced.
T1 0-128 Sentence denotes Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins.
T2 129-330 Sentence denotes Previously, beta 1,3-galactosyltransferase-deficient (Tn+) and normal (TF+) T-lymphocyte clones have been established from a patient suffering from Tn-syndrome [Thurnher et al. (1992) Eur J Immunol 22:
T3 331-340 Sentence denotes 1835-42].
T4 341-660 Sentence denotes Tn+ T lymphocytes express only Tn antigen GalNAc alpha 1-O-R) while other O-glycan structures such as sialosyl-Tn (Neu5Ac alpha 2,6GalNAc alpha 1-O-R) or TF (Gal beta 1-3GalNAc alpha 1-O-R) antigens are absent from these cells as shown by flow cytometry using specific mABs for TF and sialosyl-Tn antigen, respectively.
T5 661-729 Sentence denotes Normal T lymphocytes express the TF antigen and derivatives thereof.
T6 730-856 Sentence denotes The surface glycans of Tn+ and TF+ cells were then analysed by flow cytometry using the following sialic acid-binding lectins:
T7 857-977 Sentence denotes Amaranthus caudatus (ACA), Maackia amurensis (MAA), Limax flavus (LFA), Sambucus nigra (SNA) and Triticum vulgare (WGA).
T8 978-1052 Sentence denotes Equal and weak binding of MAA and SNA to both TF+ and Tn+ cells was found.
T9 1053-1121 Sentence denotes WGA, LFA and ACA bound more strongly to TF+ cells than to Tn+ cells.
T10 1122-1189 Sentence denotes Binding of ACA to TF+ cells was enhanced after sialidase treatment.
T11 1190-1455 Sentence denotes To investigate the possible biological consequences of hyposialylation, binding of three sialic acid-dependent adhesion molecules to Tn+ and TF+ cells was estimated using radiolabelled Fc-chimeras of sialoadhesin (Sn), myelin-associated glycoprotein (MAG) and CD22.
T12 1456-1531 Sentence denotes Equal and strong binding of human CD22 to both TF+ and Tn+ cells was found.
T13 1532-1655 Sentence denotes Whereas binding of Sn and MAG to TF+ cells was strong (100%), binding to Tn+ cells amounted only to 33% (Sn) and 19% (MAG).
T14 1656-1851 Sentence denotes These results indicate that the in vivo interactions of T lymphocytes in the Tn syndrome with CD22 are not likely to be affected, whereas adhesion mediated by Sn or MAG could be strongly reduced.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins.
T2 129-330 Sentence denotes Previously, beta 1,3-galactosyltransferase-deficient (Tn+) and normal (TF+) T-lymphocyte clones have been established from a patient suffering from Tn-syndrome [Thurnher et al. (1992) Eur J Immunol 22:
T3 331-340 Sentence denotes 1835-42].
T4 341-660 Sentence denotes Tn+ T lymphocytes express only Tn antigen GalNAc alpha 1-O-R) while other O-glycan structures such as sialosyl-Tn (Neu5Ac alpha 2,6GalNAc alpha 1-O-R) or TF (Gal beta 1-3GalNAc alpha 1-O-R) antigens are absent from these cells as shown by flow cytometry using specific mABs for TF and sialosyl-Tn antigen, respectively.
T5 661-729 Sentence denotes Normal T lymphocytes express the TF antigen and derivatives thereof.
T6 730-856 Sentence denotes The surface glycans of Tn+ and TF+ cells were then analysed by flow cytometry using the following sialic acid-binding lectins:
T7 857-977 Sentence denotes Amaranthus caudatus (ACA), Maackia amurensis (MAA), Limax flavus (LFA), Sambucus nigra (SNA) and Triticum vulgare (WGA).
T8 978-1052 Sentence denotes Equal and weak binding of MAA and SNA to both TF+ and Tn+ cells was found.
T9 1053-1121 Sentence denotes WGA, LFA and ACA bound more strongly to TF+ cells than to Tn+ cells.
T10 1122-1189 Sentence denotes Binding of ACA to TF+ cells was enhanced after sialidase treatment.
T11 1190-1455 Sentence denotes To investigate the possible biological consequences of hyposialylation, binding of three sialic acid-dependent adhesion molecules to Tn+ and TF+ cells was estimated using radiolabelled Fc-chimeras of sialoadhesin (Sn), myelin-associated glycoprotein (MAG) and CD22.
T12 1456-1531 Sentence denotes Equal and strong binding of human CD22 to both TF+ and Tn+ cells was found.
T13 1532-1655 Sentence denotes Whereas binding of Sn and MAG to TF+ cells was strong (100%), binding to Tn+ cells amounted only to 33% (Sn) and 19% (MAG).
T14 1656-1851 Sentence denotes These results indicate that the in vivo interactions of T lymphocytes in the Tn syndrome with CD22 are not likely to be affected, whereas adhesion mediated by Sn or MAG could be strongly reduced.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 372-382 Glycan denotes Tn antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI
T2 383-389 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 456-462 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 635-645 Glycan denotes Tn antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 372-382 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Tn antigen http://www.glycoepitope.jp/epitopes/EP0021
T2 635-645 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Tn antigen http://www.glycoepitope.jp/epitopes/EP0021

GlyCosmos15-Lectin-Jamboree

Id Subject Object Predicate Lexical cue glycosmos_id
T1 878-881 Lectin denotes ACA GL_004187
T2 945-948 Lectin denotes SNA GL_003701
T3 972-975 Lectin denotes WGA GL_003502
T4 1012-1015 Lectin denotes SNA GL_003701
T5 1053-1056 Lectin denotes WGA GL_003502
T6 1066-1069 Lectin denotes ACA GL_004187
T7 1133-1136 Lectin denotes ACA GL_004187

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 30-35 OrganismTaxon denotes human 9606
T2 254-261 OrganismTaxon denotes patient 9606
T3 857-876 OrganismTaxon denotes Amaranthus caudatus 3567
T4 878-881 OrganismTaxon denotes ACA 3567
T5 884-901 OrganismTaxon denotes Maackia amurensis 37501
T6 903-906 OrganismTaxon denotes MAA 37501
T7 909-921 OrganismTaxon denotes Limax flavus 36461
T8 923-926 OrganismTaxon denotes LFA 36461
T9 929-943 OrganismTaxon denotes Sambucus nigra 4202
T10 945-948 OrganismTaxon denotes SNA 4202
T11 954-970 OrganismTaxon denotes Triticum vulgare 4565
T12 1004-1007 OrganismTaxon denotes MAA 37501
T13 1012-1015 OrganismTaxon denotes SNA 4202
T14 1058-1061 OrganismTaxon denotes LFA 36461
T15 1066-1069 OrganismTaxon denotes ACA 3567
T16 1133-1136 OrganismTaxon denotes ACA 3567
T17 1484-1489 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 36-48 Body_part denotes T-lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T2 205-217 Body_part denotes T-lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T3 345-358 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T4 668-681 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T5 868-876 Body_part denotes caudatus http://purl.obolibrary.org/obo/UBERON_0001873
T6 1409-1415 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T7 1712-1725 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 36-48 Cell denotes T-lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T2 38-48 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 205-217 Cell denotes T-lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T4 207-217 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T5 345-358 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T6 668-681 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T7 1712-1725 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084