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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.
T2 129-364 Sentence denotes Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism(s) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.
T3 365-592 Sentence denotes Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.
T4 593-746 Sentence denotes We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.
T5 747-1019 Sentence denotes Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).
T6 1020-1257 Sentence denotes No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.
T7 1258-1455 Sentence denotes We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.
T1 0-128 Sentence denotes Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.
T2 129-364 Sentence denotes Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism(s) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.
T3 365-592 Sentence denotes Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.
T4 593-746 Sentence denotes We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.
T5 747-1019 Sentence denotes Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).
T6 1020-1257 Sentence denotes No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.
T7 1258-1455 Sentence denotes We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 95-105 protein denotes NF-kappa B
T2 106-127 protein denotes transcription factors
T3 426-459 protein denotes intercellular adhesion molecule-1
T4 461-467 protein denotes ICAM-1
T5 472-490 protein denotes adhesion molecules
T6 615-631 cell_line denotes monocytic (U937)
T7 638-675 cell_line denotes bronchial epithelial (H292) cell-line
T8 728-734 protein denotes ICAM-1
T9 774-795 DNA denotes human ICAM-1 promoter
T10 866-894 protein denotes tumour necrosis factor-alpha
T11 896-905 protein denotes TNF-alpha
T12 918-924 protein denotes ICAM-1
T13 962-1005 DNA denotes nuclear factor (NF-kappa B) target sequence
T14 1023-1059 DNA denotes glucocorticoid recognition sequences
T15 1080-1095 DNA denotes promoter region
T16 1162-1194 DNA denotes multimerized NF-kappa B sequence
T17 1216-1225 protein denotes TNF-alpha
T18 1247-1256 cell_line denotes 293 cells
T19 1305-1328 protein denotes glucocorticoid receptor
T20 1333-1363 protein denotes nuclear factor-kappa B factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-128 Sentence denotes Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.
S2 129-364 Sentence denotes Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism(s) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.
S3 365-592 Sentence denotes Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.
S4 593-746 Sentence denotes We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.
S5 747-1019 Sentence denotes Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).
S6 1020-1257 Sentence denotes No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.
S7 1258-1455 Sentence denotes We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 75-90 NP denotes glucocorticoids
C10 95-127 NP denotes NF-kappa B transcription factors
C2 159-174 NP denotes glucocorticoids
C5 221-233 NP denotes inflammation
C3 235-261 NP denotes the molecular mechanism(s)
C4 265-270 NP denotes which
C6 527-539 NP denotes inflammation
C8 960-1018 NP denotes a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC)
C9 1158-1194 NP denotes the multimerized NF-kappa B sequence
C11 1333-1363 NP denotes nuclear factor-kappa B factors
R1 C2 C1 coref-ident glucocorticoids,glucocorticoids
R2 C4 C3 coref-relat which,the molecular mechanism(s)
R3 C6 C5 coref-ident inflammation,inflammation
R4 C9 C8 coref-ident the multimerized NF-kappa B sequence,a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC)
R5 C11 C10 coref-ident nuclear factor-kappa B factors,NF-kappa B transcription factors

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Molecular mechanisms
T2 24-38 other_name denotes steroid action
T3 75-90 lipid denotes glucocorticoids
T4 95-105 protein_complex denotes NF-kappa B
T5 106-127 protein_family_or_group denotes transcription factors
T6 159-174 lipid denotes glucocorticoids
T7 221-233 other_name denotes inflammation
T8 239-258 other_name denotes molecular mechanism
T9 318-326 multi_cell denotes patients
T10 332-338 other_name denotes asthma
T11 426-459 protein_molecule denotes intercellular adhesion molecule-1
T12 461-467 protein_molecule denotes ICAM-1
T13 472-490 protein_family_or_group denotes adhesion molecules
T14 527-539 other_name denotes inflammation
T15 615-631 cell_line denotes monocytic (U937)
T16 638-675 cell_line denotes bronchial epithelial (H292) cell-line
T17 676-689 lipid denotes dexamethasone
T18 728-734 protein_molecule denotes ICAM-1
T19 774-779 DNA_domain_or_region denotes human
T20 780-786 protein_molecule denotes ICAM-1
T21 819-855 other_organic_compound denotes 12-O-tetradecanoylphorbol 13-acetate
T22 857-860 other_organic_compound denotes TPA
T23 866-894 protein_molecule denotes tumour necrosis factor-alpha
T24 896-905 protein_molecule denotes TNF-alpha
T25 918-924 protein_molecule denotes ICAM-1
T26 962-976 protein_family_or_group denotes nuclear factor
T27 978-988 protein_complex denotes NF-kappa B
T28 1007-1017 polynucleotide denotes TGGAAATTCC
T29 1023-1037 lipid denotes glucocorticoid
T30 1080-1095 DNA_domain_or_region denotes promoter region
T31 1100-1113 lipid denotes dexamethasone
T32 1162-1174 DNA_domain_or_region denotes multimerized
T33 1175-1185 protein_complex denotes NF-kappa B
T34 1216-1225 protein_molecule denotes TNF-alpha
T35 1247-1256 cell_line denotes 293 cells
T36 1305-1319 lipid denotes glucocorticoid
T37 1333-1363 protein_family_or_group denotes nuclear factor-kappa B factors