PubMed:8865848 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8865848","sourcedb":"PubMed","sourceid":"8865848","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8865848","text":"Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein.\nThe expression of cyclin E in human colorectal adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in the colorectal carcinogenesis. The expression of cyclin E was detected in 25% (91/358) of the adenomas and 56% (149/267) of the adenocarcinomas. The incidence of strongly positive cases was significantly higher in the adenocarcinomas (20%) than in the adenomas (5%) (P \u003c 0.01). Among adenomas, a significant correlation was noticed between the expression of cyclin E and the grade of atypia. The incidence of cyclin E expression was significantly higher in the adenocarcinomas without an adenoma component (62%; 104/169) than in those with this component (46%; 45/98) (P \u003c 0.05). Furthermore, the incidence of the cyclin E expression was higher in stages 1 and 2 carcinoma than in stage 0 and stages 3 and 4 carcinoma. The expression of cyclin E was the most prominent in tumors invading the submucosa and muscularis propria. The expression of cyclin E was significantly correlated with the proliferative activity of the tumor cells measured by Ki-67 antigen expression (P \u003c 0.01). It was also correlated with the expression of p53 protein in the tumor cells (P \u003c 0.01). Overexpression of cyclin E and subsequent deregulation of cell cycle may contribute to the development and early progression of the colorectal carcinomas.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1069,"end":1078},"obj":"http://purl.obolibrary.org/obo/UBERON_0000009"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":891,"end":897},"obj":"gene:5111"},{"id":"T1","span":{"begin":940,"end":949},"obj":"disease:C0007097"},{"id":"T2","span":{"begin":891,"end":897},"obj":"gene:5111"},{"id":"T3","span":{"begin":985,"end":994},"obj":"disease:C0007097"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":129,"end":307},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":308,"end":421},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":422,"end":554},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":555,"end":668},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":669,"end":856},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":857,"end":995},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":996,"end":1102},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1103,"end":1258},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1259,"end":1347},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1348,"end":1502},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"T2","span":{"begin":129,"end":307},"obj":"Sentence"},{"id":"T3","span":{"begin":308,"end":421},"obj":"Sentence"},{"id":"T4","span":{"begin":422,"end":554},"obj":"Sentence"},{"id":"T5","span":{"begin":555,"end":668},"obj":"Sentence"},{"id":"T6","span":{"begin":669,"end":856},"obj":"Sentence"},{"id":"T7","span":{"begin":857,"end":995},"obj":"Sentence"},{"id":"T8","span":{"begin":996,"end":1102},"obj":"Sentence"},{"id":"T9","span":{"begin":1103,"end":1258},"obj":"Sentence"},{"id":"T10","span":{"begin":1259,"end":1347},"obj":"Sentence"},{"id":"T11","span":{"begin":1348,"end":1502},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1069,"end":1078},"obj":"http://purl.obolibrary.org/obo/UBERON_0000009"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T302","span":{"begin":14,"end":20},"obj":"gene:5111"},{"id":"T303","span":{"begin":26,"end":65},"obj":"disease:C1302401"},{"id":"T304","span":{"begin":116,"end":119},"obj":"gene:7157"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T302","obj":"T303"},{"id":"R2","pred":"associated_with","subj":"T302","obj":"T303"},{"id":"R3","pred":"associated_with","subj":"T304","obj":"T303"},{"id":"R4","pred":"associated_with","subj":"T304","obj":"T303"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T302","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T303","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T304","pred":"source","obj":"DisGeNet-2017-sample"}]},{"pr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