PubMed:8858156 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":230,"end":237},"obj":"Cell"},{"id":"T2","span":{"begin":576,"end":583},"obj":"Cell"},{"id":"T3","span":{"begin":740,"end":747},"obj":"Cell"},{"id":"T4","span":{"begin":910,"end":917},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000236"}],"text":"Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.\nWe previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells. Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types. The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly. All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID. Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells. These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells."}

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"S2","span":{"begin":76,"end":193},"obj":"Sentence"},{"id":"S3","span":{"begin":194,"end":350},"obj":"Sentence"},{"id":"S4","span":{"begin":351,"end":526},"obj":"Sentence"},{"id":"S5","span":{"begin":527,"end":644},"obj":"Sentence"},{"id":"S6","span":{"begin":645,"end":748},"obj":"Sentence"},{"id":"S7","span":{"begin":749,"end":918},"obj":"Sentence"}],"text":"Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.\nWe previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells. Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types. The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly. All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID. Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells. These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":15},"obj":"NP"},{"id":"C5","span":{"begin":65,"end":74},"obj":"NP"},{"id":"C2","span":{"begin":119,"end":137},"obj":"NP"},{"id":"C3","span":{"begin":138,"end":142},"obj":"NP"},{"id":"C4","span":{"begin":369,"end":378},"obj":"NP"},{"id":"C6","span":{"begin":434,"end":443},"obj":"NP"},{"id":"C8","span":{"begin":576,"end":583},"obj":"NP"},{"id":"C11","span":{"begin":638,"end":643},"obj":"NP"},{"id":"C7","span":{"begin":673,"end":682},"obj":"NP"},{"id":"C9","span":{"begin":740,"end":747},"obj":"NP"},{"id":"C10","span":{"begin":779,"end":787},"obj":"NP"},{"id":"C12","span":{"begin":823,"end":828},"obj":"NP"},{"id":"C13","span":{"begin":791,"end":828},"obj":"NP"},{"id":"C14","span":{"begin":829,"end":833},"obj":"NP"},{"id":"C15","span":{"begin":910,"end":917},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C4"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C1"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C11"},{"id":"R8","pred":"coref-relat","subj":"C14","obj":"C13"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C9"}],"text":"Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.\nWe previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells. Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types. The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly. All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID. Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells. These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"protein_subunit"},{"id":"T2","span":{"begin":21,"end":39},"obj":"protein_subunit"},{"id":"T3","span":{"begin":40,"end":45},"obj":"protein_complex"},{"id":"T4","span":{"begin":65,"end":74},"obj":"protein_molecule"},{"id":"T5","span":{"begin":160,"end":165},"obj":"protein_complex"},{"id":"T6","span":{"begin":215,"end":237},"obj":"cell_type"},{"id":"T7","span":{"begin":272,"end":275},"obj":"protein_molecule"},{"id":"T8","span":{"begin":279,"end":286},"obj":"other_name"},{"id":"T9","span":{"begin":313,"end":318},"obj":"protein_complex"},{"id":"T10","span":{"begin":355,"end":359},"obj":"DNA_domain_or_region"},{"id":"T11","span":{"begin":369,"end":378},"obj":"protein_molecule"},{"id":"T12","span":{"begin":406,"end":423},"obj":"protein_domain_or_region"},{"id":"T13","span":{"begin":434,"end":443},"obj":"protein_molecule"},{"id":"T14","span":{"begin":448,"end":457},"obj":"protein_molecule"},{"id":"T15","span":{"begin":469,"end":498},"obj":"protein_domain_or_region"},{"id":"T16","span":{"begin":552,"end":565},"obj":"RNA_molecule"},{"id":"T17","span":{"begin":576,"end":583},"obj":"cell_type"},{"id":"T18","span":{"begin":638,"end":643},"obj":"protein_complex"},{"id":"T19","span":{"begin":673,"end":682},"obj":"protein_molecule"},{"id":"T20","span":{"begin":740,"end":747},"obj":"cell_type"},{"id":"T21","span":{"begin":779,"end":787},"obj":"protein_molecule"},{"id":"T22","span":{"begin":823,"end":828},"obj":"protein_complex"},{"id":"T23","span":{"begin":867,"end":880},"obj":"other_name"},{"id":"T24","span":{"begin":910,"end":917},"obj":"cell_type"}],"text":"Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.\nWe previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells. Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types. The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly. All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID. Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells. These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":104,"end":114},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":119,"end":124},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"2081351"},{"id":"A3","pred":"db_id","subj":"T2","obj":"32281"},{"id":"A4","pred":"db_id","subj":"T2","obj":"7215"},{"id":"A5","pred":"db_id","subj":"T5","obj":"9606"}],"text":"Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.\nWe previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells. Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types. The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly. All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID. Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells. These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells."}