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PubMed:8843413 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 692-694 gene:367 denotes AR
T1 730-737 disease:C0040100 denotes thymoma
R1 T0 T1 associated_with AR,thymoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 58-78 cell_type denotes murine thymoma cells
T2 104-116 cell_line denotes T cell lines
T3 189-235 protein denotes glucocorticoid receptor (GR) N-terminal domain
T4 320-338 cell_line denotes human T cell lines
T5 363-380 protein denotes N-terminal domain
T6 439-441 protein denotes GR
T7 548-584 protein denotes GR N-terminal transactivation domain
T8 648-650 protein denotes GR
T9 652-663 protein denotes GR variants
T10 673-690 protein denotes androgen receptor
T11 692-694 protein denotes AR
T12 701-743 cell_line denotes receptor-negative S49 murine thymoma cells
T13 745-747 protein denotes GR
T14 894-896 protein denotes GR
T15 933-983 DNA denotes mouse mammary tumor virus (MMTV) LTR reporter gene
T16 1010-1031 protein denotes GR chimeric receptors
T17 1054-1096 DNA denotes VP16 and E1A viral transactivation domains
T18 1113-1126 protein denotes GR N terminus
T19 1336-1338 protein denotes AR
T20 1365-1374 cell_line denotes S49 cells
T21 1588-1611 DNA denotes thymocyte-specific gene
T22 1619-1624 DNA denotes GIG18
T23 1640-1645 DNA denotes GIG18
T24 1695-1697 protein denotes AR
T25 1702-1704 protein denotes GR
T26 1725-1727 protein denotes AR
T27 1782-1791 cell_line denotes S49 cells
T28 1812-1817 DNA denotes GIG18
T29 2076-2078 protein denotes GR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8843413-3#45#47#gene2908 548-550 gene2908 denotes GR
8843413-3#170#187#gene367 673-690 gene367 denotes androgen receptor
8843413-3#189#191#gene367 692-694 gene367 denotes AR
8843413-3#227#234#diseaseC0040100 730-737 diseaseC0040100 denotes thymoma
8843413-4#149#151#gene2908 894-896 gene2908 denotes GR
8843413-4#194#207#diseaseC1458155 939-952 diseaseC1458155 denotes mammary tumor
45#47#gene2908227#234#diseaseC0040100 8843413-3#45#47#gene2908 8843413-3#227#234#diseaseC0040100 associated_with GR,thymoma
170#187#gene367227#234#diseaseC0040100 8843413-3#170#187#gene367 8843413-3#227#234#diseaseC0040100 associated_with androgen receptor,thymoma
189#191#gene367227#234#diseaseC0040100 8843413-3#189#191#gene367 8843413-3#227#234#diseaseC0040100 associated_with AR,thymoma
149#151#gene2908194#207#diseaseC1458155 8843413-4#149#151#gene2908 8843413-4#194#207#diseaseC1458155 associated_with GR,mammary tumor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-79 Sentence denotes Transcriptional control of steroid-regulated apoptosis in murine thymoma cells.
S2 80-287 Sentence denotes Early studies in murine T cell lines indicated that transcriptional transactivation functions encoded in the glucocorticoid receptor (GR) N-terminal domain are required for glucocorticoid-mediated apoptosis.
S3 288-502 Sentence denotes However, more recent studies in human T cell lines have suggested that the N-terminal domain is not necessary for steroid-regulated apoptosis and that GR-mediated transrepression may be the more critical mechanism.
S4 503-744 Sentence denotes To better understand the contribution of the GR N-terminal transactivation domain in mediating murine thymocyte apoptosis, we stably transfected GR, GR variants, and the androgen receptor (AR) into receptor-negative S49 murine thymoma cells.
S5 745-997 Sentence denotes GR expression levels were shown to be rate-limiting for initiating the apoptotic pathway, and a positive correlation between steroid sensitivity and GR-mediated induction of an integrated mouse mammary tumor virus (MMTV) LTR reporter gene was observed.
S6 998-1308 Sentence denotes Analysis of GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus revealed that even low level expression of these receptors resulted in both enhanced steroid sensitivity and MMTV induction, thus supporting a role for transactivation in apoptosis.
S7 1309-1496 Sentence denotes In contrast, we found that AR can initiate apoptosis in S49 cells after treatment with 5 alpha-dihydrotestosterone, despite its relative inability to induce high level expression of MMTV.
S8 1497-1625 Sentence denotes To investigate this further, we examined the steroid-regulated expression of an endogenous thymocyte-specific gene called GIG18.
S9 1626-1895 Sentence denotes We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells.
S10 1896-2123 Sentence denotes Taken together, these results support our conclusion that transcriptional transactivation is a necessary signaling component of S49 cell apoptosis, although an additional role for GR-mediated transrepression cannot be excluded.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C3 27-54 NP denotes steroid-regulated apoptosis
C26 132-163 NP denotes transcriptional transactivation
C1 185-235 NP denotes the glucocorticoid receptor (GR) N-terminal domain
C2 359-380 NP denotes the N-terminal domain
C4 402-429 NP denotes steroid-regulated apoptosis
C7 439-442 NP denotes GR-
C29 439-466 NP denotes GR-mediated transrepression
C5 544-584 NP denotes the GR N-terminal transactivation domain
C6 648-650 NP denotes GR
C15 669-695 NP denotes the androgen receptor (AR)
C8 894-897 NP denotes GR-
C9 1010-1126 NP denotes GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus
C10 1170-1185 NP denotes these receptors
C11 1298-1307 NP denotes apoptosis
C14 1336-1338 NP denotes AR
C12 1352-1361 NP denotes apoptosis
C21 1365-1374 NP denotes S49 cells
C13 1433-1436 NP denotes its
C16 1574-1624 NP denotes an endogenous thymocyte-specific gene called GIG18
C17 1640-1645 NP denotes GIG18
C18 1695-1697 NP denotes AR
C19 1702-1704 NP denotes GR
C20 1725-1727 NP denotes AR
C22 1782-1791 NP denotes S49 cells
C23 1812-1817 NP denotes GIG18
C24 1934-1948 NP denotes our conclusion
C25 1949-1953 NP denotes that
C27 1954-1985 NP denotes transcriptional transactivation
C30 2076-2079 NP denotes GR-
C28 2076-2103 NP denotes GR-mediated transrepression
R1 C2 C1 coref-ident the N-terminal domain,the glucocorticoid receptor (GR) N-terminal domain
R2 C4 C3 coref-ident steroid-regulated apoptosis,steroid-regulated apoptosis
R3 C5 C1 coref-ident the GR N-terminal transactivation domain,the glucocorticoid receptor (GR) N-terminal domain
R4 C6 C7 coref-ident GR,GR-
R5 C8 C6 coref-ident GR-,GR
R6 C10 C9 coref-ident these receptors,GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus
R7 C14 C15 coref-ident AR,the androgen receptor (AR)
R8 C12 C11 coref-ident apoptosis,apoptosis
R9 C13 C14 coref-pron its,AR
R10 C17 C16 coref-ident GIG18,an endogenous thymocyte-specific gene called GIG18
R11 C18 C14 coref-ident AR,AR
R12 C19 C8 coref-ident GR,GR-
R13 C20 C18 coref-ident AR,AR
R14 C22 C21 coref-ident S49 cells,S49 cells
R15 C23 C17 coref-ident GIG18,GIG18
R16 C25 C24 coref-relat that,our conclusion
R17 C27 C26 coref-ident transcriptional transactivation,transcriptional transactivation
R18 C30 C29 coref-ident GR-,GR-mediated transrepression
R19 C28 C19 coref-ident GR-mediated transrepression,GR

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 27-54 other_name denotes steroid-regulated apoptosis
T2 58-78 cell_type denotes murine thymoma cells
T3 104-116 cell_line denotes T cell lines
T4 132-173 other_name denotes transcriptional transactivation functions
T5 189-203 lipid denotes glucocorticoid
T6 214-216 protein_family_or_group denotes GR
T7 253-267 lipid denotes glucocorticoid
T8 320-325 cell_line denotes human
T9 326-338 cell_line denotes T cell lines
T10 363-380 protein_domain_or_region denotes N-terminal domain
T11 402-429 other_name denotes steroid-regulated apoptosis
T12 439-441 protein_family_or_group denotes GR
T13 548-550 protein_family_or_group denotes GR
T14 648-650 protein_family_or_group denotes GR
T15 652-654 protein_family_or_group denotes GR
T16 673-690 protein_family_or_group denotes androgen receptor
T17 692-694 protein_family_or_group denotes AR
T18 701-722 cell_line denotes receptor-negative S49
T19 723-743 cell_type denotes murine thymoma cells
T20 745-747 protein_family_or_group denotes GR
T21 816-833 other_name denotes apoptotic pathway
T22 870-889 other_name denotes steroid sensitivity
T23 894-896 protein_family_or_group denotes GR
T24 933-958 virus denotes mouse mammary tumor virus
T25 1010-1012 protein_family_or_group denotes GR
T26 1113-1115 protein_family_or_group denotes GR
T27 1146-1166 other_name denotes low level expression
T28 1212-1231 other_name denotes steroid sensitivity
T29 1236-1240 virus denotes MMTV
T30 1298-1307 other_name denotes apoptosis
T31 1336-1338 protein_family_or_group denotes AR
T32 1352-1361 other_name denotes apoptosis
T33 1365-1374 cell_line denotes S49 cells
T34 1396-1423 lipid denotes 5 alpha-dihydrotestosterone
T35 1491-1495 virus denotes MMTV
T36 1542-1570 other_name denotes steroid-regulated expression
T37 1588-1611 DNA_domain_or_region denotes thymocyte-specific gene
T38 1619-1624 DNA_domain_or_region denotes GIG18
T39 1640-1645 DNA_domain_or_region denotes GIG18
T40 1695-1697 protein_family_or_group denotes AR
T41 1702-1704 protein_family_or_group denotes GR
T42 1725-1727 protein_family_or_group denotes AR
T43 1782-1791 cell_line denotes S49 cells
T44 1812-1817 DNA_domain_or_region denotes GIG18
T45 1847-1869 other_name denotes early apoptotic events
T46 1954-1985 other_name denotes transcriptional transactivation
T47 2033-2042 other_name denotes apoptosis
T48 2076-2078 protein_family_or_group denotes GR