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PubMed:8829135 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.
T2 143-276 Sentence denotes Nefiracetam is a novel pyrrolidone derivative which attenuates scopolamine-induced learning and post-training consolidation deficits.
T3 277-502 Sentence denotes Given that apomorphine inhibits passive avoidance retention when given during training or in a defined 10-12h post-training period, we evaluated the ability of nefiracetam to attenuate amnesia induced by dopaminergic agonism.
T4 503-716 Sentence denotes A step-down passive avoidance paradigm was employed and nefiracetam (3 mg/kg) and apomorphine (0.5 mg/kg) were given alone or in combination during training and at the 10-12h post-training period of consolidation.
T5 717-844 Sentence denotes Co-administration of nefiracetam and apomorphine during training or 10h thereafter produced no significant anti-amnesic effect.
T6 845-1016 Sentence denotes However, administration of nefiracetam during training completely reversed the amnesia induced by apomorphine at the 10h post-training time and the converse was also true.
T7 1017-1243 Sentence denotes These effects were not mediated by a dopaminergic mechanism as nefiracetam, at millimolar concentrations, failed to displace either [3H]SCH 23390 or [3H]spiperone binding from D1 or D2 dopamine receptor subtypes, respectively.
T8 1244-1385 Sentence denotes It is suggested that nefiracetam augments molecular processes in the early stages of events which ultimately lead to consolidation of memory.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
175 0-11 ChemicalEntity denotes Nefiracetam MESH:C058876
176 13-20 ChemicalEntity denotes DM-9384 MESH:C058876
177 31-42 ChemicalEntity denotes apomorphine MESH:D001058
178 51-58 DiseaseOrPhenotypicFeature denotes amnesia MESH:D000647
179 143-154 ChemicalEntity denotes Nefiracetam MESH:C058876
180 166-177 ChemicalEntity denotes pyrrolidone MESH:D011760
181 206-217 ChemicalEntity denotes scopolamine MESH:D012601
182 226-275 DiseaseOrPhenotypicFeature denotes learning and post-training consolidation deficits MESH:D007859
183 288-299 ChemicalEntity denotes apomorphine MESH:D001058
184 437-448 ChemicalEntity denotes nefiracetam MESH:C058876
185 462-469 DiseaseOrPhenotypicFeature denotes amnesia MESH:D000647
186 481-501 ChemicalEntity denotes dopaminergic agonism MESH:D018491
187 559-570 ChemicalEntity denotes nefiracetam MESH:C058876
188 585-596 ChemicalEntity denotes apomorphine MESH:D001058
189 738-749 ChemicalEntity denotes nefiracetam MESH:C058876
190 754-765 ChemicalEntity denotes apomorphine MESH:D001058
191 829-836 DiseaseOrPhenotypicFeature denotes amnesic MESH:D000647
192 872-883 ChemicalEntity denotes nefiracetam MESH:C058876
193 924-931 DiseaseOrPhenotypicFeature denotes amnesia MESH:D000647
194 943-954 ChemicalEntity denotes apomorphine MESH:D001058
195 1080-1091 ChemicalEntity denotes nefiracetam MESH:C058876
196 1150-1152 ChemicalEntity denotes 3H MESH:D014316
197 1153-1162 ChemicalEntity denotes SCH 23390 MESH:C534628
198 1167-1169 ChemicalEntity denotes 3H MESH:D014316
199 1170-1179 ChemicalEntity denotes spiperone MESH:D013134
200 1193-1219 GeneOrGeneProduct denotes D1 or D2 dopamine receptor NCBIGene:1812|NCBIGene:1813
201 1265-1276 ChemicalEntity denotes nefiracetam MESH:C058876

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 900-910 DiseaseOrPhenotypicFeature denotes completely 0700063

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 43-50 GeneOrGeneProduct denotes induced
T2 160-165 GeneOrGeneProduct denotes novel
T3 195-205 GeneOrGeneProduct denotes attenuates
T4 218-225 GeneOrGeneProduct denotes induced
T5 239-243 GeneOrGeneProduct denotes post
T6 355-371 GeneOrGeneProduct denotes training or in a
T7 387-391 GeneOrGeneProduct denotes post
T8 401-407 GeneOrGeneProduct denotes period
T9 452-461 GeneOrGeneProduct denotes attenuate
T10 470-477 GeneOrGeneProduct denotes induced
T11 505-509 GeneOrGeneProduct denotes step
T12 574-576 GeneOrGeneProduct denotes mg
T13 602-604 GeneOrGeneProduct denotes mg
T14 678-682 GeneOrGeneProduct denotes post
T15 692-698 GeneOrGeneProduct denotes period
T16 932-939 GeneOrGeneProduct denotes induced
T17 966-970 GeneOrGeneProduct denotes post
T18 980-984 GeneOrGeneProduct denotes time
T19 1040-1048 GeneOrGeneProduct denotes mediated
T20 1133-1141 GeneOrGeneProduct denotes displace
T21 1180-1187 GeneOrGeneProduct denotes binding
T22 1199-1219 GeneOrGeneProduct denotes D2 dopamine receptor
T23 1296-1305 GeneOrGeneProduct denotes processes
T24 1313-1318 GeneOrGeneProduct denotes early

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 160-165 GeneOrGeneProduct denotes novel
T2 239-243 GeneOrGeneProduct denotes post
T3 387-391 GeneOrGeneProduct denotes post
T4 401-407 GeneOrGeneProduct denotes period
T5 505-509 GeneOrGeneProduct denotes step
T6 678-682 GeneOrGeneProduct denotes post
T7 692-698 GeneOrGeneProduct denotes period
T8 966-970 GeneOrGeneProduct denotes post
T9 1133-1141 GeneOrGeneProduct denotes displace
T10 1180-1187 GeneOrGeneProduct denotes binding
T11 1199-1219 GeneOrGeneProduct denotes D2 dopamine receptor
T12 1313-1318 GeneOrGeneProduct denotes early

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 51-58 DiseaseOrPhenotypicFeature denotes amnesia D000647
T2 100-109 DiseaseOrPhenotypicFeature denotes emergence D004630
T3 462-469 DiseaseOrPhenotypicFeature denotes amnesia D000647
T4 924-931 DiseaseOrPhenotypicFeature denotes amnesia D000647

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 401-407 GeneOrGeneProduct denotes period
T2 692-698 GeneOrGeneProduct denotes period
T3 1133-1141 GeneOrGeneProduct denotes displace
T4 1199-1219 GeneOrGeneProduct denotes D2 dopamine receptor

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 13-15 DiseaseOrPhenotypicFeature denotes DM 0016367|0005015
T3 51-58 DiseaseOrPhenotypicFeature denotes amnesia 0001152
T4 462-469 DiseaseOrPhenotypicFeature denotes amnesia 0001152
T5 924-931 DiseaseOrPhenotypicFeature denotes amnesia 0001152

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 13-15 DiseaseOrPhenotypicFeature denotes DM DISEASE
T2 51-58 DiseaseOrPhenotypicFeature denotes amnesia D000647
T3 226-275 DiseaseOrPhenotypicFeature denotes learning and post-training consolidation deficits DISEASE
T4 462-469 DiseaseOrPhenotypicFeature denotes amnesia D000647
T5 829-836 DiseaseOrPhenotypicFeature denotes amnesic DISEASE
T6 924-931 DiseaseOrPhenotypicFeature denotes amnesia D000647

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 13-15 DiseaseOrPhenotypicFeature denotes DM DISEASE
T2 51-58 DiseaseOrPhenotypicFeature denotes amnesia D000647
T3 226-275 DiseaseOrPhenotypicFeature denotes learning and post-training consolidation deficits DISEASE
T4 462-469 DiseaseOrPhenotypicFeature denotes amnesia D000647
T5 829-836 DiseaseOrPhenotypicFeature denotes amnesic DISEASE
T6 924-931 DiseaseOrPhenotypicFeature denotes amnesia D000647

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-11 ChemicalEntity denotes Nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T3 13-20 ChemicalEntity denotes DM-9384 C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T5 31-42 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T7 143-154 ChemicalEntity denotes Nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T9 166-177 ChemicalEntity denotes pyrrolidone D011760
T10 206-217 ChemicalEntity denotes scopolamine D012601|http://purl.obolibrary.org/obo/CHEBI_16794
T12 288-299 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T14 437-448 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T16 481-501 ChemicalEntity denotes dopaminergic agonism ChemicalEntity
T17 559-570 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T19 585-596 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T21 738-749 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T23 754-765 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T25 872-883 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T27 943-954 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T29 1054-1066 ChemicalEntity denotes dopaminergic ChemicalEntity
T30 1080-1091 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T32 1153-1162 ChemicalEntity denotes SCH 23390 C534628|http://purl.obolibrary.org/obo/CHEBI_73297
T34 1170-1179 ChemicalEntity denotes spiperone D013134|http://purl.obolibrary.org/obo/CHEBI_9233
T36 1202-1210 ChemicalEntity denotes dopamine D004298|http://purl.obolibrary.org/obo/CHEBI_59905|http://purl.obolibrary.org/obo/CHEBI_18243
T39 1265-1276 ChemicalEntity denotes nefiracetam C058876|http://purl.obolibrary.org/obo/CHEBI_135004
T41 1353-1357 ChemicalEntity denotes lead D007854

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T41 1353-1357 ChemicalEntity denotes lead D007854
T39 1265-1276 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T36 1202-1210 ChemicalEntity denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905|D004298
T34 1170-1179 ChemicalEntity denotes spiperone http://purl.obolibrary.org/obo/CHEBI_9233|D013134
T32 1153-1162 ChemicalEntity denotes SCH 23390 http://purl.obolibrary.org/obo/CHEBI_73297|C534628
T30 1080-1091 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T29 1054-1066 ChemicalEntity denotes dopaminergic ChemicalEntity
T27 943-954 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T25 872-883 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T23 754-765 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T21 738-749 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T19 585-596 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T17 559-570 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T16 481-501 ChemicalEntity denotes dopaminergic agonism ChemicalEntity
T14 437-448 ChemicalEntity denotes nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T12 288-299 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T10 206-217 ChemicalEntity denotes scopolamine http://purl.obolibrary.org/obo/CHEBI_16794|D012601
T9 166-177 ChemicalEntity denotes pyrrolidone D011760
T7 143-154 ChemicalEntity denotes Nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T5 31-42 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T3 13-20 ChemicalEntity denotes DM-9384 http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T1 0-11 ChemicalEntity denotes Nefiracetam http://purl.obolibrary.org/obo/CHEBI_135004|C058876
T4 1199-1219 GeneOrGeneProduct denotes D2 dopamine receptor
T2628 1133-1141 GeneOrGeneProduct denotes displace
T2 692-698 GeneOrGeneProduct denotes period
T47990 401-407 GeneOrGeneProduct denotes period
T6 924-931 DiseaseOrPhenotypicFeature denotes amnesia D000647
T48888 829-836 DiseaseOrPhenotypicFeature denotes amnesic DISEASE
T53027 462-469 DiseaseOrPhenotypicFeature denotes amnesia D000647
T22570 226-275 DiseaseOrPhenotypicFeature denotes learning and post-training consolidation deficits DISEASE
T41600 51-58 DiseaseOrPhenotypicFeature denotes amnesia D000647
T67295 13-15 DiseaseOrPhenotypicFeature denotes DM DISEASE