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sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase.
T2 145-355 Sentence denotes The growth-promoting effects of gastrin on normal and neoplastic gastrointestinal tissues have been shown to be mediated by the gastrin/CCKB receptor, which belongs to the family of G protein-coupled receptors.
T3 356-447 Sentence denotes However, the downstream signaling pathways activated by gastrin are not well characterized.
T4 448-631 Sentence denotes In the present study, we demonstrate that gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), the major cytoplasmic substrate of the insulin receptor.
T5 632-764 Sentence denotes The gastrin-induced phosphorylation of IRS-1 was rapid and transient, occurring within 30 s of treatment and diminishing thereafter.
T6 765-880 Sentence denotes IRS-1 binds several proteins containing Src homology 2 domains through its multiple tyrosine phosphorylation sites.
T7 881-1051 Sentence denotes Following gastrin stimulation, we observed a time- and dose-dependent association of IRS-1 with the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI 3-kinase).
T8 1052-1324 Sentence denotes In addition, activation of PI 3-kinase was detected in anti-IRS-1 immunoprecipitates from gastrin-treated cells, suggesting that tyrosine phosphorylation of IRS-1, which leads to the rapid recruitment of p85, might be one mechanism used by gastrin to activate PI 3-kinase.
T9 1325-1528 Sentence denotes We have previously reported that tyrosine phosphorylation of Shc and its association with the Grb2-Sos complex may contribute to the activation of the mitogen-activated protein kinase pathway by gastrin.
T10 1529-1627 Sentence denotes We report here that Grb2 also interacts with tyrosine-phosphorylated IRS-1 in response to gastrin.
T11 1628-1870 Sentence denotes Taken together, our results suggest that IRS-1 may serve as a converging target in the signaling pathways stimulated by receptors that belong to different families, such as the gastrin/CCKB G protein-coupled receptor and the insulin receptor.
T1 0-144 Sentence denotes Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase.
T2 145-355 Sentence denotes The growth-promoting effects of gastrin on normal and neoplastic gastrointestinal tissues have been shown to be mediated by the gastrin/CCKB receptor, which belongs to the family of G protein-coupled receptors.
T3 356-447 Sentence denotes However, the downstream signaling pathways activated by gastrin are not well characterized.
T4 448-631 Sentence denotes In the present study, we demonstrate that gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), the major cytoplasmic substrate of the insulin receptor.
T5 632-764 Sentence denotes The gastrin-induced phosphorylation of IRS-1 was rapid and transient, occurring within 30 s of treatment and diminishing thereafter.
T6 765-880 Sentence denotes IRS-1 binds several proteins containing Src homology 2 domains through its multiple tyrosine phosphorylation sites.
T7 881-1051 Sentence denotes Following gastrin stimulation, we observed a time- and dose-dependent association of IRS-1 with the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI 3-kinase).
T8 1052-1324 Sentence denotes In addition, activation of PI 3-kinase was detected in anti-IRS-1 immunoprecipitates from gastrin-treated cells, suggesting that tyrosine phosphorylation of IRS-1, which leads to the rapid recruitment of p85, might be one mechanism used by gastrin to activate PI 3-kinase.
T9 1325-1528 Sentence denotes We have previously reported that tyrosine phosphorylation of Shc and its association with the Grb2-Sos complex may contribute to the activation of the mitogen-activated protein kinase pathway by gastrin.
T10 1529-1627 Sentence denotes We report here that Grb2 also interacts with tyrosine-phosphorylated IRS-1 in response to gastrin.
T11 1628-1870 Sentence denotes Taken together, our results suggest that IRS-1 may serve as a converging target in the signaling pathways stimulated by receptors that belong to different families, such as the gastrin/CCKB G protein-coupled receptor and the insulin receptor.

AIMed

Id Subject Object Predicate Lexical cue
T1 0-7 protein denotes Gastrin
T2 47-75 protein denotes insulin receptor substrate 1
T3 101-105 protein denotes Grb2
T4 114-143 protein denotes phosphatidylinositol 3-kinase
T5 177-184 protein denotes gastrin
T6 273-280 protein denotes gastrin
T7 281-294 protein denotes CCKB receptor
T8 412-419 protein denotes gastrin
T9 490-497 protein denotes gastrin
T10 537-565 protein denotes insulin receptor substrate 1
T11 567-572 protein denotes IRS-1
T12 614-630 protein denotes insulin receptor
T13 636-643 protein denotes gastrin
T14 671-676 protein denotes IRS-1
T15 765-770 protein denotes IRS-1
T16 891-898 protein denotes gastrin
T17 966-971 protein denotes IRS-1
T18 981-984 protein denotes p85
T19 1007-1036 protein denotes phosphatidylinositol 3-kinase
T20 1038-1049 protein denotes PI 3-kinase
T21 1079-1090 protein denotes PI 3-kinase
T22 1112-1117 protein denotes IRS-1
T23 1142-1149 protein denotes gastrin
T24 1209-1214 protein denotes IRS-1
T25 1256-1259 protein denotes p85
T26 1292-1299 protein denotes gastrin
T27 1312-1323 protein denotes PI 3-kinase
T28 1386-1389 protein denotes Shc
T29 1419-1423 protein denotes Grb2
T30 1424-1427 protein denotes Sos
T31 1476-1508 protein denotes mitogen-activated protein kinase
T32 1520-1527 protein denotes gastrin
T33 1549-1553 protein denotes Grb2
T34 1598-1603 protein denotes IRS-1
T35 1619-1626 protein denotes gastrin
T36 1669-1674 protein denotes IRS-1
T37 1805-1812 protein denotes gastrin
T38 1813-1844 protein denotes CCKB G protein-coupled receptor
T39 1853-1869 protein denotes insulin receptor

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 585-596 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737