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sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes.
T2 79-213 Sentence denotes AP-1 has been shown to behave as a redox-sensitive transcription factor that can be activated by both oxidant and antioxidant stimuli.
T3 214-309 Sentence denotes However, the mechanisms involved in the activation of AP-1 by antioxidants are largely unknown.
T4 310-525 Sentence denotes In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.
T5 526-741 Sentence denotes This activation differed substantially from that mediated by phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore or produced by costimulation with antibodies against the T cell receptor-CD3 complex and to CD28.
T6 742-907 Sentence denotes The activation of JNK by classical T cell stimuli was transient, whereas that mediated by PDTC and butylated hydroxyanisole (but not N-acetylcysteine) was sustained.
T7 908-1113 Sentence denotes The kinetics of JNK activation correlated with the expression of c-jun which was transient after stimulation with PMA plus ionophore and prolonged in response to PDTC, which also transiently induced c-fos.
T8 1114-1334 Sentence denotes In addition, JNK activation by PMA plus ionophore was sensitive to inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation, which failed to inhibit the activation mediated by PDTC.
T9 1335-1655 Sentence denotes Transfection of trans-dominant negative expression vectors of ras and raf, together with AP-1-dependent reporter constructs, as well as Western blot analysis using anti-ERK (extracellular signal-regulated kinase) antibodies, indicated that the Ras/Raf/ERK pathway did not appear to mediate the effect of the antioxidant.
T10 1656-1805 Sentence denotes However, the combined treatment with PDTC and PMA, two agents that synergize on AP-1 activation, resulted in the persistent phosphorylation of ERK-2.
T11 1806-1959 Sentence denotes In conclusion, our results identify JNK as a target of antioxidant agents which can be regulated differentially under oxidant and antioxidant conditions.
T1 0-78 Sentence denotes JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes.
T2 79-213 Sentence denotes AP-1 has been shown to behave as a redox-sensitive transcription factor that can be activated by both oxidant and antioxidant stimuli.
T3 214-309 Sentence denotes However, the mechanisms involved in the activation of AP-1 by antioxidants are largely unknown.
T4 310-525 Sentence denotes In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.
T5 526-741 Sentence denotes This activation differed substantially from that mediated by phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore or produced by costimulation with antibodies against the T cell receptor-CD3 complex and to CD28.
T6 742-907 Sentence denotes The activation of JNK by classical T cell stimuli was transient, whereas that mediated by PDTC and butylated hydroxyanisole (but not N-acetylcysteine) was sustained.
T7 908-1113 Sentence denotes The kinetics of JNK activation correlated with the expression of c-jun which was transient after stimulation with PMA plus ionophore and prolonged in response to PDTC, which also transiently induced c-fos.
T8 1114-1334 Sentence denotes In addition, JNK activation by PMA plus ionophore was sensitive to inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation, which failed to inhibit the activation mediated by PDTC.
T9 1335-1655 Sentence denotes Transfection of trans-dominant negative expression vectors of ras and raf, together with AP-1-dependent reporter constructs, as well as Western blot analysis using anti-ERK (extracellular signal-regulated kinase) antibodies, indicated that the Ras/Raf/ERK pathway did not appear to mediate the effect of the antioxidant.
T10 1656-1805 Sentence denotes However, the combined treatment with PDTC and PMA, two agents that synergize on AP-1 activation, resulted in the persistent phosphorylation of ERK-2.
T11 1806-1959 Sentence denotes In conclusion, our results identify JNK as a target of antioxidant agents which can be regulated differentially under oxidant and antioxidant conditions.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes JNK
T2 5-30 protein denotes c-Jun NH2-terminal kinase
T3 64-77 cell_type denotes T lymphocytes
T4 79-83 protein denotes AP-1
T5 114-150 protein denotes redox-sensitive transcription factor
T6 268-272 protein denotes AP-1
T7 475-478 protein denotes JNK
T8 480-505 protein denotes c-Jun NH2-terminal kinase
T9 510-524 cell_line denotes Jurkat T cells
T10 678-688 protein denotes antibodies
T11 701-728 protein denotes T cell receptor-CD3 complex
T12 736-740 protein denotes CD28
T13 760-763 protein denotes JNK
T14 924-927 protein denotes JNK
T15 973-978 DNA denotes c-jun
T16 1107-1112 DNA denotes c-fos
T17 1127-1130 protein denotes JNK
T18 1230-1246 protein denotes protein kinase C
T19 1351-1393 DNA denotes trans-dominant negative expression vectors
T20 1397-1400 DNA denotes ras
T21 1405-1408 DNA denotes raf
T22 1424-1458 DNA denotes AP-1-dependent reporter constructs
T23 1499-1558 protein denotes anti-ERK (extracellular signal-regulated kinase) antibodies
T24 1736-1740 protein denotes AP-1
T25 1799-1804 protein denotes ERK-2
T26 1842-1845 protein denotes JNK

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-78 Sentence denotes JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes.
S2 79-213 Sentence denotes AP-1 has been shown to behave as a redox-sensitive transcription factor that can be activated by both oxidant and antioxidant stimuli.
S3 214-309 Sentence denotes However, the mechanisms involved in the activation of AP-1 by antioxidants are largely unknown.
S4 310-525 Sentence denotes In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.
S5 526-741 Sentence denotes This activation differed substantially from that mediated by phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore or produced by costimulation with antibodies against the T cell receptor-CD3 complex and to CD28.
S6 742-907 Sentence denotes The activation of JNK by classical T cell stimuli was transient, whereas that mediated by PDTC and butylated hydroxyanisole (but not N-acetylcysteine) was sustained.
S7 908-1113 Sentence denotes The kinetics of JNK activation correlated with the expression of c-jun which was transient after stimulation with PMA plus ionophore and prolonged in response to PDTC, which also transiently induced c-fos.
S8 1114-1334 Sentence denotes In addition, JNK activation by PMA plus ionophore was sensitive to inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation, which failed to inhibit the activation mediated by PDTC.
S9 1335-1655 Sentence denotes Transfection of trans-dominant negative expression vectors of ras and raf, together with AP-1-dependent reporter constructs, as well as Western blot analysis using anti-ERK (extracellular signal-regulated kinase) antibodies, indicated that the Ras/Raf/ERK pathway did not appear to mediate the effect of the antioxidant.
S10 1656-1805 Sentence denotes However, the combined treatment with PDTC and PMA, two agents that synergize on AP-1 activation, resulted in the persistent phosphorylation of ERK-2.
S11 1806-1959 Sentence denotes In conclusion, our results identify JNK as a target of antioxidant agents which can be regulated differentially under oxidant and antioxidant conditions.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C7 0-31 NP denotes JNK (c-Jun NH2-terminal kinase)
C3 48-77 NP denotes antioxidants in T lymphocytes
C39 35-77 NP denotes a target for antioxidants in T lymphocytes
C5 79-83 NP denotes AP-1
C1 112-150 NP denotes a redox-sensitive transcription factor
C2 151-155 NP denotes that
C6 268-272 NP denotes AP-1
C4 276-288 NP denotes antioxidants
C16 383-417 NP denotes pyrrolidine dithiocarbamate (PDTC)
C18 419-443 NP denotes butylated hydroxyanisole
C8 475-524 NP denotes JNK (c-Jun NH2-terminal kinase) in Jurkat T cells
C9 526-541 NP denotes This activation
C10 570-574 NP denotes that
C30 587-624 NP denotes phorbol 12-myristate 13-acetate (PMA)
C27 587-643 NP denotes phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore
C12 742-756 NP denotes The activation
C11 760-763 NP denotes JNK
C13 815-819 NP denotes that
C17 832-836 NP denotes PDTC
C19 841-865 NP denotes butylated hydroxyanisole
C14 955-978 NP denotes the expression of c-jun
C15 979-984 NP denotes which
C29 1022-1025 NP denotes PMA
C28 1022-1040 NP denotes PMA plus ionophore
C20 1070-1074 NP denotes PDTC
C21 1076-1081 NP denotes which
C31 1145-1148 NP denotes PMA
C26 1145-1163 NP denotes PMA plus ionophore
C23 1181-1276 NP denotes inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation
C24 1278-1283 NP denotes which
C22 1329-1333 NP denotes PDTC
C36 1693-1697 NP denotes PDTC
C32 1702-1705 NP denotes PMA
C25 1693-1705 NP denotes PDTC and PMA
C35 1707-1717 NP denotes two agents
C34 1718-1722 NP denotes that
C33 1707-1751 NP denotes two agents that synergize on AP-1 activation
C37 1842-1845 NP denotes JNK
C38 1849-1879 NP denotes a target of antioxidant agents
C40 1880-1885 NP denotes which
R1 C2 C1 coref-relat that,a redox-sensitive transcription factor
R2 C6 C5 coref-ident AP-1,AP-1
R3 C4 C3 coref-ident antioxidants,antioxidants in T lymphocytes
R4 C8 C7 coref-ident JNK (c-Jun NH2-terminal kinase) in Jurkat T cells,JNK (c-Jun NH2-terminal kinase)
R5 C10 C9 coref-pron that,This activation
R6 C11 C8 coref-ident JNK,JNK (c-Jun NH2-terminal kinase) in Jurkat T cells
R7 C13 C12 coref-xxx that,The activation
R8 C17 C16 coref-ident PDTC,pyrrolidine dithiocarbamate (PDTC)
R9 C19 C18 coref-ident butylated hydroxyanisole,butylated hydroxyanisole
R10 C15 C14 coref-relat which,the expression of c-jun
R11 C29 C30 coref-ident PMA,phorbol 12-myristate 13-acetate (PMA)
R12 C28 C27 coref-ident PMA plus ionophore,phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore
R13 C20 C17 coref-ident PDTC,PDTC
R14 C21 C20 coref-relat which,PDTC
R15 C31 C29 coref-ident PMA,PMA
R16 C26 C28 coref-ident PMA plus ionophore,PMA plus ionophore
R17 C24 C23 coref-relat which,"inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation"
R18 C22 C20 coref-ident PDTC,PDTC
R19 C32 C26 coref-ident PMA,PMA plus ionophore
R20 C25 C22 coref-ident PDTC and PMA,PDTC
R21 C35 C36 coref-appos two agents,PDTC
R22 C34 C33 coref-relat that,two agents that synergize on AP-1 activation
R23 C37 C11 coref-ident JNK,JNK
R24 C38 C39 coref-ident a target of antioxidant agents,a target for antioxidants in T lymphocytes
R25 C40 C38 coref-relat which,a target of antioxidant agents

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_molecule denotes JNK
T2 5-30 protein_molecule denotes c-Jun NH2-terminal kinase
T3 48-60 other_organic_compound denotes antioxidants
T4 64-77 cell_type denotes T lymphocytes
T5 79-83 protein_molecule denotes AP-1
T6 114-150 protein_family_or_group denotes redox-sensitive transcription factor
T7 268-272 protein_molecule denotes AP-1
T8 276-288 other_organic_compound denotes antioxidants
T9 383-410 other_organic_compound denotes pyrrolidine dithiocarbamate
T10 412-416 other_organic_compound denotes PDTC
T11 419-443 other_organic_compound denotes butylated hydroxyanisole
T12 449-464 amino_acid_monomer denotes Nacetylcysteine
T13 475-478 protein_molecule denotes JNK
T14 480-505 protein_molecule denotes c-Jun NH2-terminal kinase
T15 510-524 cell_line denotes Jurkat T cells
T16 587-618 other_organic_compound denotes phorbol 12-myristate 13-acetate
T17 620-623 other_organic_compound denotes PMA
T18 629-633 atom denotes Ca2+
T19 678-688 protein_family_or_group denotes antibodies
T20 701-728 protein_complex denotes T cell receptor-CD3 complex
T21 736-740 protein_molecule denotes CD28
T22 760-763 protein_molecule denotes JNK
T23 767-791 other_name denotes classical T cell stimuli
T24 832-836 other_organic_compound denotes PDTC
T25 841-865 other_organic_compound denotes butylated hydroxyanisole
T26 875-891 amino_acid_monomer denotes N-acetylcysteine
T27 924-927 protein_molecule denotes JNK
T28 973-978 DNA_domain_or_region denotes c-jun
T29 1022-1025 other_organic_compound denotes PMA
T30 1070-1074 other_organic_compound denotes PDTC
T31 1107-1112 DNA_domain_or_region denotes c-fos
T32 1127-1130 protein_molecule denotes JNK
T33 1145-1148 other_organic_compound denotes PMA
T34 1224-1228 atom denotes Ca2+
T35 1230-1246 protein_molecule denotes protein kinase C
T36 1329-1333 other_organic_compound denotes PDTC
T37 1351-1393 DNA_molecule denotes trans-dominant negative expression vectors
T38 1397-1400 DNA_domain_or_region denotes ras
T39 1405-1408 DNA_domain_or_region denotes raf
T40 1424-1428 protein_molecule denotes AP-1
T41 1471-1492 other_name denotes Western blot analysis
T42 1499-1509 protein_family_or_group denotes anti-ERK (
T43 1509-1546 protein_molecule denotes extracellular signal-regulated kinase
T44 1693-1697 other_organic_compound denotes PDTC
T45 1702-1705 other_organic_compound denotes PMA
T46 1736-1740 protein_molecule denotes AP-1
T47 1799-1804 protein_molecule denotes ERK-2
T48 1842-1845 protein_molecule denotes JNK
T49 1861-1879 other_organic_compound denotes antioxidant agents

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 620-623 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T3 1022-1025 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T5 1145-1148 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T7 1702-1705 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 64-77 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T2 701-707 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 777-783 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T4 1509-1522 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 64-77 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T2 517-524 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 701-707 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 777-783 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084