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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-57 Sentence denotes Regulation of sialoadhesin expression on rat macrophages.
T2 58-156 Sentence denotes Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.
T3 157-281 Sentence denotes Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
T4 282-415 Sentence denotes It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
T5 416-621 Sentence denotes We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
T6 622-796 Sentence denotes The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
T7 797-885 Sentence denotes Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
T8 886-983 Sentence denotes Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
T9 984-1203 Sentence denotes Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
T10 1204-1342 Sentence denotes Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
T11 1343-1518 Sentence denotes The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
T12 1519-1651 Sentence denotes Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
T13 1652-1840 Sentence denotes This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.
T1 0-57 Sentence denotes Regulation of sialoadhesin expression on rat macrophages.
T2 58-156 Sentence denotes Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.
T3 157-281 Sentence denotes Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
T4 282-415 Sentence denotes It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
T5 416-621 Sentence denotes We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
T6 622-796 Sentence denotes The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
T7 797-885 Sentence denotes Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
T8 886-983 Sentence denotes Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
T9 984-1203 Sentence denotes Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
T10 1204-1342 Sentence denotes Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
T11 1343-1518 Sentence denotes The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
T12 1519-1651 Sentence denotes Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
T13 1652-1840 Sentence denotes This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 157-281 DRI_Background denotes Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
T2 282-415 DRI_Challenge denotes It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
T3 416-621 DRI_Outcome denotes We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
T4 622-796 DRI_Background denotes The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
T5 797-885 DRI_Outcome denotes Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
T6 886-983 DRI_Background denotes Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
T7 984-1203 DRI_Outcome denotes Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
T8 1204-1342 DRI_Outcome denotes Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
T9 1343-1518 DRI_Background denotes The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
T10 1519-1651 DRI_Outcome denotes Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
T11 1652-1840 DRI_Outcome denotes This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-26 protein denotes sialoadhesin
T2 41-56 cell_type denotes rat macrophages
T3 106-114 protein denotes IFN-beta
T4 116-125 protein denotes IFN-gamma
T5 127-131 protein denotes IL-4
T6 157-169 protein denotes Sialoadhesin
T7 175-203 protein denotes macrophage-restricted member
T8 211-225 protein denotes Ig superfamily
T9 254-280 cell_type denotes lymphoid and myeloid cells
T10 320-331 cell_type denotes macrophages
T11 450-462 protein denotes sialoadhesin
T12 525-537 protein denotes sialoadhesin
T13 569-584 cell_type denotes rat macrophages
T14 593-620 cell_line denotes rat macrophage cell line R2
T15 626-635 protein denotes cytokines
T16 636-644 protein denotes IFN-beta
T17 646-655 protein denotes IFN-gamma
T18 657-661 protein denotes IL-4
T19 698-710 protein denotes sialoadhesin
T20 783-795 protein denotes sialoadhesin
T21 797-809 protein denotes Sialoadhesin
T22 874-884 cell_type denotes human RBCs
T23 1035-1044 protein denotes cytokines
T24 1114-1126 protein denotes sialoadhesin
T25 1144-1152 protein denotes IFN-beta
T26 1157-1161 protein denotes IL-4
T27 1185-1194 protein denotes IFN-gamma
T28 1229-1238 protein denotes IFN-gamma
T29 1287-1295 protein denotes IFN-beta
T30 1300-1304 protein denotes IL-4
T31 1361-1373 protein denotes sialoadhesin
T32 1405-1416 protein denotes GC receptor
T33 1429-1455 protein denotes mineralocorticoid receptor
T34 1552-1563 cell_type denotes macrophages
T35 1638-1650 protein denotes sialoadhesin
T36 1712-1724 protein denotes sialoadhesin
T37 1739-1754 cell_type denotes rat macrophages
T38 1797-1805 protein denotes IFN-beta
T39 1807-1831 protein denotes T cell-derived cytokines

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 14-37 NP denotes sialoadhesin expression
C1 0-37 NP denotes Regulation of sialoadhesin expression
C3 41-56 NP denotes rat macrophages
C4 71-86 NP denotes glucocorticoids
C5 106-155 NP denotes IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide
C6 157-169 NP denotes Sialoadhesin
C7 173-225 NP denotes a macrophage-restricted member of the Ig superfamily
C8 226-230 NP denotes that
C9 282-284 NP denotes It
C11 450-473 NP denotes sialoadhesin expression
C10 432-473 NP denotes the regulation of sialoadhesin expression
C12 497-517 NP denotes glucocorticoids (GC)
C13 525-548 NP denotes sialoadhesin expression
C14 622-670 NP denotes The cytokines IFN-beta, IFN-gamma, IL-4, and LPS
C15 698-721 NP denotes sialoadhesin expression
C16 725-735 NP denotes themselves
C17 783-795 NP denotes sialoadhesin
C18 797-820 NP denotes Sialoadhesin expression
C19 931-941 NP denotes regulation
C20 1028-1030 NP denotes GC
C21 1035-1048 NP denotes cytokines/LPS
C22 1114-1137 NP denotes sialoadhesin expression
C23 1144-1152 NP denotes IFN-beta
C24 1157-1161 NP denotes IL-4
C25 1185-1194 NP denotes IFN-gamma
C26 1199-1202 NP denotes LPS
C27 1229-1238 NP denotes IFN-gamma
C28 1243-1246 NP denotes LPS
C29 1287-1295 NP denotes IFN-beta
C30 1300-1304 NP denotes IL-4
C31 1339-1341 NP denotes GC
C33 1361-1384 NP denotes sialoadhesin expression
C32 1343-1384 NP denotes The regulation of sialoadhesin expression
C34 1567-1584 NP denotes the adrenal gland
C35 1586-1628 NP denotes the major site of endogenous GC production
C36 1638-1650 NP denotes sialoadhesin
C37 1681-1683 NP denotes GC
C38 1712-1735 NP denotes sialoadhesin expression
C39 1739-1754 NP denotes rat macrophages
C40 1797-1805 NP denotes IFN-beta
C41 1836-1839 NP denotes LPS
R1 C8 C7 coref-relat that,a macrophage-restricted member of the Ig superfamily
R2 C9 C6 coref-pron It,Sialoadhesin
R3 C11 C2 coref-ident sialoadhesin expression,sialoadhesin expression
R4 C10 C1 coref-ident the regulation of sialoadhesin expression,Regulation of sialoadhesin expression
R5 C12 C4 coref-ident glucocorticoids (GC),glucocorticoids
R6 C13 C11 coref-ident sialoadhesin expression,sialoadhesin expression
R7 C14 C5 coref-ident "The cytokines IFN-beta, IFN-gamma, IL-4, and LPS","IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide"
R8 C15 C13 coref-ident sialoadhesin expression,sialoadhesin expression
R9 C16 C14 coref-pron themselves,"The cytokines IFN-beta, IFN-gamma, IL-4, and LPS"
R10 C17 C6 coref-ident sialoadhesin,Sialoadhesin
R11 C18 C15 coref-ident Sialoadhesin expression,sialoadhesin expression
R12 C19 C10 coref-ident regulation,the regulation of sialoadhesin expression
R13 C20 C12 coref-ident GC,glucocorticoids (GC)
R14 C21 C14 coref-ident cytokines/LPS,"The cytokines IFN-beta, IFN-gamma, IL-4, and LPS"
R15 C22 C18 coref-ident sialoadhesin expression,Sialoadhesin expression
R16 C27 C25 coref-ident IFN-gamma,IFN-gamma
R17 C28 C26 coref-ident LPS,LPS
R18 C29 C23 coref-ident IFN-beta,IFN-beta
R19 C30 C24 coref-ident IL-4,IL-4
R20 C31 C20 coref-ident GC,GC
R21 C33 C22 coref-ident sialoadhesin expression,sialoadhesin expression
R22 C32 C10 coref-ident The regulation of sialoadhesin expression,the regulation of sialoadhesin expression
R23 C35 C34 coref-appos the major site of endogenous GC production,the adrenal gland
R24 C36 C17 coref-ident sialoadhesin,sialoadhesin
R25 C37 C31 coref-ident GC,GC
R26 C38 C33 coref-ident sialoadhesin expression,sialoadhesin expression
R27 C39 C3 coref-ident rat macrophages,rat macrophages
R28 C40 C29 coref-ident IFN-beta,IFN-beta
R29 C41 C28 coref-ident LPS,LPS

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-57 Sentence denotes Regulation of sialoadhesin expression on rat macrophages.
S2 58-156 Sentence denotes Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.
S3 157-281 Sentence denotes Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
S4 282-415 Sentence denotes It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
S5 416-621 Sentence denotes We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
S6 622-796 Sentence denotes The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
S7 797-885 Sentence denotes Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
S8 886-983 Sentence denotes Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
S9 984-1203 Sentence denotes Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
S10 1204-1342 Sentence denotes Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
S11 1343-1518 Sentence denotes The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
S12 1519-1651 Sentence denotes Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
S13 1652-1840 Sentence denotes This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-26 protein_molecule denotes sialoadhesin
T2 41-56 cell_type denotes rat macrophages
T3 71-86 lipid denotes glucocorticoids
T4 106-114 protein_molecule denotes IFN-beta
T5 116-125 protein_molecule denotes IFN-gamma
T6 127-131 protein_molecule denotes IL-4
T7 137-155 lipid denotes lipopolysaccharide
T8 157-169 protein_molecule denotes Sialoadhesin
T9 175-203 protein_family_or_group denotes macrophage-restricted member
T10 211-225 protein_family_or_group denotes Ig superfamily
T11 320-331 cell_type denotes macrophages
T12 335-351 tissue denotes lymphoid tissues
T13 359-379 other_name denotes chronic inflammation
T14 450-462 protein_molecule denotes sialoadhesin
T15 497-512 lipid denotes glucocorticoids
T16 514-516 lipid denotes GC
T17 525-537 protein_molecule denotes sialoadhesin
T18 569-572 cell_type denotes rat
T19 573-584 cell_type denotes macrophages
T20 593-620 cell_line denotes rat macrophage cell line R2
T21 626-635 protein_family_or_group denotes cytokines
T22 636-644 protein_molecule denotes IFN-beta
T23 646-655 protein_molecule denotes IFN-gamma
T24 657-661 protein_molecule denotes IL-4
T25 667-670 lipid denotes LPS
T26 698-710 protein_molecule denotes sialoadhesin
T27 758-760 lipid denotes GC
T28 783-795 protein_molecule denotes sialoadhesin
T29 797-809 protein_molecule denotes Sialoadhesin
T30 848-868 other_name denotes cell adhesion assays
T31 874-884 cell_type denotes human RBCs
T32 886-915 other_name denotes Northern blotting experiments
T33 972-982 other_name denotes mRNA level
T34 1028-1030 lipid denotes GC
T35 1035-1044 protein_family_or_group denotes cytokines
T36 1044-1048 lipid denotes /LPS
T37 1086-1088 lipid denotes GC
T38 1114-1126 protein_molecule denotes sialoadhesin
T39 1144-1152 protein_molecule denotes IFN-beta
T40 1157-1161 protein_molecule denotes IL-4
T41 1185-1194 protein_molecule denotes IFN-gamma
T42 1199-1202 lipid denotes LPS
T43 1229-1238 protein_molecule denotes IFN-gamma
T44 1243-1246 lipid denotes LPS
T45 1287-1295 protein_molecule denotes IFN-beta
T46 1300-1304 protein_molecule denotes IL-4
T47 1339-1341 lipid denotes GC
T48 1361-1373 protein_molecule denotes sialoadhesin
T49 1405-1407 lipid denotes GC
T50 1429-1455 protein_family_or_group denotes mineralocorticoid receptor
T51 1497-1517 other_name denotes specific antagonists
T52 1552-1563 cell_type denotes macrophages
T53 1604-1614 other_name denotes endogenous
T54 1615-1617 lipid denotes GC
T55 1638-1650 protein_molecule denotes sialoadhesin
T56 1681-1683 lipid denotes GC
T57 1693-1708 other_name denotes primary inducer
T58 1712-1724 protein_molecule denotes sialoadhesin
T59 1739-1754 cell_type denotes rat macrophages
T60 1797-1805 protein_molecule denotes IFN-beta
T61 1807-1821 protein_family_or_group denotes T cell-derived
T62 1822-1831 protein_family_or_group denotes cytokines
T63 1836-1839 lipid denotes LPS