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PubMed:8810619 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
T2 117-364 Sentence denotes Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.
T3 365-546 Sentence denotes In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.
T4 547-979 Sentence denotes Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).
T5 980-1072 Sentence denotes We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).
T6 1073-1239 Sentence denotes Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.
T7 1240-1334 Sentence denotes Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise).
T8 1335-1507 Sentence denotes We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.
T1 0-116 Sentence denotes Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
T2 117-364 Sentence denotes Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.
T3 365-546 Sentence denotes In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.
T4 547-979 Sentence denotes Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).
T5 980-1072 Sentence denotes We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).
T6 1073-1239 Sentence denotes Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.
T7 1240-1334 Sentence denotes Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise).
T8 1335-1507 Sentence denotes We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 19-29 protein denotes NF-kappa B
T2 34-42 protein denotes cytokine
T3 62-66 protein denotes HOCI
T4 167-175 protein denotes cytokine
T5 258-266 protein denotes protease
T6 584-627 protein denotes transcription factor nuclear factor-kappa B
T7 629-639 protein denotes NK-kappa B
T8 675-683 protein denotes cytokine
T9 684-697 protein denotes interleukin-8
T10 699-703 protein denotes IL-8
T11 708-732 cell_line denotes cultured human monocytes
T12 794-821 protein denotes tumor necrosis factor-alpha
T13 823-832 protein denotes TNF-alpha
T14 835-844 protein denotes IL-1 beta
T15 846-850 protein denotes IL-6
T16 852-856 protein denotes IL-8
T17 858-906 protein denotes granulocyte-macrophage colony-stimulating factor
T18 908-914 protein denotes GM-CSF

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-9 NP denotes Tyloxapol
C2 217-311 NP denotes abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions
C3 312-316 NP denotes that
C4 421-430 NP denotes tyloxapol
C5 432-545 NP denotes an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis
C6 547-556 NP denotes Tyloxapol
C7 671-704 NP denotes the cytokine interleukin-8 (IL-8)
C8 852-856 NP denotes IL-8
C9 1010-1019 NP denotes tyloxapol
C10 1073-1082 NP denotes Tyloxapol
C11 1240-1249 NP denotes Tyloxapol
C12 1352-1361 NP denotes tyloxapol
R1 C3 C2 coref-relat that,"abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions"
R2 C4 C1 coref-ident tyloxapol,Tyloxapol
R3 C5 C4 coref-appos an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis,tyloxapol
R4 C6 C4 coref-ident Tyloxapol,tyloxapol
R5 C8 C7 coref-ident IL-8,the cytokine interleukin-8 (IL-8)
R6 C9 C6 coref-ident tyloxapol,Tyloxapol
R7 C10 C9 coref-ident Tyloxapol,tyloxapol
R8 C11 C10 coref-ident Tyloxapol,Tyloxapol
R9 C12 C11 coref-ident tyloxapol,Tyloxapol

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
S2 117-364 Sentence denotes Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.
S3 365-546 Sentence denotes In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.
S4 547-979 Sentence denotes Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).
S5 980-1072 Sentence denotes We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).
S6 1073-1239 Sentence denotes Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.
S7 1240-1334 Sentence denotes Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise).
S8 1335-1507 Sentence denotes We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-9 other_organic_compound denotes Tyloxapol
T2 19-29 protein_complex denotes NF-kappa B
T3 34-42 protein_family_or_group denotes cytokine
T4 62-66 protein_molecule denotes HOCI
T5 93-115 other_name denotes cystic fibrosis sputum
T6 117-146 multi_cell denotes Cystic fibrosis (CF) patients
T7 167-175 protein_family_or_group denotes cytokine
T8 258-266 protein_family_or_group denotes protease
T9 350-363 other_name denotes physiotherapy
T10 421-430 other_organic_compound denotes tyloxapol
T11 435-480 other_organic_compound denotes alkylaryl polyether alcohol polymer detergent
T12 502-517 other_organic_compound denotes mucolytic agent
T13 521-545 other_name denotes adult chronic bronchitis
T14 547-556 other_organic_compound denotes Tyloxapol
T15 584-627 protein_complex denotes transcription factor nuclear factor-kappa B
T16 629-639 protein_complex denotes NK-kappa B
T17 675-683 protein_family_or_group denotes cytokine
T18 684-697 protein_molecule denotes interleukin-8
T19 699-703 protein_molecule denotes IL-8
T20 708-732 cell_line denotes cultured human monocytes
T21 747-765 lipid denotes lipopolysaccharide
T22 767-770 lipid denotes LPS
T23 794-821 protein_molecule denotes tumor necrosis factor-alpha
T24 823-832 protein_molecule denotes TNF-alpha
T25 835-844 protein_molecule denotes IL-1 beta
T26 846-850 protein_molecule denotes IL-6
T27 852-856 protein_molecule denotes IL-8
T28 858-906 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T29 908-914 protein_molecule denotes GM-CSF
T30 925-937 other_organic_compound denotes eiconsanoids
T31 938-952 other_organic_compound denotes thromboxane A2
T32 957-971 other_organic_compound denotes leukotriene B4
T33 973-977 other_organic_compound denotes LTB4
T34 1010-1019 other_organic_compound denotes tyloxapol
T35 1032-1043 other_name denotes antioxidant
T36 1048-1065 inorganic denotes hydroxyl radicals
T37 1068-1070 inorganic denotes OH
T38 1073-1082 other_organic_compound denotes Tyloxapol
T39 1139-1156 inorganic denotes hypochlorous acid
T40 1158-1162 inorganic denotes HOCl
T41 1205-1209 inorganic denotes HOCl
T42 1240-1249 other_organic_compound denotes Tyloxapol
T43 1280-1289 other_name denotes CF sputum
T44 1352-1361 other_organic_compound denotes tyloxapol
T45 1393-1417 other_name denotes antiinflammatory therapy
T46 1422-1437 other_name denotes CF lung disease
T47 1479-1489 other_name denotes secretions
T48 1497-1506 other_name denotes CF airway