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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-241 Sentence denotes Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.
T2 242-400 Sentence denotes There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease.
T3 401-601 Sentence denotes A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopeptide-induced immune cell signaling events.
T4 602-805 Sentence denotes Like LPS, purified native B. burgdorferi OspA and synthetic analogs of OspA, OspB, and two T. pallidum lipoproteins (Tpp47 and Tpp17) all induced NF-kappa B translocation in THP-1 human monocytoid cells.
T5 806-885 Sentence denotes Acylation of OspA and the synthetic peptides was requisite for cell activation.
T6 886-933 Sentence denotes Polymyxin B abrogated only the response to LPS.
T7 934-1236 Sentence denotes By using 70Z/3-derived pre-B-cell lines either lacking or expressing human CD14 (the LPS receptor), it was observed that expression of human CD14 imparted responsiveness to LPS but not to OspA or spirochetal lipopeptides (assessed by induction of NF-kappa B and expression of surface immunoglobulin M).
T8 1237-1697 Sentence denotes Finally, the biological relevance of the observation that T. pallidum lipoproteins-lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission.
T9 1698-1961 Sentence denotes The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.
T1 0-241 Sentence denotes Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.
T2 242-400 Sentence denotes There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease.
T3 401-601 Sentence denotes A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopeptide-induced immune cell signaling events.
T4 602-805 Sentence denotes Like LPS, purified native B. burgdorferi OspA and synthetic analogs of OspA, OspB, and two T. pallidum lipoproteins (Tpp47 and Tpp17) all induced NF-kappa B translocation in THP-1 human monocytoid cells.
T5 806-885 Sentence denotes Acylation of OspA and the synthetic peptides was requisite for cell activation.
T6 886-933 Sentence denotes Polymyxin B abrogated only the response to LPS.
T7 934-1236 Sentence denotes By using 70Z/3-derived pre-B-cell lines either lacking or expressing human CD14 (the LPS receptor), it was observed that expression of human CD14 imparted responsiveness to LPS but not to OspA or spirochetal lipopeptides (assessed by induction of NF-kappa B and expression of surface immunoglobulin M).
T8 1237-1697 Sentence denotes Finally, the biological relevance of the observation that T. pallidum lipoproteins-lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission.
T9 1698-1961 Sentence denotes The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-35 cell_type denotes human monocytic cells
T2 39-95 protein denotes Treponema pallidum and Borrelia burgdorferi lipoproteins
T3 230-240 protein denotes NF-kappa B
T4 276-288 protein denotes lipoproteins
T5 612-647 protein denotes purified native B. burgdorferi OspA
T6 673-677 protein denotes OspA
T7 679-683 protein denotes OspB
T8 693-717 protein denotes T. pallidum lipoproteins
T9 719-724 protein denotes Tpp47
T10 729-734 protein denotes Tpp17
T11 748-758 protein denotes NF-kappa B
T12 776-804 cell_type denotes THP-1 human monocytoid cells
T13 819-823 protein denotes OspA
T14 943-973 cell_line denotes 70Z/3-derived pre-B-cell lines
T15 1003-1013 protein denotes human CD14
T16 1019-1031 protein denotes LPS receptor
T17 1069-1079 protein denotes human CD14
T18 1122-1126 protein denotes OspA
T19 1130-1154 protein denotes spirochetal lipopeptides
T20 1181-1191 protein denotes NF-kappa B
T21 1210-1234 protein denotes surface immunoglobulin M
T22 1295-1319 protein denotes T. pallidum lipoproteins
T23 1345-1355 protein denotes NF-kappa B
T24 1360-1368 protein denotes cytokine
T25 1383-1392 cell_type denotes monocytes
T26 1761-1785 protein denotes spirochetal lipoproteins

genia-medco-coref

Id Subject Object Predicate Lexical cue
C5 39-95 NP denotes Treponema pallidum and Borrelia burgdorferi lipoproteins
C1 136-145 NP denotes a pathway
C2 160-164 NP denotes that
C7 168-186 NP denotes lipopolysaccharide
C17 200-240 NP denotes the transcriptional activator NF-kappa B
C3 251-270 NP denotes increasing evidence
C4 271-275 NP denotes that
C6 276-335 NP denotes lipoproteins of Treponema pallidum and Borrelia burgdorferi
C11 510-535 NP denotes lipopolysaccharide (LPS)-
C10 607-610 NP denotes LPS
C12 673-677 NP denotes OspA
C13 819-823 NP denotes OspA
C14 929-932 NP denotes LPS
C15 1107-1110 NP denotes LPS
C16 1122-1126 NP denotes OspA
C18 1181-1191 NP denotes NF-kappa B
C20 1274-1289 NP denotes the observation
C21 1290-1294 NP denotes that
C19 1345-1355 NP denotes NF-kappa B
C23 1743-1755 NP denotes the proposal
C24 1756-1760 NP denotes that
C25 1790-1793 NP denotes LPS
C26 1861-1865 NP denotes that
R1 C2 C1 coref-pron that,a pathway
R2 C4 C3 coref-relat that,increasing evidence
R3 C6 C5 coref-ident lipoproteins of Treponema pallidum and Borrelia burgdorferi,Treponema pallidum and Borrelia burgdorferi lipoproteins
R4 C11 C7 coref-ident lipopolysaccharide (LPS)-,lipopolysaccharide
R5 C10 C11 coref-ident LPS,lipopolysaccharide (LPS)-
R6 C13 C12 coref-ident OspA,OspA
R7 C14 C10 coref-ident LPS,LPS
R8 C15 C14 coref-ident LPS,LPS
R9 C16 C13 coref-ident OspA,OspA
R10 C18 C17 coref-ident NF-kappa B,the transcriptional activator NF-kappa B
R11 C21 C20 coref-ident that,the observation
R12 C19 C18 coref-ident NF-kappa B,NF-kappa B
R13 C24 C23 coref-relat that,the proposal
R14 C25 C15 coref-ident LPS,LPS
R15 C26 C23 coref-relat that,the proposal

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-241 Sentence denotes Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.
S2 242-400 Sentence denotes There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease.
S3 401-601 Sentence denotes A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopeptide-induced immune cell signaling events.
S4 602-805 Sentence denotes Like LPS, purified native B. burgdorferi OspA and synthetic analogs of OspA, OspB, and two T. pallidum lipoproteins (Tpp47 and Tpp17) all induced NF-kappa B translocation in THP-1 human monocytoid cells.
S5 806-885 Sentence denotes Acylation of OspA and the synthetic peptides was requisite for cell activation.
S6 886-933 Sentence denotes Polymyxin B abrogated only the response to LPS.
S7 934-1236 Sentence denotes By using 70Z/3-derived pre-B-cell lines either lacking or expressing human CD14 (the LPS receptor), it was observed that expression of human CD14 imparted responsiveness to LPS but not to OspA or spirochetal lipopeptides (assessed by induction of NF-kappa B and expression of surface immunoglobulin M).
S8 1237-1697 Sentence denotes Finally, the biological relevance of the observation that T. pallidum lipoproteins-lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission.
S9 1698-1961 Sentence denotes The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-35 cell_type denotes human monocytic cells
T2 100-122 peptide denotes synthetic lipopeptides
T3 168-186 lipid denotes lipopolysaccharide
T4 230-240 protein_complex denotes NF-kappa B
T5 276-288 protein_family_or_group denotes lipoproteins
T6 292-310 mono_cell denotes Treponema pallidum
T7 315-335 mono_cell denotes Borrelia burgdorferi
T8 344-366 other_name denotes inflammatory mediators
T9 374-382 other_name denotes syphilis
T10 387-399 other_name denotes Lyme disease
T11 607-610 lipid denotes LPS
T12 612-627 protein_molecule denotes purified native
T13 628-642 mono_cell denotes B. burgdorferi
T14 673-677 protein_molecule denotes OspA
T15 679-683 protein_molecule denotes OspB
T16 693-704 mono_cell denotes T. pallidum
T17 719-724 protein_molecule denotes Tpp47
T18 729-734 protein_molecule denotes Tpp17
T19 748-758 protein_complex denotes NF-kappa B
T20 776-804 cell_type denotes THP-1 human monocytoid cells
T21 819-823 protein_molecule denotes OspA
T22 832-850 peptide denotes synthetic peptides
T23 886-897 other_organic_compound denotes Polymyxin B
T24 929-932 lipid denotes LPS
T25 943-973 cell_line denotes 70Z/3-derived pre-B-cell lines
T26 1003-1013 protein_molecule denotes human CD14
T27 1019-1022 lipid denotes LPS
T28 1069-1079 protein_molecule denotes human CD14
T29 1107-1110 lipid denotes LPS
T30 1122-1126 protein_molecule denotes OspA
T31 1130-1154 protein_family_or_group denotes spirochetal lipopeptides
T32 1181-1191 protein_complex denotes NF-kappa B
T33 1210-1234 protein_molecule denotes surface immunoglobulin M
T34 1295-1306 mono_cell denotes T. pallidum
T35 1345-1355 protein_complex denotes NF-kappa B
T36 1360-1368 protein_family_or_group denotes cytokine
T37 1383-1392 cell_type denotes monocytes
T38 1458-1486 virus denotes human immunodeficiency virus
T39 1608-1626 tissue denotes syphilitic chancre
T40 1655-1683 virus denotes human immunodeficiency virus
T41 1761-1785 protein_family_or_group denotes spirochetal lipoproteins
T42 1790-1793 lipid denotes LPS
T43 1837-1856 other_name denotes cell surface events
T44 1870-1888 other_name denotes signaling pathways
T45 1942-1960 other_name denotes cellular responses