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PubMed:8728315 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Interaction of a recombinant form of apolipoprotein[a] with human fibroblasts and with the human hepatoma cell line HepG2.
TextSentencer_T2 123-258 Sentence denotes We have studied the binding, uptake, and degradation of a recombinant form of apolipoprotein[a] (r-apo[a]) using a cultured cell model.
TextSentencer_T3 259-510 Sentence denotes In HepG2 cells and in human fibroblasts, r-apo[a] complexed with low density lipoprotein(LDL) is bound and internalized via high affinity (Kd = 10 nM) receptors; in both cell types, low affinity (Kd = 200-300 nM) sites also mediate free apo[a] uptake.
TextSentencer_T4 511-620 Sentence denotes Using competition studies, we found that the high affinity binding component corresponds to the LDL receptor.
TextSentencer_T5 621-891 Sentence denotes Involvement of the LDL receptor in r-apo[a] uptake by fibroblasts was confirmed using fibroblasts derived from an individual homozygous for familial hypercholesterolemia; in contrast to normal fibroblasts, these cells lacked the high affinity r-apo[a] binding component.
TextSentencer_T6 892-1066 Sentence denotes Cell association of 125I-labeled r-apo[a] was increased and decreased concomitantly with the up- and down-regulation of the LDL receptor in response to a number of compounds.
TextSentencer_T7 1067-1379 Sentence denotes The addition of alpha 2-macroglobulin as well as treatment with heparinase, chondroitinase ABC, and sodium chlorate did not decrease total specific binding of r-apo[a], suggesting that neither the low density lipoprotein receptor-related protein nor cell surface proteoglycans are involved in r-apo[a] clearance.
TextSentencer_T8 1380-1714 Sentence denotes The low affinity binding component present in both fibroblasts and HepG2 cells likely corresponds to the plasminogen receptor, as binding of r-apo[a] to these sites was specifically decreased by the addition of plasminogen or the lysine analogue epsilon-aminocaproic acid, but not by the addition of tissue-type plasminogen activator.
TextSentencer_T9 1715-1874 Sentence denotes Heparin abolished uptake of r-apo[a] by the LDL receptor component only; this indicates that apo[a] must be associated with LDL to be cleared by this receptor.
TextSentencer_T10 1875-2032 Sentence denotes In contrast, free apo[a] can be effectively cleared by the plasminogen receptor which may represent a significant route of clearance for free apo[a] in vivo.
T1 0-122 Sentence denotes Interaction of a recombinant form of apolipoprotein[a] with human fibroblasts and with the human hepatoma cell line HepG2.
T2 123-258 Sentence denotes We have studied the binding, uptake, and degradation of a recombinant form of apolipoprotein[a] (r-apo[a]) using a cultured cell model.
T3 259-510 Sentence denotes In HepG2 cells and in human fibroblasts, r-apo[a] complexed with low density lipoprotein(LDL) is bound and internalized via high affinity (Kd = 10 nM) receptors; in both cell types, low affinity (Kd = 200-300 nM) sites also mediate free apo[a] uptake.
T4 511-620 Sentence denotes Using competition studies, we found that the high affinity binding component corresponds to the LDL receptor.
T5 621-891 Sentence denotes Involvement of the LDL receptor in r-apo[a] uptake by fibroblasts was confirmed using fibroblasts derived from an individual homozygous for familial hypercholesterolemia; in contrast to normal fibroblasts, these cells lacked the high affinity r-apo[a] binding component.
T6 892-1066 Sentence denotes Cell association of 125I-labeled r-apo[a] was increased and decreased concomitantly with the up- and down-regulation of the LDL receptor in response to a number of compounds.
T7 1067-1379 Sentence denotes The addition of alpha 2-macroglobulin as well as treatment with heparinase, chondroitinase ABC, and sodium chlorate did not decrease total specific binding of r-apo[a], suggesting that neither the low density lipoprotein receptor-related protein nor cell surface proteoglycans are involved in r-apo[a] clearance.
T8 1380-1714 Sentence denotes The low affinity binding component present in both fibroblasts and HepG2 cells likely corresponds to the plasminogen receptor, as binding of r-apo[a] to these sites was specifically decreased by the addition of plasminogen or the lysine analogue epsilon-aminocaproic acid, but not by the addition of tissue-type plasminogen activator.
T9 1715-1874 Sentence denotes Heparin abolished uptake of r-apo[a] by the LDL receptor component only; this indicates that apo[a] must be associated with LDL to be cleared by this receptor.
T10 1875-2032 Sentence denotes In contrast, free apo[a] can be effectively cleared by the plasminogen receptor which may represent a significant route of clearance for free apo[a] in vivo.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 37-53 gene:4018 denotes apolipoprotein[a
T1 97-105 disease:C0023903 denotes hepatoma
T2 37-53 gene:4018 denotes apolipoprotein[a
T3 97-105 disease:C2239176 denotes hepatoma
R1 T0 T1 associated_with apolipoprotein[a,hepatoma
R2 T2 T3 associated_with apolipoprotein[a,hepatoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T743 640-652 gene:3949 denotes LDL receptor
T744 761-790 disease:C0020445 denotes familial hypercholesterolemia
R1 T743 T744 associated_with LDL receptor,familial hypercholesterolemia
R2 T743 T744 associated_with LDL receptor,familial hypercholesterolemia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1680-1686 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1680-1686 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue