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PubMed:8720080 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-131 Sentence denotes Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions.
TextSentencer_T2 132-381 Sentence denotes CAMPATH-1H (where CAMPATH is a trade mark of Wellcome group companies), a humanized IgG antibody used in the therapy of lymphoma, leukaemia and rheumatoid arthritis, has been expressed in Chinese hamster ovary, Y0 myeloma and NS0 myeloma cell lines.
TextSentencer_T3 382-496 Sentence denotes These engineered cell lines were grown under different culture conditions, and the antibody isolated and purified.
TextSentencer_T4 497-775 Sentence denotes N-Linked oligosaccharides, on the CH2 heavy chain region of the antibody, were isolated and analysed by hydrazinolysis, high-performance anion-exchange chromatography with pulsed amperometric detection, laser-desorption mass spectrometry and sequential exoglycosidase treatment.
TextSentencer_T5 776-981 Sentence denotes Both the glycosylation pattern and the biological activity of CAMPATH-1H, as measured by antibody-dependent cell-mediated cytotoxicity, were markedly affected by the cell line used to express the antibody.
TextSentencer_T6 982-1085 Sentence denotes It is concluded that glycosylation of the antibody may be important in the clinical outcome of therapy.
T1 0-131 Sentence denotes Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions.
T2 132-381 Sentence denotes CAMPATH-1H (where CAMPATH is a trade mark of Wellcome group companies), a humanized IgG antibody used in the therapy of lymphoma, leukaemia and rheumatoid arthritis, has been expressed in Chinese hamster ovary, Y0 myeloma and NS0 myeloma cell lines.
T3 382-496 Sentence denotes These engineered cell lines were grown under different culture conditions, and the antibody isolated and purified.
T4 497-775 Sentence denotes N-Linked oligosaccharides, on the CH2 heavy chain region of the antibody, were isolated and analysed by hydrazinolysis, high-performance anion-exchange chromatography with pulsed amperometric detection, laser-desorption mass spectrometry and sequential exoglycosidase treatment.
T5 776-981 Sentence denotes Both the glycosylation pattern and the biological activity of CAMPATH-1H, as measured by antibody-dependent cell-mediated cytotoxicity, were markedly affected by the cell line used to express the antibody.
T6 982-1085 Sentence denotes It is concluded that glycosylation of the antibody may be important in the clinical outcome of therapy.
T1 0-131 Sentence denotes Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions.
T2 132-381 Sentence denotes CAMPATH-1H (where CAMPATH is a trade mark of Wellcome group companies), a humanized IgG antibody used in the therapy of lymphoma, leukaemia and rheumatoid arthritis, has been expressed in Chinese hamster ovary, Y0 myeloma and NS0 myeloma cell lines.
T3 382-496 Sentence denotes These engineered cell lines were grown under different culture conditions, and the antibody isolated and purified.
T4 497-775 Sentence denotes N-Linked oligosaccharides, on the CH2 heavy chain region of the antibody, were isolated and analysed by hydrazinolysis, high-performance anion-exchange chromatography with pulsed amperometric detection, laser-desorption mass spectrometry and sequential exoglycosidase treatment.
T5 776-981 Sentence denotes Both the glycosylation pattern and the biological activity of CAMPATH-1H, as measured by antibody-dependent cell-mediated cytotoxicity, were markedly affected by the cell line used to express the antibody.
T6 982-1085 Sentence denotes It is concluded that glycosylation of the antibody may be important in the clinical outcome of therapy.

ICD10

Id Subject Object Predicate Lexical cue
T1 262-271 http://purl.bioontology.org/ontology/ICD10/C95.9 denotes leukaemia
T2 276-296 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T3 287-296 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 216-219 FMAID:167179 denotes IgG
_T2 220-228 FMAID:167180 denotes antibody
_T3 336-341 FMAID:7209 denotes ovary
_T4 336-341 FMAID:93687 denotes ovary
_T5 465-473 FMAID:167180 denotes antibody
_T6 506-522 FMAID:82742 denotes oligosaccharides
_T7 506-522 FMAID:196731 denotes oligosaccharides
_T8 561-569 FMAID:167180 denotes antibody
_T9 865-873 FMAID:167180 denotes antibody
_T10 972-980 FMAID:167180 denotes antibody
_T11 1024-1032 FMAID:167180 denotes antibody

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 186-191 http://purl.bioontology.org/ontology/STY/T096 denotes group
T2 276-286 http://purl.bioontology.org/ontology/NCBITAXON/572355 denotes rheumatoid
T3 700-705 http://purl.bioontology.org/ontology/NCBITAXON/62990 denotes laser

GO-BP

Id Subject Object Predicate Lexical cue
T1 0-13 http://purl.obolibrary.org/obo/GO_0070085 denotes Glycosylation
T2 785-798 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 1003-1016 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 640-648 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T5 884-910 http://purl.obolibrary.org/obo/GO_0001909 denotes cell-mediated cytotoxicity
T6 884-910 http://purl.obolibrary.org/obo/GO_0001913 denotes cell-mediated cytotoxicity
T7 884-910 http://purl.obolibrary.org/obo/GO_0042267 denotes cell-mediated cytotoxicity
T8 884-910 http://purl.obolibrary.org/obo/GO_0090634 denotes cell-mediated cytotoxicity

GO-MF

Id Subject Object Predicate Lexical cue
T1 220-228 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2 465-473 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T3 561-569 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4 865-873 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5 972-980 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6 1024-1032 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T1 75-79 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 370-374 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 399-403 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 884-888 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 942-946 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 216-228 http://purl.obolibrary.org/obo/GO_0071736 denotes IgG antibody

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 206-215 http://edamontology.org/topic_2815 denotes humanized
T2 717-734 http://edamontology.org/topic_3520 denotes mass spectrometry
T3 717-734 http://edamontology.org/topic_0134 denotes mass spectrometry

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 75-89 http://edamontology.org/data_0963 denotes cell lines and
T2 689-698 http://edamontology.org/operation_2423 denotes detection
T3 717-734 http://edamontology.org/data_3147 denotes mass spectrometry
T4 717-734 http://edamontology.org/data_2536 denotes mass spectrometry
T5 853-861 http://edamontology.org/data_3108 denotes measured

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 252-260 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062
T2 276-296 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T3 346-353 Disease denotes myeloma http://purl.obolibrary.org/obo/MONDO_0005170|http://purl.obolibrary.org/obo/MONDO_0009693
T5 362-369 Disease denotes myeloma http://purl.obolibrary.org/obo/MONDO_0005170|http://purl.obolibrary.org/obo/MONDO_0009693

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 320-335 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 336-341 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 252-260 Phenotype denotes lymphoma HP:0002665
T2 262-271 Phenotype denotes leukaemia HP:0001909
T3 276-296 Phenotype denotes rheumatoid arthritis HP:0001370