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Id Subject Object Predicate Lexical cue
T1 0-148 DRI_Background denotes Endocrine ductal carcinoma in situ (E-DCIS) of the breast: a form of low-grade DCIS with distinctive clinicopathologic and biologic characteristics.
T2 149-229 DRI_Background denotes Endocrine ductal carcinoma in situ (E-DCIS), first characterized by Cross et al.
T3 230-362 DRI_Background denotes in 1985, is an uncommon entity, and there is little information on its pathobiologic features and natural history in the literature.
T4 363-514 DRI_Outcome denotes This report describes the largest series of 34 cases: 14 cases were pure in situ (group A), and 20 were accompanied by an invasive component (group B).
T5 515-642 DRI_Approach denotes All except three patients were over the age of 60 years, with the mean being 69.5 years for group A and 72.6 years for group B.
T6 643-726 DRI_Approach denotes Except for six patients in group A who had nipple discharge, all had a breast mass.
T7 727-920 DRI_Background denotes On follow-up, one of five group A patients developed local recurrence 5 years after mastectomy, and two of seven group B patients developed another invasive primary in the contralateral breast.
T8 921-1057 DRI_Unspecified denotes Histologically, E-DCIS showed expansile intraductal growths forming solid sheets and festoons traversed by delicate fibrovascular septa.
T9 1058-1152 DRI_Outcome denotes Accumulation of basophilic mucin might be found within the growth and the fibrovascular septa.
T10 1153-1202 DRI_Approach denotes There were variable degrees of stromal sclerosis.
T11 1203-1326 DRI_Background denotes In some cases, the solid intraductal cellular proliferations were focally punctuated by microglandular spaces and rosettes.
T12 1327-1354 DRI_Unspecified denotes Comedo necrosis was absent.
T13 1355-1494 DRI_Outcome denotes Intraductal papillomas were found in the immediate vicinity of the tumors in 18 cases and invariably showed pagetoid involvement by E-DCIS.
T14 1495-1585 DRI_Approach denotes Pagetoid spread into the adjacent ducts and ductules was also a common feature (17 cases).
T15 1586-1742 DRI_Background denotes The tumor cells were polygonal, oval, or spindly, often with eccentrically placed, bland-looking, ovoid nuclei and abundant eosinophilic granular cytoplasm.
T16 1743-1789 DRI_Background denotes Intracellular mucin was commonly demonstrable.
T17 1790-1913 DRI_Background denotes Immunostaining for myoepithelium using muscle-specific actin antibody confirmed the in situ nature of the E-DCIS component.
T18 1914-2067 DRI_Outcome denotes The majority of tumor cells showed strong staining with the neuroendocrine markers chromogranin, synaptophysin, and neuron-specific enolase (monoclonal).
T19 2068-2271 DRI_Outcome denotes Immunostaining also dramatically highlighted the pagetoid spread into the papillomas and ductules by outlining the tumor cells between the negatively stained residual ductal epithelium and myoepithelium.
T20 2272-2366 DRI_Outcome denotes All cases were immunoreactive for estrogen and progesterone receptor, but not p53 and c-erbB2.
T21 2367-2392 DRI_Unspecified denotes The Ki-67 index was < 5%.
T22 2393-2506 DRI_Background denotes Ultrastructural studies on four cases showed many dense-core neurosecretory granules and larger mucigen granules.
T23 2507-2722 DRI_Background denotes In group B cases, the invasive component, which comprised 5-95% of the tumor, included colloid carcinoma, 12; "carcinoid" tumor, 3; mixed "carcinoid"/colloid carcinoma, 4; and small cell neuroendocrine carcinoma, 1.
T24 2723-2808 DRI_Background denotes Neuroendocrine markers were also consistently demonstrable in the invasive component.
T25 2809-3024 DRI_Background denotes In conclusion, E-DCIS is predominantly a disease of older women that is frequently accompanied by papillomas in the vicinity and may present as nipple discharge (an uncommon presentation in the usual forms of DCIS).
T26 3025-3134 DRI_Outcome denotes It can mimic epitheliosis histologically, but the pagetoid spread is a helpful clue to its neoplastic nature.
T27 3135-3292 DRI_Background denotes The bland nuclear morphology, lack of necrosis, and biologic marker profile suggest that E-DCIS is a form of low-grade DCIS despite its solid growth pattern.
T28 3293-3503 DRI_Background denotes The invasive carcinomas associated with E-DCIS are also neuroendocrine programmed rather than the usual types of ductal carcinomas, suggesting that E-DCIS represents a biologically distinctive category of DCIS.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-9 CHEBI:24621 denotes Endocrine
T4 10-34 D002285 denotes ductal carcinoma in situ
T5 10-34 D002285 denotes ductal carcinoma in situ
T11 38-42 CVCL_5552 denotes DCIS
T10 38-42 D002285 denotes DCIS
T12 38-42 D002285 denotes DCIS
T13 51-57 UBERON:0000310 denotes breast
T15 79-83 CVCL_5552 denotes DCIS
T14 79-83 D002285 denotes DCIS
T16 79-83 D002285 denotes DCIS
T19 159-183 D002285 denotes ductal carcinoma in situ
T20 159-183 D002285 denotes ductal carcinoma in situ
T26 187-191 CVCL_5552 denotes DCIS
T25 187-191 D002285 denotes DCIS
T27 187-191 D002285 denotes DCIS
T28 431-435 PR:Q8FYW3 denotes pure
T29 431-435 PR:Q54QE4 denotes pure
T30 431-435 PR:P52558 denotes pure
T31 431-435 PR:P0AG18 denotes pure
T33 431-435 PR:000023640 denotes pure
T32 431-435 GO:0034023 denotes pure
T34 686-692 UBERON:0002030 denotes nipple
T35 714-720 UBERON:0000310 denotes breast
T36 786-796 D012008 denotes recurrence
T37 786-796 D012008 denotes recurrence
T38 913-919 UBERON:0000310 denotes breast
T40 939-943 CVCL_5552 denotes DCIS
T39 939-943 D002285 denotes DCIS
T41 939-943 D002285 denotes DCIS
T42 1051-1056 UBERON:0003037 denotes septa
T43 1085-1090 CHEBI:7010 denotes mucin
T44 1085-1090 D009077 denotes mucin
T45 1146-1151 UBERON:0003037 denotes septa
T46 1192-1201 D012598 denotes sclerosis
T47 1192-1201 D012598 denotes sclerosis
T48 1334-1342 GO:0019835 denotes necrosis
T49 1334-1342 GO:0008219 denotes necrosis
T52 1334-1342 GO:0008220 denotes necrosis
T53 1334-1342 GO:0001906 denotes necrosis
T54 1334-1342 GO:0070265 denotes necrosis
T50 1334-1342 D009336 denotes necrosis
T51 1334-1342 D009336 denotes necrosis
T55 1355-1377 D018300 denotes Intraductal papillomas
T56 1355-1377 D018300 denotes Intraductal papillomas
T59 1422-1428 D009369 denotes tumors
T60 1422-1428 D009369 denotes tumors
T62 1489-1493 CVCL_5552 denotes DCIS
T61 1489-1493 D002285 denotes DCIS
T63 1489-1493 D002285 denotes DCIS
T64 1529-1534 UBERON:0000058 denotes ducts
T65 1590-1595 D009369 denotes tumor
T66 1590-1595 D009369 denotes tumor
T67 1618-1622 PR:P01012 denotes oval
T68 1627-1634 PR:000029767 denotes spindly
T69 1690-1696 CHEBI:33252 denotes nuclei
T70 1732-1741 GO:0005737 denotes cytoplasm
T71 1743-1756 GO:0005622 denotes Intracellular
T72 1757-1762 CHEBI:7010 denotes mucin
T73 1757-1762 D009077 denotes mucin
T74 1809-1822 UBERON:0000420 denotes myoepithelium
T75 1829-1835 UBERON:0001630 denotes muscle
T76 1829-1835 UBERON:0005090 denotes muscle
T77 1845-1850 P53491 denotes actin
T78 1845-1850 P45520 denotes actin
T79 1845-1850 O00937 denotes actin
T80 1845-1850 Q05214 denotes actin
T81 1845-1850 P13363 denotes actin
T82 1845-1850 Q39596 denotes actin
T83 1845-1850 P30161 denotes actin
T84 1845-1850 P53476 denotes actin
T85 1845-1850 P51775 denotes actin
T86 1845-1850 P60011 denotes actin
T87 1845-1850 Q9P4D1 denotes actin
T88 1845-1850 P50138 denotes actin
T89 1845-1850 O65314 denotes actin
T90 1845-1850 P26183 denotes actin
T91 1845-1850 Q75D00 denotes actin
T92 1845-1850 P53502 denotes actin
T93 1845-1850 P11426 denotes actin
T94 1845-1850 P80709 denotes actin
T95 1845-1850 Q8X119 denotes actin
T96 1845-1850 Q6TCF2 denotes actin
T97 1845-1850 Q99023 denotes actin
T98 1845-1850 A5DQP9 denotes actin
T99 1845-1850 P60009 denotes actin
T100 1845-1850 O65315 denotes actin
T101 1845-1850 P26182 denotes actin
T102 1845-1850 Q9UVF3 denotes actin
T1000 2306-2314 D004967 denotes estrogen
T103 1845-1850 Q2U7A3 denotes actin
T104 1845-1850 Q92192 denotes actin
T105 1845-1850 Q9UVZ8 denotes actin
T106 1845-1850 P53689 denotes actin
T107 1845-1850 P68555 denotes actin
T108 1845-1850 P53455 denotes actin
T109 1845-1850 O13419 denotes actin
T110 1845-1850 P60010 denotes actin
T111 1845-1850 Q39758 denotes actin
T112 1845-1850 P81085 denotes actin
T113 1845-1850 P48465 denotes actin
T114 1845-1850 P78711 denotes actin
T115 1845-1850 P17128 denotes actin
T116 1845-1850 P91754 denotes actin
T117 1845-1850 Q24733 denotes actin
T118 1845-1850 P14235 denotes actin
T119 1845-1850 Q92193 denotes actin
T120 1845-1850 Q11212 denotes actin
T121 1845-1850 P45521 denotes actin
T122 1845-1850 P53477 denotes actin
T123 1845-1850 P53499 denotes actin
T124 1845-1850 P24902 denotes actin
T125 1845-1850 Q8SWN8 denotes actin
T126 1845-1850 O17320 denotes actin
T127 1845-1850 P10365 denotes actin
T129 1845-1850 O16808 denotes actin
T130 1845-1850 P53498 denotes actin
T131 1845-1850 Q9UVX4 denotes actin
T132 1845-1850 O81221 denotes actin
T133 1845-1850 P20904 denotes actin
T134 1845-1850 O65316 denotes actin
T135 1845-1850 O74258 denotes actin
T136 1845-1850 P53500 denotes actin
T137 1845-1850 P10989 denotes actin
T138 1845-1850 P90689 denotes actin
T128 1845-1850 D000199 denotes actin
T139 1851-1859 GO:0019815 denotes antibody
T140 1851-1859 GO:0042571 denotes antibody
T141 1851-1859 GO:0019814 denotes antibody
T142 1851-1859 GO:0003823 denotes antibody
T144 1898-1902 CVCL_5552 denotes DCIS
T143 1898-1902 D002285 denotes DCIS
T145 1898-1902 D002285 denotes DCIS
T146 1930-1935 D009369 denotes tumor
T147 1930-1935 D009369 denotes tumor
T148 2011-2024 P08247 denotes synaptophysin
T149 2011-2024 P20488 denotes synaptophysin
T151 2011-2024 PR:000015890 denotes synaptophysin
T152 2011-2024 Q5YJC1 denotes synaptophysin
T154 2011-2024 Q62277 denotes synaptophysin
T155 2011-2024 P07825 denotes synaptophysin
T150 2011-2024 D016708 denotes synaptophysin
T153 2011-2024 D016708 denotes synaptophysin
T156 2030-2036 CL:0000540 denotes neuron
T157 2030-2053 P17183 denotes neuron-specific enolase
T159 2030-2053 P09104 denotes neuron-specific enolase
T160 2030-2053 PR:000007081 denotes neuron-specific enolase
T161 2030-2053 P07323 denotes neuron-specific enolase
T158 2030-2053 D010751 denotes neuron-specific enolase
T993 2142-2152 D010212 denotes papillomas
T994 2142-2152 D010212 denotes papillomas
T995 2183-2188 D009369 denotes tumor
T996 2183-2188 D009369 denotes tumor
T997 2235-2252 UBERON:0034969 denotes ductal epithelium
T999 2257-2270 UBERON:0000420 denotes myoepithelium
T1001 2306-2314 D004967 denotes estrogen
T1002 2306-2314 CHEBI:50114 denotes estrogen
T1004 2319-2331 8727 denotes progesterone
T1007 2319-2340 Q9GLW0 denotes progesterone receptor
T1008 2319-2340 A7XW16 denotes progesterone receptor
T1009 2319-2340 A7X8C2 denotes progesterone receptor
T1010 2319-2340 Q00175 denotes progesterone receptor
T1011 2319-2340 A7X8B5 denotes progesterone receptor
T1012 2319-2340 Q8AYI2 denotes progesterone receptor
T1013 2319-2340 A7X8C7 denotes progesterone receptor
T1014 2319-2340 Q63449 denotes progesterone receptor
T1015 2319-2340 A7X8C9 denotes progesterone receptor
T1016 2319-2340 Q28590 denotes progesterone receptor
T1017 2319-2340 A7X8B9 denotes progesterone receptor
T1018 2319-2340 A7X8D4 denotes progesterone receptor
T1019 2319-2340 A7X8B3 denotes progesterone receptor
T1020 2319-2340 P07812 denotes progesterone receptor
T1021 2319-2340 A7XW20 denotes progesterone receptor
T1022 2319-2340 A7X8B7 denotes progesterone receptor
T1023 2319-2340 A7XW25 denotes progesterone receptor
T1024 2319-2340 P06401 denotes progesterone receptor
T1025 2319-2340 PR:000012621 denotes progesterone receptor
T1026 2319-2340 P79373 denotes progesterone receptor
T1027 2319-2340 P06186 denotes progesterone receptor
T1028 2319-2340 A7X8C4 denotes progesterone receptor
T1030 2319-2340 A7X8D2 denotes progesterone receptor
T1029 2319-2340 D011980 denotes progesterone receptor
T1031 2350-2353 PR:P04637 denotes p53
T1032 2350-2353 PR:000003035 denotes p53
T1033 2350-2353 PR:P02340 denotes p53
T1034 2350-2353 PR:Q42578 denotes p53
T1035 2350-2353 PR:P10361 denotes p53
T1036 2358-2364 PR:P04412 denotes c-erbB
T1039 2360-2365 PR:P70424 denotes erbB2
T1040 2360-2365 PR:P06494 denotes erbB2
T1041 2360-2365 PR:P04626 denotes erbB2
T1042 2360-2365 PR:000002082 denotes erbB2
T1043 2449-2453 GO:0019013 denotes core
T1044 2578-2583 D009369 denotes tumor
T1045 2578-2583 D009369 denotes tumor
T1046 2594-2601 D003102 denotes colloid
T1047 2594-2601 D003102 denotes colloid
T1048 2594-2611 D002288 denotes colloid carcinoma
T1049 2594-2611 D002288 denotes colloid carcinoma
T1054 2618-2634 D002276 denotes carcinoid" tumor
T1055 2618-2634 D002276 denotes carcinoid" tumor
T1058 2646-2655 D002276 denotes carcinoid
T1059 2646-2655 D002276 denotes carcinoid
T1060 2657-2664 D003102 denotes colloid
T1061 2657-2664 D003102 denotes colloid
T1062 2657-2674 D002288 denotes colloid carcinoma
T1063 2657-2674 D002288 denotes colloid carcinoma
T1066 2694-2718 D018278 denotes neuroendocrine carcinoma
T1067 2694-2718 D018278 denotes neuroendocrine carcinoma
T1071 2826-2830 CVCL_5552 denotes DCIS
T1070 2826-2830 D002285 denotes DCIS
T1072 2826-2830 D002285 denotes DCIS
T1073 2850-2857 D004194 denotes disease
T1074 2850-2857 D004194 denotes disease
T1075 2907-2917 D010212 denotes papillomas
T1076 2907-2917 D010212 denotes papillomas
T1077 2953-2959 UBERON:0002030 denotes nipple
T1079 3018-3022 CVCL_5552 denotes DCIS
T1078 3018-3022 D002285 denotes DCIS
T1080 3018-3022 D002285 denotes DCIS
T1081 3032-3037 CVCL_Z366 denotes mimic
T1082 3145-3163 GO:0006997 denotes nuclear morphology
T1083 3165-3169 PR:Q9V853 denotes lack
T1084 3173-3181 GO:0019835 denotes necrosis
T1085 3173-3181 GO:0008219 denotes necrosis
T1088 3173-3181 GO:0008220 denotes necrosis
T1089 3173-3181 GO:0001906 denotes necrosis
T1090 3173-3181 GO:0070265 denotes necrosis
T1086 3173-3181 D009336 denotes necrosis
T1087 3173-3181 D009336 denotes necrosis
T1091 3187-3202 D015415 denotes biologic marker
T1092 3187-3202 D015415 denotes biologic marker
T1094 3226-3230 CVCL_5552 denotes DCIS
T1093 3226-3230 D002285 denotes DCIS
T1095 3226-3230 D002285 denotes DCIS
T1097 3254-3258 CVCL_5552 denotes DCIS
T1096 3254-3258 D002285 denotes DCIS
T1098 3254-3258 D002285 denotes DCIS
T1099 3277-3291 GO:0007150 denotes growth pattern
T1100 3277-3291 GO:0040007 denotes growth pattern
T1101 3306-3316 D002277 denotes carcinomas
T1102 3306-3316 D002277 denotes carcinomas
T1104 3335-3339 CVCL_5552 denotes DCIS
T1103 3335-3339 D002285 denotes DCIS
T1105 3335-3339 D002285 denotes DCIS
T1106 3406-3423 D044584 denotes ductal carcinomas
T1107 3406-3423 D044584 denotes ductal carcinomas
T1111 3443-3447 CVCL_5552 denotes DCIS
T1110 3443-3447 D002285 denotes DCIS
T1112 3443-3447 D002285 denotes DCIS
T1114 3498-3502 CVCL_5552 denotes DCIS
T1113 3498-3502 D002285 denotes DCIS
T1115 3498-3502 D002285 denotes DCIS