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PubMed:8704165 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1453-1458 gene:3659 denotes IRF-1
T1 1659-1675 disease:C0023470 denotes myeloid leukemia
R1 T0 T1 associated_with IRF-1,myeloid leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-54 protein denotes interferon regulatory factor-1
T2 74-87 cell_type denotes myeloid cells
T3 256-265 cell_line denotes APL cells
T4 271-290 cell_type denotes mature granulocytes
T5 434-447 cell_line denotes NB4 cell line
T6 598-607 cell_line denotes APL cells
T7 617-652 protein denotes interferon (IFN) regulatory factors
T8 654-659 protein denotes IRF-1
T9 664-669 protein denotes IRF-2
T10 681-708 protein denotes IFN-inducible gene products
T11 834-844 DNA denotes IRF-1 gene
T12 883-888 protein denotes IRF-2
T13 893-924 protein denotes 2'-5' oligoadenylate synthetase
T14 1015-1025 DNA denotes IRF-1 gene
T15 1040-1045 cell_line denotes HL-60
T16 1047-1051 cell_line denotes U937
T17 1057-1068 cell_line denotes THP-1 cells
T18 1151-1161 DNA denotes IRF-1 gene
T19 1196-1205 protein denotes IFN-gamma
T20 1209-1218 cell_line denotes NB4 cells
T21 1399-1409 DNA denotes IRF-1 gene
T22 1453-1458 protein denotes IRF-1
T23 1651-1655 protein denotes IFNs
T24 1659-1681 cell_line denotes myeloid leukemia cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8704165-10#31#36#gene3659 1453-1458 gene3659 denotes IRF-1
8704165-10#237#253#diseaseC0023470 1659-1675 diseaseC0023470 denotes myeloid leukemia
31#36#gene3659237#253#diseaseC0023470 8704165-10#31#36#gene3659 8704165-10#237#253#diseaseC0023470 associated_with IRF-1,myeloid leukemia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C31 24-70 NP denotes interferon regulatory factor-1 gene expression
C1 89-119 NP denotes All-trans-retinoic acid (ATRA)
C2 162-196 NP denotes acute promyelocytic leukemia (APL)
C3 198-202 NP denotes ATRA
C9 256-265 NP denotes APL cells
C4 338-343 NP denotes ATRA-
C5 430-447 NP denotes The NB4 cell line
C6 449-454 NP denotes which
C7 505-508 NP denotes APL
C8 598-607 NP denotes APL cells
C10 758-762 NP denotes ATRA
C12 766-795 NP denotes the expression of these genes
C11 810-814 NP denotes ATRA
C13 834-855 NP denotes IRF-1 gene expression
C14 883-946 NP denotes IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression
C15 984-993 NP denotes NB4 cells
C16 995-999 NP denotes ATRA
C17 1015-1036 NP denotes IRF-1 gene expression
C18 1040-1068 NP denotes HL-60, U937, and THP-1 cells
C19 1070-1075 NP denotes which
C20 1091-1095 NP denotes ATRA
C21 1151-1172 NP denotes IRF-1 gene expression
C22 1187-1191 NP denotes ATRA
C23 1209-1218 NP denotes NB4 cells
C24 1220-1224 NP denotes ATRA
C26 1426-1431 NP denotes ATRA-
C27 1453-1458 NP denotes IRF-1
C28 1460-1521 NP denotes an activator of transcription and repressor of transformation
C29 1565-1570 NP denotes ATRA-
C30 1642-1646 NP denotes ATRA
R1 C3 C1 coref-ident ATRA,All-trans-retinoic acid (ATRA)
R2 C4 C3 coref-ident ATRA-,ATRA
R3 C6 C5 coref-relat which,The NB4 cell line
R4 C7 C2 coref-ident APL,acute promyelocytic leukemia (APL)
R5 C8 C9 coref-ident APL cells,APL cells
R6 C10 C4 coref-ident ATRA,ATRA-
R7 C12 C31 coref-ident the expression of these genes,interferon regulatory factor-1 gene expression
R8 C11 C10 coref-ident ATRA,ATRA
R9 C13 C12 coref-part-whole IRF-1 gene expression,the expression of these genes
R10 C14 C12 coref-part-whole IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression,the expression of these genes
R11 C15 C5 coref-ident NB4 cells,The NB4 cell line
R12 C16 C11 coref-ident ATRA,ATRA
R13 C17 C13 coref-ident IRF-1 gene expression,IRF-1 gene expression
R14 C19 C18 coref-relat which,"HL-60, U937, and THP-1 cells"
R15 C20 C11 coref-ident ATRA,ATRA
R16 C21 C17 coref-ident IRF-1 gene expression,IRF-1 gene expression
R17 C22 C20 coref-ident ATRA,ATRA
R18 C23 C15 coref-ident NB4 cells,NB4 cells
R19 C24 C22 coref-ident ATRA,ATRA
R20 C26 C24 coref-ident ATRA-,ATRA
R21 C28 C27 coref-appos an activator of transcription and repressor of transformation,IRF-1
R22 C29 C26 coref-ident ATRA-,ATRA-
R23 C30 C29 coref-ident ATRA,ATRA-

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-88 Sentence denotes Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
S2 89-197 Sentence denotes All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL).
S3 198-291 Sentence denotes ATRA induces both in vitro and in vivo differentiation of APL cells into mature granulocytes.
S4 292-429 Sentence denotes However, the molecular mechanisms involved in ATRA-dependent growth inhibition and cellular differentiation are not presently understood.
S5 430-608 Sentence denotes The NB4 cell line, which is derived from the bone marrow of a patient with APL during relapse, can be used as a model system to study the growth and differentiation of APL cells.
S6 609-796 Sentence denotes Because interferon (IFN) regulatory factors (IRF-1 and IRF-2) and other IFN-inducible gene products regulate cell growth, we analyzed the effects of ATRA on the expression of these genes.
S7 797-968 Sentence denotes We show that ATRA directly activates IRF-1 gene expression, followed by activation of IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression with slower kinetics.
S8 969-1117 Sentence denotes In addition to NB4 cells, ATRA also activated IRF-1 gene expression in HL-60, U937, and THP-1 cells, which all respond to ATRA by growth inhibition.
S9 1118-1219 Sentence denotes A more than additive increase in IRF-1 gene expression was seen with ATRA and IFN-gamma in NB4 cells.
S10 1220-1421 Sentence denotes ATRA did not activate nuclear factor kappa B or signal transducer and activator of transcription (STAT) activation pathways, suggesting that an alternate mechanism is involved in IRF-1 gene activation.
S11 1422-1682 Sentence denotes The ATRA-induced expression of IRF-1, an activator of transcription and repressor of transformation, may be one of the molecular mechanisms of ATRA-induced growth inhibition, and the basis for the synergistic actions of ATRA and IFNs in myeloid leukemia cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-13 other_organic_compound denotes Retinoic acid
T2 24-54 protein_molecule denotes interferon regulatory factor-1
T3 74-87 cell_type denotes myeloid cells
T4 89-112 other_organic_compound denotes All-trans-retinoic acid
T5 114-118 other_organic_compound denotes ATRA
T6 162-190 other_name denotes acute promyelocytic leukemia
T7 192-195 other_name denotes APL
T8 198-202 other_organic_compound denotes ATRA
T9 256-265 cell_line denotes APL cells
T10 271-290 cell_type denotes mature granulocytes
T11 338-342 other_organic_compound denotes ATRA
T12 434-447 cell_line denotes NB4 cell line
T13 475-486 tissue denotes bone marrow
T14 492-499 multi_cell denotes patient
T15 505-508 other_name denotes APL
T16 598-607 cell_line denotes APL cells
T17 617-652 protein_family_or_group denotes interferon (IFN) regulatory factors
T18 654-659 protein_molecule denotes IRF-1
T19 664-669 protein_molecule denotes IRF-2
T20 681-708 protein_family_or_group denotes IFN-inducible gene products
T21 718-729 other_name denotes cell growth
T22 758-762 other_organic_compound denotes ATRA
T23 810-814 other_organic_compound denotes ATRA
T24 834-844 DNA_domain_or_region denotes IRF-1 gene
T25 883-888 protein_molecule denotes IRF-2
T26 893-924 protein_family_or_group denotes 2'-5' oligoadenylate synthetase
T27 995-999 other_organic_compound denotes ATRA
T28 1015-1025 DNA_domain_or_region denotes IRF-1 gene
T29 1040-1045 cell_line denotes HL-60
T30 1047-1051 cell_line denotes U937
T31 1057-1068 cell_line denotes THP-1 cells
T32 1091-1095 other_organic_compound denotes ATRA
T33 1099-1116 other_name denotes growth inhibition
T34 1151-1161 DNA_domain_or_region denotes IRF-1 gene
T35 1187-1191 other_organic_compound denotes ATRA
T36 1196-1205 protein_molecule denotes IFN-gamma
T37 1209-1218 cell_line denotes NB4 cells
T38 1220-1224 other_organic_compound denotes ATRA
T39 1399-1409 DNA_domain_or_region denotes IRF-1 gene
T40 1426-1430 other_organic_compound denotes ATRA
T41 1453-1458 protein_molecule denotes IRF-1
T42 1565-1569 other_organic_compound denotes ATRA
T43 1619-1638 other_name denotes synergistic actions
T44 1642-1646 other_organic_compound denotes ATRA
T45 1651-1655 protein_family_or_group denotes IFNs
T46 1659-1681 cell_line denotes myeloid leukemia cells