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sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc.
T2 110-267 Sentence denotes The cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.
T3 268-441 Sentence denotes Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.
T4 442-652 Sentence denotes To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.
T5 653-770 Sentence denotes The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).
T6 771-952 Sentence denotes The amino acid sequence of NFATc.beta differs from that of NFATc. alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.
T7 953-1211 Sentence denotes Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.
T8 1212-1369 Sentence denotes Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.
T9 1370-1573 Sentence denotes However, NFATc.beta neither bound to the kappa3 element (an NFAT-binding site) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.
T10 1574-1710 Sentence denotes These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.
T1 0-109 Sentence denotes Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc.
T2 110-267 Sentence denotes The cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.
T3 268-441 Sentence denotes Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.
T4 442-652 Sentence denotes To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.
T5 653-770 Sentence denotes The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).
T6 771-952 Sentence denotes The amino acid sequence of NFATc.beta differs from that of NFATc. alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.
T7 953-1211 Sentence denotes Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.
T8 1212-1369 Sentence denotes Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.
T9 1370-1573 Sentence denotes However, NFATc.beta neither bound to the kappa3 element (an NFAT-binding site) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.
T10 1574-1710 Sentence denotes These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1204-1210 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 41-45 protein denotes NFAT
T2 47-82 protein denotes nuclear factor of activated T cells
T3 103-108 protein denotes NFATc
T4 114-185 protein denotes cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells
T5 187-191 protein denotes NFAT
T6 241-255 DNA denotes cytokine genes
T7 259-266 cell_type denotes T cells
T8 277-281 protein denotes NFAT
T9 333-351 cell_type denotes non-T immune cells
T10 357-381 DNA denotes NFAT gene family members
T11 433-440 cell_type denotes T cells
T12 466-470 protein denotes NFAT
T13 483-496 cell_type denotes human B cells
T14 545-558 protein denotes NFAT proteins
T15 615-625 DNA denotes cDNA clone
T16 635-651 cell_line denotes Raji B cell line
T17 657-667 DNA denotes cDNA clone
T18 691-701 protein denotes NFATc.beta
T19 710-733 protein denotes NFAT gene family member
T20 734-739 protein denotes NFATc
T21 757-768 protein denotes NFATc.alpha
T22 775-794 protein denotes amino acid sequence
T23 798-808 protein denotes NFATc.beta
T24 830-835 protein denotes NFATc
T25 856-880 protein denotes NH2-terminal 29 residues
T26 918-930 protein denotes 142 residues
T27 938-951 protein denotes COOH terminus
T28 1042-1054 RNA denotes mRNA species
T29 1058-1084 RNA denotes 2.7 and 4.5 kilobase pairs
T30 1095-1120 DNA denotes NFATc.beta-specific probe
T31 1139-1161 RNA denotes 4.5-kilobase pair mRNA
T32 1236-1246 protein denotes NFATc.beta
T33 1276-1315 DNA denotes interleukin-2 NFAT-driven reporter gene
T34 1319-1342 cell_line denotes stimulated Jurkat cells
T35 1379-1389 protein denotes NFATc.beta
T36 1411-1425 DNA denotes kappa3 element
T37 1430-1447 DNA denotes NFAT-binding site
T38 1456-1492 DNA denotes tumor necrosis factor-alpha promoter
T39 1511-1547 DNA denotes tumor necrosis factor-alpha promoter
T40 1631-1640 DNA denotes NFAT gene
T41 1695-1709 DNA denotes cytokine genes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 37-108 NP denotes the NFAT (nuclear factor of activated T cells) gene family member NFATc
C9 20-108 NP denotes a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc
C2 259-266 NP denotes T cells
C3 433-440 NP denotes T cells
C4 613-651 NP denotes a cDNA clone from the Raji B cell line
C5 653-667 NP denotes The cDNA clone
C11 676-689 NP denotes a new isoform
C7 691-701 NP denotes NFATc.beta
C8 706-739 NP denotes the NFAT gene family member NFATc
C10 676-769 NP denotes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha)
C15 771-794 NP denotes The amino acid sequence
C12 798-808 NP denotes NFATc.beta
C13 822-826 NP denotes that
C14 830-842 NP denotes NFATc. alpha
C16 1095-1106 NP denotes NFATc.beta-
C17 1135-1161 NP denotes the 4.5-kilobase pair mRNA
C18 1162-1167 NP denotes which
C19 1236-1246 NP denotes NFATc.beta
C20 1379-1389 NP denotes NFATc.beta
R1 C3 C2 coref-ident T cells,T cells
R2 C5 C4 coref-ident The cDNA clone,a cDNA clone from the Raji B cell line
R3 C7 C11 coref-appos NFATc.beta,a new isoform
R4 C8 C1 coref-ident the NFAT gene family member NFATc,the NFAT (nuclear factor of activated T cells) gene family member NFATc
R5 C10 C9 coref-ident "a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha)",a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc
R6 C12 C7 coref-ident NFATc.beta,NFATc.beta
R7 C13 C15 coref-pron that,The amino acid sequence
R8 C14 C8 coref-ident NFATc. alpha,the NFAT gene family member NFATc
R9 C16 C12 coref-ident NFATc.beta-,NFATc.beta
R10 C18 C17 coref-relat which,the 4.5-kilobase pair mRNA
R11 C19 C16 coref-ident NFATc.beta,NFATc.beta-
R12 C20 C19 coref-ident NFATc.beta,NFATc.beta

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-109 Sentence denotes Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc.
S2 110-267 Sentence denotes The cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.
S3 268-441 Sentence denotes Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.
S4 442-652 Sentence denotes To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.
S5 653-770 Sentence denotes The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).
S6 771-952 Sentence denotes The amino acid sequence of NFATc.beta differs from that of NFATc. alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.
S7 953-1211 Sentence denotes Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.
S8 1212-1369 Sentence denotes Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.
S9 1370-1573 Sentence denotes However, NFATc.beta neither bound to the kappa3 element (an NFAT-binding site) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.
S10 1574-1710 Sentence denotes These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 41-45 protein_family_or_group denotes NFAT
T2 47-82 protein_family_or_group denotes nuclear factor of activated T cells
T3 103-108 protein_molecule denotes NFATc
T4 114-127 other_organic_compound denotes cyclosporin A
T5 129-132 other_organic_compound denotes CsA
T6 134-139 other_organic_compound denotes FK506
T7 187-191 protein_family_or_group denotes NFAT
T8 217-237 other_name denotes inducible expression
T9 241-255 DNA_family_or_group denotes cytokine genes
T10 259-266 cell_type denotes T cells
T11 277-281 protein_family_or_group denotes NFAT
T12 333-351 cell_type denotes non-T immune cells
T13 357-361 protein_family_or_group denotes NFAT
T14 433-440 cell_type denotes T cells
T15 466-470 protein_family_or_group denotes NFAT
T16 483-496 cell_type denotes human B cells
T17 545-549 protein_family_or_group denotes NFAT
T18 615-625 DNA_family_or_group denotes cDNA clone
T19 635-651 cell_line denotes Raji B cell line
T20 657-667 DNA_family_or_group denotes cDNA clone
T21 691-701 protein_molecule denotes NFATc.beta
T22 710-714 protein_family_or_group denotes NFAT
T23 734-739 protein_family_or_group denotes NFATc
T24 757-768 protein_molecule denotes NFATc.alpha
T25 775-794 protein_domain_or_region denotes amino acid sequence
T26 798-808 protein_molecule denotes NFATc.beta
T27 830-835 protein_family_or_group denotes NFATc
T28 856-880 protein_domain_or_region denotes NH2-terminal 29 residues
T29 918-930 protein_domain_or_region denotes 142 residues
T30 938-951 protein_domain_or_region denotes COOH terminus
T31 1042-1054 RNA_family_or_group denotes mRNA species
T32 1095-1105 protein_molecule denotes NFATc.beta
T33 1139-1161 RNA_molecule denotes 4.5-kilobase pair mRNA
T34 1236-1246 protein_molecule denotes NFATc.beta
T35 1276-1289 protein_molecule denotes interleukin-2
T36 1290-1294 protein_family_or_group denotes NFAT
T37 1319-1329 cell_line denotes stimulated
T38 1330-1342 cell_line denotes Jurkat cells
T39 1348-1351 other_organic_compound denotes CsA
T40 1379-1389 protein_molecule denotes NFATc.beta
T41 1411-1425 DNA_domain_or_region denotes kappa3 element
T42 1430-1434 protein_family_or_group denotes NFAT
T43 1456-1492 DNA_domain_or_region denotes tumor necrosis factor-alpha promoter
T44 1511-1547 DNA_domain_or_region denotes tumor necrosis factor-alpha promoter
T45 1551-1572 other_name denotes cotransfection assays
T46 1631-1635 protein_family_or_group denotes NFAT
T47 1661-1681 other_name denotes inducible expression
T48 1695-1709 DNA_family_or_group denotes cytokine genes

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 41-45 Gene denotes NFAT
T3 84-88 Gene denotes gene
T4 103-108 Protein denotes NFATc
T5 129-132 Protein denotes CsA
T6 187-191 Protein denotes NFAT
T8 241-255 Gene denotes cytokine genes
T9 259-266 Cell denotes T cells
T10 277-281 Protein denotes NFAT
T11 333-351 Cell denotes non-T immune cells
T12 357-366 Gene denotes NFAT gene
T13 433-440 Cell denotes T cells
T14 466-470 Protein denotes NFAT
T15 483-488 Eukaryote denotes human
T16 489-496 Cell denotes B cells
T17 516-529 Gene denotes cytokine gene
T18 545-558 Protein denotes NFAT proteins
T19 615-625 DNA denotes cDNA clone
T20 635-651 Cell denotes Raji B cell line
T21 657-667 DNA denotes cDNA clone
T22 691-701 Protein denotes NFATc.beta
T23 710-719 Gene denotes NFAT gene
T24 734-739 Gene denotes NFATc
T25 757-768 Protein denotes NFATc.alpha
T26 775-794 AminoAcid denotes amino acid sequence
T27 798-808 Protein denotes NFATc.beta
T28 830-842 Protein denotes NFATc. alpha
T29 1042-1046 MessengerRNA denotes mRNA
T30 1095-1105 Protein denotes NFATc.beta
T31 1157-1161 MessengerRNA denotes mRNA
T33 1204-1210 Tissue denotes spleen
T35 1236-1246 Protein denotes NFATc.beta
T37 1276-1289 Protein denotes interleukin-2
T38 1302-1315 ReporterGene denotes reporter gene
T39 1330-1342 Cell denotes Jurkat cells
T40 1348-1351 Peptide denotes CsA
T41 1631-1640 Gene denotes NFAT gene
T44 1695-1709 Gene denotes cytokine genes
T45 1290-1294 Protein denotes NFAT
E1 227-237 GeneExpression denotes expression
E2 1187-1196 Transcription denotes expressed
E3 1212-1232 GeneExpression denotes Transient expression
E4 1262-1272 PositiveRegulation denotes activating
E5 1652-1660 RegulatoryProcess denotes regulate
E6 1671-1681 GeneExpression denotes expression
R1 E1 T9 locatedIn expression,T cells
R2 T10 T11 locatedIn NFAT,non-T immune cells
R3 T12 T13 locatedIn NFAT gene,T cells
R4 T14 T16 locatedIn NFAT,B cells
R5 T16 T15 fromSpecies B cells,human
R6 T19 T20 locatedIn cDNA clone,Raji B cell line
R7 T21 T22 encodes cDNA clone,NFATc.beta
R9 T27 T26 hasPart NFATc.beta,amino acid sequence
R10 E2 T33 locatedIn expressed,spleen
R11 E4 T39 locatedIn activating,Jurkat cells
R13 T8 E1 hasPatient cytokine genes,expression
R14 T31 E2 hasPatient mRNA,expressed
R15 T35 E3 hasPatient NFATc.beta,Transient expression
R16 E3 E4 hasAgent Transient expression,activating
R17 T38 E4 hasPatient reporter gene,activating
R18 T41 E5 hasAgent NFAT gene,regulate
R19 E6 E5 hasPatient expression,regulate
R20 T44 E6 hasPatient cytokine genes,expression

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1204-1210 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1456-1461 Phenotype denotes tumor HP:0002664
T2 1511-1516 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1456-1461 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 1511-1516 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 483-488 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 339-351 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T2 640-646 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T3 1204-1210 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 75-82 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 178-185 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 259-266 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 339-351 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T5 433-440 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 489-496 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T7 640-646 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236