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PubMed:8702838 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 71-80 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 91-108 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T4 228-237 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T6 242-259 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T7 457-466 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T8 789-798 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T10 831-853 Cell denotes vein endothelial cells http://purl.obolibrary.org/obo/CL:0002543
T11 1468-1477 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T13 1482-1499 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115

sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.
T2 110-260 Sentence denotes The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.
T3 261-532 Sentence denotes In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.
T4 533-706 Sentence denotes Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.
T5 707-958 Sentence denotes Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).
T6 959-1153 Sentence denotes Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.
T7 1154-1371 Sentence denotes Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.
T8 1372-1547 Sentence denotes This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.
T1 0-109 Sentence denotes Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.
T2 110-260 Sentence denotes The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.
T3 261-532 Sentence denotes In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.
T4 533-706 Sentence denotes Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.
T5 707-958 Sentence denotes Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).
T6 959-1153 Sentence denotes Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.
T7 1154-1371 Sentence denotes Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.
T8 1372-1547 Sentence denotes This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 831-835 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 29-38 protein denotes NF-kappaB
T2 114-134 protein denotes NF-kappaB/Rel family
T3 138-159 protein denotes transcription factors
T4 212-237 cell_type denotes activated human monocytes
T5 242-259 cell_type denotes endothelial cells
T6 390-417 protein denotes tumor necrosis factor alpha
T7 419-427 protein denotes TNFalpha
T8 430-443 protein denotes tissue factor
T9 445-486 protein denotes endothelial leukocyte adhesion molecule-1
T10 492-531 DNA denotes vascular cell adhesion molecule-1 genes
T11 638-646 protein denotes TNFalpha
T12 651-664 protein denotes tissue factor
T13 720-729 protein denotes NF-kappaB
T14 783-810 cell_line denotes human monocytic THP-1 cells
T15 815-853 cell_type denotes human umbilical vein endothelial cells
T16 914-931 protein denotes catalytic subunit
T17 935-951 protein denotes protein kinase A
T18 953-956 protein denotes PKA
T19 1014-1021 protein denotes p50/p65
T20 1026-1048 protein denotes c-Rel/p65 heterodimers
T21 1084-1087 protein denotes p65
T22 1113-1121 protein denotes TNFalpha
T23 1149-1152 protein denotes p65
T24 1223-1230 DNA denotes plasmid
T25 1242-1267 DNA denotes multimerized kappaB sites
T26 1271-1274 protein denotes p65
T27 1346-1363 protein denotes catalytic subunit
T28 1367-1370 protein denotes PKA
T29 1412-1415 protein denotes PKA
T30 1459-1464 DNA denotes genes
T31 1468-1477 cell_type denotes monocytes
T32 1482-1499 cell_type denotes endothelial cells
T33 1514-1523 protein denotes NF-kappaB

genia-medco-coref

Id Subject Object Predicate Lexical cue
C34 0-19 NP denotes Elevated cyclic AMP
C32 29-39 NP denotes NF-kappaB-
C12 29-61 NP denotes NF-kappaB-mediated transcription
C28 65-108 NP denotes human monocytic cells and endothelial cells
C29 212-259 NP denotes activated human monocytes and endothelial cells
C3 288-311 NP denotes the molecular mechanism
C4 315-320 NP denotes which
C5 321-327 NP denotes agents
C6 328-332 NP denotes that
C7 386-428 NP denotes the tumor necrosis factor alpha (TNFalpha)
C9 533-566 NP denotes Both forskolin and dibutyryl cAMP
C10 568-573 NP denotes which
C11 638-646 NP denotes TNFalpha
C13 720-730 NP denotes NF-kappaB-
C14 871-884 NP denotes elevated cAMP
C22 935-957 NP denotes protein kinase A (PKA)
C24 910-957 NP denotes the catalytic subunit of protein kinase A (PKA)
C15 959-972 NP denotes Elevated cAMP
C17 1084-1087 NP denotes p65
C16 1113-1122 NP denotes TNFalpha-
C18 1149-1152 NP denotes p65
C19 1271-1274 NP denotes p65
C20 1292-1298 NP denotes agents
C21 1299-1303 NP denotes that
C23 1367-1370 NP denotes PKA
C25 1342-1370 NP denotes the catalytic subunit of PKA
C26 1412-1415 NP denotes PKA
C30 1468-1499 NP denotes monocytes and endothelial cells
C33 1514-1524 NP denotes NF-kappaB-
C31 1514-1546 NP denotes NF-kappaB-mediated transcription
R1 C29 C28 coref-other activated human monocytes and endothelial cells,human monocytic cells and endothelial cells
R2 C4 C3 coref-relat which,the molecular mechanism
R3 C6 C5 coref-relat that,agents
R4 C10 C9 coref-relat which,Both forskolin and dibutyryl cAMP
R5 C11 C7 coref-ident TNFalpha,the tumor necrosis factor alpha (TNFalpha)
R6 C13 C12 coref-ident NF-kappaB-,NF-kappaB-mediated transcription
R7 C14 C34 coref-other elevated cAMP,Elevated cyclic AMP
R8 C15 C14 coref-ident Elevated cAMP,elevated cAMP
R9 C16 C11 coref-ident TNFalpha-,TNFalpha
R10 C18 C17 coref-ident p65,p65
R11 C19 C18 coref-ident p65,p65
R12 C21 C20 coref-relat that,agents
R13 C23 C22 coref-ident PKA,protein kinase A (PKA)
R14 C25 C24 coref-ident the catalytic subunit of PKA,the catalytic subunit of protein kinase A (PKA)
R15 C26 C23 coref-ident PKA,PKA
R16 C30 C28 coref-ident monocytes and endothelial cells,human monocytic cells and endothelial cells
R17 C33 C32 coref-ident NF-kappaB-,NF-kappaB-
R18 C31 C13 coref-ident NF-kappaB-mediated transcription,NF-kappaB-

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-109 Sentence denotes Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.
S2 110-260 Sentence denotes The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.
S3 261-532 Sentence denotes In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.
S4 533-706 Sentence denotes Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.
S5 707-958 Sentence denotes Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).
S6 959-1153 Sentence denotes Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.
S7 1154-1371 Sentence denotes Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.
S8 1372-1547 Sentence denotes This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 9-19 nucleotide denotes cyclic AMP
T2 29-38 protein_complex denotes NF-kappaB
T3 114-123 protein_complex denotes NF-kappaB
T4 138-159 protein_family_or_group denotes transcription factors
T5 212-237 cell_type denotes activated human monocytes
T6 242-259 cell_type denotes endothelial cells
T7 341-359 nucleotide denotes intracellular cAMP
T8 390-417 protein_molecule denotes tumor necrosis factor alpha
T9 419-427 protein_molecule denotes TNFalpha
T10 430-443 protein_family_or_group denotes tissue factor
T11 445-486 protein_molecule denotes endothelial leukocyte adhesion molecule-1
T12 492-525 protein_molecule denotes vascular cell adhesion molecule-1
T13 538-547 other_organic_compound denotes forskolin
T14 552-566 nucleotide denotes dibutyryl cAMP
T15 582-600 nucleotide denotes intracellular cAMP
T16 638-646 protein_molecule denotes TNFalpha
T17 651-664 protein_family_or_group denotes tissue factor
T18 720-729 protein_complex denotes NF-kappaB
T19 783-810 cell_line denotes human monocytic THP-1 cells
T20 815-835 cell_type denotes human umbilical vein
T21 836-853 cell_type denotes endothelial cells
T22 880-884 nucleotide denotes cAMP
T23 914-931 protein_subunit denotes catalytic subunit
T24 935-951 protein_molecule denotes protein kinase A
T25 953-956 protein_molecule denotes PKA
T26 968-972 nucleotide denotes cAMP
T27 989-1010 other_name denotes nuclear translocation
T28 1014-1021 protein_complex denotes p50/p65
T29 1026-1048 protein_complex denotes c-Rel/p65 heterodimers
T30 1059-1080 other_name denotes nuclear translocation
T31 1084-1087 protein_subunit denotes p65
T32 1113-1121 protein_molecule denotes TNFalpha
T33 1149-1152 protein_subunit denotes p65
T34 1223-1230 DNA_molecule denotes plasmid
T35 1242-1267 DNA_domain_or_region denotes multimerized kappaB sites
T36 1271-1274 protein_subunit denotes p65
T37 1312-1316 nucleotide denotes cAMP
T38 1346-1363 protein_subunit denotes catalytic subunit
T39 1367-1370 protein_molecule denotes PKA
T40 1412-1415 protein_molecule denotes PKA
T41 1459-1464 DNA_family_or_group denotes genes
T42 1468-1477 cell_type denotes monocytes
T43 1482-1499 cell_type denotes endothelial cells
T44 1514-1523 protein_complex denotes NF-kappaB

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 390-395 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 65-70 OrganismTaxon denotes human 9606
T2 222-227 OrganismTaxon denotes human 9606
T3 783-788 OrganismTaxon denotes human 9606
T4 815-820 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 91-108 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 228-237 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 242-259 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T5 341-354 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 430-436 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T7 457-466 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T8 582-595 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T9 651-657 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 821-835 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T11 836-853 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T12 1468-1477 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T14 1482-1499 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 831-835 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 390-395 Phenotype denotes tumor HP:0002664