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PubMed:8702737 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
T2 114-339 Sentence denotes The high affinity interleukin-6 (IL-6) signaling complex consists of IL-6 and two membrane-associated receptor components: a low affinity but specific IL-6 receptor and the affinity converter/signal transducing protein gp130.
T3 340-616 Sentence denotes Monomeric (IL-6M) and dimeric (IL-6D) forms of Escherichia coli-derived human IL-6 and the extracellular ("soluble") portions of the IL-6 receptor (sIL-6R) and gp130 have been purified in order to investigate the effect of IL-6 dimerization on binding to the receptor complex.
T4 617-834 Sentence denotes Although IL-6D has a higher binding affinity for immobilized sIL-6R, as determined by biosensor analysis employing surface plasmon resonance detection, IL-6M is more potent than IL-6D in a STAT3 phosphorylation assay.
T5 835-1082 Sentence denotes The difference in potency is significantly less pronounced when measured in the murine 7TD1 hybridoma growth factor assay and the human hepatoma HepG2 bioassay due to time-dependent dissociation at 37 degrees C of IL-6 dimers into active monomers.
T6 1083-1216 Sentence denotes The increased binding affinity of IL-6D appears to be due to its ability to cross-link two sIL-6R molecules on the biosensor surface.
T7 1217-1430 Sentence denotes Studies of the IL-6 ternary complex formation demonstrated that the reduced biological potency of IL-6D resulted from a decreased ability of the IL-6D (sIL-6R)2 complex to couple with the soluble portion of gp130.
T8 1431-1582 Sentence denotes These data imply that IL-6-induced dimerization of sIL-6R is not the driving force in promoting formation of the hexameric (IL-6 IL-6R gp130)2 complex.
T9 1583-1696 Sentence denotes A model is presented whereby the trimeric complex of IL-6R, gp130, and IL-6M forms before the functional hexamer.
T10 1697-1861 Sentence denotes Due to its increased affinity for the IL-6R but its decreased ability to couple with gp130, we suggest that a stable IL-6 dimer may be an efficient IL-6 antagonist.
T1 0-113 Sentence denotes Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
T2 114-339 Sentence denotes The high affinity interleukin-6 (IL-6) signaling complex consists of IL-6 and two membrane-associated receptor components: a low affinity but specific IL-6 receptor and the affinity converter/signal transducing protein gp130.
T3 340-616 Sentence denotes Monomeric (IL-6M) and dimeric (IL-6D) forms of Escherichia coli-derived human IL-6 and the extracellular ("soluble") portions of the IL-6 receptor (sIL-6R) and gp130 have been purified in order to investigate the effect of IL-6 dimerization on binding to the receptor complex.
T4 617-834 Sentence denotes Although IL-6D has a higher binding affinity for immobilized sIL-6R, as determined by biosensor analysis employing surface plasmon resonance detection, IL-6M is more potent than IL-6D in a STAT3 phosphorylation assay.
T5 835-1082 Sentence denotes The difference in potency is significantly less pronounced when measured in the murine 7TD1 hybridoma growth factor assay and the human hepatoma HepG2 bioassay due to time-dependent dissociation at 37 degrees C of IL-6 dimers into active monomers.
T6 1083-1216 Sentence denotes The increased binding affinity of IL-6D appears to be due to its ability to cross-link two sIL-6R molecules on the biosensor surface.
T7 1217-1430 Sentence denotes Studies of the IL-6 ternary complex formation demonstrated that the reduced biological potency of IL-6D resulted from a decreased ability of the IL-6D (sIL-6R)2 complex to couple with the soluble portion of gp130.
T8 1431-1582 Sentence denotes These data imply that IL-6-induced dimerization of sIL-6R is not the driving force in promoting formation of the hexameric (IL-6 IL-6R gp130)2 complex.
T9 1583-1696 Sentence denotes A model is presented whereby the trimeric complex of IL-6R, gp130, and IL-6M forms before the functional hexamer.
T10 1697-1861 Sentence denotes Due to its increased affinity for the IL-6R but its decreased ability to couple with gp130, we suggest that a stable IL-6 dimer may be an efficient IL-6 antagonist.

AIMed

Id Subject Object Predicate Lexical cue
T1 13-26 protein denotes interleukin-6
T2 28-32 protein denotes IL-6
T3 91-104 protein denotes IL-6.receptor
T4 132-145 protein denotes interleukin-6
T5 147-151 protein denotes IL-6
T6 183-187 protein denotes IL-6
T7 265-278 protein denotes IL-6 receptor
T8 333-338 protein denotes gp130
T9 351-356 protein denotes IL-6M
T10 371-376 protein denotes IL-6D
T11 418-422 protein denotes IL-6
T12 473-486 protein denotes IL-6 receptor
T13 488-494 protein denotes sIL-6R
T14 500-505 protein denotes gp130
T15 563-567 protein denotes IL-6
T16 626-631 protein denotes IL-6D
T17 678-684 protein denotes sIL-6R
T18 769-774 protein denotes IL-6M
T19 795-800 protein denotes IL-6D
T20 1049-1053 protein denotes IL-6
T21 1117-1122 protein denotes IL-6D
T22 1174-1180 protein denotes sIL-6R
T23 1232-1236 protein denotes IL-6
T24 1315-1320 protein denotes IL-6D
T25 1362-1367 protein denotes IL-6D
T26 1369-1375 protein denotes sIL-6R
T27 1424-1429 protein denotes gp130
T28 1453-1457 protein denotes IL-6
T29 1482-1488 protein denotes sIL-6R
T30 1555-1559 protein denotes IL-6
T31 1560-1565 protein denotes IL-6R
T32 1566-1571 protein denotes gp130
T33 1636-1641 protein denotes IL-6R
T34 1643-1648 protein denotes gp130
T35 1654-1659 protein denotes IL-6M
T36 1735-1740 protein denotes IL-6R
T37 1782-1787 protein denotes gp130
T38 1814-1818 protein denotes IL-6
T39 1845-1849 protein denotes IL-6

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 971-979 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 387-403 OrganismTaxon denotes Escherichia coli 562
T2 412-417 OrganismTaxon denotes human 9606
T3 965-970 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 196-204 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 431-444 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576