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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-165 Sentence denotes Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
T2 166-384 Sentence denotes In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
T3 385-580 Sentence denotes Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
T4 581-860 Sentence denotes Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
T5 861-1032 Sentence denotes We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
T6 1033-1133 Sentence denotes Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
T7 1134-1250 Sentence denotes However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
T8 1251-1395 Sentence denotes This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
T9 1396-1615 Sentence denotes These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.
T1 0-165 Sentence denotes Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
T2 166-384 Sentence denotes In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
T3 385-580 Sentence denotes Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
T4 581-860 Sentence denotes Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
T5 861-1032 Sentence denotes We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
T6 1033-1133 Sentence denotes Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
T7 1134-1250 Sentence denotes However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
T8 1251-1395 Sentence denotes This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
T9 1396-1615 Sentence denotes These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.

sentences

Id Subject Object Predicate Lexical cue
T1 0-165 Sentence denotes Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
T2 166-384 Sentence denotes In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
T3 385-580 Sentence denotes Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
T4 581-860 Sentence denotes Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
T5 861-1032 Sentence denotes We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
T6 1033-1133 Sentence denotes Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
T7 1134-1250 Sentence denotes However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
T8 1251-1395 Sentence denotes This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
T9 1396-1615 Sentence denotes These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.
T1 0-165 Sentence denotes Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
T2 166-384 Sentence denotes In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
T3 385-580 Sentence denotes Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
T4 581-860 Sentence denotes Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
T5 861-1032 Sentence denotes We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
T6 1033-1133 Sentence denotes Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
T7 1134-1250 Sentence denotes However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
T8 1251-1395 Sentence denotes This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
T9 1396-1615 Sentence denotes These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 83-100 protein denotes interleukin 1beta
T2 105-113 protein denotes NFkappaB
T3 134-142 protein denotes NFkappaB
T4 169-184 cell_type denotes human monocytes
T5 186-203 protein denotes interleukin 1beta
T6 361-378 protein denotes interleukin 1beta
T7 399-416 protein denotes interleukin 1beta
T8 427-436 protein denotes cytokines
T9 446-459 protein denotes interleukin 6
T10 464-491 protein denotes tumor necrosis factor alpha
T11 549-569 protein denotes transcription factor
T12 571-579 protein denotes NFkappaB
T13 645-660 protein denotes tyrosine kinase
T14 692-700 protein denotes NFkappaB
T15 755-763 protein denotes NFkappaB
T16 795-810 protein denotes tyrosine kinase
T17 894-917 cell_line denotes pro-monocytic cell line
T18 919-924 cell_line denotes THP-1
T19 971-988 protein denotes interleukin 1beta
T20 1005-1020 protein denotes tyrosine kinase
T21 1124-1132 protein denotes NFkappaB
T22 1161-1176 protein denotes tyrosine kinase
T23 1202-1210 protein denotes NFkappaB
T24 1300-1308 protein denotes NFkappaB
T25 1328-1343 protein denotes tyrosine kinase
T26 1354-1358 protein denotes AP-1
T27 1471-1493 protein denotes inflammatory mediators
T28 1503-1518 protein denotes tyrosine kinase
T29 1529-1544 protein denotes tyrosine kinase

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 83-100 NP denotes interleukin 1beta
C6 134-164 NP denotes NFkappaB nuclear translocation
C3 399-416 NP denotes interleukin 1beta
C4 545-569 NP denotes the transcription factor
C5 571-579 NP denotes NFkappaB
C7 692-722 NP denotes NFkappaB nuclear translocation
C20 795-819 NP denotes tyrosine kinase activity
C21 780-819 NP denotes the absence of tyrosine kinase activity
C8 884-917 NP denotes the human pro-monocytic cell line
C9 919-924 NP denotes THP-1
C10 971-988 NP denotes interleukin 1beta
C11 1124-1132 NP denotes NFkappaB
C14 1161-1185 NP denotes tyrosine kinase activity
C15 1146-1185 NP denotes the absence of tyrosine kinase activity
C12 1202-1210 NP denotes NFkappaB
C13 1300-1309 NP denotes NFkappaB;
C17 1328-1352 NP denotes tyrosine kinase activity
C16 1313-1352 NP denotes the absence of tyrosine kinase activity
C18 1503-1527 NP denotes tyrosine kinase activity
C19 1529-1553 NP denotes tyrosine kinase activity
R1 C3 C1 coref-ident interleukin 1beta,interleukin 1beta
R2 C5 C4 coref-appos NFkappaB,the transcription factor
R3 C7 C6 coref-ident NFkappaB nuclear translocation,NFkappaB nuclear translocation
R4 C9 C8 coref-appos THP-1,the human pro-monocytic cell line
R5 C10 C3 coref-ident interleukin 1beta,interleukin 1beta
R6 C11 C5 coref-ident NFkappaB,NFkappaB
R7 C14 C20 coref-ident tyrosine kinase activity,tyrosine kinase activity
R8 C15 C21 coref-ident the absence of tyrosine kinase activity,the absence of tyrosine kinase activity
R9 C12 C11 coref-ident NFkappaB,NFkappaB
R10 C13 C12 coref-ident NFkappaB;,NFkappaB
R11 C17 C14 coref-ident tyrosine kinase activity,tyrosine kinase activity
R12 C16 C15 coref-ident the absence of tyrosine kinase activity,the absence of tyrosine kinase activity
R13 C18 C17 coref-ident tyrosine kinase activity,tyrosine kinase activity
R14 C19 C18 coref-ident tyrosine kinase activity,tyrosine kinase activity

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-165 Sentence denotes Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
S2 166-384 Sentence denotes In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
S3 385-580 Sentence denotes Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
S4 581-860 Sentence denotes Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
S5 861-1032 Sentence denotes We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
S6 1033-1133 Sentence denotes Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
S7 1134-1250 Sentence denotes However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
S8 1251-1395 Sentence denotes This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
S9 1396-1615 Sentence denotes These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-34 other_name denotes Protein-tyrosine kinase activation
T2 51-79 other_name denotes lipopolysaccharide induction
T3 83-100 protein_molecule denotes interleukin 1beta
T4 105-113 protein_complex denotes NFkappaB
T5 134-142 protein_complex denotes NFkappaB
T6 169-184 cell_type denotes human monocytes
T7 186-203 protein_molecule denotes interleukin 1beta
T8 227-251 other_name denotes steady state mRNA levels
T9 281-299 lipid denotes lipopolysaccharide
T10 361-378 protein_molecule denotes interleukin 1beta
T11 399-416 protein_molecule denotes interleukin 1beta
T12 427-436 protein_family_or_group denotes cytokines
T13 446-459 protein_molecule denotes interleukin 6
T14 464-491 protein_molecule denotes tumor necrosis factor alpha
T15 549-569 protein_family_or_group denotes transcription factor
T16 571-579 protein_complex denotes NFkappaB
T17 618-636 lipid denotes lipopolysaccharide
T18 645-653 amino_acid_monomer denotes tyrosine
T19 692-700 protein_complex denotes NFkappaB
T20 701-722 other_name denotes nuclear translocation
T21 755-763 protein_complex denotes NFkappaB
T22 795-803 amino_acid_monomer denotes tyrosine
T23 894-917 cell_line denotes pro-monocytic cell line
T24 919-924 cell_line denotes THP-1
T25 930-948 lipid denotes lipopolysaccharide
T26 971-988 protein_molecule denotes interleukin 1beta
T27 1005-1013 amino_acid_monomer denotes tyrosine
T28 1071-1089 lipid denotes lipopolysaccharide
T29 1099-1120 other_name denotes nuclear translocation
T30 1124-1132 protein_complex denotes NFkappaB
T31 1161-1169 amino_acid_monomer denotes tyrosine
T32 1202-1210 protein_complex denotes NFkappaB
T33 1224-1237 other_name denotes transcription
T34 1270-1283 other_name denotes transcription
T35 1300-1308 protein_complex denotes NFkappaB
T36 1328-1336 amino_acid_monomer denotes tyrosine
T37 1354-1358 protein_molecule denotes AP-1
T38 1430-1448 lipid denotes lipopolysaccharide
T39 1471-1493 protein_family_or_group denotes inflammatory mediators
T40 1503-1511 amino_acid_monomer denotes tyrosine
T41 1529-1537 amino_acid_monomer denotes tyrosine
T42 1576-1594 lipid denotes lipopolysaccharide

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 464-469 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 464-469 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 169-174 OrganismTaxon denotes human 9606
T2 888-893 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 175-184 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 175-184 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 894-907 Cell denotes pro-monocytic http://purl.obolibrary.org/obo/CL:0000559