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PubMed:8683110 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 96-100 gene:3558 denotes IL-2
T1 30-36 disease:C3825627 denotes stress
R1 T0 T1 associated_with IL-2,stress

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 77-82 DNA denotes c-jun
T2 96-109 DNA denotes IL-2 promoter
T3 124-138 cell_line denotes Jurkat T cells
T4 374-385 protein denotes c-Fos/c-Jun
T5 386-390 protein denotes AP-1
T6 399-434 protein denotes nuclear factor of activated T cells
T7 436-441 protein denotes NF-AT
T8 474-488 cell_line denotes Jurkat T cells
T9 575-579 protein denotes AP-1
T10 619-624 DNA denotes c-jun
T11 633-643 RNA denotes c-fos mRNA
T12 675-680 DNA denotes c-jun
T13 730-746 RNA denotes mRNA transcripts
T14 855-860 DNA denotes c-jun
T15 878-953 DNA denotes proximal jun1 tumor promoter-responsive element (TRE)-like promoter element
T16 992-1010 DNA denotes consensus AP-1 TRE
T17 1015-1034 DNA denotes jun TRE-like motifs
T18 1126-1131 protein denotes c-Fos
T19 1133-1138 protein denotes c-Jun
T20 1144-1148 protein denotes JunD
T21 1230-1249 DNA denotes reporter constructs
T22 1265-1307 DNA denotes AP-1-TRE, NF-AT, and IL-2 promoter regions
T23 1319-1328 RNA denotes IL-2 mRNA
T24 1433-1438 protein denotes NF-AT
T25 1443-1457 DNA denotes IL-2 reporters
T26 1487-1496 RNA denotes IL-2 mRNA
T27 1589-1594 protein denotes NF-AT
T28 1645-1659 protein denotes NFAT complexes
T29 1697-1712 protein denotes NF-AT complexes
T30 1798-1804 cell_type denotes T cell
T31 1876-1880 protein denotes AP-1
T32 1895-1900 DNA denotes c-jun
T33 1939-1943 protein denotes IL-2
T34 1948-1953 protein denotes NF-AT

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 20-36 other_name denotes oxidative stress
T2 47-73 other_name denotes transcriptional activation
T3 77-82 DNA_domain_or_region denotes c-jun
T4 96-109 DNA_domain_or_region denotes IL-2 promoter
T5 124-138 cell_line denotes Jurkat T cells
T6 160-176 other_name denotes oxidative stress
T7 201-228 other_name denotes T cell functional responses
T8 315-331 other_name denotes oxidative stress
T9 374-385 protein_molecule denotes c-Fos/c-Jun
T10 386-390 protein_molecule denotes AP-1
T11 399-434 protein_complex denotes nuclear factor of activated T cells
T12 436-441 protein_complex denotes NF-AT
T13 474-488 cell_line denotes Jurkat T cells
T14 537-541 inorganic denotes H2O2
T15 575-579 protein_molecule denotes AP-1
T16 619-624 RNA_molecule denotes c-jun
T17 633-643 RNA_molecule denotes c-fos mRNA
T18 675-680 DNA_domain_or_region denotes c-jun
T19 684-688 inorganic denotes H2O2
T20 730-746 RNA_family_or_group denotes mRNA transcripts
T21 792-795 other_organic_compound denotes PMA
T22 855-860 DNA_domain_or_region denotes c-jun
T23 878-953 DNA_domain_or_region denotes proximal jun1 tumor promoter-responsive element (TRE)-like promoter element
T24 992-1001 DNA_domain_or_region denotes consensus
T25 1002-1006 protein_molecule denotes AP-1
T26 1015-1034 DNA_domain_or_region denotes jun TRE-like motifs
T27 1076-1080 other_organic_compound denotes PHA/
T28 1080-1083 other_organic_compound denotes PMA
T29 1126-1131 protein_molecule denotes c-Fos
T30 1133-1138 protein_molecule denotes c-Jun
T31 1144-1148 protein_molecule denotes JunD
T32 1159-1163 other_organic_compound denotes PHA/
T33 1163-1166 other_organic_compound denotes PMA
T34 1230-1249 DNA_family_or_group denotes reporter constructs
T35 1265-1269 protein_molecule denotes AP-1
T36 1275-1280 DNA_domain_or_region denotes NF-AT
T37 1286-1290 protein_molecule denotes IL-2
T38 1319-1328 RNA_molecule denotes IL-2 mRNA
T39 1374-1378 inorganic denotes H2O2
T40 1403-1429 other_name denotes transcriptional activation
T41 1433-1438 protein_complex denotes NF-AT
T42 1443-1457 DNA_domain_or_region denotes IL-2 reporters
T43 1487-1491 protein_molecule denotes IL-2
T44 1522-1526 other_organic_compound denotes PHA/
T45 1526-1529 other_organic_compound denotes PMA
T46 1589-1594 protein_complex denotes NF-AT
T47 1645-1659 protein_complex denotes NFAT complexes
T48 1697-1702 protein_complex denotes NF-AT
T49 1741-1758 other_name denotes oxidative signals
T50 1798-1804 cell_type denotes T cell
T51 1848-1862 other_name denotes cellular redox
T52 1876-1880 protein_molecule denotes AP-1
T53 1895-1900 DNA_domain_or_region denotes c-jun
T54 1906-1935 other_name denotes transcriptional up-regulation
T55 1939-1943 protein_molecule denotes IL-2
T56 1948-1953 protein_complex denotes NF-AT

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 20-36 NP denotes oxidative stress
C3 0-36 NP denotes Sublethal levels of oxidative stress
C10 77-82 NP denotes c-jun
C2 160-176 NP denotes oxidative stress
C4 140-176 NP denotes Sublethal levels of oxidative stress
C5 315-331 NP denotes oxidative stress
C6 395-442 NP denotes the nuclear factor of activated T cells (NF-AT)
C7 537-541 NP denotes H2O2
C9 619-624 NP denotes c-jun
C11 675-680 NP denotes c-jun
C8 684-688 NP denotes H2O2
C12 752-769 NP denotes oxidative signals
C18 1002-1010 NP denotes AP-1 TRE
C13 1055-1072 NP denotes oxidative signals
C15 1076-1083 NP denotes PHA/PMA
C14 1133-1138 NP denotes c-Jun
C16 1159-1166 NP denotes PHA/PMA
C17 1175-1192 NP denotes oxidative signals
C19 1261-1273 NP denotes the AP-1-TRE
C20 1275-1280 NP denotes NF-AT
C21 1374-1378 NP denotes H2O2
C22 1433-1438 NP denotes NF-AT
C23 1522-1529 NP denotes PHA/PMA
C24 1589-1594 NP denotes NF-AT
C27 1741-1758 NP denotes oxidative signals
C28 1895-1900 NP denotes c-jun
C30 1948-1953 NP denotes NF-AT
R1 C2 C1 coref-ident oxidative stress,oxidative stress
R2 C4 C3 coref-ident Sublethal levels of oxidative stress,Sublethal levels of oxidative stress
R3 C5 C2 coref-ident oxidative stress,oxidative stress
R4 C9 C10 coref-ident c-jun,c-jun
R5 C11 C9 coref-ident c-jun,c-jun
R6 C8 C7 coref-ident H2O2,H2O2
R7 C13 C12 coref-ident oxidative signals,oxidative signals
R8 C14 C11 coref-ident c-Jun,c-jun
R9 C16 C15 coref-ident PHA/PMA,PHA/PMA
R10 C17 C13 coref-ident oxidative signals,oxidative signals
R11 C19 C18 coref-ident the AP-1-TRE,AP-1 TRE
R12 C20 C6 coref-ident NF-AT,the nuclear factor of activated T cells (NF-AT)
R13 C21 C8 coref-ident H2O2,H2O2
R14 C22 C20 coref-ident NF-AT,NF-AT
R15 C23 C16 coref-ident PHA/PMA,PHA/PMA
R16 C24 C22 coref-ident NF-AT,NF-AT
R17 C27 C17 coref-ident oxidative signals,oxidative signals
R18 C28 C14 coref-ident c-jun,c-Jun
R19 C30 C24 coref-ident NF-AT,NF-AT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-139 Sentence denotes Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells.
S2 140-272 Sentence denotes Sublethal levels of oxidative stress are well known to alter T cell functional responses, but the underlying mechanisms are unknown.
S3 273-443 Sentence denotes The current study examined the effects of oxidative stress on transcriptional activities mediated by c-Fos/c-Jun AP-1 and the nuclear factor of activated T cells (NF-AT).
S4 444-644 Sentence denotes The present results show that Jurkat T cells acutely exposed to micromolar concentrations of H2O2 exhibit substantial increases in AP-1 binding activity and the expression of c-jun but not c-fos mRNA.
S5 645-954 Sentence denotes The preferential induction of c-jun by H2O2 did not represent redox stabilization of mRNA transcripts, and oxidative signals closely resembled PHA/PMA stimulation by effectively transactivating the full length c-jun promoter via the proximal jun1 tumor promoter-responsive element (TRE)-like promoter element.
S6 955-1149 Sentence denotes Similarly, the complexes binding the consensus AP-1 TRE and jun TRE-like motifs in cells exposed to oxidative signals or PHA/PMA were indistinguishable, being composed of c-Fos, c-Jun, and JunD.
S7 1150-1340 Sentence denotes However, PHA/PMA but not oxidative signals induced the coordinate activation of reporter constructs containing the AP-1-TRE, NF-AT, and IL-2 promoter regions along with IL-2 mRNA expression.
S8 1341-1530 Sentence denotes Furthermore, sublethal levels of H2O2 actively suppressed the transcriptional activation of NF-AT and IL-2 reporters as well as the expression of IL-2 mRNA in cells stimulated with PHA/PMA.
S9 1531-1713 Sentence denotes Gel shift analysis revealed that oxidative suppression of NF-AT represented inhibition in the early generation of NFAT complexes rather than the binding of preformed NF-AT complexes.
S10 1714-1954 Sentence denotes These results suggest that oxidative signals can positively and negatively regulate T cell transcriptional events and that changes in cellular redox can uncouple AP-1 regulation of c-jun from transcriptional up-regulation of IL-2 via NF-AT.