PubMed:8676521 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8676521","sourcedb":"PubMed","sourceid":"8676521","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8676521","text":"Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity.\nB-cell immortalization by Epstein-Barr virus (EBV) is dependent on permanent control of the cellular processes which normally regulate cell division and apoptosis, functions possessed by p53 in a number of normal cell types. In studies initiated to evaluate relationships between EBV latent genes and p53, p53 levels were found to increase approximately 10-fold 4 to 5 days after EBV infection of purified resting human B cells; the induced p53 was transcriptionally active. 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