> top > docs > PubMed:8663478 > annotations

PubMed:8663478 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
T2 107-261 Sentence denotes Platelet-derived growth factor (PDGF) induces the expression of human stromelysin-1, a matrix metalloproteinase involved in tumor invasion and metastasis.
T3 262-577 Sentence denotes Here it is shown that stromelysin-1 gene induction by PDGF depends on Ras and involves three previously identified promoter elements (the stromelysin-1 PDGF-responsive element (SPRE) site, the two head-to-head polyomavirus enhancer A-binding protein-3 (PEA3) sites, and the activator protein-1 (AP-1) binding site).
T4 578-771 Sentence denotes During mitogenic induction, these responsive elements appear to be organized in two independent transcriptional units, SPRE-AP-1 and PEA3-AP-1, which result from specific element cross-talking.
T5 772-945 Sentence denotes Interestingly, expression of a dominant negative mutant of Raf-1 significantly interfered with the induction through PEA3-AP-1 but not with that operating through SPRE-AP-1.
T6 946-1142 Sentence denotes Conversely, only the induction operating through SPRE-AP-1 was affected significantly by the expression of a dominant negative mutant of the atypical lambda/iota protein kinase C (lambda/iotaPKC).
T7 1143-1400 Sentence denotes These data strongly suggest that the signal triggered by PDGF flows through Ras and bifurcates toward two distinct pathways, one operating through Raf and involving PEA3-AP-1 and the other one Raf-independent, operating through lambda/iotaPKC and SPRE-AP-1.
T8 1401-1555 Sentence denotes Furthermore, we present evidence suggesting that the novel SPRE-binding transcription factor SPBP cross-couples with c-Jun to transactivate the SPRE site.
T1 0-106 Sentence denotes Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
T2 107-261 Sentence denotes Platelet-derived growth factor (PDGF) induces the expression of human stromelysin-1, a matrix metalloproteinase involved in tumor invasion and metastasis.
T3 262-577 Sentence denotes Here it is shown that stromelysin-1 gene induction by PDGF depends on Ras and involves three previously identified promoter elements (the stromelysin-1 PDGF-responsive element (SPRE) site, the two head-to-head polyomavirus enhancer A-binding protein-3 (PEA3) sites, and the activator protein-1 (AP-1) binding site).
T4 578-771 Sentence denotes During mitogenic induction, these responsive elements appear to be organized in two independent transcriptional units, SPRE-AP-1 and PEA3-AP-1, which result from specific element cross-talking.
T5 772-945 Sentence denotes Interestingly, expression of a dominant negative mutant of Raf-1 significantly interfered with the induction through PEA3-AP-1 but not with that operating through SPRE-AP-1.
T6 946-1142 Sentence denotes Conversely, only the induction operating through SPRE-AP-1 was affected significantly by the expression of a dominant negative mutant of the atypical lambda/iota protein kinase C (lambda/iotaPKC).
T7 1143-1400 Sentence denotes These data strongly suggest that the signal triggered by PDGF flows through Ras and bifurcates toward two distinct pathways, one operating through Raf and involving PEA3-AP-1 and the other one Raf-independent, operating through lambda/iotaPKC and SPRE-AP-1.
T8 1401-1555 Sentence denotes Furthermore, we present evidence suggesting that the novel SPRE-binding transcription factor SPBP cross-couples with c-Jun to transactivate the SPRE site.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 459-463 http://purl.obolibrary.org/obo/MAT_0000294 denotes head
T2 467-471 http://purl.obolibrary.org/obo/MAT_0000294 denotes head

relna

Id Subject Object Predicate Lexical cue
T1 87-100 Protein denotes stromelysin-1
T2 177-190 Protein denotes stromelysin-1
T3 284-297 Protein denotes stromelysin-1
T4 400-413 Protein denotes stromelysin-1
T5 472-513 DNA denotes polyomavirus enhancer A-binding protein-3
T6 515-519 DNA denotes PEA3
T7 711-715 DNA denotes PEA3
T8 831-836 Protein denotes Raf-1
T9 889-893 DNA denotes PEA3
T10 1308-1312 DNA denotes PEA3
T11 1518-1523 DNA denotes c-Jun

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 459-463 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294
T2 467-471 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 231-236 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 231-236 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 81-86 OrganismTaxon denotes human 9606
T2 171-176 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 107-115 Body_part denotes Platelet http://purl.obolibrary.org/obo/CL_0000233
T2 459-463 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T3 467-471 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T4 1096-1102 Body_part denotes lambda http://purl.obolibrary.org/obo/UBERON_0013424
T5 1126-1132 Body_part denotes lambda http://purl.obolibrary.org/obo/UBERON_0013424
T6 1371-1377 Body_part denotes lambda http://purl.obolibrary.org/obo/UBERON_0013424

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 107-115 Cell denotes Platelet http://purl.obolibrary.org/obo/CL:0000233