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PubMed:8663380 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 10-15 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T2 231-236 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T3 459-478 Cell denotes structural and cell http://purl.obolibrary.org/obo/CL:0000293
T4 679-684 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T5 1211-1216 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T6 1357-1362 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124

sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
T2 115-271 Sentence denotes The transcription and transformation activity of c-Jun is governed by a 27-amino acid regulatory motif, labeled the delta-domain, which is deleted in v-Jun.
T3 272-426 Sentence denotes We have previously shown that c-Jun is a potent inhibitor of the rat prolactin (rPRL) promoter activity induced by either oncogenic Ras or phorbol esters.
T4 427-692 Sentence denotes Here, we have characterized the structural and cell-specific requirements for this c-Jun inhibitory response, and we show that this c-Jun inhibitory response mapped to the rPRL footprint II repressor site, was pituitary-specific and required the c-Jun delta-domain.
T5 693-873 Sentence denotes Moreover, alteration of any one of these features (e.g., cis-element, trans-factor, or cell-specific background) switched c-Jun to a transcriptional activator of the rPRL promoter.
T6 874-1029 Sentence denotes In HeLa nonpituitary cells, c-Jun alone activated the rPRL promoter via the most proximal GHF-1/Pit-1 binding site, footprint I, and synergized with GHF-1.
T7 1030-1111 Sentence denotes Finally, recombinant GHF-1 interacted directly with c-Jun but not c-Fos proteins.
T8 1112-1376 Sentence denotes These data provide important fundamental insights into the molecular mechanisms by which the c-Jun delta-domain functions as a modulatory switch and further imply that the functional role of c-Jun is dictated by cell-specific influences and the delta-domain motif.
T1 0-114 Sentence denotes The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
T2 115-271 Sentence denotes The transcription and transformation activity of c-Jun is governed by a 27-amino acid regulatory motif, labeled the delta-domain, which is deleted in v-Jun.
T3 272-426 Sentence denotes We have previously shown that c-Jun is a potent inhibitor of the rat prolactin (rPRL) promoter activity induced by either oncogenic Ras or phorbol esters.
T4 427-692 Sentence denotes Here, we have characterized the structural and cell-specific requirements for this c-Jun inhibitory response, and we show that this c-Jun inhibitory response mapped to the rPRL footprint II repressor site, was pituitary-specific and required the c-Jun delta-domain.
T5 693-873 Sentence denotes Moreover, alteration of any one of these features (e.g., cis-element, trans-factor, or cell-specific background) switched c-Jun to a transcriptional activator of the rPRL promoter.
T6 874-1029 Sentence denotes In HeLa nonpituitary cells, c-Jun alone activated the rPRL promoter via the most proximal GHF-1/Pit-1 binding site, footprint I, and synergized with GHF-1.
T7 1030-1111 Sentence denotes Finally, recombinant GHF-1 interacted directly with c-Jun but not c-Fos proteins.
T8 1112-1376 Sentence denotes These data provide important fundamental insights into the molecular mechanisms by which the c-Jun delta-domain functions as a modulatory switch and further imply that the functional role of c-Jun is dictated by cell-specific influences and the delta-domain motif.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 88-97 http://purl.obolibrary.org/obo/MAT_0000077 denotes pituitary
T2 637-646 http://purl.obolibrary.org/obo/MAT_0000077 denotes pituitary
T3 955-963 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-22 protein denotes c-Jun delta-domain
T2 32-55 DNA denotes neuroendocrine promoter
T3 164-169 protein denotes c-Jun
T4 187-217 protein denotes 27-amino acid regulatory motif
T5 231-243 protein denotes delta-domain
T6 265-270 protein denotes v-Jun
T7 302-307 protein denotes c-Jun
T8 337-366 DNA denotes rat prolactin (rPRL) promoter
T9 394-407 protein denotes oncogenic Ras
T10 510-515 protein denotes c-Jun
T11 559-564 protein denotes c-Jun
T12 599-631 DNA denotes rPRL footprint II repressor site
T13 673-691 protein denotes c-Jun delta-domain
T14 750-761 DNA denotes cis-element
T15 763-775 DNA denotes trans-factor
T16 815-820 protein denotes c-Jun
T17 826-851 protein denotes transcriptional activator
T18 859-872 DNA denotes rPRL promoter
T19 877-900 cell_line denotes HeLa nonpituitary cells
T20 902-907 protein denotes c-Jun
T21 928-941 DNA denotes rPRL promoter
T22 964-988 DNA denotes GHF-1/Pit-1 binding site
T23 990-1001 DNA denotes footprint I
T24 1023-1028 protein denotes GHF-1
T25 1051-1056 protein denotes GHF-1
T26 1082-1087 protein denotes c-Jun
T27 1096-1110 protein denotes c-Fos proteins
T28 1205-1223 protein denotes c-Jun delta-domain
T29 1303-1308 protein denotes c-Jun
T30 1357-1375 protein denotes delta-domain motif

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
S2 115-271 Sentence denotes The transcription and transformation activity of c-Jun is governed by a 27-amino acid regulatory motif, labeled the delta-domain, which is deleted in v-Jun.
S3 272-426 Sentence denotes We have previously shown that c-Jun is a potent inhibitor of the rat prolactin (rPRL) promoter activity induced by either oncogenic Ras or phorbol esters.
S4 427-692 Sentence denotes Here, we have characterized the structural and cell-specific requirements for this c-Jun inhibitory response, and we show that this c-Jun inhibitory response mapped to the rPRL footprint II repressor site, was pituitary-specific and required the c-Jun delta-domain.
S5 693-873 Sentence denotes Moreover, alteration of any one of these features (e.g., cis-element, trans-factor, or cell-specific background) switched c-Jun to a transcriptional activator of the rPRL promoter.
S6 874-1029 Sentence denotes In HeLa nonpituitary cells, c-Jun alone activated the rPRL promoter via the most proximal GHF-1/Pit-1 binding site, footprint I, and synergized with GHF-1.
S7 1030-1111 Sentence denotes Finally, recombinant GHF-1 interacted directly with c-Jun but not c-Fos proteins.
S8 1112-1376 Sentence denotes These data provide important fundamental insights into the molecular mechanisms by which the c-Jun delta-domain functions as a modulatory switch and further imply that the functional role of c-Jun is dictated by cell-specific influences and the delta-domain motif.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C7 0-22 NP denotes The c-Jun delta-domain
C1 164-169 NP denotes c-Jun
C10 185-217 NP denotes a 27-amino acid regulatory motif
C9 227-243 NP denotes the delta-domain
C3 245-250 NP denotes which
C4 302-307 NP denotes c-Jun
C5 505-535 NP denotes this c-Jun inhibitory response
C6 554-584 NP denotes this c-Jun inhibitory response
C8 669-691 NP denotes the c-Jun delta-domain
C11 815-820 NP denotes c-Jun
C13 855-872 NP denotes the rPRL promoter
C12 902-907 NP denotes c-Jun
C14 924-941 NP denotes the rPRL promoter
C15 1082-1087 NP denotes c-Jun
C16 1167-1191 NP denotes the molecular mechanisms
C17 1195-1200 NP denotes which
C18 1201-1223 NP denotes the c-Jun delta-domain
C19 1303-1308 NP denotes c-Jun
C20 1353-1375 NP denotes the delta-domain motif
R1 C9 C10 coref-ident the delta-domain,a 27-amino acid regulatory motif
R2 C3 C10 coref-relat which,a 27-amino acid regulatory motif
R3 C4 C1 coref-ident c-Jun,c-Jun
R4 C6 C5 coref-ident this c-Jun inhibitory response,this c-Jun inhibitory response
R5 C8 C7 coref-ident the c-Jun delta-domain,The c-Jun delta-domain
R6 C11 C4 coref-ident c-Jun,c-Jun
R7 C12 C11 coref-ident c-Jun,c-Jun
R8 C14 C13 coref-ident the rPRL promoter,the rPRL promoter
R9 C15 C12 coref-ident c-Jun,c-Jun
R10 C17 C16 coref-relat which,the molecular mechanisms
R11 C18 C8 coref-ident the c-Jun delta-domain,the c-Jun delta-domain
R12 C19 C15 coref-ident c-Jun,c-Jun
R13 C20 C10 coref-ident the delta-domain motif,a 27-amino acid regulatory motif

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-9 protein_molecule denotes c-Jun
T2 32-55 DNA_domain_or_region denotes neuroendocrine promoter
T3 119-160 other_name denotes transcription and transformation activity
T4 164-169 protein_molecule denotes c-Jun
T5 187-217 protein_domain_or_region denotes 27-amino acid regulatory motif
T6 231-243 protein_domain_or_region denotes delta-domain
T7 265-270 protein_molecule denotes v-Jun
T8 302-307 protein_molecule denotes c-Jun
T9 337-366 DNA_domain_or_region denotes rat prolactin (rPRL) promoter
T10 394-407 protein_molecule denotes oncogenic Ras
T11 411-425 other_organic_compound denotes phorbol esters
T12 474-500 other_name denotes cell-specific requirements
T13 510-515 protein_molecule denotes c-Jun
T14 559-564 protein_molecule denotes c-Jun
T15 599-631 DNA_domain_or_region denotes rPRL footprint II repressor site
T16 673-678 protein_molecule denotes c-Jun
T17 750-761 DNA_family_or_group denotes cis-element
T18 763-775 DNA_family_or_group denotes trans-factor
T19 780-804 other_name denotes cell-specific background
T20 815-820 protein_molecule denotes c-Jun
T21 826-851 protein_family_or_group denotes transcriptional activator
T22 859-872 DNA_domain_or_region denotes rPRL promoter
T23 877-900 cell_line denotes HeLa nonpituitary cells
T24 902-907 protein_molecule denotes c-Jun
T25 928-941 DNA_domain_or_region denotes rPRL promoter
T26 964-988 DNA_domain_or_region denotes GHF-1/Pit-1 binding site
T27 990-1001 DNA_domain_or_region denotes footprint I
T28 1023-1028 protein_molecule denotes GHF-1
T29 1051-1056 protein_molecule denotes GHF-1
T30 1082-1087 protein_molecule denotes c-Jun
T31 1096-1110 protein_molecule denotes c-Fos proteins
T32 1205-1210 protein_molecule denotes c-Jun
T33 1239-1256 other_name denotes modulatory switch
T34 1303-1308 protein_molecule denotes c-Jun
T35 1357-1375 protein_domain_or_region denotes delta-domain motif

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 88-97 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T2 637-646 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 337-340 OrganismTaxon denotes rat 10114|10116

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 88-97 Body_part denotes pituitary http://purl.obolibrary.org/obo/MAT_0000077
T2 637-646 Body_part denotes pituitary http://purl.obolibrary.org/obo/MAT_0000077
T3 955-963 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 88-97 Body_part denotes pituitary http://purl.obolibrary.org/obo/UBERON_0000007
T2 459-478 Body_part denotes structural and cell http://purl.obolibrary.org/obo/CL_0000293
T3 637-646 Body_part denotes pituitary http://purl.obolibrary.org/obo/UBERON_0000007