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sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.
T2 132-308 Sentence denotes The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages.
T3 309-434 Sentence denotes A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation.
T4 435-775 Sentence denotes In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream of the major transcription start site were generated and tested for promoter activity in various hematopoietic and nonhematopoietic cell types.
T5 776-933 Sentence denotes The -1053/+34 construct allowed promoter activity only in cells of hematopoietic origin, and tissue specificity was conserved in all other constructs tested.
T6 934-1009 Sentence denotes The region downstream of -90 appeared critical for basal promoter activity.
T7 1010-1203 Sentence denotes It contains two potential Ets binding sites conserved in the murine gammac promoter gene, one of which was found essential for functional promoter activity as determined by mutational analysis.
T8 1204-1383 Sentence denotes The functional Ets binding site was found to bind Ets family proteins, principally GA-binding protein and Elf-1 and could be transactivated by GABPalpha and -beta synergistically.
T9 1384-1539 Sentence denotes These results indicate that, as already reported for the IL2Rbeta promoter, GA-binding protein is an essential component of gammac basal promoter activity.
T10 1540-1725 Sentence denotes Although GABP expression is not restricted to the hematopoietic lineage, its interaction with other specific factors may contribute to the tissue-specific expression of the gammac gene.
T1 0-131 Sentence denotes Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.
T2 132-308 Sentence denotes The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages.
T3 309-434 Sentence denotes A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation.
T4 435-775 Sentence denotes In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream of the major transcription start site were generated and tested for promoter activity in various hematopoietic and nonhematopoietic cell types.
T5 776-933 Sentence denotes The -1053/+34 construct allowed promoter activity only in cells of hematopoietic origin, and tissue specificity was conserved in all other constructs tested.
T6 934-1009 Sentence denotes The region downstream of -90 appeared critical for basal promoter activity.
T7 1010-1203 Sentence denotes It contains two potential Ets binding sites conserved in the murine gammac promoter gene, one of which was found essential for functional promoter activity as determined by mutational analysis.
T8 1204-1383 Sentence denotes The functional Ets binding site was found to bind Ets family proteins, principally GA-binding protein and Elf-1 and could be transactivated by GABPalpha and -beta synergistically.
T9 1384-1539 Sentence denotes These results indicate that, as already reported for the IL2Rbeta promoter, GA-binding protein is an essential component of gammac basal promoter activity.
T10 1540-1725 Sentence denotes Although GABP expression is not restricted to the hematopoietic lineage, its interaction with other specific factors may contribute to the tissue-specific expression of the gammac gene.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 321-327 gene:3561 denotes gammac
T1 341-382 disease:C1279481 denotes X-linked severe combined immunodeficiency
R1 T0 T1 associated_with gammac,X-linked severe combined immunodeficiency

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 32-58 DNA denotes gammac chain gene promoter
T2 75-91 DNA denotes Ets binding site
T3 112-130 protein denotes GA-binding protein
T4 136-148 protein denotes gammac chain
T5 174-192 protein denotes cytokine receptors
T6 194-212 protein denotes interleukin (IL)-2
T7 214-218 protein denotes IL-4
T8 220-224 protein denotes IL-7
T9 226-230 protein denotes IL-9
T10 236-241 protein denotes IL-15
T11 285-307 cell_type denotes hematopoietic lineages
T12 471-492 DNA denotes human gammac promoter
T13 508-547 DNA denotes minimal tissue-specific promoter region
T14 561-583 DNA denotes 5'-deletion constructs
T15 607-631 DNA denotes 1053 base pairs upstream
T16 639-669 DNA denotes major transcription start site
T17 729-774 cell_type denotes hematopoietic and nonhematopoietic cell types
T18 780-799 DNA denotes -1053/+34 construct
T19 843-863 cell_type denotes hematopoietic origin
T20 1036-1053 DNA denotes Ets binding sites
T21 1071-1098 DNA denotes murine gammac promoter gene
T22 1219-1235 DNA denotes Ets binding site
T23 1254-1273 protein denotes Ets family proteins
T24 1287-1305 protein denotes GA-binding protein
T25 1310-1315 protein denotes Elf-1
T26 1347-1356 protein denotes GABPalpha
T27 1361-1366 protein denotes -beta
T28 1441-1458 DNA denotes IL2Rbeta promoter
T29 1460-1478 protein denotes GA-binding protein
T30 1549-1553 protein denotes GABP
T31 1590-1611 cell_type denotes hematopoietic lineage
T32 1640-1656 protein denotes specific factors
T33 1713-1724 DNA denotes gammac gene

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8663060-2#12#18#gene3561 321-327 gene3561 denotes gammac
8663060-2#32#73#diseaseC1279481 341-382 diseaseC1279481 denotes X-linked severe combined immunodeficiency
12#18#gene356132#73#diseaseC1279481 8663060-2#12#18#gene3561 8663060-2#32#73#diseaseC1279481 associated_with gammac,X-linked severe combined immunodeficiency

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-131 Sentence denotes Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.
S2 132-308 Sentence denotes The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages.
S3 309-434 Sentence denotes A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation.
S4 435-775 Sentence denotes In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream of the major transcription start site were generated and tested for promoter activity in various hematopoietic and nonhematopoietic cell types.
S5 776-933 Sentence denotes The -1053/+34 construct allowed promoter activity only in cells of hematopoietic origin, and tissue specificity was conserved in all other constructs tested.
S6 934-1009 Sentence denotes The region downstream of -90 appeared critical for basal promoter activity.
S7 1010-1203 Sentence denotes It contains two potential Ets binding sites conserved in the murine gammac promoter gene, one of which was found essential for functional promoter activity as determined by mutational analysis.
S8 1204-1383 Sentence denotes The functional Ets binding site was found to bind Ets family proteins, principally GA-binding protein and Elf-1 and could be transactivated by GABPalpha and -beta synergistically.
S9 1384-1539 Sentence denotes These results indicate that, as already reported for the IL2Rbeta promoter, GA-binding protein is an essential component of gammac basal promoter activity.
S10 1540-1725 Sentence denotes Although GABP expression is not restricted to the hematopoietic lineage, its interaction with other specific factors may contribute to the tissue-specific expression of the gammac gene.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C4 28-58 NP denotes the gammac chain gene promoter
C10 112-130 NP denotes GA-binding protein
C1 132-148 NP denotes The gammac chain
C2 152-242 NP denotes a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15)
C3 262-267 NP denotes which
C5 467-492 NP denotes the human gammac promoter
C6 1022-1098 NP denotes two potential Ets binding sites conserved in the murine gammac promoter gene
C7 1107-1112 NP denotes which
C8 1100-1112 NP denotes one of which
C9 1287-1305 NP denotes GA-binding protein
C11 1460-1478 NP denotes GA-binding protein
C12 1549-1564 NP denotes GABP expression
C13 1613-1616 NP denotes its
R1 C3 C2 coref-relat which,"a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15)"
R2 C5 C4 coref-ident the human gammac promoter,the gammac chain gene promoter
R3 C7 C6 coref-relat which,two potential Ets binding sites conserved in the murine gammac promoter gene
R4 C8 C6 coref-part-whole one of which,two potential Ets binding sites conserved in the murine gammac promoter gene
R5 C9 C10 coref-ident GA-binding protein,GA-binding protein
R6 C11 C9 coref-ident GA-binding protein,GA-binding protein
R7 C13 C12 coref-pron its,GABP expression

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-24 other_name denotes Tissue-specific activity
T2 32-49 DNA_domain_or_region denotes gammac chain gene
T3 75-91 DNA_domain_or_region denotes Ets binding site
T4 112-130 protein_family_or_group denotes GA-binding protein
T5 136-148 protein_subunit denotes gammac chain
T6 174-192 protein_family_or_group denotes cytokine receptors
T7 194-212 protein_molecule denotes interleukin (IL)-2
T8 214-218 protein_molecule denotes IL-4
T9 220-224 protein_molecule denotes IL-7
T10 226-230 protein_molecule denotes IL-9
T11 236-241 protein_molecule denotes IL-15
T12 285-307 cell_type denotes hematopoietic lineages
T13 341-382 other_name denotes X-linked severe combined immunodeficiency
T14 411-433 other_name denotes T cell differentiation
T15 471-492 DNA_domain_or_region denotes human gammac promoter
T16 508-547 DNA_domain_or_region denotes minimal tissue-specific promoter region
T17 561-583 DNA_family_or_group denotes 5'-deletion constructs
T18 607-631 DNA_domain_or_region denotes 1053 base pairs upstream
T19 639-669 DNA_domain_or_region denotes major transcription start site
T20 700-717 other_name denotes promoter activity
T21 780-799 DNA_molecule denotes -1053/+34 construct
T22 808-825 other_name denotes promoter activity
T23 843-863 cell_type denotes hematopoietic origin
T24 869-887 other_name denotes tissue specificity
T25 991-1008 other_name denotes promoter activity
T26 1036-1053 DNA_domain_or_region denotes Ets binding sites
T27 1071-1098 DNA_domain_or_region denotes murine gammac promoter gene
T28 1148-1165 other_name denotes promoter activity
T29 1183-1202 other_name denotes mutational analysis
T30 1219-1235 DNA_domain_or_region denotes Ets binding site
T31 1254-1273 protein_family_or_group denotes Ets family proteins
T32 1287-1305 protein_family_or_group denotes GA-binding protein
T33 1310-1315 protein_molecule denotes Elf-1
T34 1347-1356 protein_molecule denotes GABPalpha
T35 1361-1366 protein_molecule denotes -beta
T36 1441-1458 DNA_domain_or_region denotes IL2Rbeta promoter
T37 1460-1478 protein_family_or_group denotes GA-binding protein
T38 1508-1520 other_name denotes gammac basal
T39 1521-1538 other_name denotes promoter activity
T40 1549-1553 protein_molecule denotes GABP
T41 1590-1611 cell_type denotes hematopoietic lineage
T42 1640-1656 protein_family_or_group denotes specific factors
T43 1679-1705 other_name denotes tissue-specific expression
T44 1713-1724 DNA_domain_or_region denotes gammac gene

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 350-382 Phenotype denotes severe combined immunodeficiency HP:0004430

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 341-382 Disease denotes X-linked severe combined immunodeficiency http://purl.obolibrary.org/obo/MONDO_0010315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 471-476 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-6 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 411-417 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 516-522 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 589-596 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T5 869-875 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 1679-1685 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 411-417 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 985-990 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T3 1515-1520 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324