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sentences

Id Subject Object Predicate Lexical cue
T1 0-22 Sentence denotes Globin gene switching.
T2 23-160 Sentence denotes In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.
T3 161-417 Sentence denotes To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.
T4 418-624 Sentence denotes In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.
T5 625-754 Sentence denotes In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.
T6 755-916 Sentence denotes In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.
T7 917-1174 Sentence denotes The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.
T8 1175-1602 Sentence denotes Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.
T1 0-22 Sentence denotes Globin gene switching.
T2 23-160 Sentence denotes In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.
T3 161-417 Sentence denotes To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.
T4 418-624 Sentence denotes In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.
T5 625-754 Sentence denotes In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.
T6 755-916 Sentence denotes In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.
T7 917-1174 Sentence denotes The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.
T8 1175-1602 Sentence denotes Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 63-86 DNA denotes human beta-globin locus
T2 90-105 cell_type denotes erythroid cells
T3 140-151 DNA denotes globin gene
T4 253-276 DNA denotes human beta-globin locus
T5 331-346 cell_type denotes erythroid cells
T6 425-445 DNA denotes locus control region
T7 447-450 DNA denotes LCR
T8 459-476 DNA denotes beta-globin locus
T9 500-505 protein denotes NF-E2
T10 510-514 protein denotes AP-1
T11 520-533 DNA denotes GATA-1 motifs
T12 591-609 DNA denotes adult globin genes
T13 660-677 DNA denotes GT (CACCC) motifs
T14 758-774 DNA denotes promoter regions
T15 780-806 DNA denotes actively transcribed genes
T16 893-915 DNA denotes CACCC and CCAAT motifs
T17 921-950 cell_type denotes adult globin expressing cells
T18 996-1025 cell_type denotes fetal globin expressing cells
T19 1033-1056 DNA denotes 3' regulatory sequences
T20 1069-1102 DNA denotes Agamma- and the beta-globin genes
T21 1131-1142 DNA denotes 3' elements
T22 1146-1162 DNA denotes beta-globin gene
T23 1281-1293 DNA denotes globin genes
T24 1313-1350 DNA denotes gamma- and beta-globin gene promoters
T25 1361-1370 DNA denotes GT motifs
T26 1378-1395 DNA denotes beta-globin locus
T27 1396-1399 DNA denotes LCR
T28 1457-1473 DNA denotes beta-globin gene
T29 1546-1561 protein denotes LCR holocomplex
T30 1571-1601 DNA denotes fetal or the adult globin gene

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-55 other_name denotes vivo protein-DNA interactions
T2 63-86 DNA_domain_or_region denotes human beta-globin locus
T3 90-105 cell_type denotes erythroid cells
T4 140-151 DNA_domain_or_region denotes globin gene
T5 181-205 other_name denotes protein-DNA interactions
T6 253-276 DNA_domain_or_region denotes human beta-globin locus
T7 293-330 other_name denotes in vivo dimethyl sulfate footprinting
T8 331-346 cell_type denotes erythroid cells
T9 425-445 DNA_domain_or_region denotes locus control region
T10 447-450 DNA_domain_or_region denotes LCR
T11 459-476 DNA_domain_or_region denotes beta-globin locus
T12 478-496 other_name denotes in vivo footprints
T13 500-505 protein_molecule denotes NF-E2
T14 510-514 protein_molecule denotes AP-1
T15 520-533 DNA_domain_or_region denotes GATA-1 motifs
T16 591-609 DNA_family_or_group denotes adult globin genes
T17 638-656 other_name denotes in vivo footprints
T18 660-677 DNA_domain_or_region denotes GT (CACCC) motifs
T19 758-774 DNA_domain_or_region denotes promoter regions
T20 780-806 DNA_family_or_group denotes actively transcribed genes
T21 921-950 cell_type denotes adult globin expressing cells
T22 996-1025 cell_type denotes fetal globin expressing cells
T23 1033-1056 DNA_domain_or_region denotes 3' regulatory sequences
T24 1131-1142 DNA_domain_or_region denotes 3' elements
T25 1146-1162 DNA_family_or_group denotes beta-globin gene
T26 1212-1236 other_name denotes protein-DNA interactions
T27 1281-1293 DNA_family_or_group denotes globin genes
T28 1361-1370 DNA_domain_or_region denotes GT motifs
T29 1378-1395 DNA_domain_or_region denotes beta-globin locus
T30 1396-1399 DNA_domain_or_region denotes LCR
T31 1423-1447 other_name denotes developmental regulation
T32 1451-1456 other_name denotes human
T33 1457-1473 DNA_domain_or_region denotes beta-globin gene
T34 1546-1549 DNA_domain_or_region denotes LCR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-22 Sentence denotes Globin gene switching.
S2 23-160 Sentence denotes In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.
S3 161-417 Sentence denotes To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.
S4 418-624 Sentence denotes In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.
S5 625-754 Sentence denotes In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.
S6 755-916 Sentence denotes In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.
S7 917-1174 Sentence denotes The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.
S8 1175-1602 Sentence denotes Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 31-55 NP denotes protein-DNA interactions
C3 59-86 NP denotes the human beta-globin locus
C5 117-159 NP denotes the fetal or the adult globin gene program
C7 90-159 NP denotes erythroid cells expressing the fetal or the adult globin gene program
C2 177-205 NP denotes the protein-DNA interactions
C4 249-276 NP denotes the human beta-globin locus
C6 358-416 NP denotes either the fetal or the adult globin developmental program
C8 331-416 NP denotes erythroid cells expressing either the fetal or the adult globin developmental program
C9 455-476 NP denotes the beta-globin locus
C18 574-609 NP denotes the fetal or the adult globin genes
C10 716-753 NP denotes the fetal or the adult globin program
C11 695-753 NP denotes the cells expressing the fetal or the adult globin program
C16 1146-1173 NP denotes beta-globin gene expression
C12 1212-1236 NP denotes protein-DNA interactions
C13 1200-1236 NP denotes the bulk of protein-DNA interactions
C14 1237-1241 NP denotes that
C15 1374-1399 NP denotes the beta-globin locus LCR
C17 1451-1484 NP denotes human beta-globin gene expression
C19 1567-1601 NP denotes the fetal or the adult globin gene
R1 C2 C1 coref-ident the protein-DNA interactions,protein-DNA interactions
R2 C4 C3 coref-ident the human beta-globin locus,the human beta-globin locus
R3 C6 C5 coref-ident either the fetal or the adult globin developmental program,the fetal or the adult globin gene program
R4 C8 C7 coref-ident erythroid cells expressing either the fetal or the adult globin developmental program,erythroid cells expressing the fetal or the adult globin gene program
R5 C9 C4 coref-ident the beta-globin locus,the human beta-globin locus
R6 C10 C6 coref-ident the fetal or the adult globin program,either the fetal or the adult globin developmental program
R7 C11 C8 coref-ident the cells expressing the fetal or the adult globin program,erythroid cells expressing either the fetal or the adult globin developmental program
R8 C12 C2 coref-ident protein-DNA interactions,the protein-DNA interactions
R9 C14 C13 coref-relat that,the bulk of protein-DNA interactions
R10 C15 C9 coref-ident the beta-globin locus LCR,the beta-globin locus
R11 C17 C16 coref-ident human beta-globin gene expression,beta-globin gene expression
R12 C19 C18 coref-ident the fetal or the adult globin gene,the fetal or the adult globin genes

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-68 OrganismTaxon denotes human 9606
T2 253-258 OrganismTaxon denotes human 9606
T3 1451-1456 OrganismTaxon denotes human 9606