> top > docs > PubMed:8662666 > annotations

PubMed:8662666 JSONTXT

Annnotations TAB JSON ListView MergeView

Test-Species-PubTator

Id Subject Object Predicate Lexical cue resolved_to
2 43-91 Gene denotes granulocyte-macrophage colony-stimulating factor 1437
3 111-116 Species denotes human 9606
30 126-174 Gene denotes Granulocyte-macrophage colony-stimulating factor 1437
31 176-182 Gene denotes GM-CSF 1437
32 313-319 Gene denotes GM-CSF 1437
33 394-400 Gene denotes GM-CSF 1437
34 466-482 Disease denotes myeloid leukemia MESH:D007951
35 487-507 Disease denotes chronic inflammation MESH:D007249
36 512-521 Gene denotes NF-kappaB 4790
37 550-556 Gene denotes GM-CSF 1437
38 731-746 Chemical denotes oligonucleotide MESH:D009841
39 842-848 Gene denotes GM-CSF 1437
40 879-894 Chemical denotes oligonucleotide MESH:D009841
41 945-951 Gene denotes GM-CSF 1437
42 1218-1227 Gene denotes NF-kappaB 4790
43 1252-1258 Gene denotes GM-CSF 1437
44 1268-1271 Chemical denotes GM3 -
45 1312-1317 Species denotes human 9606
46 1318-1346 Species denotes T-cell lymphotrophic virus-1
47 1434-1440 Gene denotes GM-CSF 1437
48 1453-1461 CellLine denotes Jurkat T CVCL:0065
49 1478-1481 Chemical denotes GM3 -
50 1530-1536 Gene denotes GM-CSF 1437
51 1574-1582 CellLine denotes Jurkat T CVCL:0065
52 1608-1621 Gene denotes interleukin 3 3562
53 1696-1702 Gene denotes GM-CSF 1437
54 1785-1791 Gene denotes GM-CSF 1437
55 1878-1884 Gene denotes GM-CSF 1437

Test-Species-PubDictionaries

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes human 9606
T2 1312-1317 OrganismTaxon denotes human 9606

Test-Species-PubDictionaries-PubMedBERT

Id Subject Object Predicate Lexical cue db_id
T1 4-11 Species denotes triplex 451987
T2 111-116 Species denotes human 9606
T3 356-362 Species denotes normal 2974449
T4 756-762 Species denotes triple 451987
T5 763-768 Species denotes helix 1407192
T6 1116-1123 Species denotes triplex 451987
T7 1161-1168 Species denotes Triplex 451987
T8 1272-1276 Species denotes also 209674
T9 1312-1317 Species denotes human 9606
T10 1318-1346 Species denotes T-cell lymphotrophic virus-1 194440
T11 1347-1350 Species denotes Tax 1369706
T12 1641-1645 Species denotes same 582003
T13 1807-1814 Species denotes triplex 451987

GlyCosmos15-Species-PubTator

Id Subject Object Predicate Lexical cue db_id
3 111-116 Species denotes human 9606
45 1312-1317 Species denotes human 9606
46 1318-1346 Species denotes T-cell lymphotrophic virus-1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 896-899 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 1075-1078 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 1182-1185 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 1268-1271 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 1478-1481 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
T2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
T3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
T4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
T5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
T6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
T7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
T8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
T9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
T10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
T11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
T12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.
T1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
T2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
T3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
T4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
T5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
T6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
T7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
T8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
T9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
T10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
T11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
T12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 896-899 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 896-899 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 1075-1078 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 1075-1078 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 1182-1185 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 1182-1185 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 1268-1271 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 1268-1271 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 1478-1481 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 1478-1481 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 952-960 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
T2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
T3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
T4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
T5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
T6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
T7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
T8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
T9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
T10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
T11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
T12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.
T1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
T2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
T3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
T4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
T5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
T6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
T7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
T8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
T9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
T10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
T11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
T12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 313-319 gene:1437 denotes GM-CSF
T1 466-482 disease:C0023470 denotes myeloid leukemia
T2 394-400 gene:1437 denotes GM-CSF
T3 466-482 disease:C0023470 denotes myeloid leukemia
R1 T0 T1 associated_with GM-CSF,myeloid leukemia
R2 T2 T3 associated_with GM-CSF,myeloid leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 43-96 DNA denotes granulocyte-macrophage colony-stimulating factor gene
T2 126-174 protein denotes Granulocyte-macrophage colony-stimulating factor
T3 176-182 protein denotes GM-CSF
T4 313-319 protein denotes GM-CSF
T5 512-521 protein denotes NF-kappaB
T6 550-565 DNA denotes GM-CSF promoter
T7 647-660 DNA denotes reporter gene
T8 706-713 cell_type denotes T cells
T9 791-810 DNA denotes regulatory sequence
T10 842-848 protein denotes GM-CSF
T11 919-937 DNA denotes purine-rich region
T12 945-969 DNA denotes GM-CSF proximal promoter
T13 990-1004 DNA denotes kappaB element
T14 1036-1043 protein denotes DNase I
T15 1133-1159 DNA denotes double-stranded DNA target
T16 1194-1236 protein denotes recombinant and nuclear NF-kappaB proteins
T17 1252-1266 DNA denotes GM-CSF element
T18 1312-1350 protein denotes human T-cell lymphotrophic virus-1 Tax
T19 1374-1384 protein denotes luciferase
T20 1434-1449 DNA denotes GM-CSF promoter
T21 1453-1467 cell_line denotes Jurkat T cells
T22 1530-1541 RNA denotes GM-CSF mRNA
T23 1574-1588 cell_line denotes Jurkat T cells
T24 1608-1626 RNA denotes interleukin 3 mRNA
T25 1674-1688 DNA denotes kappaB element
T26 1696-1711 DNA denotes GM-CSF promoter
T27 1785-1796 DNA denotes GM-CSF gene
T28 1878-1889 DNA denotes GM-CSF gene

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8662666-2#9#15#gene1437 313-319 gene1437 denotes GM-CSF
8662666-2#90#96#gene1437 394-400 gene1437 denotes GM-CSF
8662666-2#162#178#diseaseC0023470 466-482 diseaseC0023470 denotes myeloid leukemia
9#15#gene1437162#178#diseaseC0023470 8662666-2#9#15#gene1437 8662666-2#162#178#diseaseC0023470 associated_with GM-CSF,myeloid leukemia
90#96#gene1437162#178#diseaseC0023470 8662666-2#90#96#gene1437 8662666-2#162#178#diseaseC0023470 associated_with GM-CSF,myeloid leukemia

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 other_name denotes DNA triplex formation
T2 43-91 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T3 126-174 protein_molecule denotes Granulocyte-macrophage colony-stimulating factor
T4 176-182 protein_molecule denotes GM-CSF
T5 313-319 protein_molecule denotes GM-CSF
T6 512-521 protein_complex denotes NF-kappaB
T7 550-556 protein_molecule denotes GM-CSF
T8 647-660 DNA_family_or_group denotes reporter gene
T9 706-713 cell_type denotes T cells
T10 731-746 polynucleotide denotes oligonucleotide
T11 791-810 DNA_domain_or_region denotes regulatory sequence
T12 842-848 protein_molecule denotes GM-CSF
T13 871-894 polynucleotide denotes 15-base oligonucleotide
T14 896-899 polynucleotide denotes GM3
T15 919-937 DNA_domain_or_region denotes purine-rich region
T16 945-951 protein_molecule denotes GM-CSF
T17 990-1004 DNA_domain_or_region denotes kappaB element
T18 1006-1031 other_name denotes Gel mobility shift assays
T19 1036-1043 protein_molecule denotes DNase I
T20 1075-1078 polynucleotide denotes GM3
T21 1088-1123 DNA_substructure denotes sequence-specific collinear triplex
T22 1133-1159 DNA_domain_or_region denotes double-stranded DNA target
T23 1161-1178 other_name denotes Triplex formation
T24 1182-1185 polynucleotide denotes GM3
T25 1252-1258 protein_molecule denotes GM-CSF
T26 1268-1271 polynucleotide denotes GM3
T27 1312-1346 virus denotes human T-cell lymphotrophic virus-1
T28 1374-1384 protein_molecule denotes luciferase
T29 1434-1440 protein_molecule denotes GM-CSF
T30 1453-1467 cell_line denotes Jurkat T cells
T31 1478-1481 polynucleotide denotes GM3
T32 1530-1536 protein_molecule denotes GM-CSF
T33 1574-1588 cell_line denotes Jurkat T cells
T34 1608-1621 protein_molecule denotes interleukin 3
T35 1674-1688 DNA_domain_or_region denotes kappaB element
T36 1696-1702 protein_molecule denotes GM-CSF
T37 1740-1766 other_name denotes transcriptional activation
T38 1785-1791 protein_molecule denotes GM-CSF
T39 1798-1824 other_name denotes Colinear triplex formation
T40 1845-1870 other_name denotes transcriptional repressor
T41 1878-1884 protein_molecule denotes GM-CSF

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
S2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
S3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
S4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
S5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
S6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
S7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
S8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
S9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
S10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
S11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
S12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C7 111-124 NP denotes human T cells
C1 126-183 NP denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF)
C2 187-214 NP denotes a hemopoietic growth factor
C3 215-219 NP denotes that
C4 313-319 NP denotes GM-CSF
C5 394-400 NP denotes GM-CSF
C6 546-565 NP denotes the GM-CSF promoter
C13 574-592 NP denotes the kappaB element
C8 706-713 NP denotes T cells
C9 869-894 NP denotes A 15-base oligonucleotide
C10 896-899 NP denotes GM3
C11 941-969 NP denotes the GM-CSF proximal promoter
C12 971-976 NP denotes which
C14 986-1004 NP denotes the kappaB element
C15 1075-1078 NP denotes GM3
C16 1129-1132 NP denotes its
C17 1182-1185 NP denotes GM3
C18 1248-1266 NP denotes the GM-CSF element
C19 1268-1271 NP denotes GM3
C20 1430-1449 NP denotes the GM-CSF promoter
C22 1453-1467 NP denotes Jurkat T cells
C21 1478-1481 NP denotes GM3
C23 1574-1588 NP denotes Jurkat T cells
C24 1637-1651 NP denotes the same cells
C25 1692-1711 NP denotes the GM-CSF promoter
C26 1670-1711 NP denotes the kappaB element in the GM-CSF promoter
C27 1979-1991 NP denotes this protein
R1 C3 C2 coref-relat that,a hemopoietic growth factor
R2 C4 C1 coref-ident GM-CSF,Granulocyte-macrophage colony-stimulating factor (GM-CSF)
R3 C5 C4 coref-ident GM-CSF,GM-CSF
R4 C13 C6 coref-ident the kappaB element,the GM-CSF promoter
R5 C8 C7 coref-ident T cells,human T cells
R6 C10 C9 coref-appos GM3,A 15-base oligonucleotide
R7 C11 C6 coref-other the GM-CSF proximal promoter,the GM-CSF promoter
R8 C12 C11 coref-relat which,the GM-CSF proximal promoter
R9 C14 C13 coref-ident the kappaB element,the kappaB element
R10 C15 C10 coref-ident GM3,GM3
R11 C16 C15 coref-pron its,GM3
R12 C17 C15 coref-ident GM3,GM3
R13 C18 C11 coref-ident the GM-CSF element,the GM-CSF proximal promoter
R14 C19 C17 coref-ident GM3,GM3
R15 C20 C6 coref-ident the GM-CSF promoter,the GM-CSF promoter
R16 C21 C19 coref-ident GM3,GM3
R17 C23 C22 coref-ident Jurkat T cells,Jurkat T cells
R18 C24 C23 coref-ident the same cells,Jurkat T cells
R19 C25 C20 coref-ident the GM-CSF promoter,the GM-CSF promoter
R20 C26 C13 coref-ident the kappaB element in the GM-CSF promoter,the kappaB element
R21 C27 C5 coref-ident this protein,GM-CSF

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 896-899 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 1075-1078 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 1182-1185 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 1268-1271 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1478-1481 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 952-960 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 466-482 Phenotype denotes myeloid leukemia HP:0012324

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 466-494 Disease denotes myeloid leukemia and chronic http://purl.obolibrary.org/obo/MONDO_0011996
T2 495-507 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 896-899 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 1075-1078 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 1182-1185 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 1268-1271 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1478-1481 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 466-482 Phenotype denotes myeloid leukemia HP:0012324

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes human 9606
T2 1312-1317 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 43-54 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T2 55-65 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 117-124 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 126-137 Cell denotes Granulocyte http://purl.obolibrary.org/obo/CL:0000094
T6 138-148 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 246-253 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T9 255-266 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T10 268-279 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T12 285-302 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T13 706-713 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T14 1318-1324 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T15 1460-1467 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T16 1581-1588 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 43-54 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T2 55-65 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 126-137 Body_part denotes Granulocyte http://purl.obolibrary.org/obo/CL_0000094
T4 138-148 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 255-266 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T6 268-279 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 285-302 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T8 763-768 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T9 1318-1324 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
T2 126-303 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
T3 304-508 Sentence denotes Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
T4 509-714 Sentence denotes An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
T5 715-868 Sentence denotes We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
T6 869-1005 Sentence denotes A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
T7 1006-1160 Sentence denotes Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
T8 1161-1267 Sentence denotes Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
T9 1268-1468 Sentence denotes GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
T10 1469-1652 Sentence denotes Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
T11 1653-1797 Sentence denotes We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
T12 1798-1992 Sentence denotes Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 466-494 Disease denotes myeloid leukemia and chronic MONDO:0011996

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 43-54 Body_part denotes granulocyte FMA:62854
T2 55-65 Body_part denotes macrophage FMA:63261
T3 126-137 Body_part denotes Granulocyte FMA:62854
T4 138-148 Body_part denotes macrophage FMA:63261
T5 255-266 Body_part denotes fibroblasts FMA:63877
T6 268-279 Body_part denotes macrophages FMA:63261
T7 285-302 Body_part denotes endothelial cells FMA:66772
T8 763-768 Body_part denotes helix FMA:60992

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 952-960 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes human 9606
T2 1312-1317 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 43-54 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T2 55-65 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 126-137 Body_part denotes Granulocyte http://purl.obolibrary.org/obo/CL_0000094
T4 138-148 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 255-266 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T6 268-279 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 285-302 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T8 763-768 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T9 1318-1324 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 43-54 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T2 55-65 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 117-124 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 126-137 Cell denotes Granulocyte http://purl.obolibrary.org/obo/CL:0000094
T6 138-148 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 246-253 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T9 255-266 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T10 268-279 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T12 285-302 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T13 706-713 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T14 1318-1324 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T15 1460-1467 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T16 1581-1588 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084