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PubMed:8662595 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists.
T2 112-345 Sentence denotes Residues in human leukemia inhibitory factor (hLIF) crucial for binding to both the human LIF receptor (R) and gp130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity.
T3 346-517 Sentence denotes The region of hLIF most important for binding to the hLIF-R is composed of residues from the amino terminus of the D-helix, carboxyl terminus of the B-helix, and C-D loop.
T4 518-649 Sentence denotes This site forms a distinct surface at the end of the four-helix bundle in the tertiary structure of the closely related murine LIF.
T5 650-826 Sentence denotes The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.
T6 827-988 Sentence denotes This arrangement of a few key residues surrounded by less important ones is analogous to the functional binding epitope of human growth hormone for its receptor.
T7 989-1135 Sentence denotes A second region of hLIF that includes residues from the carboxyl terminus of the D-helix and A-B loop also had a weak influence on hLIF-R binding.
T8 1136-1230 Sentence denotes Residues in hLIF from both the A- and C-helices are involved in binding the gp130 co-receptor.
T9 1231-1309 Sentence denotes Abolition of the gp130 binding site in hLIF created antagonists of LIF action.
T1 0-111 Sentence denotes Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists.
T2 112-345 Sentence denotes Residues in human leukemia inhibitory factor (hLIF) crucial for binding to both the human LIF receptor (R) and gp130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity.
T3 346-517 Sentence denotes The region of hLIF most important for binding to the hLIF-R is composed of residues from the amino terminus of the D-helix, carboxyl terminus of the B-helix, and C-D loop.
T4 518-649 Sentence denotes This site forms a distinct surface at the end of the four-helix bundle in the tertiary structure of the closely related murine LIF.
T5 650-826 Sentence denotes The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.
T6 827-988 Sentence denotes This arrangement of a few key residues surrounded by less important ones is analogous to the functional binding epitope of human growth hormone for its receptor.
T7 989-1135 Sentence denotes A second region of hLIF that includes residues from the carboxyl terminus of the D-helix and A-B loop also had a weak influence on hLIF-R binding.
T8 1136-1230 Sentence denotes Residues in hLIF from both the A- and C-helices are involved in binding the gp130 co-receptor.
T9 1231-1309 Sentence denotes Abolition of the gp130 binding site in hLIF created antagonists of LIF action.

AIMed

Id Subject Object Predicate Lexical cue
T1 56-82 protein denotes leukemia inhibitory factor
T2 130-156 protein denotes leukemia inhibitory factor
T3 158-162 protein denotes hLIF
T4 202-214 protein denotes LIF receptor
T5 223-228 protein denotes gp130
T6 288-292 protein denotes hLIF
T7 360-364 protein denotes hLIF
T8 399-405 protein denotes hLIF-R
T9 645-648 protein denotes LIF
T10 670-674 protein denotes hLIF
T11 723-729 protein denotes hLIF-R
T12 950-970 protein denotes human growth hormone
T13 1008-1012 protein denotes hLIF
T14 1120-1126 protein denotes hLIF-R
T15 1148-1152 protein denotes hLIF
T16 1212-1217 protein denotes gp130
T17 1248-1253 protein denotes gp130
T18 1270-1274 protein denotes hLIF
T19 1298-1301 protein denotes LIF

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-64 Phenotype denotes leukemia HP:0001909
T2 130-138 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 56-64 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T2 130-138 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 50-55 OrganismTaxon denotes human 9606
T2 124-129 OrganismTaxon denotes human 9606
T3 196-201 OrganismTaxon denotes human 9606
T4 950-955 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 463-468 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T2 497-502 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 576-581 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T4 1072-1077 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488