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c_corpus

Id Subject Object Predicate Lexical cue
T1 10-19 GO:0097194 denotes apoptosis
T2 10-19 GO:0006915 denotes apoptosis
T5 23-47 D002285 denotes ductal carcinoma in situ
T6 23-47 D002285 denotes ductal carcinoma in situ
T11 55-61 UBERON:0000310 denotes breast
T12 92-98 UBERON:0000310 denotes breast
T13 99-116 D044584 denotes ductal carcinomas
T14 99-116 D044584 denotes ductal carcinomas
T18 126-130 CVCL_5552 denotes DCIS
T17 126-130 D002285 denotes DCIS
T19 126-130 D002285 denotes DCIS
T20 163-171 GO:0019835 denotes necrosis
T21 163-171 GO:0008219 denotes necrosis
T24 163-171 GO:0008220 denotes necrosis
T25 163-171 GO:0001906 denotes necrosis
T26 163-171 GO:0070265 denotes necrosis
T22 163-171 D009336 denotes necrosis
T23 163-171 D009336 denotes necrosis
T27 220-230 D012008 denotes recurrence
T28 220-230 D012008 denotes recurrence
T29 259-265 UBERON:0000310 denotes breast
T30 259-272 D001943 denotes breast cancer
T31 259-272 D001943 denotes breast cancer
T32 333-343 GO:0008219 denotes cell death
T33 353-362 GO:0097194 denotes apoptosis
T34 353-362 GO:0006915 denotes apoptosis
T35 394-401 CHEBI:34922 denotes pathway
T36 465-483 GO:0008283 denotes cell proliferation
T37 470-483 UBERON:2000098 denotes proliferation
T39 516-520 CVCL_5552 denotes DCIS
T38 516-520 D002285 denotes DCIS
T40 516-520 D002285 denotes DCIS
T41 608-617 GO:0097194 denotes apoptosis
T42 608-617 GO:0006915 denotes apoptosis
T43 733-737 PR:Q9V853 denotes lack
T45 774-794 O02789 denotes terminal transferase
T46 774-794 P42118 denotes terminal transferase
T47 774-794 A4PCD4 denotes terminal transferase
T48 774-794 Q9NP87 denotes terminal transferase
T49 774-794 P06526 denotes terminal transferase
T50 774-794 Q92089 denotes terminal transferase
T51 774-794 P36195 denotes terminal transferase
T52 774-794 P09838 denotes terminal transferase
T53 774-794 PR:000006611 denotes terminal transferase
T54 774-794 Q9JIW4 denotes terminal transferase
T55 774-794 P04053 denotes terminal transferase
T56 774-794 O57486 denotes terminal transferase
T57 783-794 D014166 denotes transferase
T58 815-818 GO:0005574 denotes DNA
T60 815-818 SO:0000352 denotes DNA
T59 815-818 CHEBI:16991 denotes DNA
T61 815-818 D004247 denotes DNA
T62 815-832 GO:0006309 denotes DNA fragmentation
T63 883-892 GO:0097194 denotes apoptosis
T64 883-892 GO:0006915 denotes apoptosis
T65 962-971 SO:0000817 denotes wild-type
T66 972-975 PR:P04637 denotes p53
T67 972-975 PR:000003035 denotes p53
T68 972-975 PR:P02340 denotes p53
T69 972-975 PR:Q42578 denotes p53
T70 972-975 PR:P10361 denotes p53
T71 992-1001 GO:0097194 denotes apoptosis
T72 992-1001 GO:0006915 denotes apoptosis
T73 1028-1038 GO:0008219 denotes cell death
T74 1082-1090 GO:0019835 denotes necrosis
T75 1082-1090 GO:0008219 denotes necrosis
T78 1082-1090 GO:0008220 denotes necrosis
T79 1082-1090 GO:0001906 denotes necrosis
T80 1082-1090 GO:0070265 denotes necrosis
T76 1082-1090 D009336 denotes necrosis
T77 1082-1090 D009336 denotes necrosis
T81 1199-1207 GO:0019835 denotes necrosis
T82 1199-1207 GO:0008219 denotes necrosis
T85 1199-1207 GO:0008220 denotes necrosis
T86 1199-1207 GO:0001906 denotes necrosis
T87 1199-1207 GO:0070265 denotes necrosis
T83 1199-1207 D009336 denotes necrosis
T84 1199-1207 D009336 denotes necrosis
T89 1332-1336 CVCL_5552 denotes DCIS
T88 1332-1336 D002285 denotes DCIS
T90 1332-1336 D002285 denotes DCIS
T91 1363-1371 GO:0019835 denotes necrosis
T92 1363-1371 GO:0008219 denotes necrosis
T95 1363-1371 GO:0008220 denotes necrosis
T96 1363-1371 GO:0001906 denotes necrosis
T97 1363-1371 GO:0070265 denotes necrosis
T93 1363-1371 D009336 denotes necrosis
T94 1363-1371 D009336 denotes necrosis
T98 1422-1431 GO:0097194 denotes apoptosis
T99 1422-1431 GO:0006915 denotes apoptosis
T100 1451-1454 PR:P04637 denotes p53
T101 1451-1454 PR:000003035 denotes p53
T102 1451-1454 PR:P02340 denotes p53
T103 1451-1454 PR:Q42578 denotes p53
T104 1451-1454 PR:P10361 denotes p53
T105 1509-1517 GO:0019835 denotes necrosis
T106 1509-1517 GO:0008219 denotes necrosis
T109 1509-1517 GO:0008220 denotes necrosis
T110 1509-1517 GO:0001906 denotes necrosis
T111 1509-1517 GO:0070265 denotes necrosis
T107 1509-1517 D009336 denotes necrosis
T108 1509-1517 D009336 denotes necrosis
T113 1521-1525 CVCL_5552 denotes DCIS
T112 1521-1525 D002285 denotes DCIS
T114 1521-1525 D002285 denotes DCIS
T115 1549-1558 GO:0097194 denotes apoptosis
T116 1549-1558 GO:0006915 denotes apoptosis
T117 1594-1603 GO:0097194 denotes apoptosis
T118 1594-1603 GO:0006915 denotes apoptosis
T119 1607-1616 SO:0000119 denotes regulated
T120 1620-1623 PR:P04637 denotes p53
T121 1620-1623 PR:000003035 denotes p53
T122 1620-1623 PR:P02340 denotes p53
T123 1620-1623 PR:Q42578 denotes p53
T124 1620-1623 PR:P10361 denotes p53
T125 1649-1658 GO:0097194 denotes apoptosis
T126 1649-1658 GO:0006915 denotes apoptosis
T128 1703-1707 CVCL_5552 denotes DCIS
T127 1703-1707 D002285 denotes DCIS
T129 1703-1707 D002285 denotes DCIS
T130 1756-1766 GO:0008219 denotes cell death
T132 1770-1774 CVCL_5552 denotes DCIS
T131 1770-1774 D002285 denotes DCIS
T133 1770-1774 D002285 denotes DCIS

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T2 63-74 Sentence denotes BACKGROUND:
T3 75-273 Sentence denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T4 274-484 Sentence denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T5 485-493 Sentence denotes METHODS:
T6 494-893 Sentence denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T7 894-1039 Sentence denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T8 1040-1048 Sentence denotes RESULTS:
T9 1049-1279 Sentence denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis." Additionally, the identical regions were all strongly TUNEL-positive.
T10 1280-1372 Sentence denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T11 1373-1473 Sentence denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T12 1474-1486 Sentence denotes CONCLUSIONS:
T13 1487-1559 Sentence denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T14 1560-1624 Sentence denotes However, it is unlikely that this apoptosis is regulated by p53.
T15 1625-1812 Sentence denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.
T1 0-62 Sentence denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T2 63-74 Sentence denotes BACKGROUND:
T3 75-273 Sentence denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T4 274-484 Sentence denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T5 485-493 Sentence denotes METHODS:
T6 494-893 Sentence denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T7 894-1039 Sentence denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T8 1040-1048 Sentence denotes RESULTS:
T9 1049-1279 Sentence denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis." Additionally, the identical regions were all strongly TUNEL-positive.
T10 1280-1372 Sentence denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T11 1373-1473 Sentence denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T12 1474-1486 Sentence denotes CONCLUSIONS:
T13 1487-1559 Sentence denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T14 1560-1624 Sentence denotes However, it is unlikely that this apoptosis is regulated by p53.
T15 1625-1812 Sentence denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-62 DRI_Background denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T2 75-273 DRI_Background denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T3 274-484 DRI_Approach denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T4 494-893 DRI_Background denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T5 894-1039 DRI_Approach denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T6 1049-1209 DRI_Outcome denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis."
T7 1210-1279 DRI_Approach denotes Additionally, the identical regions were all strongly TUNEL-positive.
T8 1280-1372 DRI_Outcome denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T9 1373-1473 DRI_Background denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T10 1487-1559 DRI_Background denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T11 1560-1624 DRI_Approach denotes However, it is unlikely that this apoptosis is regulated by p53.
T12 1625-1812 DRI_Background denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.