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PubMed:8634413 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1510-1514 gene:6646 denotes STAT
T1 1551-1565 disease:C0598766 denotes leukemogenesis
R1 T0 T1 associated_with STAT,leukemogenesis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-34 protein denotes transcription factors
T2 67-89 cell_type denotes peripheral blood cells
T3 168-177 protein denotes cytokines
T4 212-223 protein denotes JAK kinases
T5 232-297 protein denotes signal transducers and activators of transcription (STAT) factors
T6 411-423 protein denotes STAT factors
T7 427-449 cell_type denotes peripheral blood cells
T8 525-561 DNA denotes beta-casein and IRF-1 gene promoters
T9 591-604 protein denotes STAT proteins
T10 630-650 cell_type denotes acute leukemia cells
T11 685-700 protein denotes protein complex
T12 765-785 DNA denotes IRF-1 gene promoters
T13 1057-1067 protein denotes antibodies
T14 1100-1113 protein denotes STAT proteins
T15 1151-1183 protein denotes STAT5- and STAT1-related factors
T16 1209-1251 protein denotes STAT1-, STAT3-, and STAT5-related proteins
T17 1338-1347 protein denotes cytokines
T18 1359-1375 protein denotes nuclear proteins
T19 1510-1523 protein denotes STAT proteins

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8634413-10#49#53#gene6646 1510-1514 gene6646 denotes STAT
8634413-10#90#104#diseaseC0598766 1551-1565 diseaseC0598766 denotes leukemogenesis
8634413-4#40#51#gene1447 525-536 gene1447 denotes beta-casein
8634413-4#56#61#gene3659 541-546 gene3659 denotes IRF-1
8634413-4#106#110#gene6646 591-595 gene6646 denotes STAT
8634413-4#145#159#diseaseC0085669 630-644 diseaseC0085669 denotes acute leukemia
8634413-5#77#88#gene1447 749-760 gene1447 denotes beta-casein
8634413-5#93#98#gene3659 765-770 gene3659 denotes IRF-1
8634413-5#184#212#diseaseC0023449 856-884 diseaseC0023449 denotes acute lymphoblastic leukemia
8634413-5#223#245#diseaseC0023467 895-917 diseaseC0023467 denotes acute myeloid leukemia
8634413-5#184#212#diseaseC0023449 856-884 diseaseC0023449 denotes acute lymphoblastic leukemia
8634413-5#223#245#diseaseC0023467 895-917 diseaseC0023467 denotes acute myeloid leukemia
8634413-5#247#250#diseaseC0023467 919-922 diseaseC0023467 denotes AML
8634413-8#11#16#gene6772 1162-1167 gene6772 denotes STAT1
8634413-8#58#63#gene6772 1209-1214 gene6772 denotes STAT1
8634413-8#50#53#diseaseC0023449 1201-1204 diseaseC0023449 denotes ALL
49#53#gene664690#104#diseaseC0598766 8634413-10#49#53#gene6646 8634413-10#90#104#diseaseC0598766 associated_with STAT,leukemogenesis
40#51#gene1447145#159#diseaseC0085669 8634413-4#40#51#gene1447 8634413-4#145#159#diseaseC0085669 associated_with beta-casein,acute leukemia
56#61#gene3659145#159#diseaseC0085669 8634413-4#56#61#gene3659 8634413-4#145#159#diseaseC0085669 associated_with IRF-1,acute leukemia
106#110#gene6646145#159#diseaseC0085669 8634413-4#106#110#gene6646 8634413-4#145#159#diseaseC0085669 associated_with STAT,acute leukemia
77#88#gene1447184#212#diseaseC0023449 8634413-5#77#88#gene1447 8634413-5#184#212#diseaseC0023449 associated_with beta-casein,acute lymphoblastic leukemia
77#88#gene1447223#245#diseaseC0023467 8634413-5#77#88#gene1447 8634413-5#223#245#diseaseC0023467 associated_with beta-casein,acute myeloid leukemia
77#88#gene1447184#212#diseaseC0023449 8634413-5#77#88#gene1447 8634413-5#184#212#diseaseC0023449 associated_with beta-casein,acute lymphoblastic leukemia
77#88#gene1447223#245#diseaseC0023467 8634413-5#77#88#gene1447 8634413-5#223#245#diseaseC0023467 associated_with beta-casein,acute myeloid leukemia
77#88#gene1447247#250#diseaseC0023467 8634413-5#77#88#gene1447 8634413-5#247#250#diseaseC0023467 associated_with beta-casein,AML
93#98#gene3659184#212#diseaseC0023449 8634413-5#93#98#gene3659 8634413-5#184#212#diseaseC0023449 associated_with IRF-1,acute lymphoblastic leukemia
93#98#gene3659223#245#diseaseC0023467 8634413-5#93#98#gene3659 8634413-5#223#245#diseaseC0023467 associated_with IRF-1,acute myeloid leukemia
93#98#gene3659184#212#diseaseC0023449 8634413-5#93#98#gene3659 8634413-5#184#212#diseaseC0023449 associated_with IRF-1,acute lymphoblastic leukemia
93#98#gene3659223#245#diseaseC0023467 8634413-5#93#98#gene3659 8634413-5#223#245#diseaseC0023467 associated_with IRF-1,acute myeloid leukemia
93#98#gene3659247#250#diseaseC0023467 8634413-5#93#98#gene3659 8634413-5#247#250#diseaseC0023467 associated_with IRF-1,AML
11#16#gene677250#53#diseaseC0023449 8634413-8#11#16#gene6772 8634413-8#50#53#diseaseC0023449 associated_with STAT1,ALL
58#63#gene677250#53#diseaseC0023449 8634413-8#58#63#gene6772 8634413-8#50#53#diseaseC0023449 associated_with STAT1,ALL

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-119 Sentence denotes STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.
S2 120-207 Sentence denotes A signal transduction pathway activated by many cytokines has recently been elaborated.
S3 208-341 Sentence denotes The JAK kinases and the signal transducers and activators of transcription (STAT) factors have been found to be essential components.
S4 342-484 Sentence denotes In this report, we describe the presence of constitutively activated STAT factors in peripheral blood cells from patients with acute leukemia.
S5 485-671 Sentence denotes We used oligonucleotide probes from the beta-casein and IRF-1 gene promoters and the ISRE probe to detect STAT proteins in nuclear extracts from acute leukemia cells in bandshift assays.
S6 672-942 Sentence denotes Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated.
S7 943-1047 Sentence denotes We used nonradioactive oligonucleotides as competitors to show the specificity of the complex formation.
S8 1048-1150 Sentence denotes Specific antibodies directed against the individual STAT proteins were used in supershift experiments.
S9 1151-1299 Sentence denotes STAT5- and STAT1-related factors were detected in ALL and STAT1-, STAT3-, and STAT5-related proteins were present in nuclear cell extracts from AML.
S10 1300-1460 Sentence denotes Since the cells were not treated with cytokines before the nuclear proteins were extracted, we conclude that these factors are constitutively activated in vivo.
S11 1461-1566 Sentence denotes It is likely that the constitutive activation of STAT proteins is a part of the events of leukemogenesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes STAT-
C3 95-118 NP denotes acute leukemia patients
C2 67-118 NP denotes peripheral blood cells from acute leukemia patients
C4 228-297 NP denotes the signal transducers and activators of transcription (STAT) factors
C6 455-483 NP denotes patients with acute leukemia
C5 427-483 NP denotes peripheral blood cells from patients with acute leukemia
C8 521-561 NP denotes the beta-casein and IRF-1 gene promoters
C7 493-561 NP denotes oligonucleotide probes from the beta-casein and IRF-1 gene promoters
C10 745-785 NP denotes the beta-casein and IRF-1 gene promoters
C9 729-785 NP denotes the probes from the beta-casein and IRF-1 gene promoters
C11 856-890 NP denotes acute lymphoblastic leukemia (ALL)
C12 895-923 NP denotes acute myeloid leukemia (AML)
C14 1151-1157 NP denotes STAT5-
C15 1162-1168 NP denotes STAT1-
C13 1151-1183 NP denotes STAT5- and STAT1-related factors
C16 1201-1204 NP denotes ALL
C18 1209-1215 NP denotes STAT1-
C19 1229-1235 NP denotes STAT5-
C17 1209-1251 NP denotes STAT1-, STAT3-, and STAT5-related proteins
C20 1295-1298 NP denotes AML
C21 1409-1422 NP denotes these factors
C22 1510-1523 NP denotes STAT proteins
R1 C4 C1 coref-ident the signal transducers and activators of transcription (STAT) factors,STAT-
R2 C5 C2 coref-ident peripheral blood cells from patients with acute leukemia,peripheral blood cells from acute leukemia patients
R3 C10 C8 coref-ident the beta-casein and IRF-1 gene promoters,the beta-casein and IRF-1 gene promoters
R4 C9 C7 coref-ident the probes from the beta-casein and IRF-1 gene promoters,oligonucleotide probes from the beta-casein and IRF-1 gene promoters
R5 C16 C11 coref-ident ALL,acute lymphoblastic leukemia (ALL)
R6 C19 C13 coref-ident STAT5-,STAT5- and STAT1-related factors
R7 C17 C15 coref-ident "STAT1-, STAT3-, and STAT5-related proteins",STAT1-
R8 C20 C12 coref-ident AML,acute myeloid leukemia (AML)
R9 C21 C14 coref-ident these factors,STAT5-
R10 C22 C18 coref-ident STAT proteins,STAT1-

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-34 protein_family_or_group denotes transcription factors
T2 67-89 cell_type denotes peripheral blood cells
T3 95-118 multi_cell denotes acute leukemia patients
T4 122-149 other_name denotes signal transduction pathway
T5 168-177 protein_family_or_group denotes cytokines
T6 212-223 protein_family_or_group denotes JAK kinases
T7 232-297 protein_family_or_group denotes signal transducers and activators of transcription (STAT) factors
T8 411-423 protein_family_or_group denotes STAT factors
T9 427-449 cell_type denotes peripheral blood cells
T10 455-463 multi_cell denotes patients
T11 469-483 other_name denotes acute leukemia
T12 493-515 polynucleotide denotes oligonucleotide probes
T13 570-580 polynucleotide denotes ISRE probe
T14 591-604 protein_family_or_group denotes STAT proteins
T15 608-624 cell_component denotes nuclear extracts
T16 630-644 other_name denotes acute leukemia
T17 654-670 other_name denotes bandshift assays
T18 681-684 other_name denotes DNA
T19 685-700 protein_complex denotes protein complex
T20 765-785 DNA_domain_or_region denotes IRF-1 gene promoters
T21 804-830 polynucleotide denotes ISRE oligonucleotide probe
T22 837-850 other_name denotes cell extracts
T23 856-884 other_name denotes acute lymphoblastic leukemia
T24 886-889 other_name denotes ALL
T25 895-917 other_name denotes acute myeloid leukemia
T26 919-922 other_name denotes AML
T27 951-982 polynucleotide denotes nonradioactive oligonucleotides
T28 1029-1046 other_name denotes complex formation
T29 1057-1067 protein_family_or_group denotes antibodies
T30 1100-1113 protein_family_or_group denotes STAT proteins
T31 1127-1149 other_name denotes supershift experiments
T32 1201-1204 other_name denotes ALL
T33 1268-1289 cell_component denotes nuclear cell extracts
T34 1295-1298 other_name denotes AML
T35 1338-1347 protein_family_or_group denotes cytokines
T36 1359-1375 protein_family_or_group denotes nuclear proteins
T37 1452-1459 other_name denotes in vivo
T38 1510-1523 protein_family_or_group denotes STAT proteins
T39 1551-1565 other_name denotes leukemogenesis