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PubMed:8632999 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
T2 102-241 Sentence denotes Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
T3 242-510 Sentence denotes Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.
T4 511-601 Sentence denotes A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.
T5 602-619 Sentence denotes R., Tortolani, A.
T6 620-647 Sentence denotes J., Cerami, A. & Tracey, K.
T7 648-662 Sentence denotes J. (1995) Mol.
T8 663-667 Sentence denotes Med.
T9 668-728 Sentence denotes 1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P.
T10 729-850 Sentence denotes S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A. & Tracey, J. (1996) J.
T11 851-855 Sentence denotes Exp.
T12 856-872 Sentence denotes Med., in press].
T13 873-1039 Sentence denotes We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
T14 1040-1372 Sentence denotes CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
T15 1373-1463 Sentence denotes However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
T16 1464-1690 Sentence denotes Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
T17 1691-1817 Sentence denotes Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
T18 1818-2004 Sentence denotes Identification of the molecular target through which CNI-1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.
T1 0-101 Sentence denotes CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
T2 102-241 Sentence denotes Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
T3 242-510 Sentence denotes Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.
T4 511-601 Sentence denotes A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.
T5 602-619 Sentence denotes R., Tortolani, A.
T6 620-647 Sentence denotes J., Cerami, A. & Tracey, K.
T7 648-662 Sentence denotes J. (1995) Mol.
T8 663-667 Sentence denotes Med.
T9 668-728 Sentence denotes 1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P.
T10 729-850 Sentence denotes S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A. & Tracey, J. (1996) J.
T11 851-855 Sentence denotes Exp.
T12 856-872 Sentence denotes Med., in press].
T13 873-1039 Sentence denotes We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
T14 1040-1372 Sentence denotes CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
T15 1373-1463 Sentence denotes However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
T16 1464-1690 Sentence denotes Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
T17 1691-1817 Sentence denotes Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
T18 1818-2004 Sentence denotes Identification of the molecular target through which CNI-1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-59 protein denotes monocyte/macrophage tumor necrosis factor
T2 102-123 protein denotes Tumor necrosis factor
T3 125-128 protein denotes TNF
T4 366-369 protein denotes TNF
T5 948-951 protein denotes TNF
T6 1012-1015 protein denotes TNF
T7 1133-1141 RNA denotes TNF mRNA
T8 1167-1192 protein denotes nuclear factor NF-kappa B
T9 1211-1222 cell_type denotes macrophages
T10 1318-1328 protein denotes NF-kappa B
T11 1368-1371 protein denotes TNF
T12 1399-1419 protein denotes 26-kDa membrane form
T13 1423-1426 protein denotes TNF
T14 1518-1521 protein denotes TNF
T15 1552-1603 DNA denotes chloram-phenicol acetyltransferase (CAT) constructs
T16 1631-1639 DNA denotes TNF gene
T17 1661-1664 protein denotes TNF
T18 1700-1730 DNA denotes 5' and 3' untranslated regions
T19 1738-1746 DNA denotes TNF gene
T20 1889-1892 protein denotes TNF

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-101 Sentence denotes CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
S2 102-241 Sentence denotes Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
S3 242-872 Sentence denotes Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G. A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K. R., Tortolani, A. J., Cerami, A. & Tracey, K. J. (1995) Mol. Med. 1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P. S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A. & Tracey, J. (1996) J. Exp. Med., in press].
S4 873-1039 Sentence denotes We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
S5 1040-1372 Sentence denotes CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
S6 1373-1463 Sentence denotes However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
S7 1464-1690 Sentence denotes Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
S8 1691-1817 Sentence denotes Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
S9 1818-2004 Sentence denotes Identification of the molecular target through which CNI-1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-8 NP denotes CNI-1493
C2 102-129 NP denotes Tumor necrosis factor (TNF)
C3 252-292 NP denotes a multivalent guanylhydrazone (CNI-1493)
C5 896-909 NP denotes the mechanism
C6 913-918 NP denotes which
C7 919-927 NP denotes CNI-1493
C4 896-961 NP denotes the mechanism by which CNI-1493 inhibits macrophage TNF synthesis
C8 981-983 NP denotes it
C9 1040-1048 NP denotes CNI-1493
C10 1279-1287 NP denotes CNI-1493
C11 1368-1371 NP denotes TNF
C12 1423-1426 NP denotes TNF
C13 1454-1462 NP denotes CNI-1493
C14 1518-1521 NP denotes TNF
C15 1627-1639 NP denotes the TNF gene
C16 1640-1644 NP denotes that
C17 1734-1746 NP denotes the TNF gene
C18 1808-1816 NP denotes CNI-1493
C19 1836-1856 NP denotes the molecular target
C20 1865-1870 NP denotes which
C21 1871-1879 NP denotes CNI-1493
R1 C3 C1 coref-ident a multivalent guanylhydrazone (CNI-1493),CNI-1493
R2 C6 C4 coref-relat which,the mechanism by which CNI-1493 inhibits macrophage TNF synthesis
R3 C7 C3 coref-ident CNI-1493,a multivalent guanylhydrazone (CNI-1493)
R4 C8 C5 coref-pron it,the mechanism
R5 C9 C7 coref-ident CNI-1493,CNI-1493
R6 C10 C9 coref-ident CNI-1493,CNI-1493
R7 C11 C2 coref-ident TNF,Tumor necrosis factor (TNF)
R8 C12 C11 coref-ident TNF,TNF
R9 C13 C10 coref-ident CNI-1493,CNI-1493
R10 C14 C12 coref-ident TNF,TNF
R11 C16 C15 coref-relat that,the TNF gene
R12 C17 C15 coref-ident the TNF gene,the TNF gene
R13 C18 C13 coref-ident CNI-1493,CNI-1493
R14 C20 C19 coref-ident which,the molecular target
R15 C21 C18 coref-ident CNI-1493,CNI-1493

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-8 other_organic_compound denotes CNI-1493
T2 18-59 protein_family_or_group denotes monocyte/macrophage tumor necrosis factor
T3 78-100 other_name denotes translation efficiency
T4 102-123 protein_family_or_group denotes Tumor necrosis factor
T5 125-128 protein_family_or_group denotes TNF
T6 182-194 other_name denotes septic shock
T7 232-240 other_name denotes cachexia
T8 254-281 other_organic_compound denotes multivalent guanylhydrazone
T9 283-291 other_organic_compound denotes CNI-1493
T10 322-343 other_name denotes macrophage activation
T11 366-369 protein_family_or_group denotes TNF
T12 919-927 other_organic_compound denotes CNI-1493
T13 948-951 protein_family_or_group denotes TNF
T14 1012-1015 protein_family_or_group denotes TNF
T15 1016-1038 other_name denotes translation efficiency
T16 1040-1048 other_organic_compound denotes CNI-1493
T17 1069-1087 lipid denotes lipopolysaccharide
T18 1133-1136 protein_family_or_group denotes TNF
T19 1167-1192 protein_molecule denotes nuclear factor NF-kappa B
T20 1200-1207 cell_component denotes nucleus
T21 1211-1222 cell_type denotes macrophages
T22 1246-1249 lipid denotes LPS
T23 1279-1287 other_organic_compound denotes CNI-1493
T24 1318-1328 protein_complex denotes NF-kappa B
T25 1368-1371 protein_family_or_group denotes TNF
T26 1399-1419 protein_molecule denotes 26-kDa membrane form
T27 1423-1426 protein_family_or_group denotes TNF
T28 1454-1462 other_organic_compound denotes CNI-1493
T29 1489-1514 other_name denotes translational suppression
T30 1518-1521 protein_family_or_group denotes TNF
T31 1552-1586 protein_molecule denotes chloram-phenicol acetyltransferase
T32 1631-1634 protein_family_or_group denotes TNF
T33 1661-1664 protein_family_or_group denotes TNF
T34 1738-1741 protein_family_or_group denotes TNF
T35 1779-1804 other_name denotes translational suppression
T36 1808-1816 other_organic_compound denotes CNI-1493
T37 1871-1879 other_organic_compound denotes CNI-1493
T38 1889-1892 protein_family_or_group denotes TNF
T39 1951-1972 other_name denotes macrophage activation
T40 1977-2003 other_name denotes mechanisms of inflammation