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sentences

Id Subject Object Predicate Lexical cue
T1 0-170 Sentence denotes Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.
T2 171-367 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.
T3 368-621 Sentence denotes Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.
T4 622-718 Sentence denotes We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.
T5 719-1049 Sentence denotes In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.
T6 1050-1120 Sentence denotes Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.
T7 1121-1235 Sentence denotes We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.
T8 1236-1332 Sentence denotes Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.
T9 1333-1499 Sentence denotes These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.
T1 0-170 Sentence denotes Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.
T2 171-367 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.
T3 368-621 Sentence denotes Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.
T4 622-718 Sentence denotes We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.
T5 719-1049 Sentence denotes In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.
T6 1050-1120 Sentence denotes Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.
T7 1121-1235 Sentence denotes We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.
T8 1236-1332 Sentence denotes Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.
T9 1333-1499 Sentence denotes These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 468-473 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 468-473 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-48 protein denotes Granulocyte-macrophage colony-stimulating factor
T2 60-64 protein denotes JAK2
T3 105-111 protein denotes p93fes
T4 113-122 protein denotes STAT1 p91
T5 128-137 protein denotes STAT3 p92
T6 141-169 cell_type denotes polymorphonuclear leukocytes
T7 171-219 protein denotes Granulocyte-macrophage colony-stimulating factor
T8 221-227 protein denotes GM-CSF
T9 377-383 protein denotes GM-CSF
T10 406-421 protein denotes tyrosine kinase
T11 442-502 cell_line denotes GM-CSF-induced peripheral blood polymorphonuclear leukocytes
T12 504-507 cell_type denotes PMN
T13 587-620 protein denotes intracellular signaling molecules
T14 652-656 protein denotes JAK2
T15 704-710 protein denotes GM-CSF
T16 714-717 cell_type denotes PMN
T17 769-841 protein denotes signal transducers and activators of transcription (STAT) family members
T18 842-851 protein denotes STAT1 p91
T19 856-865 protein denotes STAT3 p92
T20 889-912 DNA denotes c-fps/fes protooncogene
T21 949-955 protein denotes GM-CSF
T22 1004-1010 protein denotes GM-CSF
T23 1044-1048 protein denotes JAK2
T24 1059-1065 protein denotes GM-CSF
T25 1085-1089 protein denotes JAK2
T26 1094-1100 protein denotes p93fes
T27 1169-1204 protein denotes GM-CSF receptor beta common subunit
T28 1210-1214 protein denotes JAK2
T29 1264-1270 protein denotes GM-CSF
T30 1281-1300 protein denotes DNA-binding complex
T31 1320-1323 protein denotes p91
T32 1328-1331 protein denotes p92
T33 1403-1409 protein denotes GM-CSF
T34 1477-1498 cell_type denotes GM-CSF-stimulated PMN

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-170 Sentence denotes Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.
S2 171-367 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.
S3 368-621 Sentence denotes Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.
S4 622-718 Sentence denotes We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.
S5 719-1049 Sentence denotes In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.
S6 1050-1120 Sentence denotes Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.
S7 1121-1235 Sentence denotes We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.
S8 1236-1332 Sentence denotes Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.
S9 1333-1499 Sentence denotes These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-48 NP denotes Granulocyte-macrophage colony-stimulating factor
C2 113-122 NP denotes STAT1 p91
C3 128-137 NP denotes STAT3 p92
C4 171-228 NP denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF)
C5 321-324 NP denotes its
C6 442-449 NP denotes GM-CSF-
C7 652-656 NP denotes JAK2
C8 704-710 NP denotes GM-CSF
C9 842-851 NP denotes STAT1 p91
C10 856-865 NP denotes STAT3 p92
C11 1004-1039 NP denotes GM-CSF receptor beta common subunit
C12 1044-1048 NP denotes JAK2
C13 1059-1065 NP denotes GM-CSF
C14 1085-1089 NP denotes JAK2
C15 1165-1204 NP denotes the GM-CSF receptor beta common subunit
C16 1210-1214 NP denotes JAK2
C17 1264-1270 NP denotes GM-CSF
C18 1279-1300 NP denotes a DNA-binding complex
C19 1301-1305 NP denotes that
C20 1320-1323 NP denotes p91
C21 1328-1331 NP denotes p92
C22 1403-1409 NP denotes GM-CSF
C23 1477-1484 NP denotes GM-CSF-
R1 C4 C1 coref-ident Granulocyte-macrophage colony-stimulating factor (GM-CSF),Granulocyte-macrophage colony-stimulating factor
R2 C5 C4 coref-pron its,Granulocyte-macrophage colony-stimulating factor (GM-CSF)
R3 C6 C4 coref-ident GM-CSF-,Granulocyte-macrophage colony-stimulating factor (GM-CSF)
R4 C8 C6 coref-ident GM-CSF,GM-CSF-
R5 C9 C2 coref-ident STAT1 p91,STAT1 p91
R6 C10 C3 coref-ident STAT3 p92,STAT3 p92
R7 C12 C7 coref-ident JAK2,JAK2
R8 C13 C8 coref-ident GM-CSF,GM-CSF
R9 C14 C12 coref-ident JAK2,JAK2
R10 C15 C11 coref-ident the GM-CSF receptor beta common subunit,GM-CSF receptor beta common subunit
R11 C16 C12 coref-ident JAK2,JAK2
R12 C17 C13 coref-ident GM-CSF,GM-CSF
R13 C19 C18 coref-relat that,a DNA-binding complex
R14 C20 C9 coref-ident p91,STAT1 p91
R15 C21 C10 coref-ident p92,STAT3 p92
R16 C22 C17 coref-ident GM-CSF,GM-CSF
R17 C23 C22 coref-ident GM-CSF-,GM-CSF

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-48 protein_family_or_group denotes Granulocyte-macrophage colony-stimulating factor
T2 60-64 protein_molecule denotes JAK2
T3 105-111 protein_molecule denotes p93fes
T4 113-122 protein_molecule denotes STAT1 p91
T5 128-137 protein_molecule denotes STAT3 p92
T6 141-169 cell_type denotes polymorphonuclear leukocytes
T7 171-219 protein_molecule denotes Granulocyte-macrophage colony-stimulating factor
T8 221-227 protein_molecule denotes GM-CSF
T9 239-252 other_name denotes proliferation
T10 254-269 other_name denotes differentiation
T11 275-296 other_name denotes functional activation
T12 377-383 protein_molecule denotes GM-CSF
T13 406-414 amino_acid_monomer denotes tyrosine
T14 442-448 protein_molecule denotes GM-CSF
T15 474-502 cell_type denotes polymorphonuclear leukocytes
T16 504-507 cell_type denotes PMN
T17 509-530 other_name denotes functional activation
T18 587-620 protein_family_or_group denotes intracellular signaling molecules
T19 652-656 protein_molecule denotes JAK2
T20 665-673 amino_acid_monomer denotes tyrosine
T21 704-710 protein_molecule denotes GM-CSF
T22 714-717 cell_type denotes PMN
T23 769-841 protein_family_or_group denotes signal transducers and activators of transcription (STAT) family members
T24 842-851 protein_molecule denotes STAT1 p91
T25 856-865 protein_molecule denotes STAT3 p92
T26 889-912 DNA_domain_or_region denotes c-fps/fes protooncogene
T27 920-928 amino_acid_monomer denotes tyrosine
T28 949-955 protein_molecule denotes GM-CSF
T29 1004-1010 protein_molecule denotes GM-CSF
T30 1044-1048 protein_molecule denotes JAK2
T31 1059-1065 protein_molecule denotes GM-CSF
T32 1085-1089 protein_molecule denotes JAK2
T33 1094-1100 protein_molecule denotes p93fes
T34 1169-1175 protein_molecule denotes GM-CSF
T35 1210-1214 protein_molecule denotes JAK2
T36 1264-1270 protein_molecule denotes GM-CSF
T37 1281-1300 protein_complex denotes DNA-binding complex
T38 1320-1323 protein_molecule denotes p91
T39 1328-1331 protein_molecule denotes p92
T40 1362-1389 other_name denotes signal transduction pathway
T41 1403-1409 protein_molecule denotes GM-CSF
T42 1458-1473 other_name denotes gene expression
T43 1477-1483 protein_molecule denotes GM-CSF
T44 1495-1498 cell_type denotes PMN

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 468-473 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-11 Body_part denotes Granulocyte http://purl.obolibrary.org/obo/CL_0000094
T2 12-22 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 141-169 Body_part denotes polymorphonuclear leukocytes http://purl.obolibrary.org/obo/CL_0000094|http://purl.obolibrary.org/obo/CL_0000775
T5 171-182 Body_part denotes Granulocyte http://purl.obolibrary.org/obo/CL_0000094
T6 183-193 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T7 300-317 Body_part denotes hemopoietic cells http://purl.obolibrary.org/obo/CL_0000988
T8 468-473 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 474-502 Body_part denotes polymorphonuclear leukocytes http://purl.obolibrary.org/obo/CL_0000094|http://purl.obolibrary.org/obo/CL_0000775
T11 504-507 Body_part denotes PMN http://purl.obolibrary.org/obo/CL_0000094
T12 587-600 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T13 714-717 Body_part denotes PMN http://purl.obolibrary.org/obo/CL_0000094
T14 1495-1498 Body_part denotes PMN http://purl.obolibrary.org/obo/CL_0000094

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-11 Cell denotes Granulocyte http://purl.obolibrary.org/obo/CL:0000094
T2 12-22 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 141-169 Cell denotes polymorphonuclear leukocytes http://purl.obolibrary.org/obo/CL:0000041|http://purl.obolibrary.org/obo/CL:0000043|http://purl.obolibrary.org/obo/CL:0000094|http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000767|http://purl.obolibrary.org/obo/CL:0000771|http://purl.obolibrary.org/obo/CL:0000775
T11 171-182 Cell denotes Granulocyte http://purl.obolibrary.org/obo/CL:0000094
T12 183-193 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T14 300-317 Cell denotes hemopoietic cells http://purl.obolibrary.org/obo/CL:0000988
T15 474-502 Cell denotes polymorphonuclear leukocytes http://purl.obolibrary.org/obo/CL:0000041|http://purl.obolibrary.org/obo/CL:0000043|http://purl.obolibrary.org/obo/CL:0000094|http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000767|http://purl.obolibrary.org/obo/CL:0000771|http://purl.obolibrary.org/obo/CL:0000775
T22 504-507 Cell denotes PMN http://purl.obolibrary.org/obo/CL:0000041
T23 714-717 Cell denotes PMN http://purl.obolibrary.org/obo/CL:0000041
T24 1495-1498 Cell denotes PMN http://purl.obolibrary.org/obo/CL:0000041