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PubMed:8631821 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 244-250 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T3 333-345 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T4 446-454 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T6 455-466 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 541-550 Cell denotes foam cell http://purl.obolibrary.org/obo/CL:0000891
T9 693-702 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T11 980-988 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T13 1147-1156 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T15 1845-1854 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054

sentences

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
T2 121-385 Sentence denotes CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
T3 386-467 Sentence denotes Its expression is restricted to a few cell types, including monocyte/macrophages.
T4 468-607 Sentence denotes In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
T5 608-757 Sentence denotes To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
T6 758-1033 Sentence denotes Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
T7 1034-1163 Sentence denotes Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
T8 1164-1361 Sentence denotes Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
T9 1362-1500 Sentence denotes Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
T10 1501-1896 Sentence denotes The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.
T1 0-120 Sentence denotes Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
T2 121-385 Sentence denotes CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
T3 386-467 Sentence denotes Its expression is restricted to a few cell types, including monocyte/macrophages.
T4 468-607 Sentence denotes In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
T5 608-757 Sentence denotes To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
T6 758-1033 Sentence denotes Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
T7 1034-1163 Sentence denotes Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
T8 1164-1361 Sentence denotes Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
T9 1362-1500 Sentence denotes Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
T10 1501-1896 Sentence denotes The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 96-104 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1541-1544 gene:10153 denotes CBF
T1 1597-1619 disease:C0023467 denotes acute myeloid leukemia
R1 T0 T1 associated_with CBF,acute myeloid leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 50-74 DNA denotes human CD36 gene promoter
T2 105-119 DNA denotes PEBP2/CBF site
T3 121-125 protein denotes CD36
T4 144-156 protein denotes glycoprotein
T5 218-232 protein denotes thrombospondin
T6 234-257 protein denotes collagens type I and IV
T7 268-291 protein denotes low density lipoprotein
T8 333-345 cell_type denotes erythrocytes
T9 446-466 cell_type denotes monocyte/macrophages
T10 484-488 protein denotes CD36
T11 520-535 cell_type denotes apoptotic cells
T12 574-606 protein denotes oxidized low density lipoprotein
T13 680-684 protein denotes CD36
T14 743-756 DNA denotes CD36 promoter
T15 794-815 DNA denotes 5'-deletion fragments
T16 823-836 DNA denotes CD36 promoter
T17 848-858 protein denotes luciferase
T18 887-910 DNA denotes 158 base pairs upstream
T19 920-949 DNA denotes transcription initiation site
T20 1019-1032 DNA denotes reporter gene
T21 1081-1104 DNA denotes nucleotides -158 to -90
T22 1147-1162 cell_type denotes monocytic cells
T23 1199-1207 DNA denotes -158/-90
T24 1236-1257 protein denotes transcription factors
T25 1265-1343 protein denotes polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family
T26 1347-1360 DNA denotes position -103
T27 1380-1394 DNA denotes PEBP2/CBF site
T28 1431-1448 protein denotes PEBP2/CBF factors
T29 1490-1499 DNA denotes CD36 gene
T30 1535-1551 protein denotes PEBP2/CBF family
T31 1666-1688 DNA denotes myeloid-specific genes
T32 1702-1717 protein denotes myeloperoxidase
T33 1719-1727 protein denotes elastase
T34 1737-1771 protein denotes colony-stimulating factor receptor
T35 1823-1841 DNA denotes CD36 gene promoter
T36 1845-1860 cell_type denotes monocytic cells
T37 1879-1895 protein denotes PEBP2/CBF family

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8631821-9#40#43#gene10153 1541-1544 gene10153 denotes CBF
8631821-9#96#118#diseaseC0023467 1597-1619 diseaseC0023467 denotes acute myeloid leukemia
40#43#gene1015396#118#diseaseC0023467 8631821-9#40#43#gene10153 8631821-9#96#118#diseaseC0023467 associated_with CBF,acute myeloid leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-120 Sentence denotes Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
S2 121-385 Sentence denotes CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
S3 386-467 Sentence denotes Its expression is restricted to a few cell types, including monocyte/macrophages.
S4 468-607 Sentence denotes In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
S5 608-757 Sentence denotes To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
S6 758-1033 Sentence denotes Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
S7 1034-1163 Sentence denotes Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
S8 1164-1361 Sentence denotes Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
S9 1362-1500 Sentence denotes Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
S10 1501-1896 Sentence denotes The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 46-74 NP denotes the human CD36 gene promoter
C2 94-119 NP denotes a proximal PEBP2/CBF site
C3 121-125 NP denotes CD36
C4 169-195 NP denotes a single polypeptide chain
C5 197-202 NP denotes which
C6 386-389 NP denotes Its
C7 418-466 NP denotes a few cell types, including monocyte/macrophages
C8 471-482 NP denotes these cells
C9 484-488 NP denotes CD36
C10 617-641 NP denotes the molecular mechanisms
C11 642-646 NP denotes that
C13 693-708 NP denotes monocytic cells
C12 676-708 NP denotes the CD36 gene in monocytic cells
C14 739-756 NP denotes the CD36 promoter
C15 819-836 NP denotes the CD36 promoter
C16 916-949 NP denotes the transcription initiation site
C17 1041-1057 NP denotes the above region
C18 1147-1162 NP denotes monocytic cells
C19 1188-1207 NP denotes the region -158/-90
C21 1261-1343 NP denotes the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family
C20 1217-1360 NP denotes a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103
C22 1376-1394 NP denotes the PEBP2/CBF site
C23 1486-1499 NP denotes the CD36 gene
C25 1531-1551 NP denotes the PEBP2/CBF family
C24 1520-1551 NP denotes members of the PEBP2/CBF family
C27 1845-1860 NP denotes monocytic cells
C26 1819-1860 NP denotes the CD36 gene promoter in monocytic cells
C29 1875-1895 NP denotes the PEBP2/CBF family
C28 1864-1895 NP denotes members of the PEBP2/CBF family
R1 C5 C4 coref-relat which,a single polypeptide chain
R2 C6 C3 coref-pron Its,CD36
R3 C8 C7 coref-ident these cells,"a few cell types, including monocyte/macrophages"
R4 C9 C3 coref-ident CD36,CD36
R5 C11 C10 coref-relat that,the molecular mechanisms
R6 C14 C1 coref-ident the CD36 promoter,the human CD36 gene promoter
R7 C15 C14 coref-ident the CD36 promoter,the CD36 promoter
R8 C17 C16 coref-ident the above region,the transcription initiation site
R9 C18 C13 coref-ident monocytic cells,monocytic cells
R10 C19 C17 coref-ident the region -158/-90,the above region
R11 C20 C2 coref-other a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103,a proximal PEBP2/CBF site
R12 C22 C2 coref-ident the PEBP2/CBF site,a proximal PEBP2/CBF site
R13 C23 C12 coref-ident the CD36 gene,the CD36 gene in monocytic cells
R14 C25 C21 coref-ident the PEBP2/CBF family,the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family
R15 C27 C18 coref-ident monocytic cells,monocytic cells
R16 C26 C15 coref-ident the CD36 gene promoter in monocytic cells,the CD36 promoter
R17 C29 C25 coref-ident the PEBP2/CBF family,the PEBP2/CBF family
R18 C28 C24 coref-ident members of the PEBP2/CBF family,members of the PEBP2/CBF family

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 50-74 DNA_domain_or_region denotes human CD36 gene promoter
T2 105-119 DNA_domain_or_region denotes PEBP2/CBF site
T3 121-125 protein_molecule denotes CD36
T4 144-156 protein_molecule denotes glycoprotein
T5 171-195 peptide denotes single polypeptide chain
T6 218-232 protein_molecule denotes thrombospondin
T7 268-291 protein_complex denotes low density lipoprotein
T8 293-304 lipid denotes fatty acids
T9 306-327 lipid denotes anionic phospholipids
T10 333-345 cell_type denotes erythrocytes
T11 363-384 mono_cell denotes Plasmodium falciparum
T12 446-466 cell_type denotes monocyte/macrophages
T13 484-488 protein_molecule denotes CD36
T14 504-516 other_name denotes phagocytosis
T15 520-535 cell_type denotes apoptotic cells
T16 574-606 protein_complex denotes oxidized low density lipoprotein
T17 680-684 protein_molecule denotes CD36
T18 743-747 protein_molecule denotes CD36
T19 794-815 DNA_molecule denotes 5'-deletion fragments
T20 823-827 protein_molecule denotes CD36
T21 848-858 protein_molecule denotes luciferase
T22 887-910 DNA_domain_or_region denotes 158 base pairs upstream
T23 920-949 DNA_domain_or_region denotes transcription initiation site
T24 980-1011 other_name denotes monocyte-specific transcription
T25 1019-1032 DNA_family_or_group denotes reporter gene
T26 1081-1104 DNA_domain_or_region denotes nucleotides -158 to -90
T27 1147-1162 cell_type denotes monocytic cells
T28 1199-1207 DNA_domain_or_region denotes -158/-90
T29 1236-1257 protein_family_or_group denotes transcription factors
T30 1265-1343 protein_family_or_group denotes polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family
T31 1347-1360 DNA_domain_or_region denotes position -103
T32 1380-1394 DNA_domain_or_region denotes PEBP2/CBF site
T33 1431-1448 protein_family_or_group denotes PEBP2/CBF factors
T34 1456-1482 other_name denotes constitutive transcription
T35 1490-1494 protein_molecule denotes CD36
T36 1535-1551 protein_family_or_group denotes PEBP2/CBF family
T37 1555-1580 other_name denotes chromosome translocations
T38 1597-1619 other_name denotes acute myeloid leukemia
T39 1666-1688 DNA_family_or_group denotes myeloid-specific genes
T40 1702-1717 protein_molecule denotes myeloperoxidase
T41 1719-1727 protein_molecule denotes elastase
T42 1737-1771 protein_family_or_group denotes colony-stimulating factor receptor
T43 1823-1827 protein_molecule denotes CD36
T44 1845-1860 cell_type denotes monocytic cells
T45 1879-1895 protein_family_or_group denotes PEBP2/CBF family

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 96-104 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 541-550 Phenotype denotes foam cell HP:0003651
T2 1597-1619 Phenotype denotes acute myeloid leukemia HP:0004808

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1597-1619 Disease denotes acute myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0015667|http://purl.obolibrary.org/obo/MONDO_0018874

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 50-55 OrganismTaxon denotes human 9606
T2 363-384 OrganismTaxon denotes Plasmodium falciparum 5833

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 333-345 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T2 446-454 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 455-466 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T5 980-988 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T7 1555-1565 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694