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sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway.
T2 88-289 Sentence denotes The mechanism of action of the immunosuppressive drug cyclosporin A (CsA) is the inactivation of the Ca2+/calmodulin-dependent serine-threonine phosphatase calcineurin by the drug-immunophilin complex.
T3 290-461 Sentence denotes Inactive calcineurin is unable to activate the nuclear factor of activated T cells (NFAT), a transcription factor required for expression of the interleukin 2 (IL-2) gene.
T4 462-533 Sentence denotes IL-2 production by CsA-treated cells is therefore dramatically reduced.
T5 534-683 Sentence denotes We demonstrate here, however, that NFAT can be activated, and significant levels of IL-2 can be produced by the CsA-resistant CD28-signaling pathway.
T6 684-926 Sentence denotes In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.
T7 927-1104 Sentence denotes Electrophoretic mobility shift assay showed the induction of a CsA-resistant NFAT complex in the nuclear extracts of peripheral blood T cells stimulated with PMA plus alphaCD28.
T8 1105-1197 Sentence denotes Peripheral blood T cells stimulated with PMA/alphaCD28 produced IL-2 in the presence of CsA.
T9 1198-1319 Sentence denotes Collectively, these data suggest that NFAT can be activated and IL-2 can be produced in a calcineurin independent manner.
T1 0-87 Sentence denotes Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway.
T2 88-289 Sentence denotes The mechanism of action of the immunosuppressive drug cyclosporin A (CsA) is the inactivation of the Ca2+/calmodulin-dependent serine-threonine phosphatase calcineurin by the drug-immunophilin complex.
T3 290-461 Sentence denotes Inactive calcineurin is unable to activate the nuclear factor of activated T cells (NFAT), a transcription factor required for expression of the interleukin 2 (IL-2) gene.
T4 462-533 Sentence denotes IL-2 production by CsA-treated cells is therefore dramatically reduced.
T5 534-683 Sentence denotes We demonstrate here, however, that NFAT can be activated, and significant levels of IL-2 can be produced by the CsA-resistant CD28-signaling pathway.
T6 684-926 Sentence denotes In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.
T7 927-1104 Sentence denotes Electrophoretic mobility shift assay showed the induction of a CsA-resistant NFAT complex in the nuclear extracts of peripheral blood T cells stimulated with PMA plus alphaCD28.
T8 1105-1197 Sentence denotes Peripheral blood T cells stimulated with PMA/alphaCD28 produced IL-2 in the presence of CsA.
T9 1198-1319 Sentence denotes Collectively, these data suggest that NFAT can be activated and IL-2 can be produced in a calcineurin independent manner.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1055-1060 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1055-1060 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 1116-1121 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 1116-1121 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-49 protein denotes nuclear factor of activated T cells
T2 189-243 protein denotes Ca2+/calmodulin-dependent serine-threonine phosphatase
T3 244-255 protein denotes calcineurin
T4 263-288 protein denotes drug-immunophilin complex
T5 299-310 protein denotes calcineurin
T6 337-372 protein denotes nuclear factor of activated T cells
T7 374-378 protein denotes NFAT
T8 383-403 protein denotes transcription factor
T9 435-460 DNA denotes interleukin 2 (IL-2) gene
T10 462-466 protein denotes IL-2
T11 481-498 cell_line denotes CsA-treated cells
T12 569-573 protein denotes NFAT
T13 618-622 protein denotes IL-2
T14 660-664 protein denotes CD28
T15 733-737 protein denotes NFAT
T16 743-800 DNA denotes IL-2 promoter-beta-galactosidase reporter gene constructs
T17 867-871 protein denotes CD28
T18 990-1016 protein denotes CsA-resistant NFAT complex
T19 1044-1068 cell_type denotes peripheral blood T cells
T20 1094-1103 protein denotes alphaCD28
T21 1105-1129 cell_type denotes Peripheral blood T cells
T22 1149-1159 protein denotes /alphaCD28
T23 1169-1173 protein denotes IL-2
T24 1236-1240 protein denotes NFAT
T25 1262-1266 protein denotes IL-2
T26 1288-1299 protein denotes calcineurin

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-87 Sentence denotes Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway.
S2 88-289 Sentence denotes The mechanism of action of the immunosuppressive drug cyclosporin A (CsA) is the inactivation of the Ca2+/calmodulin-dependent serine-threonine phosphatase calcineurin by the drug-immunophilin complex.
S3 290-461 Sentence denotes Inactive calcineurin is unable to activate the nuclear factor of activated T cells (NFAT), a transcription factor required for expression of the interleukin 2 (IL-2) gene.
S4 462-533 Sentence denotes IL-2 production by CsA-treated cells is therefore dramatically reduced.
S5 534-683 Sentence denotes We demonstrate here, however, that NFAT can be activated, and significant levels of IL-2 can be produced by the CsA-resistant CD28-signaling pathway.
S6 684-926 Sentence denotes In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.
S7 927-1104 Sentence denotes Electrophoretic mobility shift assay showed the induction of a CsA-resistant NFAT complex in the nuclear extracts of peripheral blood T cells stimulated with PMA plus alphaCD28.
S8 1105-1197 Sentence denotes Peripheral blood T cells stimulated with PMA/alphaCD28 produced IL-2 in the presence of CsA.
S9 1198-1319 Sentence denotes Collectively, these data suggest that NFAT can be activated and IL-2 can be produced in a calcineurin independent manner.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-49 NP denotes nuclear factor of activated T cells
C2 55-69 NP denotes cyclosporin A-
C3 115-161 NP denotes the immunosuppressive drug cyclosporin A (CsA)
C4 333-379 NP denotes the nuclear factor of activated T cells (NFAT)
C5 381-460 NP denotes a transcription factor required for expression of the interleukin 2 (IL-2) gene
C6 481-485 NP denotes CsA-
C7 569-573 NP denotes NFAT
C8 618-622 NP denotes IL-2
C9 646-650 NP denotes CsA-
C10 733-738 NP denotes NFAT-
C11 922-925 NP denotes CsA
C12 990-994 NP denotes CsA-
C14 1085-1103 NP denotes PMA plus alphaCD28
C13 1044-1103 NP denotes peripheral blood T cells stimulated with PMA plus alphaCD28
C16 1146-1159 NP denotes PMA/alphaCD28
C15 1105-1159 NP denotes Peripheral blood T cells stimulated with PMA/alphaCD28
C17 1169-1173 NP denotes IL-2
C18 1193-1196 NP denotes CsA
C19 1236-1240 NP denotes NFAT
C20 1262-1266 NP denotes IL-2
R1 C3 C2 coref-ident the immunosuppressive drug cyclosporin A (CsA),cyclosporin A-
R2 C4 C1 coref-ident the nuclear factor of activated T cells (NFAT),nuclear factor of activated T cells
R3 C5 C4 coref-appos a transcription factor required for expression of the interleukin 2 (IL-2) gene,the nuclear factor of activated T cells (NFAT)
R4 C6 C3 coref-ident CsA-,the immunosuppressive drug cyclosporin A (CsA)
R5 C7 C4 coref-ident NFAT,the nuclear factor of activated T cells (NFAT)
R6 C9 C6 coref-ident CsA-,CsA-
R7 C10 C7 coref-ident NFAT-,NFAT
R8 C11 C9 coref-ident CsA,CsA-
R9 C12 C11 coref-ident CsA-,CsA
R10 C16 C14 coref-ident PMA/alphaCD28,PMA plus alphaCD28
R11 C15 C13 coref-ident Peripheral blood T cells stimulated with PMA/alphaCD28,peripheral blood T cells stimulated with PMA plus alphaCD28
R12 C17 C8 coref-ident IL-2,IL-2
R13 C18 C12 coref-ident CsA,CsA-
R14 C19 C10 coref-ident NFAT,NFAT-
R15 C20 C17 coref-ident IL-2,IL-2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-41 protein_family_or_group denotes nuclear factor of activated
T2 42-49 cell_type denotes T cells
T3 55-68 other_organic_compound denotes cyclosporin A
T4 119-141 other_organic_compound denotes immunosuppressive drug
T5 142-155 other_organic_compound denotes cyclosporin A
T6 157-160 other_organic_compound denotes CsA
T7 189-193 atom denotes Ca2+
T8 244-255 protein_molecule denotes calcineurin
T9 263-288 protein_complex denotes drug-immunophilin complex
T10 299-310 protein_molecule denotes calcineurin
T11 337-372 protein_family_or_group denotes nuclear factor of activated T cells
T12 374-378 protein_family_or_group denotes NFAT
T13 383-403 protein_family_or_group denotes transcription factor
T14 435-450 DNA_domain_or_region denotes interleukin 2 (
T15 450-454 protein_molecule denotes IL-2
T16 462-466 protein_molecule denotes IL-2
T17 481-484 other_organic_compound denotes CsA
T18 569-573 protein_family_or_group denotes NFAT
T19 618-622 protein_molecule denotes IL-2
T20 646-649 other_organic_compound denotes CsA
T21 660-664 protein_molecule denotes CD28
T22 687-716 other_name denotes transient transfection assays
T23 733-737 protein_family_or_group denotes NFAT
T24 743-747 protein_molecule denotes IL-2
T25 823-856 other_name denotes phorbol 12-myristate 13-acetate (
T26 856-859 other_organic_compound denotes PMA
T27 867-871 protein_molecule denotes CD28
T28 922-925 other_organic_compound denotes CsA
T29 927-963 other_name denotes Electrophoretic mobility shift assay
T30 990-993 other_organic_compound denotes CsA
T31 1004-1008 protein_family_or_group denotes NFAT
T32 1024-1040 cell_component denotes nuclear extracts
T33 1044-1068 cell_type denotes peripheral blood T cells
T34 1085-1088 other_organic_compound denotes PMA
T35 1094-1103 protein_molecule denotes alphaCD28
T36 1105-1129 cell_type denotes Peripheral blood T cells
T37 1146-1149 other_organic_compound denotes PMA
T38 1149-1159 protein_molecule denotes /alphaCD28
T39 1169-1173 protein_molecule denotes IL-2
T40 1193-1196 other_organic_compound denotes CsA
T41 1236-1240 protein_family_or_group denotes NFAT
T42 1262-1266 protein_molecule denotes IL-2
T43 1288-1299 protein_molecule denotes calcineurin

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1055-1060 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 1116-1121 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 856-859 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T3 1085-1088 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T5 1146-1149 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1055-1060 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 1116-1121 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 42-49 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 365-372 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 1061-1068 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 1122-1129 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084