PubMed:8626528 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":158,"end":171},"obj":"Cell"},{"id":"T2","span":{"begin":211,"end":217},"obj":"Cell"},{"id":"T3","span":{"begin":284,"end":291},"obj":"Cell"},{"id":"T4","span":{"begin":355,"end":367},"obj":"Cell"},{"id":"T5","span":{"begin":357,"end":367},"obj":"Cell"},{"id":"T6","span":{"begin":508,"end":514},"obj":"Cell"},{"id":"T7","span":{"begin":763,"end":770},"obj":"Cell"},{"id":"T8","span":{"begin":949,"end":956},"obj":"Cell"},{"id":"T9","span":{"begin":998,"end":1004},"obj":"Cell"},{"id":"T10","span":{"begin":1069,"end":1075},"obj":"Cell"},{"id":"T11","span":{"begin":1185,"end":1191},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000542"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000084"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":268},"obj":"Sentence"},{"id":"T3","span":{"begin":269,"end":379},"obj":"Sentence"},{"id":"T4","span":{"begin":380,"end":534},"obj":"Sentence"},{"id":"T5","span":{"begin":535,"end":612},"obj":"Sentence"},{"id":"T6","span":{"begin":613,"end":854},"obj":"Sentence"},{"id":"T7","span":{"begin":855,"end":1055},"obj":"Sentence"},{"id":"T8","span":{"begin":1056,"end":1130},"obj":"Sentence"},{"id":"T9","span":{"begin":1131,"end":1262},"obj":"Sentence"},{"id":"T10","span":{"begin":1263,"end":1356},"obj":"Sentence"},{"id":"T11","span":{"begin":1357,"end":1592},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":268},"obj":"Sentence"},{"id":"T3","span":{"begin":269,"end":379},"obj":"Sentence"},{"id":"T4","span":{"begin":380,"end":534},"obj":"Sentence"},{"id":"T5","span":{"begin":535,"end":612},"obj":"Sentence"},{"id":"T6","span":{"begin":613,"end":854},"obj":"Sentence"},{"id":"T7","span":{"begin":855,"end":1055},"obj":"Sentence"},{"id":"T8","span":{"begin":1056,"end":1130},"obj":"Sentence"},{"id":"T9","span":{"begin":1131,"end":1262},"obj":"Sentence"},{"id":"T10","span":{"begin":1263,"end":1356},"obj":"Sentence"},{"id":"T11","span":{"begin":1357,"end":1592},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":46,"end":67},"obj":"DNA"},{"id":"T2","span":{"begin":79,"end":101},"obj":"DNA"},{"id":"T3","span":{"begin":118,"end":131},"obj":"protein"},{"id":"T4","span":{"begin":158,"end":171},"obj":"cell_type"},{"id":"T5","span":{"begin":211,"end":226},"obj":"protein"},{"id":"T6","span":{"begin":231,"end":254},"obj":"protein"},{"id":"T7","span":{"begin":263,"end":267},"obj":"protein"},{"id":"T8","span":{"begin":284,"end":291},"obj":"cell_type"},{"id":"T9","span":{"begin":303,"end":316},"obj":"protein"},{"id":"T10","span":{"begin":318,"end":322},"obj":"protein"},{"id":"T11","span":{"begin":384,"end":388},"obj":"protein"},{"id":"T12","span":{"begin":432,"end":453},"obj":"DNA"},{"id":"T13","span":{"begin":455,"end":461},"obj":"DNA"},{"id":"T14","span":{"begin":539,"end":545},"obj":"DNA"},{"id":"T15","span":{"begin":581,"end":611},"obj":"DNA"},{"id":"T16","span":{"begin":638,"end":644},"obj":"DNA"},{"id":"T17","span":{"begin":725,"end":770},"obj":"protein"},{"id":"T18","span":{"begin":772,"end":781},"obj":"protein"},{"id":"T19","span":{"begin":824,"end":853},"obj":"protein"},{"id":"T20","span":{"begin":868,"end":877},"obj":"protein"},{"id":"T21","span":{"begin":949,"end":956},"obj":"cell_type"},{"id":"T22","span":{"begin":1040,"end":1044},"obj":"protein"},{"id":"T23","span":{"begin":1120,"end":1129},"obj":"protein"},{"id":"T24","span":{"begin":1242,"end":1251},"obj":"protein"},{"id":"T25","span":{"begin":1288,"end":1292},"obj":"protein"},{"id":"T26","span":{"begin":1346,"end":1355},"obj":"protein"},{"id":"T27","span":{"begin":1427,"end":1436},"obj":"protein"},{"id":"T28","span":{"begin":1470,"end":1474},"obj":"protein"},{"id":"T29","span":{"begin":1571,"end":1575},"obj":"protein"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"S2","span":{"begin":144,"end":268},"obj":"Sentence"},{"id":"S3","span":{"begin":269,"end":379},"obj":"Sentence"},{"id":"S4","span":{"begin":380,"end":534},"obj":"Sentence"},{"id":"S5","span":{"begin":535,"end":612},"obj":"Sentence"},{"id":"S6","span":{"begin":613,"end":854},"obj":"Sentence"},{"id":"S7","span":{"begin":855,"end":1055},"obj":"Sentence"},{"id":"S8","span":{"begin":1056,"end":1130},"obj":"Sentence"},{"id":"S9","span":{"begin":1131,"end":1262},"obj":"Sentence"},{"id":"S10","span":{"begin":1263,"end":1356},"obj":"Sentence"},{"id":"S11","span":{"begin":1357,"end":1592},"obj":"Sentence"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":22,"end":30},"obj":"NP"},{"id":"C2","span":{"begin":31,"end":35},"obj":"NP"},{"id":"C3","span":{"begin":42,"end":67},"obj":"NP"},{"id":"C4","span":{"begin":75,"end":101},"obj":"NP"},{"id":"C5","span":{"begin":118,"end":142},"obj":"NP"},{"id":"C6","span":{"begin":380,"end":397},"obj":"NP"},{"id":"C7","span":{"begin":407,"end":462},"obj":"NP"},{"id":"C8","span":{"begin":463,"end":467},"obj":"NP"},{"id":"C9","span":{"begin":677,"end":782},"obj":"NP"},{"id":"C10","span":{"begin":783,"end":787},"obj":"NP"},{"id":"C11","span":{"begin":868,"end":877},"obj":"NP"},{"id":"C12","span":{"begin":949,"end":956},"obj":"NP"},{"id":"C13","span":{"begin":957,"end":961},"obj":"NP"},{"id":"C14","span":{"begin":1120,"end":1129},"obj":"NP"},{"id":"C15","span":{"begin":1242,"end":1261},"obj":"NP"},{"id":"C16","span":{"begin":1274,"end":1277},"obj":"NP"},{"id":"C17","span":{"begin":1288,"end":1303},"obj":"NP"},{"id":"C18","span":{"begin":1305,"end":1318},"obj":"NP"},{"id":"C20","span":{"begin":1346,"end":1355},"obj":"NP"},{"id":"C19","span":{"begin":1329,"end":1355},"obj":"NP"},{"id":"C21","span":{"begin":1427,"end":1436},"obj":"NP"},{"id":"C23","span":{"begin":1470,"end":1485},"obj":"NP"},{"id":"C22","span":{"begin":1443,"end":1485},"obj":"NP"},{"id":"C24","span":{"begin":1487,"end":1492},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C3"},{"id":"R4","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-relat","subj":"C10","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R9","pred":"coref-pron","subj":"C16","obj":"C18"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C5"},{"id":"R11","pred":"coref-ident","subj":"C20","obj":"C14"},{"id":"R12","pred":"coref-ident","subj":"C19","obj":"C15"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C20"},{"id":"R14","pred":"coref-ident","subj":"C23","obj":"C17"},{"id":"R15","pred":"coref-relat","subj":"C24","obj":"C22"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":46,"end":67},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":79,"end":101},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":118,"end":131},"obj":"protein_molecule"},{"id":"T4","span":{"begin":158,"end":171},"obj":"cell_type"},{"id":"T5","span":{"begin":211,"end":226},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":231,"end":254},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":263,"end":267},"obj":"protein_molecule"},{"id":"T8","span":{"begin":284,"end":291},"obj":"cell_type"},{"id":"T9","span":{"begin":303,"end":316},"obj":"protein_molecule"},{"id":"T10","span":{"begin":318,"end":322},"obj":"protein_molecule"},{"id":"T11","span":{"begin":355,"end":378},"obj":"other_name"},{"id":"T12","span":{"begin":384,"end":388},"obj":"protein_molecule"},{"id":"T13","span":{"begin":432,"end":436},"obj":"protein_molecule"},{"id":"T14","span":{"begin":455,"end":461},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":498,"end":533},"obj":"other_name"},{"id":"T16","span":{"begin":539,"end":545},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":581,"end":611},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":638,"end":644},"obj":"DNA_domain_or_region"},{"id":"T19","span":{"begin":725,"end":762},"obj":"protein_molecule"},{"id":"T20","span":{"begin":763,"end":770},"obj":"cell_type"},{"id":"T21","span":{"begin":772,"end":781},"obj":"protein_molecule"},{"id":"T22","span":{"begin":824,"end":835},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":835,"end":838},"obj":"protein_family_or_group"},{"id":"T24","span":{"begin":868,"end":877},"obj":"protein_molecule"},{"id":"T25","span":{"begin":901,"end":926},"obj":"other_name"},{"id":"T26","span":{"begin":949,"end":956},"obj":"cell_type"},{"id":"T27","span":{"begin":998,"end":1012},"obj":"other_name"},{"id":"T28","span":{"begin":1040,"end":1044},"obj":"protein_molecule"},{"id":"T29","span":{"begin":1120,"end":1129},"obj":"protein_molecule"},{"id":"T30","span":{"begin":1185,"end":1210},"obj":"other_name"},{"id":"T31","span":{"begin":1242,"end":1251},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1288,"end":1292},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1305,"end":1318},"obj":"other_organic_compound"},{"id":"T34","span":{"begin":1346,"end":1355},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1427,"end":1436},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1470,"end":1474},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1571,"end":1575},"obj":"protein_molecule"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":158,"end":171},"obj":"Body_part"},{"id":"T2","span":{"begin":211,"end":217},"obj":"Body_part"},{"id":"T3","span":{"begin":355,"end":367},"obj":"Body_part"},{"id":"T4","span":{"begin":508,"end":514},"obj":"Body_part"},{"id":"T5","span":{"begin":998,"end":1004},"obj":"Body_part"},{"id":"T6","span":{"begin":1069,"end":1075},"obj":"Body_part"},{"id":"T7","span":{"begin":1185,"end":1191},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.\nActivation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation. The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals. The CD28RE sequence reveals similarity to the consensus kappaB binding motif. Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members. Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling. Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35. These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction. Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35. Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression."}