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PubMed:8625287 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-52 Sentence denotes Lack of p16/CDKN2 alterations in thyroid carcinomas.
TextSentencer_T2 53-316 Sentence denotes Exons 1-3 of the p16/CDKN2 gene and exons 4-9 of the p53 gene were screened for mutations by single-strand conformation polymorphism (SSCP) analysis and direct sequencing of PCR-amplified DNA from human primary thyroid carcinomas and thyroid carcinoma cell lines.
TextSentencer_T3 317-510 Sentence denotes The samples included 21 papillary carcinomas, 2 undifferentiated carcinomas, 1 follicular carcinoma, 1 medullary carcinoma and 2 cell lines originating from thyroid undifferentiated carcinomas.
TextSentencer_T4 511-623 Sentence denotes No homozygous deletions and mutations in the p16/CDKN2 were observed in any of the primary tumors or cell lined.
TextSentencer_T5 624-744 Sentence denotes In contrast, one of the two undifferentiated carcinomas an both cell lines demonstrated point mutations in the p53 gene.
TextSentencer_T6 745-961 Sentence denotes These results that p16/CDKN2 gene alteration is not required for malignant transformation in the thyroid, while p53 gene mutations may play a role in the progression from differentiated to undifferentiated carcinoma.
T1 0-52 Sentence denotes Lack of p16/CDKN2 alterations in thyroid carcinomas.
T2 53-316 Sentence denotes Exons 1-3 of the p16/CDKN2 gene and exons 4-9 of the p53 gene were screened for mutations by single-strand conformation polymorphism (SSCP) analysis and direct sequencing of PCR-amplified DNA from human primary thyroid carcinomas and thyroid carcinoma cell lines.
T3 317-510 Sentence denotes The samples included 21 papillary carcinomas, 2 undifferentiated carcinomas, 1 follicular carcinoma, 1 medullary carcinoma and 2 cell lines originating from thyroid undifferentiated carcinomas.
T4 511-623 Sentence denotes No homozygous deletions and mutations in the p16/CDKN2 were observed in any of the primary tumors or cell lined.
T5 624-744 Sentence denotes In contrast, one of the two undifferentiated carcinomas an both cell lines demonstrated point mutations in the p53 gene.
T6 745-961 Sentence denotes These results that p16/CDKN2 gene alteration is not required for malignant transformation in the thyroid, while p53 gene mutations may play a role in the progression from differentiated to undifferentiated carcinoma.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 768-773 gene:1017 denotes CDKN2
T1 934-960 disease:C0205698 denotes undifferentiated carcinoma
T2 768-773 gene:1029 denotes CDKN2
T3 934-960 disease:C0205698 denotes undifferentiated carcinoma
T4 857-860 gene:7157 denotes p53
T5 934-960 disease:C0205698 denotes undifferentiated carcinoma
R1 T0 T1 associated_with CDKN2,undifferentiated carcinoma
R2 T2 T3 associated_with CDKN2,undifferentiated carcinoma
R3 T4 T5 associated_with p53,undifferentiated carcinoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8625287-1#53#56#gene7157 106-109 gene7157 denotes p53
8625287-1#211#229#diseaseC0549473 264-282 diseaseC0549473 denotes thyroid carcinomas
8625287-1#234#251#diseaseC0549473 287-304 diseaseC0549473 denotes thyroid carcinoma
8625287-5#112#115#gene7157 857-860 gene7157 denotes p53
8625287-5#189#215#diseaseC0205698 934-960 diseaseC0205698 denotes undifferentiated carcinoma
53#56#gene7157211#229#diseaseC0549473 8625287-1#53#56#gene7157 8625287-1#211#229#diseaseC0549473 associated_with p53,thyroid carcinomas
53#56#gene7157234#251#diseaseC0549473 8625287-1#53#56#gene7157 8625287-1#234#251#diseaseC0549473 associated_with p53,thyroid carcinoma
112#115#gene7157189#215#diseaseC0205698 8625287-5#112#115#gene7157 8625287-5#189#215#diseaseC0205698 associated_with p53,undifferentiated carcinoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1674 12-17 gene:1017 denotes CDKN2
T1675 33-51 disease:C0549473 denotes thyroid carcinomas
R1 T1674 T1675 associated_with CDKN2,thyroid carcinomas
R2 T1674 T1675 associated_with CDKN2,thyroid carcinomas